College of Arts & Sciences Biology

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Cliff Summers

Cliff H Summers
Professor
Biology, College of Arts & Sciences
UCL Churchill-Haines Labs 168F
Phone: 605-677-6177
Research Interests:
Our laboratory focuses on the impact of social and environmental stressors on molecular, neural and endocrine responses to influence adaptive behavior and activities like learning, coping, developing social rank relationships, biological rhythms, reproduction, and social interaction. Of special interest are how and why individuals differ, and how responses are characterized temporally. The investigations include the connection between molecular, neural and endocrine responses and variability in the magnitude and way in which individuals respond to and cope with stress behaviorally. We have recently developed a new model that includes aggression, learned escape and conditioned submission. We are interested in elucidating the mechanisms by which experience modulates the responsiveness of neural and hormonal stress responses. We think it is important to relate molecular genetics, physiology and anatomy to behavior, ecology and evolution.
Education:
  • Ph D, Endocrinology, University of Colorado, 1987
  • MA, Reproductive Biology, University of Colorado, 1982
  • BS, Wildlife Biology, Colorado State University, 1978
Grants:
  • DISSERTATION RESEARCH: A New Model of Fear Conditioning , National Science Foundation, (2009 - 2010)
  • Neural Sensitivity to Stress During Drug Withdrawl, NIH, (2005)
  • Stress - Is it More than a Disease , National Institutes of Health, (2000 - 2001)
  • Stress - Is it More than a Disease? A Comparative Look at Stress and Adaptation, National Science Foundation, (2000 - 2001)
  • Neural Mechanisms of Adaptive Behavior, NIH, (2005 - 2010)
Publications:
  • Arendt, D. H., Hassell, J., Li, H., Achua, J. K., Guarnieri, D. J., DiLeone, R. J., Ronan, P., Summers, C., (2014), Anxiolytic function of the orexin 2/hypocretin A receptor in the basolateral amygdala, Psychoneuroendocrinology, vol. 40, p. 17—26. (DOI: http://dx.doi.org/10.1016/j.psyneuen.2013.10.010)
  • Ricci, L., Summers, C., Larson, E. T., O'Malley, D., Melloni, R. H., (2013), Development of aggressive phenotypes: Interactions of age, experience, and social status, Animal Behaviour, vol. 86, pp. 245-252 . (DOI: http://dx.doi.org/10.1016/j.anbehav.2013.04.011)
  • Blanchard, D. C., Summers, C., Blanchard, R. J., (2013), The role of behavior in translational models for psychopathology: Functionality and dysfunctional behaviors, Neuroscience and Biobehavioral Reviews , vol. 37, pp. 1567-1577. (DOI: http://dx.doi.org/10.1016/j.neubiorev.2013.06.008)
  • Arendt, D. H., Ronan, P., Oliver, K. D., Callahan, L. B., Summers, T. R., Summers, C., (2013), Depressive behavior and activation of the orexin/hypocretin system, Behavioral Neuroscience, vol. 127, pp. 86-94. (DOI: 10.1037/a0031442)
  • Arendt, D. H., Smith, J. P., Bastida, C. C., Prasad, M., Oliver, K. D., Eyster, K., Summers, T. R., Delville, Y., Summers, C., (2012), Contrasting hippocampal and amygdalar expression of genes related to neural plasticity during escape from social aggression, Physiology and Behavior, vol. 107, pp. 670-679 .
  • Sørensen, C., Nilsson, G. E., Summers, C., Øverli, Ø., (2012), Social stress reduces forebrain cell proliferation in rainbow trout (Oncorhynchus mykiss), Behavioural Brain Research, vol. 227, p. 311–318 .
  • Ronan, P. J., Summers, C., (2011), Molecular signaling and translational significance of the corticotropin releasing factor system , Academic Press, vol. 98 The Brain as a Drug Target, pp. 235 - 292.
  • Clotfelter , E., McNitt, M. M., Carpenter, R. E., Summers, C., (2010), Modulation of monoamine neurotransmitters in fighting fish Betta splendens exposed to waterborne phytoestrogens, Fish Physiology and Biochemistry, vol. 36, iss. published online, p. 933–943. (DOI: 10.1007/s10695-009-9370-2)
  • Ling, T. J., Summers, C., Renner, K., Watt, M., (2010), Opponent recognition and social status differentiate rapid neuroendocrine responses to social challenge, Physiol Behav, vol. 99, pp. 571-578.
  • Waters, R. P., Renner, K., Summers, C., Watt, M., Forster, G., Koch, L. G., Britten, S. L., Swallow, J., (2010), Selection for intrinsic endurance modifies endocrine stress responsiveness , Brain Research, vol. 1357, pp. 53 - 61.
  • Tokarz, R. R., Summers, C., (2010), Stress and Reproduction in Reptiles In Hormones and Reproduction of Vertebrates, Elsevier, vol. 3, pp. 169 - 213.
  • Carpenter, R. E., Korzan, W. J., Bockholt, C., Watt, M. J., Forster, G. L., Renner, K. J., Summers, C., (2009), Corticotropin releasing factor influences aggression and monoamines: Modulation of attacks and retreats, Neuroscience , vol. 158, p. 412–425.
  • Lukkes, J. L., Summers, C., Scholl, J. L., Renner, K. J., Forster, G. L., (2009), Early life social isolation alters corticotropin-releasing factor responses in adult rats, Neuroscience, vol. 158, p. 845–855.
  • Lowry, C. A., Hale, M. W., Plant, A., Windle, R. J., Shanks, N., Woods, S. A., Renner, K., Lightman, S. L., Summers, C., (2009), Fluoxetine inhibits corticotropin-releasing factor (CRF)-induced behavioral activation: evidence for convergent actions on an emotional motor system, Stress, vol. 12, pp. 225-239.
  • Lowry, C. A., Hale, M. W., Plant, A., Windle, R. J., Shanks, N., Wood, S. A., Ingram, C. D., Renner, K. J., Lightman, S., Summers, C., (2009), Fluoxetine inhibits corticotropin-releasing factor (CRF)-induced behavioural responses in rats, Stress, vol. 12, pp. 225-239.
  • Carpenter, R. E., Summers, C., (2009), Learning strategies during fear conditioning, Neurobiol Learn Mem, vol. 91, pp. 415-423.
  • Shaw, J. C., Korzan, W. J., Carpenter, R. E., Kuris, A. M., Lafferty, K. D., Summers, C., Øverli, Ø., (2009), Parasite manipulation of brain monoamines in California killifish (Fundulus parvipinnis) by the trematode Euhaplorchis californiensis, Proc R Soc B, vol. 276, pp. 1137-1146.
  • Lorenzi, V., Carpenter, R. E., Summers, C., Earley, R. L., Grober, M. S., (2009), Serotonin, social status and sex change in the bluebanded goby Lythrypnus dalli, Physiol Behav, vol. 97, p. 476–483.
  • Ling, T. J., Forster, G. L., Watt, M. J., Korzan, W. J., Renner, K. J., Summers, C., (2009), Social status differentiates rapid neuroendocrine responses to restraint stress, Physiol Behav, vol. 96, pp. 218-232.
  • Carpenter, R. E., Sabirzhanov, B., Clark, T. G., Summers, C., (2009), Oncorhynchus mykiss brain derived neurotrophic factor (BDNF) mRNA, partial coding sequences; bases 1-747 , GenBank/National Center for Biotechnology Information, U.S. National Library of Medicine , p. GU108576.1 .
  • Carpenter, R. E., Sabirzhanov, B., Clark, T. G., Summers, C., (2009), Oncorhynchus mykiss Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mRNA, partial coding sequences; bases 1-747 , GenBank/National Center for Biotechnology Information, U.S. National Library of Medicine , p. GU108575.1 .
  • Carpenter, R. E., Sabirzhanov, B., Clark, T. G., Summers, C., (2009), Oncorhynchus mykiss a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR1 subunit (GluR1) mRNA, partial coding sequences; bases 1-747 , GenBank/National Center for Biotechnology Information, U.S. National Library of Medicine , p. GU108574.1 .
  • Carpenter, R. E., Sabirzhanov, B., Clark, T. G., Summers, C., (2009), Oncorhynchus mykiss a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluR2b subunit (GluR2b) mRNA, partial coding sequences; bases 1-747 , GenBank/National Center for Biotechnology Information, U.S. National Library of Medicine , p. GU108573.1 .
  • Ling, T. J., Watt, M., Forster, G., Korzan, W. J., Renner, K., Summers, C., (2009), Social status differentiates rapid neuroendocrine responses to restraint stress, Physiology and Behavior, vol. 96, pp. 218-232.
  • Carpenter, R. E., Korzan, W. J., Bockholt, C., Watt, M., Forster, G., Renner, K., Summers, C., (2009), Corticotropin releasing factor influences aggression and monoamines:, Neuroscience, vol. 158, pp. 412-425.
  • Forster, G., Pringle, R. B., Mouw, N. J., Vuong, S. M., Watt, M., Burke, A. R., Lowry, C. A., Summers, C., Renner, K., (2008), Corticotrophin-releasing factor in the dorsal raphe increases medial prefrontal cortical serotonin via type 2 receptors and median raphé activity, European Journal of Neuroscience, vol. 28, pp. 299-310.
  • Lukkes, J. L., Forster, G. L., Renner, K. J., Summers, C., (2008), Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens, vol. 578, pp. 185-193.
  • Waters, R. P., Renner, K., Pringle, R. B., Summers, C., Britton, S. L., Koch, L. G., Swallow, J., (2008), Selection for aerobic capacity affects corticosterone, monoamines and wheel-running activity, Physiology & Behavior, vol. 93, pp. 1044-1054.
  • Ronan, P., Gaikowski, M. P., Hamilton, S. J., Buhl, K. J., Summers, C., (2007), Ammonia causes decreased brain monoamines in fathead minnows (Pimephales promelas), Brain Research, vol. 1147, pp. 184-191.
  • Korzan, W. J., Summers, C., (2007), Behavioral diversity and neurochemical plasticity: Selection of stress coping strategies that define social status, Brain, Behavior and Evolution, vol. 70, pp. 257-266.
  • Carpenter, R. E., Watt, M., Forster, G., Øverli, Ø., Bockholt, C., Renner, K., Summers, C., (2007), Corticotropin releasing factor induces anxiogenic locomotion in trout and alters serotonergic and dopaminergic activity, Hormones and Behavior, vol. 52, pp. 600-611.
  • Øverli , Ø., Sørensen, C., Pulman, K. G., Pottinger, T. G., Korzan, W. J., Summers, C., Nilsson, G., (2007), Evolution of stress coping styles: Relationships between physiological, behavioural and cognitive traits in non-mammalian vertebrates, Neuroscience and Biobehavioral Reviews , vol. 31, pp. 396-412.
  • Korzan, W. J., Höglund, E., Watt, M., Forster, G., Øverli, Ø., Lukkes, J. L., Summers, C., (2007), Memory of opponents is more potent than visual sign stimuli after social hierarchy has been established, Behavioural Brain Research, vol. 183, pp. 31-42.
  • Anderson, W., Summers, C., (2007), Neuroendocrine mechanisms, stress coping strategies, and social dominance: Comparative lessons about leadership potential, Annals American Academy of Political and Social Sciences , vol. 614, pp. 102-130.
  • Clotfelter , E., O"Hare, E. P., McNitt, M. M., Carpenter, R. E., Summers, C., (2007), Pharmacological manipulation of the serotonergic system affects aggressive behavior and brain monoamine levels in the fighting fish Betta splendens, Pharmacology, Biochemistry and Behavior , vol. 87, pp. 222-231.
  • Watt, M., Forster, G., Korzan, W. J., Renner, K., Summers, C., (2007), Rapid neuroendocrine responses evoked at the onset of social challenge, Physiology and Behavior, vol. 90, pp. 567-575.
  • Sørensen , C., Øverli, Ø., Summers, C., Nilsson , G., (2007), Social regulation of neurogenesis in teleosts, Brain,Behavior and Evolution, vol. 70, pp. 239-246.
  • Forster, G., Feng, N., Watt, M., Korzan, W. J., Mouw, N. J., Summers, C., Renner, K., (2006), Corticotropin-releasing factor in the dorsal raphe elicits temporally distinct serotonergic responses in the limbic system , Neuroscience , vol. 141, pp. 1047-1055.
  • Korzan, W. J., Øverli, Ø., Summers, C., (2006), Future social rank: Forecasting status in the green anole (Anolis carolinensis), Acta Ethologica, vol. 9, pp. 48-57.
  • Summers, C., Winberg, S., (2006), Interactions between the neural regulation of stress and aggression, Journal of Experimental Biology, vol. 209, pp. 4581 - 4589.
  • Jones, R. E., Lopez, K. H., Austin, H. B., Orlicky, D. J., Summers, C., (2006), Uterine motility in the reptile Anolis carolinensis: Interactive effects of tension, prostaglandins, calcium and vasotocin, Journal of Experimental Zoology, vol. 305A, pp. 1030 - 1040.
  • Waters, R. P., Emerson, A. J., Watt, M., Forster, G., Swallow, J., Summers, C., (2005), Stress induces rapid changes in central catecholaminergic activity in Anolis carolinensis: Restraint and forced physical activity. , Brain Research Bulletin, vol. 67, pp. 210-218.
  • Summers, C., Austin, H. B., Jones, R. E., (1985), Induction of oviposition in cycling Anolis carolinensis requires a ??-adrenoreceptor blocker and a high dosage of AVT. , General and Comparative Endocrinology, vol. 57, pp. 389-392.
  • Jones, R. E., Summers, C., (1984), Compensatory follicular hypertrophy during the ovarian cycle of the house gecko, Hemidactylus frenatus., Anatomical Record, vol. 209, pp. 59-65.
  • Summers, C., (1984), Compensatory testicular hypertrophy in the lizard Anolis carolinensis, Journal of Experimental Zoology, vol. 231, pp. 101-107.
  • Jones, R. E., Austin, H. B., Summers, C., (1984), Spontaneous rhythmic contractions of the ovarian follicular wall of a lizard (Anolis carolinensis), General and Comparative Endocrinology, vol. 56, pp. 252-257.
  • Jones, R. E., Summers, C., Lopez, K. H., (1983), Adrenergic inhibition of uterine contractions and oviposition in the lizard Anolis carolinensis, General and Comparative Endocrinology, vol. 51, pp. 77-83.
  • Jones, R. E., Summers, C., Austin, H. B., Smith, H. M., Gleeson, T. T., (1983), Ovarian, oviductal, and adrenal vascular connections in female lizards (genus Anolis), Anatomical Record, vol. 206, pp. 247-255.
  • Jones, R. E., Guillette, L. J., Summers, C., Tokarz, R. R., Crews, D., (1983), The relationship among ovarian condition, steroid horomones, and estrous behavior in Anolis carolinensis, Journal of Experimental Zoology, vol. 227, pp. 145-154.
Awards and Honors:
  • 100 peer-reviewed publications, 2013
  • Fellow, International Behavioral Neuroscience Society, 2013
  • Belbas-Larson Award for Excellence in Teaching , University of South Dakota, 2012
  • Belbas-Larson Award for Excellence in Teaching , University of South Dakota, 1995
  • Honors in Natural Resources - Wildlife Biology, Xi Sigma Pi - Omicron Chapter Colorado State University, 1977
Presentations:
  • Arendt, D. H., Hassell, J., Li, H., Achua, J. K., Guarnieri, D. J., DiLeone, R. J., Ronan, P., Summers, C. (2013, November). An anxiolytic role for the orexin 2/hypocretin A receptor in the basolateral amygdala. Presented at the Society for Neuroscience 43nd annual Meeting, San Diego, CA.
  • Smith, J. P., Achua, J. K., Callahan, L. B., Ronan, P., Summers, T. R., Summers, C. (2013, November). Patterns of neural and behavioral change during subsequent novel aggression. Presented at the Society for Neuroscience 43nd annual Meeting, San Diego, CA.
  • Arendt, D. H., Oliver, K. D., Goetz, R. A., Callahan, L. B., Summers, T. R., Ronan, P., Summers, C. (2012, October). Mapping orexin/hypocretin signaling in depression. Presented at the Society for Neuroscience 42nd annual Meeting, New Orleans, LA.
  • Smith, J. P., Ronan, P., Summers, T. R., Summers, C. (2012, October). Amygdalar gene expression following stressful social decision making. Presented at the Society for Neuroscience 42nd annual Meeting, New Orleans, LA.
  • Arendt, D. H., Kalkman, K. L., Callahan, L. B., Summers, C., Ronan, P. (2012, October). Evidence for cross-talk between corticotropin releasing factor and orexin/hypocretin systems. Presented at the Society for Neuroscience 42nd annual Meeting, New Orleans, LA.
  • Smith, J. P., Arendt, D. H., Bastida, C. C., Delville, Y., Summers, C. (2012, June). Amygdala vs hippocampus: inverse relationships in plasticity during social escape in hamsters. Presented at the Society for Behavioral Neuroendocrinology 16th annual Meeting, Madison WI.
  • Summers, C. (2012, June). Choices in Social Adaptation to Aggression: Neuromodulatory Mechanisms in Decision Making. Presented at the International Behavioral Neuroscience Society 21st annual meeting - Symposium on: Aggression, neuromodulation, and social adaptation: Lessons from multiple animal models , Kailua-Kona, HI .
  • Arendt, D. H., Oliver, K. D., Summers, C. (2012, June). Local orexinergic activation and the influence on the forced swim test. Presented at the International Behavioral Neuroscience Society 21st annual meeting, Kailua-Kona, HI .
  • Summers, T. R., Rasmussen, T. L., Carpenter, R. E., Smith, J. P., Arendt, D. H., Summers, C. (2011, November). Plasticity resulting from aggression-induced social choice in Rainbow trout. Presented at the Society for Neuroscience 41st annual Meeting, Washington, DC.
  • Smith, J. P., Arendt, D. H., Bastida, C. C., Summers, T. R., Delville, Y., Summers, C. (2011, November). Amygdala vs hippocampus: Inverse relationships in plasticity during social escape in hamsters . Presented at the Society for Neuroscience 41st annual Meeting, Washington, DC.
  • Arendt, D. H., Smith, J. P., Rasmussen, T. L., Callahan, L. B., Tschetter, K. E., Oliver, K., Summers, T. R., Ronan, P., Summers, C. (2011, November). Forced swim test affects orexinergic activity in the lateral hypothalamus . Presented at the Society for Neuroscience 41st annual Meeting, Washington, DC.
  • Smith, J. P., Arendt, D. H., Bastida, C. C., Rasmussen, T. L., Summers, T. R., Delville, Y., Summers, C. (2011, May). Anxiety is alleviated by escape from social aggression in hamsters. Presented at the International Behavioral Neuroscience Society 20th annual Meeting, Steamboat Springs, CO.
  • Arendt, D. H., Smith, J. P., Bastida, C. C., Prasad, M., Rasmussen, T. L., Summers, T. R., Delville, Y., Summers, C. (2011, May). Hippocampal gene expression during escape from social aggression in hamsters. Presented at the International Behavioral Neuroscience Society 20th annual Meeting, Steamboat Springs, CO.
  • Rasmussen, T. L., Summers, T. R., Carpenter, R. E., Smith, J. P., Arendt, D. H., Summers, C. (2011, May). Social decision making drives behavioral and neural plasticity during learned escape . Presented at the International Behavioral Neuroscience Society 20th annual Meeting, Steamboat Springs, CO.
  • Arendt, D. H., Smith, J. P., Bastida, C. C., Prasad, M., Rasmussen, T. L., Oliver, K., Carpenter, R. E., Eyster, K., Summers, T. R., Delville, Y., Summers, C. (2010, November). BDNF and escape from social aggression in hamsters . Presented at the Society for Neuroscience 40th annual Meeting, San Diego, CA.
  • Summers, C., Øverli, Ø., Sørensen, C., Nilsson, G. E. (2010, July). Sex-related differences in aggressive behavior and stress-coping in rainbow trout. Presented at the 9th Internat Cong Biol Fish, Barcelona, Spain.
  • Summers, C. (2010, January). Regulation of Social Stress, Learning and Choice . Presented at the Educational Meeting for USFWS members on USD Trout Research, Gavins Point National Fish Hatchery.
  • Summers, C. (2009, June). Social Stress, Learning and Choice. Presented at the Social modulation of hormones, brain and behaviour: integrating mechanisms and function, Lisbon, Portugal.
  • Summers, C. (2009, January). Center for Neural Mechanisms of Adaptive Behavior.