College of Arts & Sciences Biology

You are here:

Kenneth Renner

Ken Renner
Professor
Biology, College of Arts & Sciences
UCL Churchill-Haines Labs 188
Phone: 605-677-6629
Education:
  • Postdoctoral Research Scientist, Analytical Chemistry, University of Kansas, 1987
  • Postdoctoral Fellow, Neuroendocrinology, Rockefeller University, 1984
  • Ph D, Neuroendocrinology, University of Kansas, 1982
  • MS, Zoology, Emporia State University, 1978
  • BS, Biology/Chemistry, Southwestern College, 1976
Grants:
  • Neural Mechanisms Underlying an Aggresive Syndrome in Stalk-eyed Flies, NSF, (2013 - 2016)
  • Neural Sensitivity to Stress During Drug Withdrawal, NIH/NIDA , (2005 - 2010)
  • SPURA - Summer Program for Undergraduate Research in Addiction, NIH NIDA, (2013 - 2018)
  • R15 - Adolescent social stress, cortical dopamine and drug susceptibility, NIDA, (2014 - 2017)
  • IOS - Disruption to cortical dopamine systems following adolescent social stress, NSF, (2013 - 2016)
  • Supplement - Neural Sensitivity to Stress During Drug Withdrawal, NIH/NIDA, (2012 - 2013)
  • Trajectory of alterations to cortical dopamine activity in a model of teenage bullying., Joseph F. Nelson and Martha P. Nelson Faculty Research Grant, (2011 - 2012)
  • R01 - Neural sensitivity to stress during drug withdrawal , NIH, (2011 - 2016)
  • Collaborative Research: Novel Corticosterone Actions on Neurotransmitter Function, NSF, (2009 - 2014)
Publications:
  • Bubak, A. N., Grace, J. L., Watt, M., Renner, K., Swallow, J. G., (2014), Neurochemistry as a bridge between morphology and behavior: perspectives on aggression in insects., Current Zoology, vol. 60, pp. 778-790.
  • Stamper, C. E., Hennessey, P. A., Hale, M. W., Lukkes, J. L., Donner, N. C., Lowe, K. R., Paul, E. D., Spencer, R. L., Renner, K., Orchinik, M., Lowry, C. A., Role of the dorsomedial hypothalamus in glucocorticoid-mediated fast feedback inhibition of the hypothalamic-pituitary-adrenal axis, Stress.
  • Li, H., Scholl, J., Tu, W., Hassell, J., Watt, M., Forster, G., Renner, K., (2014), Serotonergic responses to stress are enhanced in the central amygdala and inhibited in the ventral hippocampus during amphetamine withdrawal., European Journal of Neuroscience, vol. 40, pp. 3684-3692.
  • Tu, W., Cook, A., Scholl, J., Mear, M., Watt, M., Renner, K., Forster, G., (2014), Serotonin in the ventral hippocampus modulates anxiety-like behavior during amphetamine withdrawal, Neuroscience, vol. 281, pp. 35-43.
  • Bubak, A. N., Renner, K., Swallow, J. G., (2014), Heightened serotonin influences contest outcome and enhances expression of high-intensity aggressive behaviors, Behavioural Brain Research, vol. 219, pp. 124-130.
  • Watt, M., Roberts, C. L., Scholl, J. L., Meyer, D. L., Miiller, L. C., Barr, J. L., Novick, A. M., Renner, K., Forster, G., (2014), Decreased prefrontal cortex dopamine activity following adolescent social defeat in male rats: role of dopamine D2 receptors., Psychopharmacology, vol. 231, pp. 1627-36. (DOI: DOI 10.1007/s00213-013-3353-9)
  • Zhao, Z., Liu, X., Jeffry, J., Karunarathne, W. K., Li, J., Munanaire, A., Zhou, X., Li, H., Sun, Y., Li, W., Wu, Z., Kim, S., Hua, F., Mo, P., Barry, D. M., Zhang, C., Kim, J., Gautam, N., Renner, K., Li, Y., Chen, Z., (2014), Descending control of itch transmission by serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling, Neuron, vol. 84, pp. 821-834.
  • Waters, R. P., Pringle, R. B., Forster, G. L., Renner, K., Malisch, J. L., Garland, T., Swallow, J., (2013), Effects of selection for increased voluntary wheel running on behavioral activity, plasma corticosterone and brain monoamines in mice, Brain Research, vol. 1508, pp. 9-22.
  • Barr, J., Scholl, J., Solanki, R., Watt, M., Lowry, C., Renner, K., Forster, G., (2013), Influence of chronic amphetamine treatment and acute withdrawal on serotonin synthesis and clearance mechanisms in the rat ventral hippocampus, European Journal of Neuroscience, vol. 37, pp. 479-90.
  • Bubak, A. N., Swallow, J. G., Renner, K., (2013), Whole brain monoamine detection and manipulation in a stalk-eyed fly, Journal of Neuroscience Methods , vol. 124, pp. 124-130.
  • Xie, K., Ge, S., Collins, V. E., Haynes, C. L., Renner, K., Meisel, R., Lujan, R., Martemyanov, K. A., (2012), Gß5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems, Psychoparmacology, vol. 219, pp. 823-834.
  • Haukenes, A. H., Barton, B. A., Renner, K., (2011), Plasma cortisol and hypothalamic monoamine responses in Yellow Perch Perca flavescens after intraperitoneal injection of lipopolysaccharide, Fish Physiology and Biochemistry, vol. 37, pp. 425-432.
  • Burke, A. R., Renner, K., Forster, G., Watt, M., (2010), Adolescent social defeat alters neural, endocrine and behavioral responses to amphetamine in adult male rats, Brain Research, vol. 1352, pp. 147-156.
  • Scholl, J. L., Renner, K., Forster, G., Tejani-Butt, S., , (2010), Central monoamine levels differ between rat strains used in studies of depressive behavior, Brain Research, vol. 1355, pp. 41-51.
  • Watt, M., Roberts, C., Renner, K., Scholl, J., Haaland, E., Forster, G., (2010), Mechanisms and consequences of disrupting cortical dopamine activity during adolescence, Neuroscience Abstracts, p. 125.
  • Ling, T. J., Summers, C., Renner, K., Watt, M., (2010), Opponent recognition and social status differentiate rapid neuroendocrine responses to social challenge, Physiol Behav, vol. 99, pp. 571-578.
  • Feng, N., Lowry, C. A., Lukkes, J. L., Orchinik, M., Forster, G., Renner, K., (2010), Organic cation transporter inhibition increases medial hypothalamic serotonin under basal conditions and during mild restraint, Brain Research, vol. 1326, pp. 105-113.
  • Waters, R. P., Renner, K., Summers, C., Watt, M., Forster, G., Koch, L. G., Britten, S. L., Swallow, J., (2010), Selection for intrinsic endurance modifies endocrine stress responsiveness , Brain Research, vol. 1357, pp. 53 - 61.
  • Swallow, J., Wroblewska, A. K., Waters, R. P., Renner, K., Britton, S. L., Koch, L. G., (2010), Self-induced adaptive plasticity for energy expenditure greater than evolutionary plasticity in rats selectively bred for high intrinsic endurance capacity, Journal of Applied Physiology , iss. 109, pp. 778-785.
  • Barr, J. L., Renner, K., Forster, G., (2010), Withdrawal from Chronic Amphetamine Produces Persistent Anxiety-like Behavior but Temporally-Limited Reductions in Monoamines and Neurogenesis in the Adult Rat Dentate Gyrus, Neuropharmacology.
  • Watt, M., Burke, A., Renner, K., Forster, G., (2009), Adolescent male rats exposed to social defeat exhibit altered anxiety behaviour and limbic monoamines as adults., Behavioral Neuroscience, iss. 123, pp. 564-576.
  • Lukkes, J., Summer, C., Scholl, J., Renner, K., Forster, G., (2009), Early life social isolation alters corticotropin-releasing factor responses in adult rats., Neuroscience, iss. 158, pp. 845-855.
  • Lowry, C. A., Hale, M. W., Plant, A., Windle, R. J., Shanks, N., Woods, S. A., Renner, K., Lightman, S. L., Summers, C., (2009), Fluoxetine inhibits corticotropin-releasing factor (CRF)-induced behavioral activation: evidence for convergent actions on an emotional motor system, Stress, vol. 12, pp. 225-239.
  • , , Watt, M., Renner, K., Forster, G., (2009), Individual differences in amphetamine sensitization, behaviour and central monoamines., Physiology and Behavior, iss. 96, pp. 493-504.
  • Feng, N., Lowry, C. A., Lukkes, J. L., Orchinik, M., Forster, G., Renner, K., (2009), Organic cation transporter block decynium 22 increases extracellular serotonin concentrations in the rat medial hypothalamus under basal and stress conditions., Society for Neuroscience Abstracts, iss. 134, p. 5.
  • Lowry, C. A., Hale, M. W., Burke, K. A., Renner, K., Moore, F. L., (2009), Fluoxetine potentiates the effects of corticotropin-releasing factor on locomotor activity and serotonergic systems in the roughskin newt, Taricha granulosa, Hormones and Behavior, vol. 56, pp. 177-184.
  • Feng, N., Telefont, M., Kelly, K., Orchinik, M., Forster, G., Renner, K., Lowry, C. A., (2009), Local perfusion of corticosterone in the rat medial hypothalamus potentiates D-fenfluramine-induced elevations of extracellular 5-HT concentrations, Hormones and Behavior, vol. 56, pp. 149-157.
  • Ling, T. J., Watt, M., Forster, G., Korzan, W. J., Renner, K., Summers, C., (2009), Social status differentiates rapid neuroendocrine responses to restraint stress, Physiology and Behavior, vol. 96, pp. 218-232.
  • Carpenter, R. E., Korzan, W. J., Bockholt, C., Watt, M., Forster, G., Renner, K., Summers, C., (2009), Corticotropin releasing factor influences aggression and monoamines:, Neuroscience, vol. 158, pp. 412-425.
  • Forster, G., Pringle, R. B., Mouw, N. J., Vuong, S. M., Watt, M., Burke, A. R., Lowry, C. A., Summers, C., Renner, K., (2008), Corticotrophin-releasing factor in the dorsal raphe increases medial prefrontal cortical serotonin via type 2 receptors and median raphé activity, European Journal of Neuroscience, vol. 28, pp. 299-310.
  • Waters, R. P., Renner, K., Pringle, R. B., Summers, C., Britton, S. L., Koch, L. G., Swallow, J., (2008), Selection for aerobic capacity affects corticosterone, monoamines and wheel-running activity, Physiology & Behavior, vol. 93, pp. 1044-1054.
  • Carpenter, R. E., Watt, M., Forster, G., Øverli, Ø., Bockholt, C., Renner, K., Summers, C., (2007), Corticotropin releasing factor induces anxiogenic locomotion in trout and alters serotonergic and dopaminergic activity, Hormones and Behavior, vol. 52, pp. 600-611.
  • Watt, M., Forster, G., Korzan, W. J., Renner, K., Summers, C., (2007), Rapid neuroendocrine responses evoked at the onset of social challenge, Physiology and Behavior, vol. 90, pp. 567-575.
  • Forster, G., Feng, N., Watt, M., Korzan, W. J., Mouw, N. J., Summers, C., Renner, K., (2006), Corticotropin-releasing factor in the dorsal raphe elicits temporally distinct serotonergic responses in the limbic system , Neuroscience , vol. 141, pp. 1047-1055.
Presentations:
  • Grace, J. L., Bubak, A. N., Watt, M., Renner, K., Swallow, J. G. (2014). The effect of heightened serotonin on aggression and mate choice in a sexually dimorphic species, Teleopsis dalmanni. Presented at the Front Range Neuroscience Group Annual Meeting, Fort Collins, CO.
  • Scholl, J., Tu, W., Cook, A., Watt, M., Renner, K., Forster, G. (2014). Serotonin in the ventral hippocampus modulates anxiety-like behavior during amphetamine withdrawal. Presented at the International Behavioral Neuroscience Society Annual Meeting, Las Vegas.
  • Grace, J. L., Bubak, A. N., Watt, M., Renner, K., Swallow, J. G. (2014). The effect of heightened serotonin on aggression and mate choice in a sexually dimorphic species, Teleopsis dalmanni. Presented at the International Society for Behavioral Ecology Congress, New York.
  • Solanki, R., Scholl, J., Watt, M., Renner, K., Forster, G. (2014). Amphetamine withdrawal alters the expression of organic cation transporter-3 in several limbic brain regions. Presented at the Society for Neuroscience Annual Meeting, Washington DC.
  • Scholl, J., Tu, W., Cook, A., Watt, M., Renner, K., Forster, G. (2014). Anxiety-like behavior in rats undergoing amphetamine withdrawal is modulated by serotonin in the ventral hippocampus. Presented at the Society for Neuroscience Annual Meeting, Washington DC.
  • Weber, M., Scholl, J., Forster, G., Renner, K., Watt, M. (2014). Changes to tyrosine hydroxylase activity in the adult medial prefrontal cortex following adolescent social defeat. Presented at the Society for Neuroscience Annual Meeting, Washington DC.
  • Bray, B., Scholl, J., Tu, W., Watt, M., Renner, K., Forster, G. (2014). Differential effects of amphetamine withdrawal on central and peripheral corticosterone levels in response to stress. Presented at the Society for Neuroscience Annual Meeting, Washington DC.
  • Rogers, J. T., Chiluwal, J., Buchanan, M. W., Renner, K. (2014, November). Organic cation 3 antagonist infusion into the mediobasal hypothalamus inhibits female sexual behavior. Presented at the Annual Faculty for Undergraduate Neuroscience Meeting, Washington, DC.
  • Bubak, A. N., Rieger, N. S., Watt, M., Renner, K., Swallow, J. G. (2014, November). David vs. Goliath: Heightened serotonin increases aggressive behavior in smaller competitors and influences the larger competitor’s fighting strategy. Presented at the Society for Neuroscience Annual Meeting, Washington DC.
  • Hassell, J. E., Li, H., Rogers, J. T., Ferrell, S., Orchinik, M., Lowry, C. A., Renner, K. (2014, November). Inhibition of organic cation transporter 3 (OCT3) in the central nucleus of the amygdala increases extracellular serotonin and reduces fear expression. Presented at the Society for Neuroscience Annual Meeting, Washington, DC.
  • Grace, J. L., Bubak, A. N., Watt, M., Renner, K., Swallow, J. G. (2014, October). All is NOT fair in love and war: the effects of heightened serotonin on aggression and mate choice in stalk-eyed flies.. Presented at the Department of Integrative Biology Seminar Series, Denver, CO.
  • Swallow, J. G., Bubak, A. N., Grace, J. L., Reiger, N. S., Renner, K. (2014, August). Neural mechanisms underlying aggression in stalk-eyed flies. Presented at the 8th International Congress of Dipterology, Potsdam, Germany.
  • Bubak, A., Renner, K., Swallow, J., Greene, M. (2014, July). Monoamines, individual decisions, and collective-organization of pavement ant wars. Presented at the 17th Congress of the International Union for the Study of Social Insects , Cairns, Australia.
  • Talboom, J. S., Molinero, J. C., Lowry, C. A., Renner, K., Orchinik, M. (2014, June). Resolving the transport kinetics of the corticosterone-sensitive organic cation transporter 3 (OCT3/Slc22a3) in the male rat brain. Presented at the 2014 Arizona Alzheimer’s Consortium Meeting, Phoenix, Arizona.
  • Renner, K. (2014, February). Organic Cation Transporters: Do they modulate rapid CNS responses to stress?. Presented at the Seminar presented to the Biology Department, Vermillion, SD.
  • Reiger, N. S., Bubak, A. N., Renner, K., Swallow, J. G. (2014, January). David vs. Goliath: Serotonin affects aggressive behaviors but not contest outcome of smaller competitors. Presented at the The Society for Integrative and Comparative Biology, Austin, Texas.
  • Scholl, J. L., Li, H., Tu, W., Hassell, J., Watt, M., Renner, K., Forster, G. (2013). Increased stress responsiveness associated with altered serotonergic and glucocorticoid function in the limbic system during amphetamine withdrawal .. Presented at the 43rd Annual Meeting of the Society for Neuroscience, San Diego, CA.
  • Watt, M., Miiller, L. C., Scholl, J. L., Renner, K., Novick, A. M., Forster, G. (2013). Trajectory of alterations to cortical dopamine activity in a model of teenage bullying .. Presented at the 43rd Annual Meeting of the Society for Neuroscience, San Diego, CA.
  • Talboom, J. S., Molinero, J., Lowry, C. A., Renner, K., Orchinik, M. (2013, November). Resolving the Transport Kinetics of the Corticosterone-Sensitive Organic Cation Transporter 3 (OCT3/Slc22a3) in the Male Rat Brain: In Vitro versus Ex Vivo. Presented at the 43rd Annual Meeting of the Society for Neuroscience, San Diego.
  • Stamper, C. E., Hennessey, P. A., Hale, M. W., Lukkes, J. L., Donner, N. C., Kenneth, L., Paul, E. D., Spencer, R. L., Renner, K., Orchinik, M., Lowry, C. A. (2013, November). Role of the dorsomedial hypothalamus in glucocorticoid-mediated fast feedback control of the hypothalamic-pituitary-adrenal axis. Presented at the 43rd Annual Meeting of the Society for Neuroscience , San Diego.
  • Tu, W., Scholl, J., Renner, K., Forster, G. (2013, November). Importance of Serotonin in the Ventral Hippocampus in Modulating Anxiety - like Behavior.. Presented at the Society for Neuroscience Undergraduate Poster Session, San Diego.
  • Bubak, A. N., Swallow, J. G., Renner, K. (2013, July). Serotonin as a mediator of aggression in a stalk-eyed fly. Presented at the Animal Behavior Society, Boulder, Colorado.
  • Rieger, N. S., Bubak, A. N., Hassell, J. E., Li, H., Renner, K., Swallow, J. G. (2012, October). Gender differences in serotonergic stress response in stalk-eyed flies(Teleopsis dalmanni). Presented at the Society for Neuroscience Annual Meeting, New Orleans.
  • Hassell, J. E., Collins, V. E., Austin, R. C., Viziteu, C., Li, H., Lowry, C. A., Orchinik, M., Renner, K. (2012, October). Intracranial delivery of corticosterone alters extracellular monoamine concentrations in dorsomedial hypothalamus and central nucleus of the amygdala under stress conditions. Presented at the Society for Neuroscience Annual Meeting, New Orleans.
  • Talboom, J. S., Molinero, J., Tompkins, H. C., Mumaw, L., Lowry, C. A., Renner, K., Orchinik, M. (2012, October). Localization of the corticosterone-sensitive organic cation transporter 3 (OCT3/Slc22a3) mRNA and protein in the male rat brain via in situ hybridization and immunohistochemistry. Presented at the Society for Neuroscience Annual Meeting, New Orleans.
  • Watt, M., Novick, A., Roberts, C., Meyer, D., Oliver, K., Scholl, J., Barr, J., Renner, K., Forster, G. (2012, October). Mechanisms underlying deficits in prefrontal cortex dopamine activity caused by adolescent social defeat . Presented at the Society for Neuroscience Annual Meeting, New Orleans.
  • Bubak, A. N., Swallow, J. G., Renner, K. (2012, October). Serotonin as a mediator of aggression in the stalk-eyed fly. Presented at the Society for Neuroscience Annual Meeting, New Orleans.
  • Li, H., Hassell, J., Scholl, J., Watt, M., Renner, K., Forster, G. (2012, October). Stress-induced increases in extracellular serotonin in the ventral hippocampus are attenuated in rats during amphetamine withdrawal. Presented at the Society for Neuroscience Annual Meeting, New Orleans.
  • Olson, D. M., Meyer, D. L., Scholl, J. L., Watt, M., Manzerra, P., Renner, K., Forster, G. (2012, October). Effects of Mild Traumatic Brain Injury and Psychosocial Stress on Limbic Monoamines and Anxiety-like Behaviors.. Presented at the Society for Neuroscience Meeting, New Orleans, LA.
  • Miiller, L., Scholl, J., Renner, K., Forster, G., Watt, M. (2012, October). Trajectory of alterations to cortical dopamine activity in a model of teenage bullying. Presented at the Society for Neuroscience Undergraduate Poster Session, New Orleans.
  • Stamper, C. E., Hennessey, P. A., Hale, M. W., Spencer, R. L., Renner, K., Orchinik, M., Lowry, C. A. (2012, June). Development of a model for investigation of mechanisms underlying glucocorticoid-mediated fast feedback control of the hypothalamic-pituitary-adrenal axis using restraint stress and an automated blood sampling system. Presented at the Neurobiology of Stress Workshop, Philadelphia, PA.
  • Lowe, K. R., Stamper, C. E., Hale, M. W., Spencer, R. L., Renner, K., Orchinik, M., Lowry, C. A. (2012, April). Automated blood sampling technology for investigation of mechanisms underlying glucocorticoid-mediated fast feedback control of the hypothalamic-pituitary-adrenal axis. Presented at the UROP/HHMI Poster Session, Boulder Colorado.
  • Li, H., Hassell, J. E., Barr, J. L., Scholl, J. L., Watt, M., Forster, G., Renner, K. (2012, April). Stress-induced increases in extracellular serotonin in the ventral hippocampus is attenuated in rats during amphetamine withdrawal. Presented at the South Dakota Academy of Science, Vermillion, SD.
  • Bubak, A. N., Swallow, J., Renner, K. (2012, January). Whole Brain Monoamine Detection and Manipulation in Stalk-eyed Flies. Presented at the Society of Integrative and Comparative Biology, Charleston, South Carolina.
  • Barr, J. L., Scholl, J. L., Lowry, C. A., Renner, K., Forster, G. L. (2011, November). Influence of chronic amphetamine treatment on serotonin reuptake in the rat ventral hippocampus. Presented at the Annual meeting for the Society for Neuroscience, Washington D.C..
  • Renner, K. (2011, November). Organic cation transporters in the brain: Do they contribute to the stress response?. Presented at the Invited seminar presented to ISU Biology Department, Pocatello, Idaho.
  • Molinero, J. C., Mumah, L., Barton, S., Orchinik, M., Lowry, C. A., Renner, K. (2010, November). Neuronal and glial localization of corticosterone-sensitive organic cation transporter 3 (OCT3) in hierarchical systems regulating the hypothalamic-pituitary-adrenal axis. Presented at the Annual meeting of the Society for Neuroscience, San Diego, CA.