College of Arts & Sciences Chemistry

David Hawkinson

David Hawkinson
Associate Professor
Chemistry, College of Arts & Sciences
UCL Churchill-Haines Labs 110
Phone: 605-677-6187
Teaching Interests:
Organic Chemistry: Physical Organic, Bioorganic, and Spectroscopy
Research Interests:
Organic Reaction Mechanisms, Bioorganic Chemistry
Education:
  • Ph D, Organic Chemistry, Northern Illinois University, 1988
  • BA, Chemistry, Augustana College, 1983
Publications:
  • Hawkinson, D., Ying, W., (2007), Relative Stabilities of Exocyclic, s-trans and Endocyclic, s-cis Dienolates: Enolization of 1-Decalenone, Journal of Organic Chemistry, vol. 72, pp. 3592-3595. (DOI: 10.1021/jo070068y)
  • Thornburg, L. D., Hénot, F., Bash, D. P., Hawkinson, D., Bartle, S. D., Pollack, R. M., (1998), Electrophilic Assistance by Asp-99 of 3-Oxo-Δ5-steroid Isomerase, Biochemistry, vol. 37, pp. 10499-10506. (DOI: 10.1021/bi980099a)
  • Hawkinson, D., Feiock, J. M., Nevy, J. B., Wu, Y., (1998), Enolization and Hydrolysis of 7-Nitroisochroman-3-one: Generation of a Relatively Stable Lactone Enolate, Journal of Organic Chemistry, vol. 63, pp. 5345-5349. (DOI: 10.1021/jo980032t)
  • Nevy, J. B., Hawkinson, D., Blotny, G., Yao, X., Pollack, R. M., (1997), Transition State Imbalance in the Deprotonation of Substituted 2-Tetralones by Hydroxide Ion, Journal of the American Chemical Society, vol. 119, pp. 12722-12726. (DOI: 10.1021/ja972600c)
  • Zawrotny, M. E., Hawkinson, D., Blotny, G., Pollack, R. M., (1996), Mechanism of Proton Transfer in the Isomerization of 5-Androstene-3,17-dione by 3-Oxo-Δ5-steroid Isomerase and its D38E Mutant, Biochemistry, vol. 35, pp. 6438-6442. (DOI: 10.1021/bi953025x)
  • Hawkinson, D., Pollack, R. M., Ambulos Jr., N. P., (1994), Evaluation of the Internal Equilibrium Constant for 3-Oxo-Δ5-steroid Isomerase Using the D38E and D38N Mutants: The Energetic Basis for Catalysis, Biochemistry, vol. 33, pp. 12172-12183. (DOI: 10.1021/bi00206a021)
  • Hawkinson, D., Pollack, R. M., (1993), Is a Proton Relay Involved in the Mechanism of 3-Oxo-Δ5-steroid Isomerase?, Biochemistry, vol. 32, pp. 694-698. (DOI: 10.1021/bi00053a038)
  • Hawkinson, D., Eames, T. C., Pollack, R. M., (1991), Energetics of 3-Oxo-Δ5-Steroid Isomerase: Source of the Catalytic Power of the Enzyme, Biochemistry, vol. 30, pp. 10849-10858. (DOI: 10.1021/bi00109a007)
  • Hawkinson, D., Eames, T. C., Pollack, R. M., (1991), Kinetic Competence of an Externally Generated Dienol Intermediate with Steroid Isomerase, Biochemistry, vol. 30, pp. 6956-6964. (DOI: 10.1021/bi00242a021)
  • Eames, T. C., Hawkinson, D., Pollack, R. M., (1990), Direct Determination of the Partitioning of an Enzyme-Bound Intermediate, Journal of the American Chemical Society, vol. 112, pp. 1996-1998. (DOI: 10.1021/ja00161a054)
  • Kevill, D. N., Adolf, H. R., Wang, A., Hawkinson, D., D'Souza, M. J., (1990), Perchlorate Esters. Part 9. Correlation of the Rates of Solvolysis of Methyl Perchlorate, Journal of the Chemical Society, Perkin Transactions II, pp. 2023-2028. (DOI: 10,1039/P29900002023)
  • Kevill, D. N., Hawkinson, D., (1990), Solvolysis of 1-Adamantyl Nitrate. A YONO2 Scale and Product Partitioning in Aqueous Ethanol, Journal of Organic Chemistry, vol. 55, pp. 5394-5399. (DOI: 10.1021/jo00306a018)
  • Kevill, D. N., Hawkinson, D., (1989), Correlation of the Rates of Solvolysis of 2-Adamantyl 2,2,2-Trifluoroethanesulfonate: A YOTr Scale, Journal of Organic Chemistry, vol. 54, pp. 154-158. (DOI: 10.1021/jo000262a035)
  • Hawkinson, D., Kevill, D. N., (1988), Studies of the Solvolysis of 2-Adamantyl Pentafluorobenzenesulfonate: A YPFBS Scale, Journal of Organic Chemistry, vol. 53, pp. 3857-3860 . (DOI: 10.1021/jo00251a039)
  • Kevill, D. N., Rissmann, T. J., Hawkinson, D., (1985), Preparation of Boron-Carbon Compositions by Chemical Vapor Deposition, Jet Propulsion Laboratory/NASA, vol. 1985.
Presentations:
  • Hawkinson, D. (2012, October). Reactivity of Esters with Anilinomagnesium Halides. Presented at the 47th Midwest Regional Meeting of the American Chemical Society, Omaha, NE.
  • Hawkinson, D., Furness, A. (2011, October). Studies of the Bodroux Reaction in Tetrahydrofuran. Presented at the 46th Midwest-39th Great Lakes Joint Regional Meeting of the American Chemical Society, Saint Louis, MO.
  • Hawkinson, D., May, S., Engebretson, D., Burum, B., Baride, A. (2010, October). Two‐photon uncaging of coumarin from cinnamate‐coated CdSe quantum dots as a model drug delivery system.. Presented at the 45th Midwest Regional Meeting of the American Chemical Society, Wichita, KS.