Brian Burrell

Brian Burrell

Associate Professor

BASIC BIOMEDICAL SCIENCES

Lee Medicine & Science Hall 266

Phone: (605) 658-6352

Email: Brian.Burrell@usd.edu

Website: http://sites.usd.edu/brian-burrell/

Teaching Interests:

Introduction to Neurobiology (BIOL 430/530) Medical Neuroscience (IMC 602) Neurobiology of Disease (NCSI 792)


Research Interests:

Neuroscience, specifically neuroplasticity related to pain signaling within the central nervous system. I am currently recruiting for graduate students to participate in an R01-funded research project on the role of endocannabinoids in pain-related sensitization and habituation. This project that will involve electrophysiological, behavioral and molecular biology approaches. Potential applicants can contact Dr. Burrell for more details (bburrell@usd.edu). Applications will be made through the USD Basic Biomedical Sciences graduate program. I highly value providing graduate training opportunities for students from diverse racial, ethnic, religious, gender, sexual orientation, and other cultural and social backgrounds. For the scientific enterprise to serve all members of our society, all members of our society must be involved in science.


Education:

  • Postdoctoral , Purdue University , 2004
  • Postdoctoral, University of Miami, 2001
  • Ph D, Ohio State University, 1995
  • BS, Ohio State University, 1990

Grants:

  • Center for Behavioral Health, South Dakota Governor's Office. Grant Role: Co-Principal. (2017 - 2022)
  • The University of South Dakota Neuroscience and Nanotechnology Network (USD-N3), NSF. Grant Role: Principal. (2016 - 2021)
  • Endovanilloid-Mediated Modulation and its Role in Habituation and Sensitization, NIH. Grant Role: Principal. (2016 - 2020)
  • Developing a full?sequence genome of the medicinal leech, USD Research. Grant Role: Principal. (2016 - 2017)
  • Consortium for Genetic Influences on Behavioral Health in South Dakota, South Dakota Governor's Office for Economic Development. Grant Role: Supporting. (2016 - 2017)
  • Developing a full?sequence genome of the medicinal leech, USD Center for Brain and Behavior Research. Grant Role: Principal. (2016 - 2017)
  • Manipulation of Neurotransmitter Signaling using Nano-Scale "Supercontainers", USD Center for Brain & Behavior Research. (2015 - 2016)
  • SPURA - Summer Program for Undergraduate Research in Addiction, NIH/NIDA. Grant Role: Co-Principal. (2013 - 2018)
  • SPURA - Summer Program for Undergraduate Research in Addiction, NIH/NIDA. Grant Role: Co-Principal. (2013 - 2018)
  • Endocannabinoid-Dependent Modulation of Nociceptive Synapses: Cellular properties and functional significance, NSF. (2011 - 2013)
  • Supplement to SD BRIN for undergraduate and high school researchers, NIH. Grant Role: Supporting. (2009 - 2010)

Publications:

Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

  • , Yanqing W., and Burrell, Brian. Differences in chloride gradients allow for three distinct types of synaptic modulation by endocannabinoids, 619-628. Vol. 116. Journal of Neurophysiology, 2016.
  • Summers, Torrie, Wang, Yanqing, , Brandon H., and Burrell, Brian. Physiological, Pharmacological, and Behavioral Evidence for a TRPA1 Channel That Can Elicit Defensive Responses in the Medicinal Leech, 3023-3031. Vol. 218. Journal of Experimental Biology, 2015. (DOI: 10.1242)
  • Wang, Yanqing, Summers, Torrie, Peterson, Warren, Miiller, Elly, and Burrell, Brian. Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses, 397-409. Vol. 298. Neuroscience, 2015. (DOI: 10.1016)
  • Hahn, Elizabeth, and Burrell, Brian. Pentylenetetrazol-induced seizure-like behavior and neural hyperactivity in the medicinal leech, 1-8. Vol. 15. Vermillion: Invertebrate Neuroscience, 2015.
  • Summers, Torrie, and Burrell, Brian. Physiological and behavioral evidence of a capsaicin-sensitive TRPV-like channel in the medicinal leech, 4167-4173. Vol. 217. Vermillion: Journal of Experimental Biology, 2014.
  • Yuan, Sharleen, and Burrell, Brian. Non-nociceptive afferent activity depresses nocifensive behavior and nociceptive synapses via an endocannabinoid-dependent mechanism., 2607-2616. Vol. 110. Journal of Neurophysiology, 2013. (DOI: 10.1152)
  • Higgins, Alexandra, Yuan, Sharleen, Wang, Yanqing, and Burrell, Brian. Differential Modulation of Nociceptive versus Non-Nociceptive Synapses by Endocannabinoids, 26. Vol. 9. Molecular Pain, 2013.
  • Yuan, Sharleen, and Burrell, Brian. Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated pre- and postsynaptic transcription and translation, 4349-4358. Vol. 33. Journal of Neuroscience, 2013.
  • Yuan, Sharleen, and Burrell, Brian. Long-term depression of nociceptive synapses by non-nociceptive afferent activity: Role of endocannabinoids, Ca2+, and calcineurin., 1-11. Vol. 1460. Brain Research, 2012.
  • Li, Qin, and Burrell, Brian. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms., 545-553. Vol. 18. Learning & Memory, 2011.
  • Grey, Kathryn B., and Burrell, Brian. Seasonal variation of long-term potentiation at a central synapse in the medicinal leech., 2534-2539. Vol. 214. J Exp Biol, 2011.
  • Grey, Kathryn, and Burrell, Brian. Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases., 2737-2746. Vol. 103. Journal of Neurophysiology, 2010.
  • Yuan, Sharleen, and Burrell, Brian. Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor., 2766-2777. Vol. 104. J Neurophsiol, 2010.
  • Li, Qin, and Burrell, Brian. Properties of cannabinoid-dependent long term depression in the leech., 841-851. Vol. 196. J Comp Physiol , 2010.
  • Crisp, Kevin, and Burrell, Brian. Cellular and behavioral properties of learning in the leech and other annelids. In Annelids as Model Systems in the Biological Sciences. In Annelids in Modern Biology. Annelids as Model Systems in the Biological Sciences, 2009.
  • Grey, Kathryn B., Moss, Brenda L., and Burrell, Brian. Molecular identification and expression of the NMDA receptor NR1 subunit in the leech., 11-20. Vol. 9. Invert. Neurosci, 2009.
  • Li, Qin, and Burrell, Brian. Two Forms of Long Term Depression in a Leech Polysynaptic Connection: One NMDA Receptor-Dependent and the other Cannabinoid-Dependent., 831-841. Vol. 195. J Comp Physiol., 2009.

Awards and Honors:

  • Chester McVay Award for Excellence in Teaching and Research, University of South Dakota Sanford School of Medicine, 2015

Presentations:

  • Wang, Yanqing, Burrell, Brian. Endovanilloid-mediated synaptic potentiation contributes to behavioral sensitization. Presented at the Society for Neuroscience Annual Meeting, Chicago, IL. (October 19, 2015)
  • Fanta, John, Burrell, Brian. The Role of Endovanilloids during Stress-Induced Modulation of Nociception. Presented at the Faculty for Undergraduate Neuroscience, Chicago, IL. (October 18, 2015)
  • Wang, Yanqing, Burrell, Brian. Three discrete mechanisms by which endovanilloids modulate synaptic transmission. Presented at the Annual Meeting of the Nebraska Physiological Society, Vermillion, SD. (October 10, 2015)
  • Summers, Torrie, Hanten, Branden, Burrell, Brian. Endocannabinoids/endovanilloids attenuate injury-induced hyperalgesia but not mechanical allodynia. Presented at the Society for Neuroscience Annual Meeting, Washington, DC. (November 18, 2014)
  • Wang, Yanqing, Burrell, Brian. Endovanilloids modulate synaptic transmission by three distinct mechanisms. Presented at the Society for Neuroscience Annual Meeting, Washington, DC. (November 18, 2014)
  • Wang, Yanqing, Burrell, Brian. Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses. Presented at the USD Sanford Research Symposium, Vermillion, SD. (May 19, 2014)
  • Wang, Yanqing, Burrell, Brian. Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses. Presented at the IdeaFest, Vermillion, SD. (April 9, 2014)
  • Summers, Torrie, Burrell, Brian. Cannabinoids differentially modulate behavioral responses to nociceptive vs non-nociceptive stimuli. Presented at the Society for Neuroscience Annual Meeting, San Diego, CA. (November 12, 2013)
  • Wang, Yanqing, Burrell, Brian. Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses. Presented at the Society for Neuroscience Annual Meeting, San Diego, CA. (November 12, 2013)
  • Burrell, Brian. What the leech can tell us about how it hurts.. Presented at the MidBrains 2013, Northfield, MN (Carleton College). (October 5, 2013)
  • , Alexandra H., Yuan, Sharleen, Burrell, Brian. Differential endocannabinoid modulation of nociceptive vs. non-nociceptive synapses. Presented at the Society for Neuroscience Annual Meeting, New Orleans, LA. (October 16, 2012)
  • Yuan, Sharleen, Burrell, Brian. Endocannabinoids depress both nociceptive synapses and nocifensive behavior via a gate control-like mechanism. Presented at the Society for Neuroscience Annual Meeting, New Orleans, LA. (October 16, 2012)
  • Summers, Torrie, Burrell, Brian. A comparison of central and peripheral effects of TRPV and TRPA activators and antagonists in the leech. Presented at the Society for Neuroscience Annual Meeting, New Orleans, LA. (October 15, 2012)
  • Burrell, Brian. What a Leech Can Tell Us About How It Hurts. Presented at the Tedx Sioux River, Sioux Falls, SD. (August 4, 2012)
  • Yuan, Sharleen, Burrell, Brian. Endocannabinoid-dependent nociceptive signaling requires both pre- and postsynaptic protein synthesis, but only postsynaptic RNA synthesis. Presented at the Society for Neuroscience Annual Meeting, Washington DC. (November 15, 2011)
  • Higgins, Alexandra, Burrell, Brian. Differential Modulation of Nociceptive versus Non-Nociceptive Synapses by Endocannabinoids. Presented at the Faculty For Undergraduate Neuroscience Symposium, Washington DC. (November 14, 2011)
  • Burrell, Brian, Hahn, Elizabeth, List, Jeb, Rasmussen, Torrie. Nocifensive response and behavioral sensitization induced by TRP activators in the leech. Presented at the Society for Neuroscience Annual Meeting, Washington DC. (November 13, 2011)