Douglas Martin

Douglas Martin

Professor

BASIC BIOMEDICAL SCIENCES

Lee Medicine & Science Hall 139

Phone: (605) 658-6318

Email: Doug.Martin@usd.edu

Research Interests:

I have a long standing interest in the physiological mechanisms that underlie the development of hypertension (high blood pressure). Hypertension afflicts approximately 30% of the population (including several members of my family). Hypertension is also a major risk factor for the development of other diseases such as renal failure, heart failure, atherosclerosis, stroke, coronary artery disease and myocardial infarction. Moreover, as of 2015 the American Heart Association reports that hypertension continues to increase in prevalence. Despite the significant health impact of hypertension, little is known about the mechanisms that trigger the development of high blood pressure. Accordingly, better understanding of the mechanisms underlying the development of high blood pressure should foster new therapeutic approaches to prevent and treat this disease.


Education:

  • Post Doctoral Fellowship, Physiology, University of Saskatchewan, 1992
  • Post Doctoral Fellowship, Pharmacology, University of Texas Health Science Center , 1991
  • Ph D, Pharmacology, University of Saskatchewan, 1988
  • BS, Biology, Carleton University, 1981

Grants:

  • Cardiac sympathetic afferent neural reflex control of venous capacitance, BBS Research Commmittee (Parson's Fund). Grant Role: Principal. (2015 - 2016)
  • COP9 Signalosome in cardiovascular control., BBS Protein quality control pilot grant. Grant Role: Principal. (2015 - Present)
  • BRIN Pilot Grant, SD Biomedical Research Infrastructure Network. Grant Role: Principal. (2012 - Present)
  • Androgens raise venous and arterial adrenergic tone., NIH. Grant Role: Principal. (2010 - 2011)

Publications:

Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

  • Martin, Douglas, and Eyster, Kathleen. Assessing direct vascular actions of estrogens. In Estrogen Receptors, edited by Kathleen Eyster. New York: Springer, 2016.
  • Martin, Douglas, and Wang, Xuejun. The COP9 Signalosome and Vascular Function: Intriguing Possibilities?, 33-52. Vol. 5, Iss. 1. Am J Cardiovasc Dis, 2015.
  • Wang, Xuejun, and Martin, Douglas. The COP9 signalosome and Cullin RING Ligases in the heart, 1-18. Vol. 5, Iss. 1. Am J Cardiovasc Dis, 2015.
  • Ranek, Mark J., Kost, Curtis, Hu, Chengjun, Martin, Douglas, and Wang, Xuejun. Muscarinic 2 Receptors Modulate Cardiac Proteasome Function in a Protein Kinase G-dependent Manner, 43-51. Epub 2014 Feb 5.. Vol. 69, Iss. 4. J Mol Cell Cardiol, 2014. (DOI: 10.1016/j.yjmcc.2014.01.017)
  • Li, Shuai, Wang, Xuejun, Li, Yi-Fan, Kost, Curtis, and Martin, Douglas. Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats., 10. Vol. 30, Iss. 8. PLOS One, 2013. (DOI: 10.1371/journal.pone.0078564 )
  • Eyster, Kathleen, Breitkopf, N P., and Martin, Douglas. Antihypertensive activity of soy and soy-derived compounds. In Soy: Nutrition, consumption and health, edited by Aamir Ahmad, 79-104. Hauppauge, NY: Nova Scientific Publishers, 2012.
  • Martin, Douglas, Klinkova, Olga, and Eyster, Kathleen. Regional differences in sexually dimorphic protein expression in the spontaneously hypertensive rat (SHR), 103-114. Vol. 362. Molecular and Cellular Biochemistry, 2012.
  • Bardal, Stan K., Waechter, Jason E., and Martin, Douglas. Applied Pharmacology. St. Louis Missouri : Elsevier/Sauders, 2011.
  • Tatchum-Talom, Rabelais, Eyster, Kathleen, Kost, Curtis, and Martin, Douglas. Blood pressure and mesenteric vascular reactivity in SHR seven months after gonadectomy, 357-364. Vol. 57. J Cardiovasc Pharm, 2011.
  • Mark-Kappeler, Connie J., Martin, Douglas, and Eyster, Kathleen. Estrogens and selective estrogen receptor modulators (SERMs) regulate gene and protein expression in the mesenteric arteries, 42-49. Vol. 55. Vascular Pharmacology, 2011. (DOI: 10.1016/j.vph.2011.05.002)
  • Song, Jin, Eyster, Kathleen, Kost, Curtis, Kjellsen, Bart, and Martin, Douglas. Involvement of protein kinase C-CPI-17 in androgen modulation of angiotensin II-renal vasoconstriction., 614-621. Vol. 85, Iss. 3. Cardiovasc Res, 2010.

Awards and Honors:

  • President, Nebraska Physiological Society, 2015
  • President, Nebraska Physiological Society, 2014
  • President Elect, Nebraska Physiological Society, 2013
  • American Physiological Society Awards Committee, American Physiological Society, 2012
  • American Heart Association Grant Peer Reviewer, American Physiological Society, 2012

Presentations:

  • Bird, Daniel, Das, Manas, Eyster, Kathleen, Inglis, Stuart, Kost, Curtis, Manzerra, Pasquale, Martin, Douglas, Percy, William, Schlenker, Evelyn, Waller, Steve. Rethinking Remediation: Raising expectations to cast a wider net.. Presented at the CGEA 2015 Spring Meeting. (April 2015)
  • Martin, Douglas, Martin, Douglas, . Effects of a proteasome inhibitor, bortezomib, on angiotensin II-induced hypertension.. Presented at the Third Symposium on Ubiquitin, Protein Quality Control, and Molecular Pathogenesis, Deadwood South Dakota. (June 2014)
  • Li, Shuai, Wang, Xuejun, Martin, Douglas. Proteasome inhibition attenuates angiotensin II-induced hypertension and vascular remodeling. Presented at the Third Symposium on Ubiquitin, Protein Quality Control, and Molecular Pathogenesis, Deadwood South Dakota. (June 2014)
  • Martin, Douglas, Wang, Xuejun, Messenger, Ford, Hannah, Kjellsen, Barton, Li, Shuai. Angiotensin II activates the proteasome and stimulates vascular smooth muscle cell proliferation.. Presented at the Experimental Biology 2014, San Diego California. (April 2014)
  • Martin, Douglas, Li, Yi-Fan, Wang, Xuejun, Kost, Curtis, Shuai, Li. A proteasome inhibitor attenuates angiotensin II induced hypertension, associated vascular remodeling, and vascular smooth muscle cell proliferation. Presented at the Nebraska Physiological Society , Omaha, Nebraska. (October 2013)
  • Ranek, Mark J., Li, Jie, Kost, Curtis, Martin, Douglas, Wang, Xuejun. Protein kinase G regulates proteasome-mediated degradation of misfolded proteins. Presented at the AHA Scientific Sessions, Los Angeles, CA. (November 6, 2012)
  • Li, Shuai, Kjellsen, Barton, Martin, Douglas. Proteasome inhibition attenuates angiotensin II-induced hypertension and vascular remodeling.. Presented at the Nebraska Physiological Society, Wayne Nebraska. (October 2012)
  • Ranek, Mark J., Martin, Douglas, Kost, Curtis, Wang, Xuejun. Activation of Protein Kinase G Enhances Proteasome-Mediated Degradation of Misfolded Proteins. Presented at the AHA Basic Cardiovascular Sciences 2012 Scientific Sessions, New Orleans, LA. (July 25, 2012)
  • Martin, Douglas, Kjellsen, Barton, Messenger, Tami. Effect of Castration on Cardiac Index in the Spontaneously Hypertensive Rat.. Presented at the Experimental Biology 2012, San Diego California. (April 2012)
  • Li, Shuai, Wang, Xuejun, Martin, Douglas. Proteasome inhibition attenuates angiotensin II-induced hypertension and vascular remodeling.. Presented at the Experimental Biology 2012, San Diego California. (April 2012)
  • Martin, Douglas. Effect of castration on PPADS modulation of portal venous responses to splanchnic nerve stimulation. Presented at the Experimental Biology 2011, Washington DC. (April 2011)
  • Martin, Douglas. Effect of castration on PPADS modulation of portal venous responses to splanchnic nerve stimulation. Presented at the Experimental Biology 2011, Washington DC. (April 2011)
  • Martin, Douglas. Effect Of PPADS On Mesenteric Arterial And Portal Venous Flow Responses To Splanchnic Nerve Stimulation. Abstract # 8737. Presented at the Experimental Biology, San Diego CA. (April 2010)