Keith Miskimins

Keith Miskimins

Professor

Obstetrics/Gynecology

Research Interests:

The Miskimins lab research focus is the protein inhibitor of cell cycle progression that is commonly down-regulated in cancer cells.


Education:

  • Ph D, Cell and Developmental Biology, University of Arizona, 1982

Publications:

Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

  • Jiang, H, Coleman, J, Miskimins, Robin, Srinivasan, R, and Miskimins, Keith. Cap-independent translation through the p27 5'-UTR., 4767-78. Vol. 35, Iss. 14. Nucleic acids research, 2007. (DOI: 10.1093/nar/gkm512)
  • Wei, Q, Miskimins, Keith, and Miskimins, Robin. Stage-specific expression of myelin basic protein in oligodendrocytes involves Nkx2.2-mediated repression that is relieved by the Sp1 transcription factor., 16284-94. Vol. 280, Iss. 16. The Journal of biological chemistry, 2005. (DOI: 10.1074/jbc.M500491200)
  • Wei, Q, Miskimins, Keith, and Miskimins, Robin. Sox10 acts as a tissue-specific transcription factor enhancing activation of the myelin basic protein gene promoter by p27Kip1 and Sp1., 796-802. Vol. 78, Iss. 6. Journal of neuroscience research, 2004. (DOI: 10.1002/jnr.20342)
  • Wang, G, Miskimins, Robin, and Miskimins, Keith. Regulation of p27(Kip1) by intracellular iron levels., 15-24. Vol. 17, Iss. 1. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2004.
  • Wang, G, Reisdorph, R, Clark, Jr, R E., Miskimins, Robin, Lindahl, Ronald, and Miskimins, Keith. Cyclin dependent kinase inhibitor p27(Kip1) is upregulated by hypoxia via an ARNT dependent pathway., 548-60. Vol. 90, Iss. 3. Journal of cellular biochemistry, 2003. (DOI: 10.1002/jcb.10621)
  • Wei, Q, Miskimins, Keith, and Miskimins, Robin. Cloning and characterization of the rat myelin basic protein gene promoter., 161-7. Vol. 313. Gene, 2003.
  • Wei, Q, Miskimins, Keith, and Miskimins, Robin. The Sp1 family of transcription factors is involved in p27(Kip1)-mediated activation of myelin basic protein gene expression., 4035-45. Vol. 23, Iss. 12. Molecular and cellular biology, 2003.
  • Jiang, H, Coleman, J, Miskimins, Robin, and Miskimins, Keith. Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells., 2. Vol. 3, Iss. 1. Cancer cell international, 2003.
  • Clark, Jr, R E., Miskimins, Keith, and Miskimins, Robin. Phosphatidylinositol-3 kinase p85 enhances expression from the myelin basic protein promoter in oligodendrocytes., 565-73. Vol. 83, Iss. 3. Journal of neurochemistry, 2002.
  • Clark, Jr, R E., Miskimins, Keith, and Miskimins, Robin. Cyclic AMP inducibility of the myelin basic protein gene promoter requires the NF1 site., 103-11. Vol. 20, Iss. 2. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2002.
  • Miskimins, Robin, Srinivasan, R, Marin-Husstege, M, Miskimins, Keith, and Casaccia-Bonnefil, P. p27(Kip1) enhances myelin basic protein gene promoter activity., 100-5. Vol. 67, Iss. 1. Journal of neuroscience research, 2002.
  • Miskimins, Keith, Wang, G, Hawkinson, M, and Miskimins, Robin. Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation., 4960-7. Vol. 21, Iss. 15. Molecular and cellular biology, 2001. (DOI: 10.1128/MCB.21.15.4960-4967.2001)
  • Miskimins, Robin, and Miskimins, Keith. A role for an AP-1-like site in the expression of the myelin basic protein gene during differentiation., 85-91. Vol. 19, Iss. 1. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2001.
  • Coleman, J, Hawkinson, M, Miskimins, Robin, and Miskimins, Keith. The major transcription initiation site of the p27Kip1 gene is conserved in human and mouse and produces a long 5'-UTR., 12. Vol. 2. BMC molecular biology, 2001.
  • Wang, G, Miskimins, Robin, and Miskimins, Keith. Mimosine arrests cells in G1 by enhancing the levels of p27(Kip1)., 64-71. Vol. 254, Iss. 1. Experimental cell research, 2000. (DOI: 10.1006/excr.1999.4743)
  • Wang, G, Miskimins, Robin, and Miskimins, Keith. The cyclin-dependent kinase inhibitor p27Kip1 is localized to the cytosol in Swiss/3T3 cells., 5204-10. Vol. 18, Iss. 37. Oncogene, 1999. (DOI: 10.1038/sj.onc.1202912)
  • Moore, B A., Miskimins, Robin, and Miskimins, Keith. ATF-1 is activated in response to UV irradiation in B16 melanoma cells., 1-6. Vol. 1, Iss. 1. Molecular cell biology research communications : MCBRC, 1999. (DOI: 10.1006/mcbr.1999.0100)
  • Boesch, J S., Miskimins, Robin, Miskimins, Keith, and Lindahl, Ronald. The same xenobiotic response element is required for constitutive and inducible expression of the mammalian aldehyde dehydrogenase-3 gene., 223-30. Vol. 361, Iss. 2. Archives of biochemistry and biophysics, 1999. (DOI: 10.1006/abbi.1998.0989)
  • Clark, R, Stewart, M, Miskimins, Keith, and Miskimins, Robin. Involvement of MAP kinase in the cyclic AMP induction of myelin basic protein gene expression., 323-31. Vol. 16, Iss. 5. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1998.
  • Friessen, A J., Miskimins, Keith, and Miskimins, Robin. Cyclin-dependent kinase inhibitor p27kip1 is expressed at high levels in cells that express a myelinating phenotype., 373-82. Vol. 50, Iss. 3. Journal of neuroscience research, 1997.
  • Miskimins, Keith, King, F, and Miskimins, Robin. Phosphatidylinositol 3-kinase inhibitor wortmannin blocks mitogenic activation of the transferrin receptor gene promoter in late G1., 565-70. Vol. 8, Iss. 5. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1997.
  • Lindahl, Ronald, Xie, Y, Boesch, J S., Miskimins, Keith, and Miskimins, Robin. Class 3 aldehyde dehydrogenase. A view from the hills., 15-8. Vol. 414. Advances in experimental medicine and biology, 1997.
  • Hirsch, S, Miskimins, Robin, and Miskimins, Keith. Mitogenic activation of the transferrin receptor gene promoter is modulated by inhibitors of tyrosine kinases and tyrosine phosphatases., 121-9. Vol. 6, Iss. 3-4. Receptors & signal transduction, 1996.
  • Miskimins, Robin, Miskimins, Keith, Bernstein, H, and Shimizu, N. Epidermal growth factor-induced topoisomerase(s). Intracellular translocation and relation to DNA synthesis., 53-62. Vol. 146, Iss. 1. Experimental cell research, 1983.