Lisa McFadden

Lisa McFadden

Assistant Professor

BASIC BIOMEDICAL SCIENCES

Lee Medicine & Science Hall 252

Phone: (605) 658-6346

Email: Lisa.McFadden@usd.edu

Research Interests:

Drug addiction is a chronic, relapsing and debilitating disorder. Understanding the biological changes underlying addiction is imperative for developing effective interventions. My laboratory's research focuses on understanding the changes in the brain that occurs following methamphetamine use in a preclinical model of drug addiction. Additionally, we strive to understand the role of sex/gender in these changes. Ultimately, the goal of this research is to use these findings to develop effective interventions for drug addiction. Now accepting students.


Education:

  • Postdoctoral, University of Utah, 2014
  • Ph D, Neuroscience and Behavioral Psychology, Northern Illinois University, 2009

Grants:

  • Serotonergic changes in the frontal cortex during methamphetamine reinstatement., NIDA/NIH. (2016 - 2019)

Publications:

Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

  • Vieira-Brock, P L., McFadden, Lisa, Nielsen, S M., Ellis, J D., Walters, E T., Stout, K A., McIntosh, J M., Wilkins, D G., Hanson, G R., and Fleckenstein, A E.. Chronic Nicotine Exposure Attenuates Methamphetamine-Induced Dopaminergic Deficits., 463-72. Vol. 355, Iss. 3. The Journal of pharmacology and experimental therapeutics, 2015. (DOI: 10.1124/jpet.114.221945)
  • Alburges, M E., Hoonakker, A J., Cordova, N M., Robson, C M., McFadden, Lisa, Martin, A L., and Hanson, G R.. Effect of low doses of methamphetamine on rat limbic-related neurotensin systems., 396-404. Vol. 69, Iss. 8. Synapse (New York, N.Y.), 2015. (DOI: 10.1002/syn.21829)
  • Vieira-Brock, P L., McFadden, Lisa, Nielsen, S M., Smith, M D., Hanson, G R., and Fleckenstein, A E.. Nicotine Administration Attenuates Methamphetamine-Induced Novel Object Recognition Deficits.. Vol. 18, Iss. 12. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 2015. (DOI: 10.1093/ijnp/pyv073)
  • McFadden, Lisa, Vieira-Brock, P L., Hanson, G R., and Fleckenstein, A E.. Prior methamphetamine self-administration attenuates the dopaminergic deficits caused by a subsequent methamphetamine exposure., 146-54. Vol. 93. Neuropharmacology, 2015. (DOI: 10.1016/j.neuropharm.2015.01.013)
  • German, C L., Baladi, M G., McFadden, Lisa, Hanson, G R., and Fleckenstein, A E.. Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease., 1005. Vol. 67. Pharmalogical Reviews, 2015.
  • Matuszewich, L, Carter, S, Anderson, E M., Friedman, R D., and McFadden, Lisa. Persistent behavioral and neurochemical sensitization to an acute injection of methamphetamine following unpredictable stress., 308-13. Vol. 272. Behavioural brain research, 2014. (DOI: 10.1016/j.bbr.2014.07.013)
  • Matuszewich, L, McFadden, Lisa, Friedman, R D., and Frye, C A.. Neurochemical and behavioral effects of chronic unpredictable stress., 557-66. Vol. 25, Iss. 5-6. Behavioural pharmacology, 2014. (DOI: 10.1097/FBP.0000000000000061)
  • McFadden, Lisa, Vieira-Brock, P L., Hanson, G R., and Fleckenstein, A E.. Methamphetamine self-administration attenuates hippocampal serotonergic deficits: role of brain-derived neurotrophic factor., 1315-20. Vol. 17, Iss. 8. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 2014. (DOI: 10.1017/S1461145714000327)
  • Alburges, M E., Hoonakker, A J., Cordova, N M., Robson, C M., McFadden, Lisa, Martin, A L., and Hanson, G R.. Responses of the rat basal ganglia neurotensin systems to low doses of methamphetamine., 2933-40. Vol. 231, Iss. 15. Psychopharmacology, 2014. (DOI: 10.1007/s00213-014-3468-7)
  • McFadden, Lisa, Hanson, G R., and Fleckenstein, A E.. The effects of methamphetamine self-administration on cortical monoaminergic deficits induced by subsequent high-dose methamphetamine administrations., 875-81. Vol. 67, Iss. 12. Synapse (New York, N.Y.), 2013. (DOI: 10.1002/syn.21696)
  • Hanson, G R., Hoonakker, A J., Robson, C M., McFadden, Lisa, Frankel, P S., and Alburges, M E.. Response of neurotensin basal ganglia systems during extinction of methamphetamine self-administration in rat., 173-81. Vol. 346, Iss. 2. The Journal of pharmacology and experimental therapeutics, 2013. (DOI: 10.1124/jpet.113.205310)
  • McFadden, Lisa, Hunt, M M., Vieira-Brock, P L., Muehle, J, Nielsen, S M., Allen, S C., Hanson, G R., and Fleckenstein, A E.. Prior methamphetamine self-administration attenuates serotonergic deficits induced by subsequent high-dose methamphetamine administrations., 87-94. Vol. 126, Iss. 1-2. Drug and alcohol dependence, 2012. (DOI: 10.1016/j.drugalcdep.2012.04.020)
  • McFadden, Lisa, Carter, S, and Matuszewich, L. Juvenile exposure to methamphetamine attenuates behavioral and neurochemical responses to methamphetamine in adult rats., 118-22. Vol. 229, Iss. 1. Behavioural brain research, 2012. (DOI: 10.1016/j.bbr.2012.01.013)
  • McFadden, Lisa, Stout, K A., Vieira-Brock, P L., Allen, S C., Nielsen, S M., Wilkins, D G., Hanson, G R., and Fleckenstein, A E.. Methamphetamine self-administration acutely decreases monoaminergic transporter function., 240-5. Vol. 66, Iss. 3. Synapse (New York, N.Y.), 2012. (DOI: 10.1002/syn.21506)
  • Hanson, G R., Hoonakker, A J., Alburges, M E., McFadden, Lisa, Robson, C M., and Frankel, P S.. Response of limbic neurotensin systems to methamphetamine self-administration., 99-107. Vol. 203. Neuroscience, 2012. (DOI: 10.1016/j.neuroscience.2011.12.037)
  • McFadden, Lisa, Hadlock, G C., Allen, S C., Vieira-Brock, P L., Stout, K A., Ellis, J D., Hoonakker, A J., Andrenyak, D M., Nielsen, S M., Wilkins, D G., Hanson, G R., and Fleckenstein, A E.. Methamphetamine self-administration causes persistent striatal dopaminergic alterations and mitigates the deficits caused by a subsequent methamphetamine exposure., 295-303. Vol. 340, Iss. 2. The Journal of pharmacology and experimental therapeutics, 2012. (DOI: 10.1124/jpet.111.188433)
  • Hadlock, G C., Webb, K M., McFadden, Lisa, Chu, P W., Ellis, J D., Allen, S C., Andrenyak, D M., Vieira-Brock, P L., German, C L., Conrad, K M., Hoonakker, A J., Gibb, J W., Wilkins, D G., Hanson, G R., and Fleckenstein, A E.. 4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse., 530-6. Vol. 339, Iss. 2. The Journal of pharmacology and experimental therapeutics, 2011. (DOI: 10.1124/jpet.111.184119)
  • McFadden, Lisa, Hoonakker, A J., Vieira-Brock, P L., Stout, K A., Sawada, N M., Ellis, J D., Allen, S C., Walters, E T., Nielsen, S M., Gibb, J W., Alburges, M E., Wilkins, D G., Hanson, G R., and Fleckenstein, A E.. Methamphetamine treatment during development attenuates the dopaminergic deficits caused by subsequent high-dose methamphetamine administration., 771-7. Vol. 65, Iss. 8. Synapse (New York, N.Y.), 2011. (DOI: 10.1002/syn.20902)
  • Frankel, P S., Hoonakker, A J., Alburges, M E., McDougall, J W., McFadden, Lisa, Fleckenstein, A E., and Hanson, G R.. Effect of methamphetamine self-administration on neurotensin systems of the basal ganglia., 809-15. Vol. 336, Iss. 3. The Journal of pharmacology and experimental therapeutics, 2011. (DOI: 10.1124/jpet.110.176610)
  • McFadden, Lisa, Paris, J J., Mitzelfelt, M S., McDonough, S, Frye, C A., and Matuszewich, L. Sex-dependent effects of chronic unpredictable stress in the water maze., 266-75. Vol. 102, Iss. 3-4. Physiology & behavior, 2011. (DOI: 10.1016/j.physbeh.2010.10.022)
  • McFadden, Lisa, and Matuszewich, L. The effects of methamphetamine exposure during preadolescence on male and female rats in the water maze., 99-109. Vol. 185, Iss. 2. Behavioural brain research, 2007. (DOI: 10.1016/j.bbr.2007.07.016)