Xuejun Wang

Xuejun Wang

Director MD/PhD Program

BASIC BIOMEDICAL SCIENCES

Lee Medicine & Science Hall 251

Phone: (605) 658-6345

Email: Xuejun.Wang@usd.edu

Bio:

Before coming to the US in 1994, Dr. Wang had studied/worked in biomedicine for 14 yrs in Wuhan, China. He was appointed Assistant Professor in 2001, promoted to Associate Professor in 2005, tenured in 2006, and became full Professor and Director of the MD/PhD program in 2006.


Teaching Interests:

Basic biomedical sciences: biochemistry and molecular biology, anatomy, histology and physiology, cell biology and transgenics.


Research Interests:

Cardiovascular Sciences. Dr. X-J Wang is currently recruiting graduate students with their doctorate research interest in line with the research directions of his laboratory, which are primarily funded by NIH R01 grants and focus on protein quality control and degradation in cardiovascular physiology and pathophysiology, molecular mechanisms of the progression from primary heart diseases to congestive heart failure, and molecular pathogenesis of misfolded proteins.


Education:

  • Postdoctoral Fellow, Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, 2001
  • Ph D, Anatomy and Structural Biology, University of South Dakota, 1998
  • MS, Pathophysiology, Hubei Medical University, 1988
  • MD, Clinical Medicine, Hubei Medical University, 1985

Grants:

  • R01: The NRF2-P62 Axis in the Crosstalk between Proteaosmal and Lysosomal Degradation, NHLBI/NIH. Grant Role: Principal. (2017 - 2021)
  • R01: The COP9 Signalosome in the Heart (HL085629-10~13), NHLBI/NIH. Grant Role: Principal. (2016 - 2020)
  • Th Effect of Neddylation Inhibition on Autophagic Flux in Cardiomyocytes, American Heart Association. Grant Role: Co-Principal. (2016 - 2016)
  • PDE1 inhibition primes the proteasome, American Heart Association. Grant Role: Co-Principal. (2015 - 2017)
  • COP9 Signalosome in cardiovascular control., BBS Protein quality control pilot grant. (2015 - Present)
  • R01: Ubiquitin receptors in cardiac proteotoxicity (HL072166-11~14), NHLBI/NIH. Grant Role: Principal. (2014 - 2018)
  • Direct proteasomal enhancement contributes to PKG-triggered cardioprotection. (Terpstra EMJ, Postdoc Fellow; Wang X, Mentor/Sponsor), NIH-F32 (NRSA). Grant Role: Co-Principal. (2014 - 2017)
  • R01: The COP9 Signalosome in the Heart (HL085629-06~09), NHLBI/NIH. Grant Role: Principal. (2012 - 2016)
  • The Ubiquitin Proteasome System in Diabetic Cardiomyopathy (Su H, PI; Wang X, Co-PI), AHA-Natinal SDG. Grant Role: Co-Principal. (2011 - 2015)
  • The Role of PKG in the Stimulation of the UPS by the Muscarinic 2 Receptor, AHA Predoc Fellowship (Ranek MJ, Predoc Fellow; Wang X, Mentor/Sponsor). Grant Role: Co-Principal. (2011 - 2012)
  • American Recovery & Reinvestment Act Summer Undergrad Research Supplement (3R01HL072166-6A1S1), NIH/NHLBI. Grant Role: Principal. (2009 - 2010)
  • PROTEASOME, PROTEIN OXIDATION, AND CARDIOMYOCYTE FUNCTION, NIH R01 (Duo-PI). Grant Role: Principal. (2008 - 2014)
  • Autophagy is activated by and compensates for proteasome malfunction in desminopathy (Zheng Q, Predoc Fellow; Wang X, Mentor), AHA-Predoc Fellowship. Grant Role: Co-Principal. (2008 - 2010)
  • AHA Established Investigator Award: Inadequate Protein Quality Control in Cardiac Remodeling and Failure, AHA National Center EIA. Grant Role: Principal. (2007 - 2012)
  • R01: The COP9 Signalosome in the Heart ( HL085629-01~05), NHLBI/NIH. Grant Role: Principal. (2007 - 2012)
  • Physiological Significance of COP9 Signalosome in Adult Hearts. (Su H, Postdoc Fellow; Wang X, Mentor, AHA-Psodoc Fellowship. Grant Role: Co-Principal. (2006 - 2008)
  • Genetic Inhibition of Proteasomal Function in the Heart. (Zheng H, Postdoc Fellow; Wang X, Mentor/Sponsor), AHA-Postdoc Fellowship. Grant Role: Co-Principal. (2006 - 2007)
  • Alpha B-crystallin modulates cardiac hypertrophic response to mechanical overload. (Kumarapeli AR, Predoc Fellow; Wang X, Mentor/Sponsor, AHA-Predoc Fellowship. Grant Role: Co-Principal. (2005 - 2006)
  • R01: Molecular pathogenesis of protein surplus cardiomyopathy (HL072166-01~10), NIH R01. Grant Role: Principal. (2003 - 2014)
  • Molecular Biology Core of the original SD Cardiovascular COBRE (1P20RR017662), NCRR/NIH. Grant Role: Principal. (2002 - 2007)
  • The ubiquitin-proteasome system in cardiac remodeling and failure (Project 1 of the original SD CArdiovascular COBRE 1P20RR017662), NCRR/NIH. Grant Role: Principal. (2002 - 2007)
  • The ubiquitin-proteasome system in crystallinopathy, American Heart Association National Center SDG. Grant Role: Principal. (2002 - 2006)

Publications:

Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

  • Wang, Xuejun, and Cui, T. Autophagy Modulation - A Potential Therapeutic Approach in Cardiac Hypertrophy., ajpheart.00145.2017. American journal of physiology. Heart and circulatory physiology, 2017. (DOI: 10.1152/ajpheart.00145.2017)
  • Xiao, L, Lan, X, Shi, X, Zhao, K, Wang, D, Wang, Xuejun, Li, F, Huang, H, and Liu, J. Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer., e2803. Vol. 8, Iss. 5. Cell death & disease, 2017. (DOI: 10.1038/cddis.2017.210)
  • Liao, Y, Liu, N, Hua, X, Cai, J, Xia, X, Wang, Xuejun, Huang, H, and Liu, Jinbao. Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor., e2585. Vol. 8, Iss. 2. Cell death & disease, 2017. (DOI: 10.1038/cddis.2016.477)
  • Li, Jie, Ma, W, Yue, G, Tang, Y, Kim, I M., Weintraub, N L., Wang, Xuejun, and Su, Huabo. Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy., 53-60. Vol. 102, Iss. 1. Journal of molecular and cellular cardiology, 2017. (DOI: 10.1016/j.yjmcc.2016.11.013)
  • Zhao, C, Chen, X, Yang, C, Zang, D, Lan, X, Liao, S, Zhang, P, Wu, J, Li, X, Liu, N, Liao, Y, Huang, H, Shi, X, Jiang, L, Liu, X, Dou, Q P., Wang, Xuejun, and Liu, J. Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases., 13942-13956. Vol. 8, Iss. 8. Oncotarget, 2017. (DOI: 10.18632/oncotarget.14572)
  • Lan, X, Zhao, C, Chen, X, Zhang, P, Zang, D, Wu, J, Chen, J, Long, H, Yang, L, Huang, H, Carter, B Z., Wang, Xuejun, Shi, X, and Liu, J. Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms., 129. Vol. 9, Iss. 1. Journal of hematology & oncology, 2016. (DOI: 10.1186/s13045-016-0359-x)
  • Zhao, Chong, Chen, Xin, Zang, Dan, Lan, Xiaoying, Liao, Siyan, Yang, Changshan, Zhang, Peiquan, Wu, Jinjie, Li, Xiaofen, Liu, Ningning, Liao, Yuning, Huang, Hongbiao, Shi, Xianping, Jiang, Lili, Liu, Xiuhua, He, Zhimin, Dou, Qing P., Wang, Xuejun, and Liu, Jinbao. A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy, 5916-5927. Vol. 35, Iss. 45. Oncogene, 2016. (DOI: 10.1038/onc.2016.114)
  • Zhao, C, Chen, X, Zang, D, Lan, X, Liao, S, Yang, C, Zhang, P, Wu, J, Li, X, Liu, N, Liao, Y, Huang, H, Shi, X, Jiang, L, Liu, X, He, Z, Wang, Xuejun, and Liu, J. Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy., 22-38. Vol. 116. Biochemical pharmacology, 2016. (DOI: 10.1016/j.bcp.2016.06.019)
  • Hou, N, Ye, B, Li, X, Margulies, K B., Xu, H, Wang, Xuejun, and Li, F. Transcription Factor 7-like 2 Mediates Canonical Wnt/?-Catenin Signaling and c-Myc Upregulation in Heart Failure., pii: e003010. Vol. 9, Iss. 6. Circulation. Heart failure, 2016. (DOI: 10.1161/CIRCHEARTFAILURE.116.003010)
  • Zhang, Lei, Hapon, M B., Goyeneche, Alicia, Srinivasan, R, Gamarra-Luques, C D., Callegari, E A., Drappeau, D D., Terpstra, E J., Pan, B, Knapp, J R., Chien, J, Wang, Xuejun, Eyster, Kathleen, and Telleria, Carlos. Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors., 1099-1117. Vol. 10, Iss. 7. Molecular oncology, 2016. (DOI: 10.1016/j.molonc.2016.05.001)
  • Liu, Jinbao, Su, Huabo, and Wang, Xuejun. The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart, 601-602. Vol. 12, Iss. 3. Autophagy, 2016. (DOI: 10.1080/15548627.2015.1136773)
  • Jiang, Lili, Zang, Dan, Yi, Songgang, Li, Xiaofen, Yang, Changshan, Dong, Xiaoxian, Zhao, Chong, Lan, Xiaoying, Chen, Xin, Liu, Shouting, Liu, Ningning, Huang, Hngbiao, Shi, Xianping, Wang, Xuejun, and Liu, Jinbao. A microRNA-mediated decrease in eukaryotic initiation factor 2? promotes cell survival during PS-341 treatment, 21565. Vol. 6. Scientific Reports, 2016. (DOI: 10.1038/srep21565)
  • Klionsky, Dan J., many others, ..., Wang, Xuejun, and many others, .... Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), 1-222. . Vol. 12, Iss. 1. Autophagy, 2016. (DOI: 10.1080/15548627.2015.1100356)
  • Qin, Qingyuan, Qu, Chen, Niu, Ting, Zang, Huimei, Qi, Lei, Lyu, Linmao, Wang, Xuejun, Janicki, Joseph S., Wang, Xing Li, and Cui, Taixing. Nrf2-mediated cardiac maladaptive remodeling and dysfunction in a setting of autophagy insufficiency, 107-117. Vol. 67, Iss. 1. Hypertension, 2016. (DOI: 10.1161/HYPERTENSIONAHA.115.06062)
  • Cui, Taixing, Lai, Y, Janicki, Joeseph, and Wang, Xuejun. Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated protein quality control in cardiomyocytes., 192-202. Vol. 21, Iss. 1. Front Biosci (Landmark Ed), 2016. (DOI: 10.2741/4384 )
  • Huang, Hongbiao, Liao, Y, Liu, N, Hua, X, Cai, J, Yang, C, Zhao, C, Chen, X, Lan, X, Zang, D, Wu, J, Li, X, Shi, X, Wang, Xuejun, and Liu, Jibao. Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo, 2796-2808 (E-pub ahead of print on 28 Nov 2015 ). Vol. 7, Iss. 3. Oncotarget, 2015. (DOI: 10.18632/oncotarget.6425)
  • Su, Huabo, Li, Jie, Zhang, Hanming, Ma, Wendy, Wei, Ning, Liu, Jinbao, and Wang, Xuejun. The COP9 signalosome controls the degradation of cytosolic misfolded proteins and protects against cardiac proteotoxicity, 956-966 (with companion editorial). Vol. 117, Iss. 11. Circ Res, 2015. (DOI: 10.1161/CIRCRESAHA.115.306783)
  • Wang, Xuejun. Chapter 12. Desmin Filaments and Desmin-related Myopathy, in Schatten H edit "The Cytoskeleton in Health and Disease". In The Cytoskeleton in Health and Disease, 281-306. New York: Springer Science & Business Media, 2015.
  • Li, Jie, Ma, Wenxia, Li, Huizhong, Hou, Ning, Wang, Xuejun, Kim, Il-Man, Li, Faqian, and Su, Huabo. NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes Proteasomal Degradation of Misfolded Proteins., 23850-23862. Vol. 290, Iss. 39. J Biol Chem, 2015. (DOI: 10.1074/jbc.M115.664375)
  • Ranek, Mark, Zheng, Hanqiao, Huang, Wei, Kumarapeli, Asnagi R., Li, Jie, Liu, Jinbao, and Wang, Xuejun. Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload, 273-281 (with companion editorial). Vol. 85, Iss. Aug. J Mol Cell Cardiol, 2015. (DOI: 10.1016/j.yjmcc.2015.06.014.)
  • Shi, Xianping, Lan, Xiaoying, Chen, Xin, Zhao, Chong, Li, Xiaofen, Liu, Shouting, Huang, Hongbiao, Liu, Ningning, Zhang, Dan, Liao, Yuning, Zhang, Peiquan, Wang, Xuejun, and Liu, Jinbao. Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition, 9694. Vol. 5. Sci Rep, 2015. (DOI: 10.1038/srep09694.)
  • Zhang, Hanming, and Wang, Xuejun. Priming the proteasome: a novel mechanism for cardioprotection by sildenafil., 177-189. Vol. 11, Iss. 2. Future Cardiology , 2015.
  • Wang, Xuejun. Entangled in a heart-ailing quandary: could modified cofilin-2 be a culprit of Alzheimer's disease of the heart? (invited editorial), 1215-1217 . Vol. 65, Iss. 12. Journal of American College of Cardiology (JACC), 2015. (DOI: doi: 10.1016/j.jacc.2015.01.035. )
  • Martin, Douglas, and Wang, Xuejun. The COP9 Signalosome and Vascular Function: Intriguing Possibilities?, 33-52. Vol. 5, Iss. 1. Am J Cardiovasc Dis, 2015.
  • Wang, Xuejun, and Martin, Douglas. The COP9 signalosome and Cullin RING Ligases in the heart, 1-18. Vol. 5, Iss. 1. Am J Cardiovasc Dis, 2015.
  • Wang, Changhua, and Wang, Xuejun. The interplay between autophagy and the ubiquitin-proteasome system in cardiac proteotoxicity, 188-94. Vol. 1852, Iss. 2. BBA - Molecular Basis of Disease, 2015. (DOI: 10.1016/j.bbadis.2014.07.028)
  • Chen, X, Shi, X, Wang, Xuejun, and Liu, Jinbao. Novel use of old drug: Anti-rheumatic agent auranofin overcomes imatinib-resistance of chronic myeloid leukemia cells., e415. Vol. 1. Can Cell Microenviron , 2014. (DOI: 10.14800/ccm.415)
  • Chen, Xin, Shi, Xianping, Zhao, Chong, Li, Xiaofen, Lan, Xiaoying, Liu, Shouting, Huang, Hongbiao, Liu, Ningning, Liao, Siyan, Song, Wenbin, Liu, Quentin, Carter, Bing Z., Dou, Q. Ping, Wang, Xuejun, and Liu, Jinbao. Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms, 9118-32.. Vol. 5, Iss. 19. Oncotarget, 2014.
  • Gupta, M K., Gulick, James, Liu, R, Wang, Xuejun, Molkentin, Jeff D., and Robbins, Jeffrey. SUMO E2 Enzyme UBC9 is Required for Efficient Protein Quality Control in Cardiomyocytes, 721-729. (with companion editorial) . Vol. 115, Iss. 8. Circ Res, 2014. (DOI: 10.1161/CIRCRESAHA.115.304760)
  • Liu, N, Li, X, Huang, H, Zhao, C, Liao, S, Yang, C, Liu, S, Song, W, Lu, X, Lan, X, Chen, X, Yi, S, Xu, L, Jiang, L, Zhao, C, Dong, X, Zhou, P, Li, S, Wang, S, Shi, X, Dou, Q P., Wang, Xuejun, and Liu, Jinbao. Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth, 5453-71 . Vol. 5, Iss. 14. Oncotarget, 2014.
  • Tian, Zongwen, Wang, Changhua, Hu, Chengjun, Tian, Yihao, Liu, Jinbao, and Wang, Xuejun. Autophagic-Lysosomal Inhibition Compromises Ubiquitin-Proteasome System Performance in a p62 Dependent Manner in Cardiomyocytes, e100715. Vol. 9, Iss. 6. PLoS ONE, 2014. (DOI: 10.1371/journal.pone.0100715)
  • Liu, Ningning, Liu, Chunjiao, Li, Xiaofen, Liao, Siyan, Song, Wenbin, Yang, Changshan, Zhao, Chong, Huang, Hongbiao, Guan, Lixia, Zhang, Peiquan, Liu, Shouting, Hua, Xianlian, Chen, Xin, Zhou, Ping, Lan, Xiaoying, Yi, Songgang, Wang, Shunqing, Wang, Xuejun, Dou, Q P., and Liu, Jinbao. A novel proteasome inhibitor inhibits tumor growth in vitro, in vivo and ex vivo via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases, 5240. PubMed PMID: 24912524; PubMed Central PMCID: PMC4050382. Vol. 4. Scientific Reports, 2014. (DOI: 10.1038/srep05240)
  • Wang, Xuejun, and Robbins, Jeffrey. Proteasomal and lysosomal protein degradation and heart disease, 16-24. Vol. 71C. J Mol Cell Cardiol, 2014. (DOI: 10.1016/j.yjmcc.2013.11.006)
  • Liu, Y., Hettinger, C. L., Zhang, Dong, Rezvani, Khosrow, Wang, Xuejun, and Wang, Hongmin. Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease, 539-47. Epub 2014 Jan 18.. Vol. 129, Iss. 3. J Neurochem, 2014. (DOI: 10.1111/jnc.12647)
  • Ranek, Mark J., Kost, Curtis, Hu, Chengjun, Martin, Douglas, and Wang, Xuejun. Muscarinic 2 Receptors Modulate Cardiac Proteasome Function in a Protein Kinase G-dependent Manner, 43-51. Epub 2014 Feb 5.. Vol. 69, Iss. 4. J Mol Cell Cardiol, 2014. (DOI: 10.1016/j.yjmcc.2014.01.017)
  • Liu, Y., Hettinger, C. L., Zhang, Dong, Rezvani, Khosrow, Wang, Xuejun, and Wang, Hongmin. The Proteasome Function Reporter GFPu Accumulates in Young Brains of the APPswe/PS1dE9 Alzheimer's Disease Mouse Model, 315-322. Epub 2013 Dec 21. . Vol. 34, Iss. 3. Cell Mol Neurobiol, 2014. (DOI: 10.1007/s10571-013-0022-9)
  • Su, Huabo, and Wang, Xuejun. Defense against proteotoxic stress in the heart: role of p62, autophagy, and ubiquitin-proteasome system. In Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, edited by M. A. Hayat, 188-202. Vol. 3. Elsevier, 2014.
  • Liu, Y., Lü, L., Hettinger, C. L., Dong, G., Zhang, Dong, Rezvani, Khosrow, Wang, Xuejun, and Wang, Hongmin. Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice, 2813-21. Vol. 34, Iss. 8. J Neurosci, 2014. (DOI: 10.1523/JNEUROSCI.3541-13.2014)
  • Shi, X, Chen, X, Li, X, Lan, X, Zhao, C, Liu, S, Huang, H, Liu, N, Liao, S, Song, W, Zhou, P, Wang, S, Wang, Xuejun, Dou, Q P., and Liu, Jinbao. Gambogic acid induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via inducing proteasome inhibition and caspase-dependent Bcr-Abl cleavage., 151-163. Epub 2013 Dec 12.. Vol. 20, Iss. 1. Clinical Cancer Research , 2014. (DOI: 10.1158/1078-0432.CCR-13-1063)
  • Liu, Shouting, Zhao, Canguo, Yang, Changshan, Li, Xiaofen, Huang, Hongbiao, Liu, Ningning, Li, Shujue, Wang, Xuejun, and Liu, Jinbao. Gambogic acid suppresses pressure overload cardiac hypertrophy in rats, 227-238. PMID:24224134 [PubMed]. Vol. 3, Iss. 4. Am J Cardiovasc Dis, 2013.
  • Li, Shuai, Wang, Xuejun, Li, Yi-Fan, Kost, Curtis, and Martin, Douglas. Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats., 10. Vol. 30, Iss. 8. PLOS One, 2013. (DOI: 10.1371/journal.pone.0078564 )
  • Su, Huabo, Li, Jie, Osinska, Hanna, Li, Faqian, Robbins, Jeffrey, Liu, Jinbao, Wei, Ning, and Wang, Xuejun. The COP9 Signalosome Is Required for Autophagy, Proteasome-Mediated Proteolysis, and Cardiomyocyte Survival in Adult Mice, 1049-1057. PMID: 23873473 [PubMed]. Vol. 6, Iss. 5. Circulation: Heart Failure, 2013. (DOI: 10.1161/?CIRCHEARTFAILURE.113.000338 )
  • Wang, Xuejun, Zhao, Canguo, Liu, Shouting, Yang, Changshan, Li, Xiaofen, Huang, Hongbiao, Liu, Ningning, Li, Shujiue, Wang, Xuejun, and Liu, Jinbao. Gambogic acid moderates cardiac responses to chronic hypoxia likely by acting on the proteasome and NF-?B pathway, 135-145. PMID: 23991348 [PubMed]. Vol. 3, Iss. 3. Am J Cardiovasc Dis, 2013.
  • Rajagopalan, Viswanathan, Zhao, Mingming, Reddy, Sushma, Fajarado, Giovanni, Wang, Xuejun, Dewey, Shannamar, Gomes, Aldrin V., and Bernstein, Daniel. Altered Ubiquitin-Proteasome Signaling in Right Ventricular Hypertrophy and Failure, H551-62. PMID: 23729213 [PubMed]. Vol. 305, Iss. 4. American Journal of Physiology - Heart and Circulatory Physiology, 2013. (DOI: 10.1152/ajpheart.00771.2012)
  • Ranek, Mark J., Terpstra, Erin J., Li, Jie, Kass, David A., and Wang, Xuejun. Protein Kinase G Positively Regulates Proteasome-mediated Degradation of Misfolded Proteins, 365-376. (with companion editorial). Vol. 128, Iss. 4. Circulation, 2013. (DOI: 10.1161/CIRCULATIONAHA.113.001971)
  • Liu, Cheng, Guo, Liquan, Menon, Suchithra, Jin, Dan, Pick, Elah, Wang, Xuejun, Deng, Xingwang, and Wei, Ning. COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase, 20443-52. PMID: 23689509 [PubMed]. Vol. 288, Iss. 28. Journal of Biological Chemistry, 2013. (DOI: 10.1074/jbc.M113.468959)
  • Lei, Daoxiong, Li, Faqian, Su, Huabo, Liu, Jinbao, Wei, Ning, and Wang, Xuejun. Hepatic Deficiency of COP9 Signalosome Subunit 8 Induces Ubiquitin-Proteasome System Impairment and Bim-mediated Apoptosis in Murine Livers, e67793. PMID: 23840878 [PubMed]. Vol. 8, Iss. 7. PLOS ONE, 2013. (DOI: 10.1371/journal.pone.0067793)
  • Wang, Xuejun. Repeated Intermittent Administration of a Ubiquitous Proteasome Inhibitor Leads to Restrictive Cardiomyopathy, 597-598. PMID: 23639782 [PubMed]. Vol. 15, Iss. 6. Oxford OX2 6DP, UK/Oxford University Press: European Journal of Heart Failure, 2013. (DOI: 10.1093/eurjhf/hft069)
  • Wang, Xuejun, and Terpstra, Erin J.. Ubiquitin Receptors and Protein Quality Control, 73-84. PMID: 23046644 [PubMed]. Vol. 55, Iss. 2. Journal of Molecular and Cellular Cardiology, 2013. (DOI: 10.1016/j.yjmcc.2012.09.012)
  • Li, Xiaofen, Liu, Shouting, Huang, Hongbiao, Liu, Ningning, Zhao, Chong, Liao, Siyan, Yang, Changshan, Liu, Yurong, Zhao, Canguo, Li, Shujue, Lu, Xiaoyu, Liu, Chunjiao, Guan, Lixia, Zhao, Kai, Shi, Xiaoqing, Song, Wenbin, Zhou, Ping, Dong, Xiaoxian, Guo, Haiping, Wen, Guanmei, Zhang, Change, Jiang, Lili, Ma, Ningfang, Li, Bing, Wang, Shunqing, Tan, Huo, Wang, Xuejun, Dou, Q P., and Liu, Jinbao. Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo, 211-222. PMID: 23260670 [PubMed]. Vol. 3, Iss. 1. Cell Reports, 2013. (DOI: doi:10.1016/j.celrep.2012.11.023)
  • Wang, Xuejun, Pattison, James S., and Su, Huabo. Posttranslational Modification and Quality Control, 367-381. PMID: 23329792 [PubMed] . Vol. 112, Iss. 2. Circulation Research, 2013. (DOI: 10.1161/CIRCRESAHA.112.268706)
  • Wang, Xuejun, Pattison, James S., and Su, Huabo. Posttranslational Modification and Quality Control, 367-381. Vol. 112, Iss. 2. Circulation Research, 2013. (DOI: 10.1161/CIRCRESAHA.112.268706)
  • Huang, Hongbiao, Liu, Ningning, Zhao, Kai, Li, Xiaofen, Liu, Shouting, Yang, Changshan, Zhao, Chong, Zhao, Canguo, Lu, Xiaoyu, Liu, Chunjiao, Guan, Lixia, Shi, Xiaoqing, Zhou, Ping, Dong, Xiaoxian, Guo, Haiping, Wen, Guanmei, Ma, Ningfang, Li, Bing, Wang, Xuejun, Dou, Q. Ping, and Liu, Jinbao. L-carnitine is an endogenous HDAC inhibitor selectively inhibiting cancer cell growth in vivo and in vitro, e49062. Vol. 7, Iss. 11. PLoS ONE, 2012. (DOI: 10.1371/journal.pone.0049062)
  • Tian, Zongwen, Zheng, Hanqiao, Li, Jie, Li, Yi-Fan, Su, Huabo, and Wang, Xuejun. Genetically Induced Moderate Inhibition of the Proteasome in Cardiomyocytes Exacerbates Myocardial Ischemia-Reperfusion Injury in Mice, 532-542. Vol. 111, Iss. 5. Circulation Research, 2012. (DOI: 10.1161/CIRCRESAHA.112.270983)
  • Wang, Xuejun, and Patterson, Cam. Chapter 27. Protein quality control in cardiomyocytes; In: Hill JA, Olson EN, eds. Muscle: Fundamental Biology and Mechanisms and Disease.. In Muscle: Fundamental Biology and Mechanisms of Disease, 353-368. Vol. 1, Iss. 1. San Diego, CA: Elsevier, 2012.
  • Klionsky, Dan J., many others, ..., Wang, Xuejun, and many others, .... Guidelines for the use and interpretation of assays for monitoring autophagy, 445-544. PMID: 22966490 [PubMed ]. Vol. 8, Iss. 4. Autophagy, 2012. (DOI: 10.4161/auto.19496)
  • Powell, Saul R., Herrmann, Joerg, Lerman, Admir, Patterson, Cam, and Wang, Xuejun. The ubiquitin-proteasome system and cardiovascular disease, 295-346. PMID: 22740087 [PubMed]. Vol. 109. San Diego, CA : Prog Mol Biol Transl Sci. , 2012. (DOI: 10.1016/B978-0-12-397863-9.00009-2)
  • Wang, Xuejun, Li, Jie, Zheng, Hanqaio, Su, Huabo, and Powell, Saul R.. Proteasome functional insufficiency in cardiac pathogenesis, H2207-H2219. Vol. 301, Iss. 6. Am J Physiol Heart Circ Physiol , 2011. (DOI: 10.1152/ajpheart.00714.2011)
  • Su, Huabo, and Wang, Xuejun. Autophagy and p62 in cardiac protein quality control, 1382-1383. Vol. 7, Iss. 11. Autophagy, 2011. (DOI: 10.4161/auto.7.11.17339)
  • Su, Huabo, Li, Faqian, Ranek, Mark J., Wei, Ning, and Wang, Xuejun. The COP9 signalosome regulates autophagosome maturation, 2117-2128. Vol. 124, Iss. 19. Circulation, 2011. (DOI: 10.1161/CIRCULATIONAHA.111.048934)
  • Zheng, Qingwen, Su, Huabo, Tian, Zongwen, and Wang, Xuejun. Proteasome malfunction activates macroautophagy in the heart, 214-226. Vol. 1, Iss. 3. Am J Cardiovasc Dis , 2011.
  • Wang, Xuejun, and Su, Huabo. FoxO3 hastens autophagy and shrinks the heart but does not curtail pathological hypertrophy in adult mice. In Cardiovascular Research, 561-562. Vol. 91, Iss. 4. Cardiovascular Research, 2011. (DOI: 10.1093/cvr/cvr196)
  • Li, Jie, Horak, K. M., Su, Huabo, Sanbe, Atsushi, Robbins, Jeff, and Wang, Xuejun. Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice.. In Journal of Clinical Investigation, 3689-3700. Vol. 121, Iss. 9. Journal of Clinical Investigation, 2011. (DOI: 10.1172/JCI45709)
  • Su, Huabo, and Wang, Xuejun. p62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic Stress, 224-228. Vol. 21, Iss. 8. Trends in Cardiovascular Medicine, 2011. (DOI: 10.1016/j.tcm.2012.05.015)
  • Zheng, Qingwen, Su, Huabo, Ranek, Mark J., and Wang, Xuejun. Autophagy and p62 in cardiac proteinopathy. In Circulation Research, 296-308. Vol. 109, Iss. 3. Circ Res, 2011. (DOI: 10.1161/CIRCRESAHA.111.244707)
  • Huang, Hongbiao, Liu, Ningning, Zhao, Kai, Zhu, Chenchen, Lu, Xiaoyu, Li, Shujue, Lian, Wen, Zhou, Ping, Dong, Xiaoxian, Zhao, Canguo, Guo, Haiping, Zhang, Change, Yang, Changshan, Wen, Guanmei, Lu, Li, Li, Xaiofen, Guan, Lixia, Liu, Chunjiao, Wang, Xuejun, Dou, Qing P., and Liu, Jinbao. Sanggenon C decreases tumor cell viability associated with proteasome inhibition. In Frontiers in Bioscience (Elite Edition), 1315-1325. Vol. 3, Iss. 3. Frontiers in Bioscience (Elite Edition), 2011.
  • Lu, Li, Qin, Aiping, Huang, Hongbiao, Zhou, Ping, Zhang, Chuanyin, Liu, Ningning, Li, Shujue, Wen, Guanmei, Zhang, Change, Dong, Weihua, Wang, Xuejun, Dou, Q. Ping, and Liu, Jinbao. Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition. In European Journal of Pharmacology, 242-247. Vol. 658, Iss. 2-3. European Journal of Pharmacology , 2011. (DOI: 10.1016/j.ejphar.2011.02.043)
  • Roberts, W. C., Springer, Matt L., Wang, Xuejun, and Wang, Dengshun. The launch of American Journal of Cardiovascular Disease, i-ii. Vol. 1, Iss. 1. Am J Cardiovasc Dis, 2011.
  • Li, Jie, Powell, Saul R., and Wang, Xuejun. Enhancing proteasome function via overexpressing PA28alpha protects against oxidative stress, 883-893. Vol. 25, Iss. 3. FASEB J, 2011. (DOI: 10.1096/fj.10-160895)
  • Li, Yi-Fan, and Wang, Xuejun. The Role of the proteasome in heart disease, 141-149. Vol. 1809, Iss. 2. Biochim Biophys Acta - Gene Regulatory Mechanisms , 2011. (DOI: 10.1016/j.bbagrm.2010.09.001)
  • Su, Huabo, Li, Jie, Menon, Suchithra, Liu, Jinbao, Kumarapeli, Asangi R., Wei, Ning, and Wang, Xuejun. Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.. In Circulation Research, 40-50. Vol. 108, Iss. 1. Circulation Research, 2011. (DOI: 10.1161/CIRCRESAHA.110.230607)
  • Huang, H, Zhang, X, Li, S, Liu, N, Lian, W, McDowell, Emily E., Zhou, P, Zhao, C, Yang, C, Wen, G, Dong, X, Lu, L, Ma, N, Dong, W, Dou, QP, Wang, Xuejun, and Liu, Jinbao. Physiological levels of ATP negatively regulate proteasome function, 1372-1385. Vol. 20, Iss. 12. Cell Research , 2010. (DOI: 10.1038/cr.2010.123)
  • Zheng, Hanqiao, Tang, Mingxin, Zheng, Qingwen, Kumarapeli, Asangi R., Horak, Kathy M., Tian, Zongwen, and Wang, Xuejun. Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy, 1418-1426. Vol. 56, Iss. 17. Journal of the American College of Cardiology , 2010. (DOI: doi:10.1016/j.jacc.2010.01.075)
  • Asangi, Kumarapeli R., Horak, Kathleen, and Wang, Xuejun. Protein quality control in protection against systolic overload cardiomyopathy: the long term role of small heat shock proteins. In American Journal of Translational Research, 390-401. Vol. 2, Iss. 4. American Journal of Translational Research, 2010.
  • Lei, Daoxiong, Li, Faqian, Su, Huabo, Tian, Zongwen, Ye, B, Wei, Ning, and Wang, Xuejun. COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation, 259-70. Vol. 18, Iss. 2. Cell Death Differ, 2010. (DOI: 10.1038/cdd.2010.98)
  • Lei, Daoxiong, Li, Faqian, Su, Huabo, Tian, Zongwen, Ye, B, Wei, Ning, and Wang, Xuejun. COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation, 259-70. Vol. 18, Iss. 2. Cell Death Differ, 2010.
  • Tang, Mingxin, Li, Jie, Wei, Huang, Su, Huabo, Liang, Qiangrong, Tian, Zongwen, Horak, Kathlene, Molkentin, Jeffery, and Wang, Xuejun. Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts, 424-33. Vol. 88, Iss. 3. Cardiovasc Res, 2010.
  • Su, Huabo, and Wang, Xuejun. The Ubiquitin-Proteasome System in Cardiac Proteinopathy: A Quality Control Perspective, 253-62. Vol. 85, Iss. 2. Cardiovasc Res, 2010.
  • Wang, Xuejun, and Su, Huabo. Unraveling enigma in the z-disks, 321-3. Vol. 107, Iss. 3. Circ Res, 2010.
  • Zheng, Qingwen, and Wang, Xuejun. Autophagy and the ubiquitin-proteasome system in cardiac dysfunction, 9-25. Vol. 52, Iss. 1. Panminerva Med, 2010.
  • Depre, Christophe, Powell, Saul R., and Wang, Xuejun. The role of the ubiquitin-proteasome pathway in cardiovascular disease, 251-252. Vol. 85, Iss. 2. Cardiovasc Res , 2010.
  • Ranek, Mark J., and Wang, Xuejun. Activation of the ubiquitin-proteasome system in doxorubicin cardiomyopathy, 389-385. Vol. 11, Iss. 6. Curr Hypertens Rep, 2009.
  • Yang, H., Zhou, P., Huang, H., Ma, N., Shen, S., Dong, W., Wang, Xuejun, Dou, Qing P., Liu, Jinbao, and . Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo, 2450-2459. Vol. 124, Iss. 10. Int J Cancer , 2009.
  • Su, Huabo, Huang, Wei, and Wang, Xuejun. The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription, 615-24. Vol. 41, Iss. 3. Int J Biochem Cell Biol, 2009.
  • Tydlacka, S., Wang, C. E., Wang, Xuejun, Li, S., and Li, Xiao J.. Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons, 13285-13295. Vol. 28, Iss. 49. The Journal of Neuroscience, 2008.
  • Liu, Jinbao, Zheng, Hanqiao, Tang, Mingxin, Ryu, Youn-Chu, and Wang, Xuejun. A therapeutic dose of doxorubicin activate ubiquitin-proteasome system mediated proteolysis by acting on both ubiquitination apparatus and the proteasome, H2541-2550. Vol. 295, Iss. 6. American Journal of Physiology Heart and Circulatory Physiology , 2008.
  • Powell, Saul R., Samuel, S M., Wang, P., Divald, A., Thirunavukkarasu, M., Koneru, S., Wang, Xuejun, and Maulik, N.. Upregulation of myocardial 11S-activated proteasome in experimental hyperglycermia, 618-621. Vol. 44, Iss. 3. J Mol Cell Cardiol, 2008.
  • Kumarapeli, Asangi R., Su, Huabo, Wei, Huang, Tang, Mingxin, Zheng, Hanqiao, Horak, Kathelene M., Li, Manxiang, and Wang, Xuejun. AlphaB-crystallin suppresses pressure overload cardiac hypertrophy. ., 1473-82. Vol. 103, Iss. 12. Circ Res, 2008.
  • Wang, Xuejun, Su, Huabo, and Mark, Ranek M.. Protein quality control and degradation in cardiomyocytes, 11-27. Vol. 457, Iss. 1. J Mol Cell Cardiol, 2008.
  • Qu, Jiaxiang, Zhou, Jibin, Yi, Xian-Ping, Dong, Baojun, Zheng, Hanqiao, Miller, Lisa M., Wang, Xuejun, Schneider, Mike D., and Li, Faqian. Cardiac-specific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction, 319-326. Vol. 43, Iss. 3. J Mol Cell Cardiol, 2007.
  • Kobayashi, S., Mao, Kai, Zheng, Hanqiao, Wang, Xuejun, Patterson, Cam, O'Connell, Tim D., and Liang, Qiangrong. Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury, 21945-21952. Vol. 282, Iss. 30. J Biol Chem, 2007.
  • Zhou, Jibin, Qu, Jiaxiang, Yi, Xian-Ping, Graber, K., Huber, L, Wang, Xuejun, Gerdes, A. M., and Li, Faqian. Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes, H270-H276. Vol. 292, Iss. 1. Am J Physiol Heart Circ Physiol, 2007.
  • Wang, Xuejun, and Robbins, Jeffrey. Heart failure and protein quality control, 1315-1328. Vol. 99, Iss. 12. Circulation Research, 2006.
  • Lindsten, K., Menendez-Benito, V., Masucci, M. G., Dantuma, Nic P., Kumarapeli, Asangi R., Horak, Kathy M., Zheng, Hanqiao, and Wang, Xuejun. GFP reporter mouse models of UPS proteolytic function, 1027-1028. Vol. 20, Iss. 7. FASEB J, 2006.
  • Liu, Jinbao, Tang, Mingxin, Mestril, Ruben, and Wang, Xuejun. Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes, 451-454. Vol. 40, Iss. 4. J Mol Cell Cardiol, 2006.
  • Liu, Jinbao, Chen, Quanhai, Huang, Wei, Horak, Kathy, Zheng, Hanqiao, Mestril, Ruben, and Wang, Xuejun. Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts, 362-364. Vol. 20, Iss. 2. FASEB Journal, 2006.
  • Tang, Yi-Da, Kuzman, J. A., Said, S., Anderson, B. E., Wang, Xuejun, and Gerdes, A. M.. Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction, 122-130. Vol. 112, Iss. 20. Circulation, 2005.
  • Chen, Quanhai, Liu, Jinbao, Horak, Kathy M., Zheng, Hanqiao, Kumarapeli, Asangi R., Li, Jie, Li, Faqian, Gerdes, A. M., Wawrousek, Eric F., and Wang, Xuejun. Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake, 1018-1026. Vol. 97, Iss. 10. Circulation Research, 2005.
  • Gard, J J., Yamada, K, Green, K G., Eloff, B C., Rosenbaum, D S., Wang, Xuejun, Robbins, Jeff, Schuessler, R B., Yamada, K A., and Saffitz, Jeff E.. Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy., 539-547. Vol. 67, Iss. 3. Cardiovasc Res, 2005.
  • Yi, Xian-Ping, Zhou, Jibin, Baker, J., Wang, Xuejun, Gerdes, A. M., and Li, Faqian. Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure, 13-23. Vol. 282, Iss. 1. Anat Rec A Discov Mol Cell Evol Biol, 2005.
  • Kumarapeli, Asangi R., and Wang, Xuejun. Genetic modification of the heart: chaperones and the cytoskeleton, 1097-1109. Vol. 37, Iss. 6. J Mol Cell Cardiol, 2004.
  • Dong, Xin, Liu, Jinbao, Zheng, Hanqiao, Glasford, Joe W., Hunag, Wei, Chen, Quan H., Harden, Niel R., Li, Faqian, Gerdes, A. M., and Wang, Xuejun. In situ dynamically monitoring the proteolytic function of the ubiquitin-proteasome system in cultured cardiac myocytes, H1417-1425. Vol. 287, Iss. 3. Am J Physiol Heart Circ Physiol, 2004.
  • Li, Faqian, Wang, Xuejun, Yi, Xian-Ping, and Gerdes, A. M.. Structural basis of ventricular remodeling: role of the myocyte, 5-8. Vol. 1, Iss. 1. Curr Heart Fail Rep, 2004.
  • Wang, Xuejun, Klevitsky, R., Huang, Wei, Glasford, Joe, Li, Faqian, and Robbins, Jeff. AlphaB-crystallin modulates protein aggregation of abnormal desmin, 998-1005. Vol. 93, Iss. 10. Circ Res, 2003.
  • Yi, Xian-Ping, Wang, Xuejun, Gerdes, A. M., and Li, Faqian. Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium, 1317-1323. Vol. 41, Iss. 6. Hypertension, 2003.
  • Gerdes, A. M., and Wang, Xuejun. Structural remodeling of cardiac myocytes in hypertrophy and progression to failure. IN: PK Singal, IMC Dixon, LA Kirshenbaum, NS Dhalla, Eds. Cardiovascular Remodeling and failure. In Cardiovascular Remodeling and failure, 183-193. Boston, MA: Klewer Academic Publishers, 2003.
  • Wang, Xuejun, Osinska, Hanna, Gerdes, A. M., and Robbins, Jeff. Desmin filaments and cardiac disease: establishing causality, S287-292. Vol. 8, Iss. 6 Suppl. J Card Fail, 2002.
  • Wu, Guangyu, Yussman, M. G., Barrett, T. J., Hahn, H. S., Osinska, Hanna, Hilliard, G. M., Wang, Xuejun, Toyokawa, T., Yatani, A., Lynch, R. A., Robbins, Jeff, and Dorn, Gerald W.. Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy, 1130-1137. Vol. 89, Iss. 12. Circ Res, 2001.
  • Wang, Xuejun, Osinska, Hanna, Klevitsky, R., Gerdes, A. M., Nieman, M., Lorenz, J., Hewett, Tim, and Robbins, Jeff. Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice, 84-91. Vol. 89, Iss. 1. Circ Res, 2001.
  • Yang, Q., Hewett, T. E., Klevitsky, R., Sanbe, A., Wang, Xuejun, and Robbins, Jeff. PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice, 80-88. Vol. 51, Iss. 1. Cardiovasc Res, 2001.
  • Wang, Xuejun, Osinska, H., Dorn, Gerald W., Nieman, M., Lorenz, Jon N., Gerdes, A. M., Witt, S., Kimball, Tom, Gulick, Jim, and Robbins, Jeff. Mouse model of desmin-related cardiomyopathy, 2402-2407. Vol. 103, Iss. 19. Circulation, 2001.
  • Sanbe, A., Nelson, D., Gulick, Jim, Setser, E., Osinska, Hanna, Wang, Xuejun, Hewett, Tim E., Klevitsky, R., Hayes, E., Warshaw, David M., and Robbins, Jeff. In vivo analysis of an essential myosin light chain mutation linked to familial hypertrophic cardiomyopathy, 296-302. Vol. 87, Iss. 4. Circ Res, 2000.
  • Milner, Derek J., Taffet, G E., Wang, Xuejun, Pham, T, Tamura, T, Hartley, C, Gerdes, A. M., and Capetanaki, Y. The absence of desmin leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic function, 2063-76. Vol. 31, Iss. 11. J Mol Cell Cardiol , 1999. (DOI: 10.1006/jmcc.1999.1037)
  • Wang, Xuejun, Li, Faqian, and Gerdes, A. M.. Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: I. Regional hemodynamics and myocyte remodeling, 307-317. Vol. 31, Iss. 2. J Mol Cell Cardiol, 1999.
  • Wang, Xuejun, Li, Faqian, Campbell, Scott E., and Gerdes, A. M.. Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling, 319-331. Vol. 31, Iss. 2. J Mol Cell Cardiol, 1999.
  • Wang, Xuejun, and Gerdes, A. M.. Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: III. Intercalated disc remodeling, 333-343. Vol. 31, Iss. 2. J Mol Cell Cardiol, 1999.
  • Li, Faqian, Wang, Xuejun, Bunger, Paul, and Gerdes, A. M.. Formation of binucleated cardiac myocytes in rat heart: I. Role of actin-myosin contractile ring, 1541-1551. Vol. 29, Iss. 6. J Mol Cell Cardiol, 1997.
  • Li, Faqian, Wang, Xuejun, and Gerdes, A. M.. Formation of binucleated cardiac myocytes in rat heart: II. Cytoskeletal organisation, 1553-1565. Vol. 29, Iss. 6. J Mol Cell Cardiol, 1997.
  • Wang, Xuejun, Li, Faqian, Said, Suleman, Capasso, Joe M., and Gerdes, A. M.. Measurement of regional myocardial blood flow in rats by unlabeled microspheres and Coulter channelyzer, H1656-1665. Vol. 271, Iss. 4 Pt 2. Am J Physiol, 1996.
  • Gerdes, A. M., Onodera, T., Wang, Xuejun, and McCune, S. A.. Myocyte remodeling during the progression to failure in rats with hypertension, 609-614. Vol. 28, Iss. 4. Hypertension, 1996.
  • Li, Faqian, Wang, Xuejun, Capasso, Joe M., and Gerdes, A. M.. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development, 1737-1746. Vol. 28, Iss. 8. J Mol Cell Cardiol, 1996.

Awards and Honors:

  • Invited to serve on the International Expert Panel, National Medical Research Council of Singapore, 2016
  • Member of the Editorial Board of Circulation Research, Circulation Research, 2016
  • Member of the Editorial Board, American Journal of Physiology - Heart and Circulatory Physiology, 2016
  • Member of the Editorial Board of Circulation Research, Circulation Research, 2015
  • Member of the Editorial Board, American Journal of Physiology - Heart and Circulatory Physiology, 2015
  • Best Poster Award, The First Annual ACRE/APS Sympoisum, Las Vegas, NV., 2014
  • Best Poster Award, The Third Symposium on Ubiquitin, Protein Quality Control, and Molecular Pathogenesis at Deadwood, SD, 2014
  • Member of the Editorial Board of Circulation Research, Circulation Research, 2014
  • Member of the Editorial Board, American Journal of Physiology - Heart and Circulatory Physiology, 2014
  • Member of the Editorial Board of Circulation Research, Circulation Research, 2013
  • Review Editor for Frontiers in Striated Muscle Physiology, 2013
  • Member of the Editorial Board, American Journal of Physiology - Heart and Circulatory Physiology, 2013
  • Distinguished Service Award, Academy of Cardiovascular Research Excellence (ACRE), 2012
  • Member of Editorial Board, Frontiers in Clinical and Translational Physiology, 2012
  • Member of the Editorial Board, American Journal of Physiology - Heart and Circulatory Physiology, 2012
  • Associate Editor-in-Chief, American Journal of Cardiovascular Disease, 2011
  • Fellow of American Physiological Society, American Physiological Society Cardiovascular Section, 2011
  • Fellow of AHA and the Council on Basic Cardiovascular Sciences, American Heart Assoication (AHA), 2010
  • Co-Chair, Melvin L. Marcus Young Investigator Award in Cardiovascular Sciences, American Heart Association, 2010
  • Co-Chair and invited speaker of the Symposium on "The Role of the Ubiquitin Proteasome System in Cardiac Disease, Diabetes, and Aging", the Experimental Biology meeting, Anaheim, CA, 2010
  • Guest Editor for the Spotlight Issue on "The Ubiquitin-Proteasome Pathway in Cardiovascular Disease", Cardiovascular Research, an official journal of European Society of Cardiology, 2010
  • Co-Chair and invited speaker, Sunday Morning Program "Protein Quality Control in Heart Disease", AHA Scientific Sessions, Orlando, FL, 2009
  • Standing Memebr of NIH CCHF Study Section (2009-2013), NIH, 2009
  • Chair, AHA National Card. Biol/Reg. Study Section 2, American Heart Association, 2009
  • Chair, the session on Genetic Models of Human Disease, AHA Scientific Sessions, New Orleans, LA., 2008
  • President's Award for Research Excellence (Established Faculty), University of South Dakota, 2008
  • Chair, Sunday Morning Program-"Protein Conformation, Degradation and Cardiac Disease", AHA Scientific Sessions, Orlando, FL, 2007
  • Established Investigator Award, American Heart Association, 2007
  • The Protein Folding Advisory Committee Best Poster Award, Cambridge Health Institute, 2005
  • Notification of Distinguished Performance, University of South Dakota School of Medicine, 2003
  • Scientist Development Award, American Heart Association National Center, 2002
  • Young Investigator Award, International Society for Heart Research (ISHR): North American Section, 2001
  • Young Investigator Award, Heart Failure Society of America, 2000
  • AHA Postdoctoral Fellowship, American Heart Association (AHA), 2000

Presentations:

  • Wang, Xuejun. Protein Degradation in Heart Failure. Presented at the the 36th Annual Conference of the North American Section of the International Society of Heart Research (NAS-ISHR), New Orleans, LA. (June 1, 2017)
  • Wang, Xuejun. Ubiquitin and ubiquitin-like proteins in cardiovascular physiology and disease. Presented at the Experimental Biology Meeting , Chicago, IL. (April 24, 2017)
  • Wang, Xuejun. Ubiquitin and ubiquitin-like proteins in the heart: an overview. Presented at the The Experimental Biology Meeting, Chicago, IL. (April 24, 2017)
  • Wang, Xuejun. The State-Of-The-Art in Cardiac Protein Misfolding. Presented at the Scientific Sessions of American Heart Association, New Orleans, Louisiana. (November 14, 2016)
  • Wang, Xuejun. An invited lecture: The COP9 signalosome: a post-transcriptional cop in the heart. Presented at the AHA Basic Cardiovascular Sciences (BCVS) 2016 Scientific Sessions: Pathways to Cardiovascular Therapeutics, Phoenix, AZ. (July 19, 2016)
  • Wu, Penglong, Zhu, Wei, Li, Jinbo, Wang, Xuejun. Cathepsin D haploinsufficiency exacerbates post-MI cardiac remodeling and malfunction by impairing autophagosome removal. Presented at the AHA Basic Cardiovascular Sciences 2016 Sceintific Sessions: Pathways to Cardiovascular Therapeutics, Phoenix, AZ. (July 19, 2016)
  • Zhang, Hanming, Wang, Xuejun. PDE1 inhibition primes the proteasome. Presented at the American Heart Association Basic Cardiovascular Sciences (BCVS) 2016 Scientific Sessions: Pathways to Cardiovascular Therapeutics, Phoenix, AZ. (July 18, 2016)
  • Wu, Penglong, Zhu, Wei, Li, Jinbo, Wang, Xuejun. Cathepsin D haploinsufficiency exacerbates post-MI cardiac remodeling and malfunction by impairing autophagosome removal. Presented at the The 3rd ACRE/APS symposium, Phoenix, AZ. (July 17, 2016)
  • Zhang, Hanming, Wang, Xuejun. PDE1 inhibition imporves cardiac protein quality control. Presented at the The 3rd ACRE/APS symposium, Phoenix, AZ. (July 17, 2016)
  • Wang, Xuejun. Protein Quality Control and Necroptosis. Presented at the Invited Seminar Series of Department of Pathology, LSU Health Science Center at Shreveport, Shreveport, LA. (May 31, 2016)
  • Wang, Xuejun. Proteasome functional insufficiency in cardiac pathogenesis. Presented at the Invited Seminar Series of the Division of Cardiology at the Shanghai 6th People's Hospital, Shanghai, China. (May 24, 2016)
  • Wang, Xuejun. The COP9 coerces lysosomes and proteasomes to police the heart. Presented at the Invited Seminar Series of College of Life Science at Shanghai Ocean University , Shanghai, China. (May 23, 2016)
  • Wang, Xuejun. The COP9 signalosome in the heart. Presented at the Invited Seminar Series of Department of Pathophysiology at Guangzhou Medical University , Guangzhou, China. (May 20, 2016)
  • Wang, Xuejun. A plenary lecture on "Dissecting UPS dysfunction promises novel therapeutic strategies for heart disease with elevated proteotoxic stress". Presented at the The 4th Wuhan International Conference on Cardimetabolic Science , Wuhan, China. (May 14, 2016)
  • Wang, Xuejun. An invited lecture on "The Interplay Between Autophagy and the Ubiquitin-Proteasome System in Cardiac Proteotoxicity". Presented at the The ASIP 2016 Annual Meeting at Experimental Biology, San Diego, CA. (April 3, 2016)
  • Wang, Xuejun. An invited lecture on "The COP9 signalosome coerces autophagy and the proteasome to police the heart". Presented at the Dept. of Biomedical Sciences Seminar Series, Old Westbury, NY 11568-8000. (March 14, 2016)
  • Wang, Xuejun. Keynote Address: Dr. Saul Powell was a pioneer and a leader for the research into proteasome dysfunction in heart disease. Presented at the The Scientific Memorial of Dr. Saul R. Powell held by the Feinstein Institute for Medical Research, Long Island, New York. (March 14, 2016)
  • Wang, Xuejun. An Invited Lecture on "Neddylation/Deneddylation, Protein Quantity & Quality Contorl, and Cardiomyocyte Necroptosis". Presented at the AHA Scientific Sessions, Orlando, FL. (November 9, 2015)
  • Wang, Xuejun, Wang, Changhua, Li, Jie, Su, Huabo, Xiao, Peng, Wang, XJ. COPS8 Inhibits Cardiomyocyte Necroptosis in Mouse Hearts via Suppressing the RIPK1-RIPK3 Pathway. Presented at the AHA Scientific Sessions, Orlando, FL. (November 9, 2015)
  • Abdullah, Ammara, Eyster, Kathleen, Bjordahl, Travis, Wang, Xuejun. Myocardial gene expression profiles in mice with perinatal cardiac knockout of COPS8. Presented at the Nebraska Physiological Society 18th Annual Meeting, Vermillion, SD. (October 10, 2015)
  • Wang, Changhua, Terpstra, Erin M., Wang, Yibin, Wang, Xuejun. Activation of the p38 branch of mitogen activated protein kinase pathway stimulates proteasome proteolytic function.. Presented at the Basic Cardiovascular Sciences (BCVS) 2015 Scientific Sessions: Pathway to Cardiovascular Therapeutics, New Orleans, LA. (July 15, 2015)
  • Terpstra, Erin M., Callegari, Eduardo, Hu, Chengjun, Zhang, Hanming, Wang, Xuejun. Proteasome priming by protein kinase G protects against myocardial ischemia-reperfusion injury. Presented at the Basic Cardiovascular Sciences (BCVS) 2015 Scientific Sessions: Pathway to Cardiovascular Therapeutics, New Orleans, LA. (July 15, 2015)
  • Li, Jie, Ma, Wenxia, Li, H, Hou, Ning, Wang, Xuejun, Kim, Il-Man, Li, Faqian, Su, Huabo. NEDD8 ultimate buster-1 long (NUB1L) protein regulates atypical neddylation and protects against myocardial ischemia-reperfusion injury. Presented at the Basic Cardiovascular Sciences (BCVS) 2015 Scientific Sessions: Pathway to Cardiovascular Therapeutics, New Orleans, LA. (July 13, 2015)
  • Wang, Xuejun. Protein Degradation in Heart Failure. Presented at the The 36th International Society for Heart Research North American Section Meeting, Seattle, WA. (June 9, 2015)
  • Su, Huabo, Li, Jie, Zhang, Hanming, Wei, Ning, Wang, Xuejun. The COP9 signalosome controls the degradation of cytosolic misfodled proteins and protects against cardiac proteotoxicity. Presented at the The 36th International Society for Heart Research North American Section Meeting, Seattle, WA. (June 8, 2015)
  • Wang, Xuejun. Inadequate Protein Quality Control in Cardiac Pathogenesis. Presented at the Invited Seminars at School of Veterinary Medicine & Biomedical Sciences, University of Nebraska-Lincoln , Lincoln, Nebraska 68583-0905. (September 29, 2014)
  • Wang, Xuejun. Inadequate Protein Quality Control in Cardiac Pathogenesis. Presented at the Invited Seminars at Molecular Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK. (August 7, 2014)
  • Wang, Xuejun, Ranek, Mark J., Terpstra, Erin J.. Priming the proteasome by PKG: a novel cardioprotective mechanism of sildenafil. Presented at the The 19th World Congress on Heart Disease, Boston, MA, USA. (July 28, 2014)
  • Wang, Changhua, Jahn, Andrea, Su, Huabo, Wang, Xuejun. Duo-impairment of the Ubiquitin-Proteasome System and Autophagy by Ablation of COP9 Signalosome Subunit 8 Activates a Programmed Necrosis Pathway Mediated by RIP1-RIP3 Kinases but not Cyclophilin D-regulated Mitochondrial Membrane Permeability. Presented at the Basic Cardiovascular Sciences 2014 Scientific Sessions: Pathway to Cardiovascular Therapeutics, Las Vegas, NV. (July 16, 2014)
  • Wang, Xuejun, Hu, Chengjun, Tian, Yihao, Wang, Hongmin. Inadequate Coupling between Ubiquitination and the Proteasome is a Major Pathogenic Factor of Myocardial Ischemia/Reperfusion Injury. Presented at the Basic Cardiovascular Sciences 2014 Scientific Sessions: Pathway to Cardiovascular Therapeutics, Las Vegas, NV. (July 16, 2014)
  • Hu, Chengjun, Wang, Xuejun, Wang, Hongmin, Tian, Yihao. Inadequate Coupling between Ubiquitination and the Proteasome is a Major Pathogenic Factor of Myocardial Ischemia/Reperfusion Injury. Presented at the The First Annual ACRE/APS Sympoisum, Las Vegas, NV. (July 13, 2014)
  • Wang, Xuejun. Protein Quality Control in Cardiac Pathogenesis. Presented at the Invited Seminars at the Institute of Molecular Medicine of Peking University , Beijing, China. (July 1, 2014)
  • Wang, Xuejun. Protein Quality Control and Degradation in Cardiac Disease. Presented at the Invited Seminars at the 2nd Affiliated Hospital of Zhejiang University Medical College, Hangzhou, Zhejiang, China. (June 25, 2014)
  • Wang, Xuejun. Protein Quality Control and Disease. Presented at the Invited Seminars at the 2nd Affiliated Hospital of Zhongnan Univeristy Xiangya Medical School , Changsha, Hunan, China. (June 20, 2014)
  • Wang, Xuejun. Inadequate Coupling between Ubiquitination and Proteasomal Degradation in Cardiac Pathogenesis. Presented at the Invited Seminars at Wuhan University College of Basic Medical Sciences, Wuhan, Hubei, China. (June 13, 2014)
  • Li, Shuai, Wang, Xuejun, Martin, Douglas. Proteasome inhibition attenuates angiotensin II-induced hypertension and vascular remodeling. Presented at the Third Symposium on Ubiquitin, Protein Quality Control, and Molecular Pathogenesis, Deadwood South Dakota. (June 2014)
  • Wang, Xuejun. Protein Quality Control and Cell Death. Presented at the Invited Seminars at Department of Anatomy and Cell Biology, University of South Carolina School of Medicine, Columbia, SC. (May 19, 2014)
  • Wang, Xuejun. Loss of Function of an Extraproteasomal Ubiquitin Receptor Ubiquilin1 in Cardiomyocytes Exacerbates Cardiac Proteotoxicity. Presented at the The 35th International Society for Heart Research North American Section Meeting, Miami Beach, Florida. (May 14, 2014)
  • Tian, Zongwen, Wang, Changhua, Hu, Chengjun, Tian, Yihao, Liu, Jinbao, Wang, Xuejun. Autophagic-Lysosomal Inhibition Compromises Ubiquitin-1 Proteasome System Performance in a p62 Dependent Manner in Cardiomyocytes. Presented at the The 35th International Society for Heart Research North American Section Meeting: "NOVEL STRATEGIES TO COMBAT HEART FAILURE, Miami Beach, Florida. (May 14, 2014)
  • Martin, Douglas, Wang, Xuejun, Messenger, Ford, Hannah, Kjellsen, Barton, Li, Shuai. Angiotensin II activates the proteasome and stimulates vascular smooth muscle cell proliferation.. Presented at the Experimental Biology 2014, San Diego California. (April 2014)
  • Day, Sharlene M., Yob, Jaime, Davis, Frank, Wang, Ping, Converso, Kimber L., Wang, Xuejun, Powell, Saul R.. Selective Inhibition of the Immunoproteasome Attenuates Adverse Left Ventricular Remodeling, Improves Cardiac Function, and Prevents Heart Failure After Myocardial Infarction. Presented at the 2013 AHA Scientific Sessions, Dallas TX. (November 19, 2013)
  • Wang, Xuejun. An invited lecture on the Interaction between Ubiquitin-Proteasome System and Autophagy in the Heart. Presented at the AHA Sceintific Sessions, Dallas TX. (November 18, 2013)
  • Terpstra, Erin J., Ranek, Mark J., Callegari, Eduardo, Wang, Xuejun. The Proteasome is a Target of Protein Kinase G. Presented at the 2013 AHA Scientific Sessions, Dallas TX. (November 17, 2013)
  • Martin, Douglas, Li, Yi-Fan, Wang, Xuejun, Kost, Curtis, Shuai, Li. A proteasome inhibitor attenuates angiotensin II induced hypertension, associated vascular remodeling, and vascular smooth muscle cell proliferation. Presented at the Nebraska Physiological Society , Omaha, Nebraska. (October 2013)
  • Ranek, Mark J., Terpstra, Erin J., Li, Jie, Kass, David A., Wang, Xuejun. Protein Kinase G Positively Regulates Proteasome-Mediated Degradation of Misfolded Proteins. Presented at the the AHA Basic Cardiovascular Sciences Scientific Sessions, Las Vegas, Nevada. (July 23, 2013)
  • Su, Huabo, Li, Jie, Wei, Ning, Wang, Xuejun. The COP9 Signalosome Subunit 8 Hypomorphism Impairs Deneddylation and Exacerbates Desmin-related Cardiomyopathy. Presented at the Experimental Biology 2013, Boston, MA. (April 22, 2013)
  • Wang, Xuejun. An invited lecture on Proteasome Dysfunction in Cardiac Pathogenesis. Presented at the Keystone Symposium on Cardiac Remodeling, Signaling, Matrix and Heart Function, Snowbird, Utah. (April 9, 2013)
  • Ranek, Mark J., Li, Jie, Kost, Curtis, Martin, Douglas, Wang, Xuejun. Protein kinase G regulates proteasome-mediated degradation of misfolded proteins. Presented at the AHA Scientific Sessions, Los Angeles, CA. (November 6, 2012)
  • Wang, Xuejun. An invited lecture on UPS Dysfunction and Regulation in Heart Failure. Presented at the AHA Scientific Sessions, Los Angeles, CA. (November 4, 2012)
  • Wang, Xuejun. The COP9 Signalosome Polices the Heart. Presented at the UIC Dept Biological Sciences Invited Seminar Series , Chicago, IL. (September 18, 2012)
  • Ranek, Mark J., Martin, Douglas, Kost, Curtis, Wang, Xuejun. Activation of Protein Kinase G Enhances Proteasome-Mediated Degradation of Misfolded Proteins. Presented at the AHA Basic Cardiovascular Sciences 2012 Scientific Sessions, New Orleans, LA. (July 25, 2012)
  • Wang, Xuejun. An invited lecture on Ubiquitination and Proteasomes: Mechanism of Heart Failure. Presented at the AHA Basic Cardiovacsular Sciences 2012 Scientific Sessions Invited Lectures, New Orleans, LA. (July 24, 2012)
  • Wang, Xuejun. Can we boost cardiac proteasomes by stimulating PKG?. Presented at the 2nd Annual PQCD Symposium, Deadwood, SD, USA. (June 14, 2012)
  • Li, Shuai, Wang, Xuejun, Martin, Douglas. Proteasome inhibition attenuates angiotensin II-induced hypertension and vascular remodeling.. Presented at the Experimental Biology 2012, San Diego California. (April 2012)
  • Wang, Xuejun, Li, Jie. State-of-the-Art Lecture: Can we treat protienopathy by upregulating 11S proteasomes?. Presented at the Protein Degradation Pathways in Health and Diseases , San Diego, CA. (January 24, 2012)
  • Ranek, Mark, Wang, Xuejun. Protein Kinase G Regulates the UPS in Cardiomyocytes. Presented at the Protein Degrdation Pathways in Health and Diseases, San Diego, CA, USA. (January 23, 2012)
  • Wang, Xuejun. Proteasome Functional Insufficiency in Cardiac Pathogenesis. Presented at the University of Minnesota Lillehei Heart Institute Lecture, Minneapolis, MN, USA. (December 7, 2011)
  • Wang, Xuejun. The COP9 Signalosome Regulates Autophagy. Presented at the Sanford Research/USD Seminar Series, Sioux Falls, SD. (November 18, 2011)
  • Wang, Xuejun. Protein Quality Control and Heart Disease. Presented at the FAU Molecular Biology and Biotechnology Seminar Series, Boca Raton, FL, USA. (November 16, 2011)
  • Wang, Xuejun. Novel regulator of the UPS. Presented at the 2011 AHA Scientific Sessions Invited Lectures, Orlando, FL, USA. (November 15, 2011)
  • Wang, Changhua, Tian, Zongwen, Zheng, Qingwen, Su, Huabo, Li, Jie, Wang, Xuejun. Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart. Presented at the AHA Basic Cardiovascular Sciences 2011 Scientific Sessions, New Orleans, LA, USA. (July 20, 2011)
  • Zheng, Qingwen, Su, Huabo, Ranek, Mark J., Wang, Xuejun. The Role of p62 in Cardiac Protein Quality Control. Presented at the AHA Basic Cardiovascular Sciences 2011 Scientific Sessions , New Orleans, LA, USA. (July 20, 2011)
  • Li, Jie, Horak, Kathleen M., Su, Huabo, Sanbe, Atsushi, Robbins, Jeffrey, Wang, Xuejun. Enhancement of Proteasomal Function Protects Against Proteinopathy and Myocardial Ischemia-Reperfusion Injury in Mice. Presented at the AHA Basic Cardiovascular Sciences 2011 Scientific Sessions, New Orleans, LA, USA. (July 19, 2011)
  • Tian, Zongwen, Zheng, Hanqiao, Wang, Xuejun. Genetically Induced Moderate Inhibition of the Proteasome in Cardiomyocytes Exacerbates Myocardial Ischemia-Reperfusion Injury in Mice. Presented at the AHA Basic Cardiovascular Sciences 2011 Scientific Sessions, New Orleans, LA, USA. (July 19, 2011)
  • Su, Huabo, Tian, Zongwen, Wang, Changhua, Said, Suleman, Ranek, Mark J., Wang, Xuejun. Impaired Autophagosome Removal in Cardiomyocytes Triggers Programmed Necrosis in Mouse Hearts. Presented at the AHA Basic Cardiovascular Sciences 2011 Scientific Sessions, New Orleans, LA, USA. (July 19, 2011)
  • Su, Huabo, Ranek, Mark J., Wei, Ning, Wang, Xuejun, . The COP9 Signalosome Regulates Autophagy. Presented at the AHA Basic Cardiovascular Sciences 2011 Scientific Sessions, New Orleans, LA. (July 19, 2011)
  • Wang, Xuejun. Protein quality control and degradation in the heart. Presented at the The Inaugural Symposium on Ubiquitin, Protein Quality Control and Molecular Pathogenesis , Vermillion, SD, USA. (June 24, 2011)
  • Zou, Jianqiu, Long, Molly, Pickner, Wyatt, Tian, Fen, Wang, Xuejun, Zhang, Dong. Localization of Ubiquitin Proteasome System (UPS) components to the Centrosomes. Presented at the Ubiquitin, Protein Quality Control, and Molecular Pathogenesis Symposium , Vermillion. (June 23, 2011)
  • Wang, Xuejun. The Ubiquitin-Proteasome System in Cardiac Remodeling and Failure. Presented at the UIC Molecular and Integrative Physiology Invited Seminars, Urbana, IL, USA. (April 28, 2011)
  • Davis, F, Predmore, J, Wang, P, Li, Jie, Su, Huabo, Converso, KL, Allen, A, Jones, R, Powell, SR, Wang, Xuejun, Day, Sharlene M.. Activation of the ubiquitin proteasome system after myocardial infraction. Presented at the AHA Scientific Sessions, Chicago, IL. (November 14, 2010)
  • Wang, Xuejun, Wang, Xuejun. COP9 signalosomes regulate proteolysis in the heart. Presented at the UCLA Symposium on Genes, Proteins, and Translational Medicine Invited Lectures, Rancho Mirage, CA. (July 18, 2010)
  • Wang, Xuejun. Proteasome functional insufficiency in cardiac proteinopathy. Presented at the EB Invited Lectures on the Role of the Ubiquitin Proteasome System in Cardiac Disease, Diabetes, and Aging, Anaheim, CA. (April 27, 2010)
  • Ranek, Mark, Wang, Xuejun. Activation of muscarinic receptor 2 stimulates proteasome function in cardiomyocytes. Presented at the Experimental Biology Meeting , Anaheim, CA. (April 27, 2010)
  • Ranek, Mark, Wang, Xuejun. Stimulation of adrenergic receptors regulates proteasome function in cardiomyocytes. Presented at the Experimental Biology Meeting , Anaheim, CA. (April 27, 2010)