Gallery 110 is located in the Warren M. Lee Center for the Fine Arts on The University of South Dakota campus. The space co-exists as conference/meeting room with exhibition space for smaller, more intimate works with just over 63 feet of wall space. Solo and small group exhibitions of works on paper are ideal shows for this space.

Gallery 110 hosts the annual fall semester Loan Show through the University Art Galleries, which loans works of art from its collection for use in public spaces on campus at no charge as part of its efforts to contribute to campus beautification and informal aesthetic education. Works on loan from the University Art Galleries may be displayed on-campus in public spaces such as offices, lounges and common areas. Gallery 110 is open weekdays between 8 a.m. and 5 p.m.