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Contact Information:
Division of Basic Biomedical Sciences
Sanford School of Medicine of The University of South Dakota
414 E.Clark Street
Vermillion, SD 57069
phone: (605)-677-5254
fax: (605)-677-6381
biomed@usd.edu
Last Modified: 08/02/07
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Dr. Yang studies signal transduction of growth factors and the mechanism of protein translation initiation. His research focuses on two important proteins, ATM and p53, which are critical for multiple physiological processes such as cell cycle progress, DNA damage repair, neuronal degeneration, and insulin resistance. His goal is to understand how ATM kinase functions in various types of cells in response to growth factors and cytotoxic stresses. He also examines how translation of p53 tumor suppressor is regulated in response to DNA damage signals.
- Halaby MJ and Yang DQ. Translational control of p53 induction: A new facet of p53 regulation and its implication for tumorigenesis and cancer therapeutics . Gene, 395(1-2):1-7. 2007. Epub 2007 Feb 16.
- Boehrs JK, He J, Halaby MJ, and Yang DQ. Constitutive Expression and Cytoplasmic Compartmentalization of ATM Protein in Differentiated Human Neuron-like SH-SY5Y Cells. Journal of Neurochemistry, 100 (2): 337-45, 2007. Epub 2006Nov 16.
- Yang D-Q, Halaby MJ, and Zhang Y. The Identification of an IRES Sequence in the 5’-Untranslated Region of p53 mRNA Provides a Novel Mechanism for the Regulation of its Translation Following DNA Damage. Oncogene, 25(33):4613-9, 2006. Epub 2006 Apr 10.
- Yang D-Q, and Kastan MB. Participation of ATM in Insulin Signalling through Phosphorylation of eIF-4E-Binding Protein 1. Nature Cell Biology, 2, 893-8, 2000.
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