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Contact Information:
Division of Basic Biomedical Sciences
Sanford School of Medicine of The University of South Dakota
414 E.Clark Street
Vermillion, SD 57069
phone: (605)-677-5254
fax: (605)-677-6381
biomed@usd.edu
Last Modified: 12/11/06
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Pasquale (Pat) Manzerra, Ph.D. (University of Toronto)
Assistant Professor
NMDA Receptor-mediated Intracellular Signaling
(605)-677-6882
pmanzerr@usd.edu
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Research Interests
The postsynaptic density (PSD) is a highly organized network of proteins found at the cytosolic surface of the postsynaptic membrane, which serves to transduce synaptic stimuli into intracellular signaling events. The NMDA receptor and its complex of associated proteins is one of several signaling networks located in the PSD which is essential for development, synaptic plasticity and both neuronal survival and cell death. The overall focus of research in Dr. Manzerra's laboratory is to explore the spatial and temporal dynamic organization of signal processing complexes in the glutamatergic PSD. Specifically, the lab investigates NMDA receptor-mediated intracellular signaling and the subsequent role in mediating physiological and pathological events. Such an examination of the modulation of synaptic signaling complexes will provide valuable insights for an understanding of the molecular basis of neurological disorders.
Publications
Oh J., Manzerra P., and Kennedy M.B. (2004). Regulation of the neuron-specific ras GTPase activating protein, SynGAP, by Ca2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 279: 17980-17988.
Canzoniero L.M.T., Babcock D.J., Gottron F.J., Grabb M.C., Manzerra P., Snider B.J., and Choi D.W. (2004). Raising Intracellular Calcium Attenuates Neuronal Apoptosis Triggered by Staurosporine or Oxygen-Glucose Deprivation in the presence of Glutamate Receptor Blockade. Neurobiol. Dis. 15: 520-528.
Canzoniero L.M.T., Manzerra P., Sheline C.T., and Choi D.W. (2003). Membrane permeant chelators can attenuate Zn2+-induced cortical neuronal death. Neuropharmacology 45: 420-428.
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