BIOC520: Medical Biochemistry			
1995: Exam 5 Part II

PART II (40 points)

1. (16 pts) Fill in each of the boxes in the table below. Be specific (ie.
use specific names when possible. 

         		 GLYCOGEN		CELL			
	         	 METABOLISM		DIVISION	VISION
	        	     (Liver)

1. LIGAND			?		EGF		PHOTON

2. RECEPTOR		beta adrenergic		?		?
		
3. RECEPTOR ACTIVATION
   MECHANISM  			?		?		?	
  	  
4. G PROTEIN			?		?		?
  		
5. EFFECTOR ENZYME		?		raf-1 kinase	?

  		 
6. 2nd MESSENGER		?		-----		-----

7. TARGET			?		?		Na+, Ca++
								Channels

8. IMMEDIATE CONSEQUENCE	?		?		?




2. (6 pts) For each of the following clotting abnormalities, give a 
plausible reason and briefly explain your answer. 

	A. This patient had internal bleeding and was vomiting blood. He 
	had no past history of any bleeding problems, either personally 
	or of family members. He had a growth that was blocking his bile 
	duct. His prothrombin time (PT) was 30 seconds but his partial 
	thromboplastin time (PTT)was normal.



	B. This patient was an infant who showed profuse bleeding after 
	his circumcision. Analysis showed a PTT of 80 seconds but a 
	normal PT. A blood mixing study corrected the PTT. The patient's 
	maternal uncle had died of excessive internal bleeding following 
	a minor car accident.




	C. This patient has a tendency to develop thromboembolism. Analysis 
	of her blood revealed an abnormally elevated level of both 
	factors Va and VIIIa.


3. (10 pts) In one sentence or phrase describe the role of Ca++ in 
the following:

	   (1) striated muscle contraction


	   (2) smooth muscle contraction


	   (3) vision


	   (4) presynaptic terminal


	   (5) blood clotting




4.  (5 pts) Matching (use each drug or reagent only once)

	_____ an antagonist of the 		a. nitroglycerine		
		progesterone receptor		b. warfarin
						c. l-dopa
	_____ an inhibitor of 			d. RU486
		cyclooxygenase			e. EDTA
						f. lithium
	_____ an activator of plasminogen	g. aspirin
						i. tamoxifen
	_____ leads to smooth muscle 		j. theophylline
		relaxation by activating	k. streptokinase
		guanylate cyclase		l. Tagamet

	_____ inhibits dephosphorylation 
		of inositol phosphates

5.  (5pts) Indicate whether the proteins described below are most likely
to be encoded by a proto-oncogene (P) or a tumor suppressor gene (T). 

_____ this protein is a transcription factor that specifically enhances
	transcription of the cyclin/CDK inhibitor p16

_____ this protein is a non-receptor tyrosine kinase that can
	phosphorylate STAT1 and PI3-kinase

_____ the function of this protein is unknown but a person homozygous for
	a deletion of the entire gene has a very high probability of 
	developing cancer

_____ this protein is a G1 cyclin

_____ this protein is a transcription factor that represses transcription
	of the c-H-ras, c-fos, c-jun and c-myc genes 

jt 9/97