Department of Biochemistry and Molecular Biology: Lindahl
Lindahl
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Ronald G. Lindahl, Ph.D.

Professor and Dean of Basic Biomedical Sciences


Cellular and Molecular Biology


University of South Dakota School of Medicine

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Education

Wayne State University, B.A. 1970
Wayne State University, Ph.D. 1973
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Professional Experience

Postdoctoral Appointee, Argonne National Laboratory, 1974-1975
University of Alabama, 1975-1989
University of South Dakota School of Medicine, 1989-present

Selected Recent Publications

Boesch, J., Lee, C. and Lindahl, R. (1996) Constitutive expression of class 3 aldehyde dehydrogenase in cultured rat corneal epithelium. J. Biol. Chem. 271:5150-5157.

Xie, Y. Q., Takimoto, K., Pitot, H.C., Miskimins, W.K. and Lindahl, R. (1996) Characterization of the rat aldehyde dehydrogenase-3 gene promoter. Nuc. Acids Res. 24:4185-4191.

Xiao, G-H., Falkner, K.C., Xie, Y.Q., Lindahl, R. and Prough, R.A. (1997) cAMP-dependent negative regulation of rat aldehyde dehydrogenase class 3 gene expression. J. Biol. Chem. 272:238.

Liu, Z.J., Sun, Y.J., Rose, J., Chung, Y.J., Hsiao, C.D., Chang, W.R., Kuo, I., Perozich, J., Lindahl, R., Hempel, J. and Wang, B.C. (1997) The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossman fold. Nature Struct. Biol., 4:317-326.

Liu, Z.J., Hempel, J., Sun, J., Rose, J., Hsiao, C.D., Chang, W.R., Chung, Y.J., Kuo, I., Lindahl, R. and Wang, B.C. (1997) Crystal structure of a class 3 aldehyde dehydrogenase at 2.6 A resolution. Adv. Exp. Med. & Biol., 414:1-7.

Lindahl, R., Xie, Y., Boesch, J.S., Miskimins, K. and Miskimins, R. (1997) Class 3 aldehyde dehydrogenase. A view from the hills. Adv. Exp. Med. & Biol., 414:15-18.

Reisdorph, R. and Lindahl, R. (1998) Hypoxia exerts cell-type specific effects on expression of the class 3 aldehyde dehydrogenase gene. Bioch. Biophys. Res. Comm., 249:709-712.

Boesch J.S., Miskimins R., Miskimins W.K.and Lindahl R. (1999) The same xenobiotic response element is required for constitutive and inducible expression of the mammalian aldehyde dehydrogenase-3 gene. Arch. Biochem. Biophys. 361:223-230.

Falkner K.C., Xiao G.H., Pinaire J.A., Pendleton M.L., Lindahl R. and Prough R.A. (1999) The negative regulation of the rat aldehyde dehydrogenase 3 gene by glucocorticoids: involvement of a single imperfect palindromic glucocorticoid responsive element. Mol. Pharmacol. 55:649-657.

Canuto R.A., Muzio G., Ferro M., Maggiora M., Federa R., Bassi A.M., Lindahl R. and Dianzani M.U. (1999) Inhibition of class-3 aldehyde dehydrogenase and cell growth by restored lipid peroxidation in hepatoma cell lines. Free Radical Biol. & Med. 26:333-340.

Hempel J., Perozich J., Chapman T., Rose J., Boesch JS., Liu ZJ., Lindahl R. and Wang BC. (1999) Aldehyde dehydrogenase catalytic mechanism. A proposal. Advances in Experimental Medicine & Biology. 463:53-59.

Burton, M. Reisdorph R., Prough R. and Lindahl R. (1999) Modulation of class 3 aldehyde dehydrogenase gene expression. An eye opening experience. Advances in Experimental Medicine & Biology. 463:165-170.

Lindahl R., Xiao GH., Falkner KC. and Prough RA. (1999) Negative regulation of rat hepatic aldehyde dehydrogenase 3 by glucocorticoids. Advances in Experimental Medicine & Biology. 463:159-164.

Perozich, J., Kuo, I., Wang, B. C., Boesch, J. S., Lindahl, R. and Hempel, J. (2000) Shifting the NAD/NADP preference in class 3 aldehyde dehydrogenase. Eur. J. Biochem. 267:6197-6203.

Reisdorph, R. and Lindahl, R. (2001) Aldehyde dehydrogenase 3 gene regulation: studies on constitutive and hypoxia-modulated expression. Chem. Biol. Interact. 130-132:227-233.

Canuto, R.A., Ferro, M., Salvo, R.A., Bassi, A.M., Trombetta, A., Maggiora, M., Martinasso, G., Lindahl, R. and Muzio, G. (2001) Increase in class 2 aldehyde dehydrogenase expression by arachidonic acid in rat hepatoma cells. Biochem. J. 357:811-818.

Perozich, J., Kuo, I., Lindahl, R. and Hempel, J. (2001) Coenzyme specificity in aldehyde dehydrogenase. Chem. Biol. Interact. 130-132:115-124.

Hempel, J., Lindahl, R., Perozich, J., Wang, B., Kuo, I., and Nicholas, H. (2001) Beyond the catalytic core of ALDH: a web of important residues begins to emerge. Chem. Biol. Interact. 130-132:39-46.

Contact Information

Cellular and Molecular Biology