Sanford School of Medicine Basic Biomedical Sciences

Brian Burrell, Ph.D.

Brian Burrell
Associate Professor
Medicine: Basic Biomedical Sciences, Health Affairs
UMS Lee Med/Sanford School of Medicine 266
Phone: 605-677-3182
Teaching Interests:
Introduction to Neurobiology (BIOL 430/530; NSCI 530) Medical Neuroscience (NCSI 531/731) Neurobiology of Disease (NCSI 792) Special Topics in Neuroscience (NCSI 790)
Research Interests:
Neuroscience, specifically neuroplasticity related to the onset and treatment of chronic pain.
Education:
  • Postdoctoral , Purdue University , 2004
  • Postdoctoral, University of Miami, 2001
  • Ph D, Ohio State University, 1995
  • BS, Ohio State University, 1990
Publications:
  • Yuan, S., Burrell, B., Non-nociceptive afferent activity depresses nocifensive behavior and nociceptive synapses via an endocannabinoid-dependent mechanism., Journal of Neurophysiology, vol. 110, pp. 2607-2616.
  • Higgins, A., Yuan, S., Wang, Y., Burrell, B., (2013), Differential Modulation of Nociceptive versus Non-Nociceptive Synapses by Endocannabinoids, Molecular Pain, vol. 9, p. 26.
  • Yuan, S., Burrell, B., (2013), Endocannabinoid-dependent long-term depression in a nociceptive synapse requires coordinated pre- and postsynaptic transcription and translation, Journal of Neuroscience, vol. 33, pp. 4349-4358.
  • Yuan, S., Burrell, B., (2012), Long-term depression of nociceptive synapses by non-nociceptive afferent activity: Role of endocannabinoids, Ca2+, and calcineurin. , Brain Research, vol. 1460, pp. 1-11.
  • Li, Q., Burrell, B., (2011), Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms., Learning & Memory, vol. 18, pp. 545-553.
  • Grey, K. B., Burrell, B., (2011), Seasonal variation of long-term potentiation at a central synapse in the medicinal leech., J Exp Biol, vol. 214, pp. 2534-2539.
  • Grey, K., Burrell, B., (2010), Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases., Journal of Neurophysiology, vol. 103, p. 2737–2746.
  • Yuan, S., Burrell, B., (2010), Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor., J Neurophsiol, vol. 104, pp. 2766-2777.
  • Li, Q., Burrell, B., (2010), Properties of cannabinoid-dependent long term depression in the leech. , J Comp Physiol , vol. 196, pp. 841-851.
  • Crisp, K., Burrell, B., (2009), Cellular and behavioral properties of learning in the leech and other annelids. In Annelids as Model Systems in the Biological Sciences, Annelids as Model Systems in the Biological Sciences.
  • Grey, K. B., Moss, B. L., Burrell, B., (2009), Molecular identification and expression of the NMDA receptor NR1 subunit in the leech., Invert. Neurosci, vol. 9, pp. 11-20.
  • Li, Q., Burrell, B., (2009), Two Forms of Long Term Depression in a Leech Polysynaptic Connection: One NMDA Receptor-Dependent and the other Cannabinoid-Dependent., J Comp Physiol., vol. 195, pp. 831-841.
Presentations:
  • Summers, T., Burrell, B. (2013, November). Cannabinoids differentially modulate behavioral responses to nociceptive vs non-nociceptive stimuli. Presented at the Society for Neuroscience Annual Meeting, San Diego, CA.
  • Wang, Y., Burrell, B. (2013, November). Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses. Presented at the Society for Neuroscience Annual Meeting, San Diego, CA.
  • Burrell, B. (2013, October). What the leech can tell us about how it hurts.. Presented at the MidBrains 2013, Northfield, MN (Carleton College).
  • , A. H., Yuan, S., Burrell, B. (2012, October). Differential endocannabinoid modulation of nociceptive vs. non-nociceptive synapses . Presented at the Society for Neuroscience Annual Meeting, New Orleans, LA.
  • Yuan, S., Burrell, B. (2012, October). Endocannabinoids depress both nociceptive synapses and nocifensive behavior via a gate control-like mechanism . Presented at the Society for Neuroscience Annual Meeting, New Orleans, LA.
  • Summers, T., Burrell, B. (2012, October). A comparison of central and peripheral effects of TRPV and TRPA activators and antagonists in the leech . Presented at the Society for Neuroscience Annual Meeting, New Orleans, LA.
  • Burrell, B. (2012, August). What a Leech Can Tell Us About How It Hurts. Presented at the Tedx Sioux River, Sioux Falls, SD.
  • Yuan, S., Burrell, B. (2011, November). Endocannabinoid-dependent nociceptive signaling requires both pre- and postsynaptic protein synthesis, but only postsynaptic RNA synthesis . Presented at the Society for Neuroscience Annual Meeting, Washington DC.
  • Higgins, A., Burrell, B. (2011, November). Differential Modulation of Nociceptive versus Non-Nociceptive Synapses by Endocannabinoids. Presented at the Faculty For Undergraduate Neuroscience Symposium, Washington DC.
  • Burrell, B., Hahn, E., List, J., Rasmussen, T. (2011, November). Nocifensive response and behavioral sensitization induced by TRP activators in the leech . Presented at the Society for Neuroscience Annual Meeting, Washington DC.
  • Burrell, B. (2011, May). What a Leech can tell us about how it hurts. Presented at the Sanford Research University of South Dakota Research Symposium, Sioux Falls, SD.