Sanford School of Medicine Basic Biomedical Sciences

Carlos Telleria, Ph.D.

Carlos Telleria
Associate Professor
Basic Biomedical Sciences, School of Medicine
UMS Lee Med/Sanford School of Medicine 252
Phone: 605-677-5161
Teaching Interests:
Cancer Biology, Endocrinology, Reproduction.
Research Interests:
The primary research interest in my laboratory is in the field of ovarian cancer biology and preclinical therapy. Current investigations are tailored to understand the molecular mechanisms driving dormancy of cancer cells that had survived chemotherapy, and to exploit protein homeostasis to develop therapies for non-dividing cancer cells.
  • Rezvani, K., Zhang, D., Wang, H., Telleria, C., Schlenker, E., Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin2 interactions in colon cancer cells , Cell death and Disease/Nature publishing group.
  • Brandhagen, B. N., Tieszen, C. R., Ulmer, T. M., Tracy, M. S., Goyeneche, A., Telleria, C., (2013), Cytostasis and morphological changes induced by mifepristone in human metastatic cancer cells involve cytoskeletal filamentous actin reorganization and impairment of cell adhesion dynamics, BMC Cancer, vol. 13, iss. 35. (DOI: 10.1186/1471-2407-13-35)
  • Vallcaneras, S. S., Delgado, S. M., Motta, A. A., Telleria, C., Rastrilla, A. M., Casais, M., (2013), Effect of prolactin actin on the coeliac glanglion via the superior ovarian nerve on ovarian function in the postpartum lactating and non-lactating rat, General and Comparative Endocrinology, vol. 184, pp. 1-8.
  • Telleria, C., (2013), Repopulation of ovarian cancer cells after chemotherapy, Libertas Academica, vol. 6, pp. 15-21. (DOI: DOI 10.4137/CGM.S11333 )
  • Wempe, S. L., Gamarra-Luques, C. D., Telleria, C., (2013), Synergistic lethality of mifepristone and LY294002 in ovarian cancer cells., Cancer Growth and Metastasis. (DOI: DOI 10.4137/CGM.S11124)
  • Sereda, G., Moorphy, R., Gamarra-Luques, C., Telleria, C., (2013), Facile Synthesis of a Phototoxic Monofunctionalized Tetraarylporphyrin as Scaffold for Porphyrin-Quinone Conjugates, Synthetic Communications, vol. 43, iss. 2, pp. 182-190.
  • Telleria, C., (2012), Drug repurposing in cancer therapy, Journal of Cancer Science and Therapy, vol. 4, iss. 7, pp. ix-xi. (DOI: 10.4172/1948-5956.1000e108)
  • Casais, M., Vallcaneras, S., Campo Verde Arbocco, F., Telleria, C., Caron, R., (2012), Estradiol promotes luteal regression through a direct effect on the ovary and an indirect effect from the celiac ganglion via the superior ovarian nerve. , Reproductive Sciences , vol. 19, iss. 4, pp. 416-422. (DOI: PMID: 22101240)
  • Gamarra-Luques, C. D., Goyeneche, A. A., Hapon, M. B., Telleria, C., (2012), Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy, BMC Cancer, iss. 12, p. 200.
  • Telleria, C., Goyeneche, A., , (2012), Antiprogestins in ovarian cancer., Intech Open Access Publisher , vol. 11, pp. 207-230.
  • Vallcaneras, S., Casais, M., Anzulovich , A., Delgado, S., Sosa, Z., Telleria, C., Rastrilla, A., (2011), Androstenedione acts on the coeliac ganglion and modulates luteal function via the superior ovarian nerve in the postpartum rat. , Journal of Steroid Biochemistry and Molecular Biology , iss. 25, pp. 243-250. (DOI: PMID: 21439382)
  • Tieszen, C., Goyeneche, A., Brandhagen, B., Ortbahn, C., Telleria, C., (2011), Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression. , BMC Cancer , iss. 11, p. 207. (DOI: 21619605)
  • Goyeneche, A., Seidel, E., Telleria, C., (2011), Growth inhibition induced by antiprogestins RU-38486, ORG-13710, and CDBG-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2, Investigational New Drugs. (DOI: PMID: 21424700)
  • Lopez-Fontana , C., Maselli, M., De Di Nasson, F., Telleria, C., Caron, R., (2011), Regulation of prolactin secretion during the estrus in rats: possible role of glucocorticoids. , Reproduction , iss. 142, pp. 477-485. (DOI: PMID: 21697336)
  • Bukovsky, A., Caudle, M., Carson, R., Gaytan, F., Huleihel, M., Kruse, A., Shatten, H., Telleria, C., (2009), Immune physiology in tissue regeneration and aging, tumor growth, and regenerative medicine, Aging, iss. 1, pp. 157-181. (DOI: PMID: 20195382)
  • Villavicencio, A., Goyeneche, A., Telleria, C., Bacallao, K., Gabler, F., Fuentes, A., Vega, M., (2009), Involvement of AKT, Ras and cell cycle regulators in the potential development of endometrial hyperplasia in women with polycystic ovarian syndrome, Gynecologic Oncology , iss. 115, pp. 102-107. (DOI: PMID: 19631369)
  • Freeburg, E., Goyeneche, A., Telleria, C., (2009), Mifepristone abrogates repopulation of ovarian cancer cells in between courses of cisplatin treatment. , International Journal of Oncology, iss. 34, pp. 743-755. (DOI: PMID: 19212679)
  • Freeburg, E., Goyeneche, A., Telleria, C., (2009), Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicity. , Cancer Cell International , iss. 9, p. 4. (DOI: PMID: 19222856)
  • Goyeneche, A., Telleria, C., (2007), Mifepristone inhibits ovarian cancer cell growth in vitro and in vivo. , Clinical Cancer Research , iss. 13, pp. 3370-3379.
  • Stocco, C., Telleria, C., (2007), The molecular control of corpus luteum formation, function and regression. , Endocrine Reviews , iss. 28, pp. 117-149. (DOI: PMID: 17077191)
  • Telleria, C., (2006), Can luteal regression be reversed? , Reproductive Biology and Endocrinology , iss. 4, p. 53. (DOI: PMID: 17074090)
  • Goyeneche, A., Harmon, J., Telleria, C., (2006), Cell death induced by serum deprivation in luteal cells involves the intrinsic pathway of apoptosis., Reproduction , iss. 131, pp. 103-111. (DOI: PMID:16388014)
  • Casais, M., Delgado, S., Sosa, Z., Telleria, C., Rastrilla, A., (2006), The celiac ganglion modulates LH-induced inhibition of androstenedione release in late pregnant rat ovaries. , Reproductive Biology and Endocrinology , iss. 4, p. 66. (DOI: PMID: 17184551)
  • Goyeneche, A., Telleria, C., (2005), Exogenous estradiol enhances apoptosis in regressing post-partum rat corpora lutea possibly mediated by prolactin. , Reproductive Biology and Endocrinology , iss. 3, p. 40. (DOI: PMID: 16131396)
  • Telleria, C., Goyeneche, A., Stocco, C., Gibori, G., (2004), . Involvement of nuclear factor kappa B in rat luteal function: potential roles as survival factor and inhibitor of 20alpha-hydroxysteroid dehydrogenase. , Journal of Molecular Endocrinology , iss. 32, pp. 365-383. (DOI: PMID: 15072545)
  • Clementi, M., Deis, R., Telleria, C., (2004), Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: effect of the deciduoma reaction. , Reproductive Biology and Endocrinology , iss. 2, p. 22. (DOI: PMID: 15140254)
  • Tessier, C., Pringent-Tessier , A., Bao, L., Telleria, C., Ferguson-Gottschall, S., Gibori, G., Bowen-Shauver, J., Horseman, N., Gibori, G., (2003), Decidual activin: its role in the apoptotic process and its regulation by prolactin. , Biology of Reproduction , iss. 68, pp. 1687-1694. (DOI: PMID: 12606360)
  • Goyeneche, A., Martinez, L., Deis, R., Gibori, G., Telleria, C., (2003), In-vivo hormonal environment leads to differential susceptibility of the corpus luteum to apoptosis in-vitro. , Biology of Reproduction , iss. 68, pp. 2322-2330. (DOI: PMID: 12606365)
  • Bowen-Shauver , J., Telleria, C., (2003), Luteal regression: a redefinition of the terms. , Reproductive Biology and Endocrinology , iss. 1, p. 28. (DOI: PMID: 12685929)
  • Goyeneche, A., Deis, R., Gibori, G., Telleria, C., (2003), Progesterone promotes survival of the rat corpus , Biology of Reproduction , iss. 68, pp. 151-158. (DOI: PMID: 12493707)
  • Goyeneche, A., Calvo, V., Gibori, G., Telleria, C., (2002), Androstenedione interferes in luteal regression by inhibiting apoptosis and stimulating progesterone production., Biology of Reproduction, iss. 66, pp. 1540-1547. (DOI: PMID: 11967221)
  • Telleria, C., Goyeneche, A., Cavicchia, J., Stati, A., Deis, R., (2001), Apoptosis induced by antigestagen RU486 in rat corpus luteum of pregnancy. , Endocrine, iss. 15, pp. 147-155. (DOI: PMID: 11720240)
  • Frasor, J., Park, K., Telleria, C., Kitamura, T., Yu-Lee, L., Djiane, J., Park-Sarge, O., Gibori, G., (2001), Different roles for Stat5a and Stat5b in prolactin stimulation of estrogen receptor alpha and beta transcription. , Molecular Endocrinology, iss. 15, pp. 2172-2181. (DOI: PMID: 11731618)
  • Bowen, J., Telleria, C., Towns, R., Keyes, P., (2000), Downregulation of long-form prolactin receptor mRNA during prolactin-induced luteal regression. , European Journal of Endocrinology, iss. 143, pp. 285-291. (DOI: PMID: 10913950)
  • Telleria, C., Stocco, C., Stati, A., Deis, R., (1999), Progesterone receptor is not required for progesterone action in the rat corpus luteum of pregnancy. , Steroids, iss. 64, pp. 760-766. (DOI: PMID: 10577832)
  • Sugino, N., Telleria, C., Tessier, C., Gibori, G., (1999), Regulation and role of the insulin-like growth factor-I system in rat luteal cells, Journal of Reproduction and Fertility, iss. 115, pp. 349-355. (DOI: PMID: 10577832)
  • Sugino, N., Telleria, C., Gibori, G., (1998), Different regulation of copper-zinc superoxide dismutase and manganese superoxide dismutase in the rat corpus luteum: Induction of manganese superoxide dismutase mRNA by inflammatory cytokines. , Biology of Reproduction , iss. 59, pp. 208-215.
  • Telleria, C., Zhong, L., Deb, S., Srivastava, R., Sugino, N., Park, K., Sarge-Park, O. O., Gibori, G., (1998), Differential expression of the estrogen receptors alpha and beta in the rat corpus luteum of pregnancy: regulation by prolactin and placental lactogens. , Endocrinology , iss. 139, pp. 2432-2442.
  • Sugino, N., Zilberstein, M., Srivastava, R., Telleria, C., Nelson, S., Risk, M., Chou, J., Gibori, G., (1998), Establishment and characterization of a simian virus 40-transformed temperature sensitive rat luteal cell line. , Endocrinology , iss. 139, pp. 1936-1942. (DOI: PMID: 9528980)
  • Telleria, C., Mezzadri, M., Deis, R., (1997), Fertility impairment after mifepristone treatment to rats on proestrus: actions on the hypothalamic-hypophyseal-ovarian axis. , Contraception , iss. 56, pp. 267-274. (DOI: PMID: 9408709)
  • Sugino, N., Telleria, C., Gibori, G., (1997), Progesterone inhibits 20alpha-hydroxysteroid dehydrogenase expression in the rat corpus luteum through the glucocorticoid receptor. , Endocrinology , iss. 138, pp. 4497-4500. (DOI: PMID: 9322971)
  • Telleria, C., Parmer, T., Zhong, L., Clarke, D., Albarracin, C., Duan, W., Linzer, D., Gibori, G., (1997), The different forms of the prolactin receptor in the rat corpus luteum: developmental expression and hormonal regulation in pregnancy. , Endocrinology , iss. 138, pp. 4812-4820. (DOI: PMID: 9348210)
  • Telleria, C., Deis, R., (1996), Reproductive function in rats after mifepristone-induced termination of pregnancy. , Contraception , iss. 53, pp. 185-190. (DOI: PMID: 8689885)
  • Telleria, C., Stocco, C., Stati, A., Rastrilla, A., Carrizo, D., Aguado, L., Deis, R., (1995), Dual regulation of luteal progesterone production by androstenedione during spontaneous and RU486-induced luteolysis in pregnant rats. , Journal of Steroid Biochemistry and Molecular Biology , iss. 55, pp. 385-393. (DOI: PMID: 8541235)
  • Telleria, C., Stocco, C., Deis, R., (1995), Luteolytic action of RU486: modulation of luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in late pregnant rats. , Journal of Steroid Biochemistry and Molecular Biology , iss. 52, pp. 567-573. (DOI: PMID: 7779760)
  • Carrizo, D., Rastrilla, A., Telleria, C., Aguado, L., (1994), Androstenedione stimulates progesterone production in corpora lutea of pregnant rats: an effect not mediated by oestrogen., Journal of Steroid Biochemistry and Molecular Biology, iss. 51, pp. 191-197. (DOI: PMID: 7981128)
  • Telleria, C., Deiss, R., (1994), Effect of RU486 on ovarian progesterone production at pro-oestrus and during pregnancy: a possible dual regulation of the biosynthesis of progesterone. , Journal of Reproduction and Fertility , iss. 102, pp. 379-384. (DOI: PMID: 7861391)
  • Telleria, C., Carrizo, D., Deis, R., (1994), Levonorgestrel inhibits luteinizing hormone-stimulated progesterone production in rat luteal cells. , Journal of Steroid Biochemistry and Molecular Biology , iss. 50, pp. 161-166. (DOI: PMID: 8049144)