Dong Zhang, Ph.D.
I obtained my Ph.D. in Biochemistry and Molecular Biology from Brandeis University. I then did my postdoc at Baylor College of Medicine and Harvard Medical School in Cancer Biology.
Biochemistry for medical school students; Cancer Biology, Molecular Biology
Breast Cancer Biology; Biological functions of BRCA1 and related tumor suppressor genes; DNA damage response and DNA repair; Cancer Stem Cells
- Ph D, Biochemistry and Molecular Biology, Brandeis University, 2001
- BS, Medical Chemistry, Beijing Medical University, 1991
- Dong, G., Gross, K., Qiao, F., Ferguson, J., Callegari, E. A., Rezvani, K., Zhang, D., Gloeckner, C. J., Ueffing, M., Wang, H., (2012), Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity., Journal of Neurochemistry, vol. 123, iss. 3, p. 437–446.
- Dong, G., Ferguson, J. M., Duling, A. J., Nicolas, R. G., Zhang, D., Rezvani, K., Fang, S., Monterio, M. J., Li, S., Li, X. J., Wang, H., (2011), Modeling Pathogenesis of Huntington’s Disease with Inducible Neuroprogenitor Cells, Cell Mol Neurobiol , vol. 31, p. 737.
- Popov, N., Wanzel, M., Madiredjo, M., Zhang, D., Beijersbergen, R., Bernards, R., Moll, R., Elledge, S. J., Eilers, M., (2007), ) The Ubiquitin-specific Protease, USP28 Is Required for Myc Stability In Human Tumor cells , Nature Cell Biology , vol. 9, pp. 765-774.
- Wang, B., Matsuoka, S., Ballif, B., Zhang, D., Smogorzewska, A., Gigi, S., Elledge, S. J., (2007), Abraxas and RAP80 Form a Novel BRCA1 Protein Complex Required for the DNA Damage Response, Science, vol. 316, p. 1194.
- Zhang, D., Zaug, K., Mak, T. W., Elledge, S. J., (2006), A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA Damage Response , Cell, vol. 126, pp. 529-542.
Awards and Honors:
- Postdoctoral Fellowship, Howard Hughes Medical Institute, 2003
- Breast Cancer Fellowship, Baylor College of Medicine, 2002
- Gillette Foundation Fellowship, Gillette Foundation, 1999
- Gillette Foundation Fellowship, Gillette Foundation, 1998
- Zou, J., Long, M., Pickner, W., Tian, F., Wang, X., Zhang, D. Localization of Ubiquitin Proteasome System (UPS) components to the Centrosomes. Presented at the Ubiquitin, Protein Quality Control, and Molecular Pathogenesis Symposium , Vermillion.
- Tian, F., Zou, J., Zhang, D. The role of USP20 in the regulation of the steady-state level of BRCA1 and DNA damage response. Presented at the Ubiquitin, Protein Quality Control, and Molecular Pathogenesis Symposium , Vermillion.
- Zhang, D. (2012, September). FANCJ regulates normal centrosome cycle and HU-induced centrosome over-amplification. Presented at the 24t h Annual Fanc oni Anemia Research Fund S c i e n t i fic Symposium, Denver, CO.
- Zhang, D. (2012, June). The role of USP20 in the regulation of BRCA1 stability. Presented at the Ubiquitin, Protein Quality Control, and Molecular Pathogenesis Symposium, Deadwood, SD.
- Zhang, D. (2012, May). A novel function of BRCA1 in the regulation of DNA damage tolerance pathway. Presented at the 3rd USD Sanford Symposium, Vermillion, SD.
- Zhang, D. (2011, December). Regulation of DNA damage response and DNA repair by ubiquitination and de-ubiquitination. Presented at the Seminar invitation at SDSU Life Science Seminar Series FY12 Fall semester, Brooks.
- Zhang, D. (2011, June). Regulation of DNA damage response by USP28, a de-ubiquitinating enzyme (DUB). Presented at the Ubiquitin, Protein Quality Control, and Molecular Pathogenesis Symposium, Vermillion.