Sanford School of Medicine Basic Biomedical Sciences

Dong Zhang, Ph.D.

Dong Zhang
Assistant Professor
Medicine: Basic Biomedical Sciences, Health Affairs
UMS Lee Med/Sanford School of Medicine 350
Phone: 605-677-5345
Bio:
I obtained my Ph.D. in Biochemistry and Molecular Biology from Brandeis University. I then did my postdoc at Baylor College of Medicine and Harvard Medical School in Cancer Biology.
Teaching Interests:
Biochemistry for medical school students; Cancer Biology, Molecular Biology
Research Interests:
Breast Cancer Biology; Biological functions of BRCA1 and related tumor suppressor genes; DNA damage response and DNA repair; Cancer Stem Cells
Education:
  • Ph D, Biochemistry and Molecular Biology, Brandeis University, 2001
  • BS, Medical Chemistry, Peking University Health Science Center, 1991
Publications:
  • Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X., Wang, H., (2014), The Proteasome Function Reporter GFPu Accumulates in Young Brains of the APPswe/PS1dE9 Alzheimer’s Disease Mouse Model, Cell Mol Neurobiol, vol. 34, iss. 3, pp. 315-322. Epub 2013 Dec 21. .
  • Rezvani, K., Zhang, D., Wang, H., Telleria, C., Schlenker, E., Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin2 interactions in colon cancer cells , Cell death and Disease/Nature publishing group.
  • Liu, Y., Lü , L., Hettinger, C. L., Dong, G., Zhang, D., Rezvani, K., Wang, X., Wang, H., (2014), Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice, J Neurosci, vol. 34, iss. 8, pp. 2813-21.
  • Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X., Wang, H., (2014), Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington’s disease, J Neurochem, p. 2014 Jan 3. doi: 10.1111/jnc.12647. [Epub ahead of print].
  • Zou, J., Tian, F., Li, J., Pickner, W., Long, M., Rezvani, K., Wang, H., Zhang, D., (2013), FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1. , Biology Open , vol. 2, p. 1022.
  • Tian, F., Sharma, S., Zou, J., Lin, S., Wang, B., Rezvani, K., Wang, H., Parvin, J. D., Ludwig, T., Canman, C. E., Zhang, D., (2013), BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade, Proc Natl Acad Sci U S A, vol. 110, iss. 33, p. 13558.
  • Zou, J., Rezvani, K., Wang, H., Lee, K. S., Zhang, D., (2013), BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stress, Cell Cycle, vol. 12, iss. 14, p. 2255.
  • Dong, G., Gross, K., Qiao, F., Ferguson, J., Callegari, E. A., Rezvani, K., Zhang, D., Gloeckner, C. J., Ueffing, M., Wang, H., (2012), Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity., Journal of Neurochemistry, vol. 123, iss. 3, p. 437–446.
  • Dong, G., Ferguson, J. M., Duling, A. J., Nicolas, R. G., Zhang, D., Rezvani, K., Fang, S., Monterio, M. J., Li, S., Li, X. J., Wang, H., (2011), Modeling Pathogenesis of Huntington’s Disease with Inducible Neuroprogenitor Cells, Cell Mol Neurobiol , vol. 31, p. 737.
  • Popov, N., Wanzel, M., Madiredjo, M., Zhang, D., Beijersbergen, R., Bernards, R., Moll, R., Elledge, S. J., Eilers, M., (2007), ) The Ubiquitin-specific Protease, USP28 Is Required for Myc Stability In Human Tumor cells , Nature Cell Biology , vol. 9, pp. 765-774.
  • Wang, B., Matsuoka, S., Ballif, B., Zhang, D., Smogorzewska, A., Gigi, S., Elledge, S. J., (2007), Abraxas and RAP80 Form a Novel BRCA1 Protein Complex Required for the DNA Damage Response, Science, vol. 316, p. 1194.
  • Zhang, D., Zaug, K., Mak, T. W., Elledge, S. J., (2006), A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA Damage Response , Cell, vol. 126, pp. 529-542.
Awards and Honors:
  • Postdoctoral Fellowship, Howard Hughes Medical Institute, 2003
  • Breast Cancer Fellowship, Baylor College of Medicine, 2002
  • Gillette Foundation Fellowship, Gillette Foundation, 1999
  • Gillette Foundation Fellowship, Gillette Foundation, 1998
Presentations:
  • Zhang, D. (2013, December). Uncovering the missing links between DNA damage response and centrosome biogenesis. Presented at the Seminar Series of Basic Biomeidical Science Division, Sanford School of Medicine, USD, Vermillion, SD.
  • Zhang, D., Zou, J. (2013, October). BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1. Presented at the 25th Annual Fanconi Anemia Research Fund Scientific Symposium, Houston, Texas.
  • Zhang, D. (2013, September). Regulation of PLK1 by BRCA1 B-complex in response to DNA damage. Presented at the Seminar Series of Laboratory of Metabolism, National Cancer Institute, Bethesda, MD.
  • Zou, J., Lee, K., Zhang, D. (2013, September). BRCA1 down-regulates the kinase activity of polo-like kinase 1 in response to replication stress. Presented at the Cold Spring Harbor Laboratory Eukaryotic DNA Replication & Genome Maintenance meeting, Cold Spring Harbor, NY.
  • Zhang, D. (2012, September). FANCJ regulates normal centrosome cycle and HU-induced centrosome over-amplification. Presented at the 24t h Annual Fanc oni Anemia Research Fund S c i e n t i fic Symposium, Denver, CO.
  • Zhang, D. (2012, June). The role of USP20 in the regulation of BRCA1 stability. Presented at the Ubiquitin, Protein Quality Control, and Molecular Pathogenesis Symposium, Deadwood, SD.
  • Zhang, D. (2012, May). A novel function of BRCA1 in the regulation of DNA damage tolerance pathway. Presented at the 3rd USD Sanford Symposium, Vermillion, SD.
  • Zhang, D. (2011, December). Regulation of DNA damage response and DNA repair by ubiquitination and de-ubiquitination. Presented at the Seminar invitation at SDSU Life Science Seminar Series FY12 Fall semester, Brooks.
  • Zou, J., Long, M., Pickner, W., Tian, F., Wang, X., Zhang, D. (2011, June). Localization of Ubiquitin Proteasome System (UPS) components to the Centrosomes. Presented at the Ubiquitin, Protein Quality Control, and Molecular Pathogenesis Symposium , Vermillion.
  • Zhang, D. (2011, June). Regulation of DNA damage response by USP28, a de-ubiquitinating enzyme (DUB). Presented at the Ubiquitin, Protein Quality Control, and Molecular Pathogenesis Symposium, Vermillion.
  • Tian, F., Zou, J., Zhang, D. (2011, June). The role of USP20 in the regulation of the steady-state level of BRCA1 and DNA damage response. Presented at the Ubiquitin, Protein Quality Control, and Molecular Pathogenesis Symposium , Vermillion.
  • Zhang, D. (2010, September). Bioenergetics and Biosynthesis of Colorectal Cancer Stem Cells.
  • Zhang, D. (2010, June). Bioenergetics and Biosynthesis of Colorectal Cancer Stem Cells.