Sanford School of Medicine Basic Biomedical Sciences

Douglas Martin, Ph.D.

Douglas Martin
Professor
Basic Biomedical Sciences, School of Medicine
UMS Lee Med/Sanford School of Medicine 139
Phone: 605-677-5162
Research Interests:
I have a long standing interest in the physiological mechanisms that underlie the development of hypertension (high blood pressure). Hypertension afflicts approximately 30% of the population (including several members of my family). Hypertension is also a major risk factor for the development of other disease such as renal failure, heart failure, atherosclerosis, stroke, coronary artery disease and myocardial infarction. Despite the significant health impact of hypertension, little is known about the mechanisms that trigger the development of high blood pressure. Accordingly, better understanding of the mechanisms underlying the development of high blood pressure should foster new therapeutic approaches to prevent and treat this disease.
Education:
  • Post Doctoral Fellowship, Physiology, University of Saskatchewan, 1992
  • Post Doctoral Fellowship, Pharmacology, University of Texas Health Science Center , 1991
  • Ph D, Pharmacology, University of Saskatchewan, 1988
  • BS, Biology, Carleton University, 1981
Publications:
  • Ranek, M. J., Kost, C., Hu, C., Martin, D., Wang, X., (2014), Muscarinic 2 Receptors Modulate Cardiac Proteasome Function in a Protein Kinase G-dependent Manner, J Mol Cell Cardiol, vol. 69, iss. 4, pp. 43-51. Epub 2014 Feb 5.. (DOI: 10.1016/j.yjmcc.2014.01.017)
  • Li, S., Wang, X., Li, Y., Kost, C., Martin, D., (2013), Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats., PLOS One, vol. 30, iss. 8, p. 10. (DOI: 10.1371/journal.pone.0078564 )
  • Martin, D., Klinkova, O., Eyster, K., (2012), Regional differences in sexually dimorphic protein expression in the spontaneously hypertensive rat (SHR), Molecular and Cellular Biochemistry, vol. 362, pp. 103-114.
  • Eyster, K., Breitkopf, N. P., Martin, D., (2012), Antihypertensive activity of soy and soy-derived compounds, Nova Scientific Publishers, pp. 79-104.
  • Bardal, S. K., Waechter, J. E., Martin, D., (2011), Applied Pharmacology, Elsevier/Sauders.
  • Tatchum-Talom, R., Eyster, K., Kost, C., Martin, D., (2011), Blood pressure and mesenteric vascular reactivity in SHR seven months after gonadectomy, J Cardiovasc Pharm, vol. 57, pp. 357-364.
  • Mark-Kappeler, C. J., Martin, D., Eyster, K., (2011), Estrogens and selective estrogen receptor modulators (SERMs) regulate gene and protein expression in the mesenteric arteries, Vascular Pharmacology, vol. 55, pp. 42-49. (DOI: 10.1016/j.vph.2011.05.002)
  • Song, J., Eyster, K., Kost, C., Kjellsen, B., Martin, D., (2010), Involvement of protein kinase C-CPI-17 in androgen modulation of angiotensin II-renal vasoconstriction. , Cardiovasc Res, vol. 85, iss. 3, pp. 614-621.
Awards and Honors:
  • American Physiological Society Awards Committee, American Physiological Society
  • President Elect, Nebraska Physiological Society , 2013
  • American Heart Association Grant Peer Reviewer, American Physiological Society, 2012
Presentations:
  • Martin, D., Wang, X., Kost, C., Shuai, L. A proteasome inhibitor attenuates hypertension and associated reactive oxygen species production, cell proliferation, and inflammation in aorta. Presented at the Sanford Health-USD Biomedical Research Symposium, Sioux Falls.
  • Martin, D., Li, Y., Wang, X., Kost, C., Shuai, L. (2013, October). A proteasome inhibitor attenuates angiotensin II induced hypertension, associated vascular remodeling, and vascular smooth muscle cell proliferation. Presented at the Nebraska Physiological Society , Omaha, Nebraska .
  • Ranek, M. J., Li, J., Kost, C., Martin, D., Wang, X. (2012, November). Protein kinase G regulates proteasome-mediated degradation of misfolded proteins. Presented at the AHA Scientific Sessions, Los Angeles, CA.
  • Li, S., Kjellsen, B., Martin, D. (2012, October). Proteasome inhibition attenuates angiotensin II-induced hypertension and vascular remodeling.. Presented at the Nebraska Physiological Society, Wayne Nebraska.
  • Ranek, M. J., Martin, D., Kost, C., Wang, X. (2012, July). Activation of Protein Kinase G Enhances Proteasome-Mediated Degradation of Misfolded Proteins . Presented at the AHA Basic Cardiovascular Sciences 2012 Scientific Sessions, New Orleans, LA.
  • Li, S., Wang, X., Martin, D. (2012, June). Proteasome inhibition attenuates angiotensin II-induced hypertension and vascular remodeling. Presented at the Second Annual Symposium on Ubiquitin, Protein Quality Control, and Molecular Pathogenesis, Deadwood South Dakota.
  • Li, S., Wang, X., Martin, D. (2012, May). Proteasome inhibition attenuates angiotensin II-induced hypertension and vascular remodeling.. Presented at the Sanford USD Symposium, Vermillion Campus.
  • Martin, D., Kjellsen, B., Messenger, T. (2012, April). Effect of Castration on Cardiac Index in the Spontaneously Hypertensive Rat.. Presented at the Experimental Biology 2012, San Diego California.
  • Li, S., Wang, X., Martin, D. (2012, April). Proteasome inhibition attenuates angiotensin II-induced hypertension and vascular remodeling.. Presented at the Experimental Biology 2012, San Diego California.
  • Li, S., Martin, D. (2012, April). Bortezomib attenuates angiotensin II-induced hypertension and vascular remodeling. Presented at the IDEA Fest , Vermillion Campus.
  • Martin, D. (2011, May). Androgens and cardiovascular control: So many possibilities, so little time. Presented at the Sanford Symposium 2011, Sioux Falls.
  • Martin, D. (2011, April). Effect of castration on PPADS modulation of portal venous responses to splanchnic nerve stimulation. Presented at the Experimental Biology 2011, Washington DC.
  • Martin, D. (2011, April). Effect of castration on PPADS modulation of portal venous responses to splanchnic nerve stimulation . Presented at the Experimental Biology 2011, Washington DC.
  • Martin, D. (2010, April). Effect Of PPADS On Mesenteric Arterial And Portal Venous Flow Responses To Splanchnic Nerve Stimulation. Abstract # 8737. Presented at the Experimental Biology, San Diego CA.