Sanford School of Medicine Basic Biomedical Sciences

Gina Forster, Ph.D.

Gina Forster
Associate Professor
Basic Biomedical Sciences, School of Medicine
UMS Lee Med/Sanford School of Medicine 259
Phone: 605-677-6883
Teaching Interests:
Neuroscience Biopsychology Neuropharmacology
Research Interests:
Neuroscience Addiction Neurobiology underlying anxiety states
Education:
  • Postdoctoral, Neuroendocrinology , University of South Dakota, 2004
  • Postdoctoral, Neuroendocrinology , Macquarie University, 2002
  • Ph D, Psychology/Neuroscience, Macquarie University, 2002
  • BS, Psychology , University of Otago, 1997
Publications:
  • Novick, A. M., Miiller, L. C., Forster, G., Watt, M., (2013), Adolescent social defeat decreases spatial working memory performance in adulthood, Behavioral and Brain Functions, vol. 9, pp. 39-50.
  • Watt, M., Roberts, C. L., Scholl, J. L., Meyer, D. L., Miiller, L. C., Barr, J. L., Novick, A. M., Renner, K., Forster, G., Decreased prefrontal cortex dopamine activity following adolescent social defeat in male rats: role of dopamine D2 receptors., Psychopharmacology, vol. Epub ahead of print.
  • Burke, A., Forster, G., Novick, A., Roberts, C., Watt, M., (2013), Effects of adolescent social defeat on adult amphetamine-induced locomotion and corticoaccumbal dopamine release in male rats, Neuropharmacology, vol. 67, pp. 359-369.
  • Waters, R. P., Pringle, R. B., Forster, G., Renner, K. J., Malisch, J. L., Garland, T., Swallow, J., (2013), Effects of selection for increased voluntary wheel running on behavioral activity, plasma corticosterone and brain monoamines in mice, Brain Research, vol. 1508, pp. 9-22.
  • Barr, J., Scholl, J., Solanki, R., Watt, M., Lowry, C., Renner, K., Forster, G., (2013), Influence of chronic amphetamine treatment and acute withdrawal on serotonin synthesis and clearance mechanisms in the rat ventral hippocampus, European Journal of Neuroscience, vol. 37, pp. 479-90.
  • Forster, G., Novick, A., Scholl, J., Watt, M., (2012), The role of the amygdala in anxiety disorders, InTech, pp. 61-102.
  • Meyer, D., Davies, D., Barr, J., Manzerra, P., Forster, G., (2012), Mild Traumatic Brain Injury in the Rat Alters Neuronal Number in the Limbic System and Increases Conditioned Fear and Anxiety-like Behaviors., Experimental Neurology, vol. 235, pp. 574-87.
  • Novick, A., Forster, G., Tejani-Butt, S., Watt, M., (2011), Adolescent social defeat alters markers of adult dopaminergic function, Brain Research Bulletin, vol. 86, pp. 123-128.
  • Burke, A., Watt, M., Forster, G., (2011), Adolescent social defeat increases adult amphetamine conditioned place preference and alters D2 dopamine receptor expression., Neuroscience, vol. 197, pp. 269-279.
  • Burke, A., Forster, G., Novick, A., Roberts, C., Watt, M., (2011), Adult amphetamine-induced locomotion and dopamine release in the medial prefrontal cortex and nucleus accumbens following adolescent social defeat in rats , Society for Neuroscience Abstracts, p. 927.10.
  • Burke, A. R., Forster, G., Novick, A. M., Watt, M., (2011), Adult medial prefrontal cortex and nucleus accumbens amphetamine-induced dopamine release following adolescent social defeat, p. 19.
  • Bledsoe, A., Oliver, K., Scholl, J., Forster, G., (2011), Anxiety states induced by post-weaning social isolation are mediated by CRF receptors in the dorsal raphe nucleus, Brain Research Bulletin, vol. 85, pp. 117-122.
  • Forster, G., Scholl, J., Reinbold, E., Oliver, K., Watt, M., (2011), Central CRF2 receptor antagonism reduces anxiety states during amphetamine withdrawal , Society for Neuroscience Abstracts, p. 901.20.
  • Miiller, L., Novick, A., Forster, G., Watt, M., (2011), Effects of adolescence social defeat on adult cognitive function and reward motivation, Faculty for Undergraduate Neuroscience Abstracts, p. 66.
  • Novick, A., Forster, G., Watt, M., (2011), Effects of adolescent social defeat on adult working memory , Society for Neuroscience Abstracts, p. 927.03.
  • Barr, J., Scholl, J., Lowry, C., Renner, K., Forster, G., (2011), Influence of chronic amphetamine treatment on serotonin reuptake mechanisms in the rat ventral hippocampus , Society for Neuroscience Abstracts, p. 472.08.
  • Roberts, C., Mingo, M., Scholl, J., Meyer, D., Oliver, K., Barr, J., Forster, G., Watt, M., (2011), Mechanisms underlying disruptions to cortical dopamine activity caused by adolescent social defeat, Faculty for Undergraduate Neuroscience Abstracts, p. 72.
  • Davies, D., Meyer, D., Barr, J., Manzerra, P., Forster, G., (2011), Mild traumatic brain injury and its effect on contextual fear conditioning and anxiety states similiar to posttraumatic stress disorder, Faculty for Undergradaute Neuroscience Abstracts, p. 40.
  • Barr, J. L., Forster, G., (2011), Serotonergic neurotransmission in the ventral hippocampus is enhanced by corticosterone and altered by chronic amphetamine treatment. , Neuroscience, vol. 182, pp. 105-114.
  • Burke, A. R., Renner, K., Forster, G., Watt, M., (2010), Adolescent social defeat alters neural, endocrine and behavioral responses to amphetamine in adult male rats, Brain Research, vol. 1352, pp. 147-156.
  • Scholl, J. L., Renner, K., Forster, G., Tejani-Butt, S., , (2010), Central monoamine levels differ between rat strains used in studies of depressive behavior, Brain Research, vol. 1355, pp. 41-51.
  • Vuong, S., Oliver, H., Scholl, J., Oliver, K., Forster, G., (2010), Increased anxiety-like behavior of rats during amphetamine withdrawal is reversed by CRF-2 receptor antagonism. , Behavioural Brain Research, iss. 208, pp. 278-281.
  • Watt, M., Roberts, C., Renner, K., Scholl, J., Haaland, E., Forster, G., (2010), Mechanisms and consequences of disrupting cortical dopamine activity during adolescence, Neuroscience Abstracts, p. 125.
  • Feng, N., Lowry, C. A., Lukkes, J. L., Orchinik, M., Forster, G., Renner, K., (2010), Organic cation transporter inhibition increases medial hypothalamic serotonin under basal conditions and during mild restraint, Brain Research, vol. 1326, pp. 105-113.
  • Waters, R. P., Renner, K., Summers, C., Watt, M., Forster, G., Koch, L. G., Britten, S. L., Swallow, J., (2010), Selection for intrinsic endurance modifies endocrine stress responsiveness , Brain Research, vol. 1357, pp. 53 - 61.
  • Barr, J. L., Renner, K., Forster, G., (2010), Withdrawal from Chronic Amphetamine Produces Persistent Anxiety-like Behavior but Temporally-Limited Reductions in Monoamines and Neurogenesis in the Adult Rat Dentate Gyrus, Neuropharmacology.
  • Watt, M., Burke, A., Renner, K., Forster, G., (2009), Adolescent male rats exposed to social defeat exhibit altered anxiety behaviour and limbic monoamines as adults., Behavioral Neuroscience, iss. 123, pp. 564-576.
  • Watt, M., Forster, G., (2009), Adolescent social defeat alters 3H MK801 binding to NMDA receptors in adult rat brain., Society for Neuroscience Abstracts, iss. 251, p. 20.
  • Lukkes, J., Mokin, M., Scholl, J., Forster, G., (2009), Adult rats exposed to early life social isolation exhibit increased anxiety and conditioned fear behavior, and altered hormonal stress responses., Hormones and Behavior, iss. 55, pp. 248-256.
  • Forster, G., (2009), Chronic amphetamine treatment increases anxiety behavior and decreases monoamines and neurogenesis in the hiippocampus., International Behavioral Neuroscience Society Annual Meeting, iss. 3.
  • , Watt, M., , Forster, G., (2009), Consequences of post-weaning social isolation on behavior and monoaminergic activity in anxiety-related neurla circuits in rats., Frontiers in Behavioral Neuroscience, iss. 3, pp. 1-12.
  • Carpenter, R., Korzan, W., Bockholt, C., Watt, M., Forster, G., (2009), Corticotropin-releasing factor influences aggression and monoamines; modulation of attacks and retreats., Neuroscience, iss. 158, pp. 412-425.
  • Lukkes, J., Summer, C., Scholl, J., Renner, K., Forster, G., (2009), Early life social isolation alters corticotropin-releasing factor responses in adult rats., Neuroscience, iss. 158, pp. 845-855.
  • Watt, M., Forster, G., (2009), Increased amphetamine conditioned place preference in adulthood following adolescent social defeat is associated with altered D2 dopamine receptors., Society for Neuroscience Abstracts, iss. 650, p. 19.
  • , , Watt, M., Renner, K., Forster, G., (2009), Individual differences in amphetamine sensitization, behaviour and central monoamines., Physiology and Behavior, iss. 96, pp. 493-504.
  • Feng, N., Telefont, M., Kelly, K., Orchinik, M., Forster, G., (2009), Local perfusion of corticosterone in a rat medial hypothalamus potentiates D-fenfluramine-induced elevations of extracellular 5-HT concentrations., Hormones and Behaviour, iss. 56, pp. 149-157.
  • Watt, M., Forster, G., (2009), Long-lasting consequences of cortical D2 dopamine receptor activation during adolescence., Society for Neuroscience Abstracts, iss. 573, p. 26.
  • Feng, N., Lowry, C. A., Lukkes, J. L., Orchinik, M., Forster, G., Renner, K., (2009), Organic cation transporter block decynium 22 increases extracellular serotonin concentrations in the rat medial hypothalamus under basal and stress conditions., Society for Neuroscience Abstracts, iss. 134, p. 5.
  • Waller, S., Forster, G., (2009), Overiview of tobacco cessation., South Dakota Journal of Medicine, iss. Secial Issue, pp. 51-56.
  • Forster, G., (2009), Reversal of anxiety behavior during amphetamine withdrawal by antagonism of corticotropin-releasing factor 2 receptors in the dorsal raphe nucleus., Society for Neuroscience Abstracts, iss. 66, p. 15.
  • , Forster, G., Watt, M., , (2009), Social status differentiates rapid neuroendocrine responses to restraint stress, Physiology and Behavior, iss. 96, pp. 218-232.
  • , Forster, G., (2009), Corticotropin-releasing factor 2 receptors as a novel therapeutic target for reducing anxiety states?, NIDA Axelrod Poster Session Proceedings, iss. 11.
  • , Forster, G., (2009), Corticotropin-releasing factor receptor antagonism within the dorsal raphe reduces social anxiety following early-life social isolation., Journal of Neuroscience, iss. 29, pp. 9955-9960.
  • Feng, N., Telefont, M., Kelly, K., Orchinik, M., Forster, G., Renner, K., Lowry, C. A., (2009), Local perfusion of corticosterone in the rat medial hypothalamus potentiates D-fenfluramine-induced elevations of extracellular 5-HT concentrations, Hormones and Behavior, vol. 56, pp. 149-157.
  • Ling, T. J., Watt, M., Forster, G., Korzan, W. J., Renner, K., Summers, C., (2009), Social status differentiates rapid neuroendocrine responses to restraint stress, Physiology and Behavior, vol. 96, pp. 218-232.
  • Carpenter, R. E., Korzan, W. J., Bockholt, C., Watt, M., Forster, G., Renner, K., Summers, C., (2009), Corticotropin releasing factor influences aggression and monoamines:, Neuroscience, vol. 158, pp. 412-425.
  • Forster, G., Pringle, R. B., Mouw, N. J., Vuong, S. M., Watt, M., Burke, A. R., Lowry, C. A., Summers, C., Renner, K., (2008), Corticotrophin-releasing factor in the dorsal raphe increases medial prefrontal cortical serotonin via type 2 receptors and median raphé activity, European Journal of Neuroscience, vol. 28, pp. 299-310.
  • Carpenter, R. E., Watt, M., Forster, G., Øverli, Ø., Bockholt, C., Renner, K., Summers, C., (2007), Corticotropin releasing factor induces anxiogenic locomotion in trout and alters serotonergic and dopaminergic activity, Hormones and Behavior, vol. 52, pp. 600-611.
  • Korzan, W. J., Höglund, E., Watt, M., Forster, G., Øverli, Ø., Lukkes, J. L., Summers, C., (2007), Memory of opponents is more potent than visual sign stimuli after social hierarchy has been established, Behavioural Brain Research, vol. 183, pp. 31-42.
  • Watt, M., Forster, G., Korzan, W. J., Renner, K., Summers, C., (2007), Rapid neuroendocrine responses evoked at the onset of social challenge, Physiology and Behavior, vol. 90, pp. 567-575.
  • Forster, G., Feng, N., Watt, M., Korzan, W. J., Mouw, N. J., Summers, C., Renner, K., (2006), Corticotropin-releasing factor in the dorsal raphe elicits temporally distinct serotonergic responses in the limbic system , Neuroscience , vol. 141, pp. 1047-1055.
  • Waters, R. P., Emerson, A. J., Watt, M., Forster, G., Swallow, J., Summers, C., (2005), Stress induces rapid changes in central catecholaminergic activity in Anolis carolinensis: Restraint and forced physical activity. , Brain Research Bulletin, vol. 67, pp. 210-218.
Awards and Honors:
  • Axelrod Travel Award, National Institute on Drug Abuse (NIDA) , 2009
  • SD Young Investigator, EPSCoR/IDeA, 2009
  • USD President’s Award for Research Excellence , University of South Dakota , 2009
  • Faculty Travel Award, University of South Dakota Research Office , 2005
  • Travel Award, Society for Integrative Biology, 2003
  • Neurochemistry Research Award , Australian Neuroscience Society , 2001
  • Student Award, Australian Neuroscience Society , 1999
  • Student Award, New Zealand Neurological Foundation , 1998
  • T.P.H. McKellar Award for first place, Honors I, Psychology, University of Otago, 1997
  • Division of Sciences Award , University of Otago , 1996
Presentations:
  • Forster, G., Olson, D., Baugh, L. A., Hansen, J. M., Gaher, R., Simons, J., Magnotta, V. (2013). Effects of heavy alcohol use on frontal cortex activity and behavior during emotional processing in veterans with PTSD.. Presented at the 43rd Annual Meeting of the Society for Neuroscience, San Diego, CA.
  • Barr, J. L., Forster, G., Unterwald, E. M. (2013). Enhanced hippocampus-mediated dopaminergic neurotransmission in the nucleus accumbens following repeated cocaine.. Presented at the 43rd Annual Meeting of the Society for Neuroscience, San Diego, CA.
  • Scholl, J. L., Li, H., Tu, W., Hassell, J., Watt, M., Renner, K., Forster, G. (2013). Increased stress responsiveness associated with altered serotonergic and glucocorticoid function in the limbic system during amphetamine withdrawal .. Presented at the 43rd Annual Meeting of the Society for Neuroscience, San Diego, CA.
  • Watt, M., Miiller, L. C., Scholl, J. L., Renner, K., Novick, A. M., Forster, G. (2013). Trajectory of alterations to cortical dopamine activity in a model of teenage bullying .. Presented at the 43rd Annual Meeting of the Society for Neuroscience, San Diego, CA.
  • Tu, W., Scholl, J., Renner, K., Forster, G. (2013, November). Importance of Serotonin in the Ventral Hippocampus in Modulating Anxiety - like Behavior.. Presented at the Society for Neuroscience Undergraduate Poster Session, San Diego.
  • Forster, G. (2013, November). Animal Models of Psychiatric Disorders: A Focus on Early Life Stress. Presented at the CBBRe Workshop, Vermillion, SD.
  • Forster, G. (2013, September). Neural and Behavioral Correlates of PTSD and Alcohol Use. Presented at the DoD Substance Abuse Research IPR, Fort Detrick, MA.
  • Davies, D., Meyer, D., Barr, J., Manzerra, P., Forster, G. (2012). Effects of mild traumatic brain injury on limbic system and anxiety states. Presented at the School of Health Sciences Research Conference.
  • Olson, D., Baugh, L. A., Gaher, R., Simons, J., Magnotta, V., Forster, G. (2012). Neural Imaging: The Effects of Alcohol Use on Emotional Processing in Posttraumatic Stress Disorder (PTSD).. Presented at the School of Health Sciences Research Conference.
  • Scholl, J., Reinbold, E., Oliver, K., Watt, M., Forster, G. (2012). Reducing Anxiety During Amphetamine Withdrawal. Presented at the School of Health Sciences Research Conference, Vermillion.
  • Novick, A., Scholl, J., Roberts, C., Tejani-Butt, S., Hassell, J., Forster, G., Watt, M. (2012, October). Altered prefrontal cortex dopamine transporter expression and function following adolescent social defeat . Presented at the Society for Neuroscience Annual Meeting, New Orleans.
  • Scholl, J., Roberts, C., Oliver, K., Forster, G., Watt, M. (2012, October). Increased fear conditioning and raphe CRF-2 receptor expression following adolescent social defeat. Presented at the Society for Neuroscience Annual Meeting, New Orleans.
  • Watt, M., Novick, A., Roberts, C., Meyer, D., Oliver, K., Scholl, J., Barr, J., Renner, K., Forster, G. (2012, October). Mechanisms underlying deficits in prefrontal cortex dopamine activity caused by adolescent social defeat . Presented at the Society for Neuroscience Annual Meeting, New Orleans.
  • Li, H., Hassell, J., Scholl, J., Watt, M., Renner, K., Forster, G. (2012, October). Stress-induced increases in extracellular serotonin in the ventral hippocampus are attenuated in rats during amphetamine withdrawal. Presented at the Society for Neuroscience Annual Meeting, New Orleans.
  • Olson, D. M., Meyer, D. L., Scholl, J. L., Watt, M., Manzerra, P., Renner, K., Forster, G. (2012, October). Effects of Mild Traumatic Brain Injury and Psychosocial Stress on Limbic Monoamines and Anxiety-like Behaviors.. Presented at the Society for Neuroscience Meeting, New Orleans, LA.
  • Davies, D., Watt, M., Meyer, D., Scholl, J., Forster, G. (2012, October). Combined Mild Traumatic Brain Injury and Psychosocial Stress Mimics Symptoms of Posttraumatic Stress Disorder in a Rat Model. Presented at the Society for Neuroscience Undergraduate Poster Session, New Orleans.
  • Miiller, L., Scholl, J., Renner, K., Forster, G., Watt, M. (2012, October). Trajectory of alterations to cortical dopamine activity in a model of teenage bullying. Presented at the Society for Neuroscience Undergraduate Poster Session, New Orleans.
  • Scholl, J., Reinbold, E., Oliver, K., Watt, M., Forster, G. (2012, June). CRF2 Receptors Mediate Anxiety States During Amphetamine Withdrawal. Presented at the International Behavioral Neuroscience Society Annual Meeting, Hawaii.
  • Davies, D., Meyer, D., Barr, J., Manzerra, P., Forster, G. (2012, May). Effects of mild traumatic brain injury on limbic system and anxiety states. Presented at the Sanford-USD Research Symposium, Vermillion.
  • Olson, D., Baugh, L. A., Gaher, R., Simons, J., Magnotta, V., Forster, G. (2012, May). Neural Imaging: The Effects of Alcohol Use on Emotional Processing in Posttraumatic Stress Disorder (PTSD).. Presented at the Sanford-USD Research Symposium, Vermillion.
  • Scholl, J., Reinbold, E., Oliver, K., Watt, M., Forster, G. (2012, May). Reducing Anxiety During Amphetamine Withdrawal. Presented at the Sanford-USD Research Symposium, Vermillion.
  • Novick, A. M., Miiller, L. C., Forster, G., Watt, M. (2012, May). Effects of adolescent social defeat on adult working memory. Presented at the Sanford Health - USD Biomedical Research Symposium, Vermillion, SD.
  • Li, H., Hassell, J. E., Barr, J. L., Scholl, J. L., Watt, M., Forster, G., Renner, K. (2012, April). Stress-induced increases in extracellular serotonin in the ventral hippocampus is attenuated in rats during amphetamine withdrawal. Presented at the South Dakota Academy of Science, Vermillion, SD.
  • Forster, G. (2011). Central CRF2 receptor antagonism reduces anxiety states during amphetamine withdrawal. Presented at the Society for Neuroscience Annual Meeting, Washington DC.
  • Forster, G. (2010). Neuropeptide modulation of serotonin and anxiety states.. Presented at the Dept of Pharmaceutical Sciences, Brookings, SD USA.
  • Forster, G. (2010). CRF receptors in the dorsal raphe nucleus mediate anxiety states induced by post-weaning social isolation. . Presented at the International Society for Behavioral Neuroscience .
  • Forster, G. (2010). Automated measures of conditioned fear behavior in the rat. Presented at the Noldus Measuring Behavior Workshop, San Diego, CA.
  • Forster, G. (2010). Neuropeptide modulation of serotonin and anxiety states.. Presented at the Sanford Research Day, Vermillion, SD.
  • Forster, G. (2010). Anxiety states induced by post-weaning social isolation are mediated by CRF receptors in the dorsal raphe nucleus.. Presented at the Society for Neuroscience Annual Meeting, San Diego, CA.
  • Forster, G. (2009). various presentations. Presented at the Neuroscience Journal Club, University of South Dakota.
  • Forster, G. (2009, November). Corticotropin-releasing factor 2 receptors as a novel therapeutic target for reducing anxiety states?. Presented at the Axelrod Neuropharmacology Symposium, Chicago, IL.
  • Forster, G. (2009, November). Reversal of anxiety behavior during amphetamine withdrawal by antagonism of corticotropin-releasing factor 2 receptors in the dorsal raphe nucleus.. Presented at the Society for Neuroscience Annual Meeting, Chicago, IL USA.
  • Forster, G. (2009, September). Neuropeptides, Serotonin and Anxiety. Presented at the Biology Department Speaker, Spearfish, SD USA.