Sanford School of Medicine Basic Biomedical Sciences

Hongmin Wang, Ph.D.

Hongmin Wang
Assistant Professor
Basic Biomedical Sciences, School of Medicine
UMS Lee Med/Sanford School of Medicine Room 344
Phone: 605-677-6408
Teaching Interests:
Biochemistry, Neuroscience, Celllular and Molecular Biology
Research Interests:
Protein degradation in neurodegeneration, molecular mechanisms of neuroprotection
Education:
  • Postdoctoral Fellow, Neurodegeneration, Johns Hopkins University School of Medicine, 2004
  • Ph D, Zoology/Neuroscience, University of Idaho, 2000
  • MS, Zoology, Shandong Normal University, China, 1988
  • BS, Biology, Shandong Normal University, China, 1986
Publications:
  • Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X., Wang, H., (2014), The Proteasome Function Reporter GFPu Accumulates in Young Brains of the APPswe/PS1dE9 Alzheimer’s Disease Mouse Model, Cell Mol Neurobiol, vol. 34, iss. 3, pp. 315-322. Epub 2013 Dec 21. .
  • Rezvani, K., Zhang, D., Wang, H., Telleria, C., Schlenker, E., Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin2 interactions in colon cancer cells , Cell death and Disease/Nature publishing group.
  • Liu, Y., Lü , L., Hettinger, C. L., Dong, G., Zhang, D., Rezvani, K., Wang, X., Wang, H., (2014), Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice, J Neurosci, vol. 34, iss. 8, pp. 2813-21.
  • Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X., Wang, H., (2014), Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington’s disease, J Neurochem, p. 2014 Jan 3. doi: 10.1111/jnc.12647. [Epub ahead of print].
  • Zou, J., Tian, F., Li, J., Pickner, W., Long, M., Rezvani, K., Wang, H., Zhang, D., (2013), FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1. , Biology Open , vol. 2, p. 1022.
  • Tian, F., Sharma, S., Zou, J., Lin, S., Wang, B., Rezvani, K., Wang, H., Parvin, J. D., Ludwig, T., Canman, C. E., Zhang, D., (2013), BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade, Proc Natl Acad Sci U S A, vol. 110, iss. 33, p. 13558.
  • Zou, J., Rezvani, K., Wang, H., Lee, K. S., Zhang, D., (2013), BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stress, Cell Cycle, vol. 12, iss. 14, p. 2255.
  • Dong, G., Gross, K., Qiao, F., Ferguson , J., Callegari, E. A., Rezvani , K., Zhang, ., Gloeckner , C. ., Ueffing , M., Wang, H., (2012), Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity (2012), J Neurochem, vol. 2012, iss. Aug 14 [Epub ahead of print].
  • Rezvani, K., Baalman, K., Teng, Y., Mee, M. P., Dawson, S. P., Wang, H., De Biasi, M., Mayer, R. J., (2012), Proteasomal degradation of the metabotropic glutamate receptor 1a is mediated by Homer-3 via the proteasomal S8 ATPase: Signal transduction and synaptic transmission (2012), J Neurochem, vol. 122, iss. 1, pp. 24-37.
  • Rezvani, K., Baalman, ., Yang, Y., Mee, M., Dawson, S., Wang, H., De Biasi, M., mayer, J., (2012), Proteasomal Degradation of the Metabotropic Glutamate Receptor 1??is Mediated by Homer-3 via the Proteasomal S8 ATPase, Journal of Neurochemistry, vol. 122, iss. 1, pp. 24-37.
  • Dong, G., Callegari , E. A., Gloeckner , C. J., Ueffing , M., Wang, H., (2012), Mass spectrometric identification of novel posttranslational modification sites in Huntingtin (2012), Proteomics, vol. 12, iss. 12, pp. 2060-4.
  • Lu, L., Wang, H., (2012), Transient focal cerebral ischemia upregulates immunoproteasomal subunits (2012), Cell Mol Neurobiol, vol. 32, iss. 6, pp. 965-70.
  • Dong, G., Callegari , E. A., Gloeckner , C. J., Ueffing, M., Wang, H., (2012), Prothymosin-a interacts with mutant Huntingtin and suppresses its cytotoxicity in Cell culture, J Biol Chem, vol. 287, iss. 2, pp. 1279-89 .
  • Wang, H., Karbowski , ., Monteiro , M. J., (2011), Mitochondrial dynamics and Huntington’s disease: A dance of fate, Mitochondrial Dynamics and Neurodegeneration, pp. 235-257.
  • Dong, G., Ferguson, J. M., Duling, A. J., Nicolas, R. G., Zhang, D., Rezvani, K., Fang, S., Monterio, M. J., Li, S., Li, X. J., Wang, H., (2011), Modeling Pathogenesis of Huntington’s Disease with Inducible Neuroprogenitor Cells, Cell Mol Neurobiol , vol. 31, p. 737.
  • Lim, P. J., Danner, R., Liang, J., Doong, H., Harman, C., Srinivasan, D., Rothenberg, C., Wang, H., Ye, Y., Fang, S., Monteiro, M. J., (2009), Ubiquilin and p97/VCP bind erasin forming a complex involved in ERAD , J Cell Biol, vol. 187, iss. 2, pp. 201-17.
  • Wang, H., Lim, P. J., Karbowski , M., Monteiro, M. J., (2009), Effects of overexpression of huntingtin on mitochondrial integrity , Hum Mol Genet , vol. 18, iss. 4, pp. 737-52.
  • Wang, H., Monteiro, M. J., (2007), Ubiquilin enhances expanded polyglutamine degradation, Biochem Biophys Res Commun, vol. 360, iss. 2, pp. 423-7.
  • Wang, H., Monteiro, M. J., (2007), Ubiquilin overexpression reduces GFP-polyalanine-induced protein aggregates and toxicity, Exp Cell Res , vol. 313, iss. 13, pp. 2810-20..
  • Yu, S. W., Andrabi (co-first authors), S. A., Wang, H., Kim, N. S., Poirier, G. G., Dawson , V. L., Dawson, T. M., (2006), Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death , Proc Natl Acad Sci USA , vol. 103, iss. 48, pp. 18314-9.
  • Andrabi , S. A., Kim (co-first authors), N. S., Yu, S. W., Wang, H., Koh, D. W., Sasaki, M., Klaus, J. A., Otsuka, T., Zhang, Z., Koehler, R. C., Hurn, P. D., Poirier, G. G., Dawson, V. L., Dawson, T. M., , (2006), Poly(ADP-ribose) (PAR) polymer is a death signal , Proc Natl Acad Sci USA , vol. 103, iss. 48, pp. 18308-13.
  • Wang, H., Yin, C., Lim, P. J., Reickher, M., Vogel, B. E., Monteiro, M. J., (2006), Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin , Hum Mol Genet, vol. 15 , iss. 6, pp. 1025-1041.
  • Wang, H., Yu, S. W., Koh, D. W., Lew, J., Coombs, C., Bowers, W., Federoff, H. J., Poirier, G. G., Dawson , T. M., Dawson, V. L., , (2004), Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death, J Neurosci, vol. 24 , iss. 48, pp. 10963-73.
  • Yu, S. W., Wang, H., Dawson , T. M., Dawson, V. L., , (2003), Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity , Neurobiol. Dis. , vol. 14, iss. 3, pp. 303-17.
  • Sheline, C. T., Wang, H., Cai, A., Dawson , V. L., Choi, D. W., (2003), Involvement of poly-ADP ribosyl polymerase-1 in fast but not slow zinc neurotoxicity , Eur J Neurosc, vol. 8, iss. 6, pp. 1402-9.
  • Wang, H., Shimoji, M., Yu, S. W., Dawson , T. M., Dawson, V. L., (2003), Apoptosis inducing factor and PARP mediated injury in the MPTP mouse model of Parkinson’s disease. Parkinson’s disease: the Life Cycle of the Dopamine Neuron , Annals of New York Acad Sci, vol. 991, pp. 132-140.
  • Wang, H., Yu* (co-first author), S. W., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M., Dawson , V. L., (2002), Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor , Science, vol. 297, iss. 5579, pp. 259-263.
  • Wang, H., Chadaram, S. R., Norton, A. S., Laskowski, M. B., (2001), Development of inhibition by ephrin-A5 on outgrowth of embryonic spinal motor neurites , J Neurobiol , vol. 47 , iss. 3, pp. 233-243.
  • Laskowski, M. B., Feng (co-first authors), , G., Feldheim, D. A., Wang, H., Lewis, R., Frisen, J., Flanagan, J. G., Sanes, J. R., (2000), Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers, Neuron, vol. 25, iss. 2, pp. 295-306.
  • Wang, H., Chadaram, S. R., Norton, A. S., Lewis, R., Boyum, J., Trumble, W., Sanes, J. R., Laskowski, M. B., (1999), Positionally selective growth of embryonic spinal cord neurites on muscle membranes , J Neurosci, vol. 19 4984-4993, iss. 12, pp. 4984-4993.
Presentations:
  • Liu, Y., Lü, L., Dong, G., Hettinger, C., Watt, M., Forster , G., Wang, X., Wang, H. (2013, November). Ubiquilin protects cells against oxidative stress and ischemic stroke caused injury in mice. Presented at the Annual Neuroscience Meeting, San Diego, CA.
  • Qiao, F., Liu, Y., Wang, H. (2013, November). Generation and characterization of transgene- and virus-free inducible pluripotent stem cells derived from Huntington’s disease patient fibroblasts. Presented at the Annual Neuroscience Meeting, San Diego, CA.
  • Hettinger , C. L., Liu, Y., Dong,, G., Lü, L., Wang, X., Watt, ., Forster, G., Wang, H. (2013, November). Ubiquilin suppresses accumulation of mutant Huntingtin and motor deficits in HD mice. Presented at the Annual Neuroscience Meeting, San Diego, CA.
  • Wang, H. (2012, August). Role of Ubiquilin in Huntington's Disease. Presented at the HD2012, Boston MA.
  • Lu, L., Hettinger, C., Dong, G., Jahn, A., Wang, X., Watt, M., Forster, , G., Wang, H. (2012, June). Characterization of Huntington’s Disease Mice Deficient in the Ubiquilin Gene . Presented at the Ubiquitin, Protein Quality Control and Molecular Pathogenesis Symposium, Deadwood SD.
  • Wang, H. (2012, June). Role of Ubiquilin in Huntington’s Disease . Presented at the Ubiquitin, Protein Quality Control and Molecular Pathogenesis Symposium, Deadwood SD.
  • Dong, G., Hettinger, C., Watt, M., Forster , G., Wang, H. (2012, May). Overexpression of Ubiquilin Reduces Mutant Huntingtin Caused toxicity in Huntington’s Disease Mice. Presented at the Sanford Health – USD Biomedical Research Symposium, Vermillion SD.
  • Lu, L., Dong, G., Hettinger, C., Watt, M., Forster, G., Wang, H. (2012, May). Ubiquilin Reduces Neuronal Damage and Facilitates Neurological Recovery Following Cerebral Ischemic Stroke . Presented at the Sanford Health – USD Biomedical Research Symposium, Vermillion SD.
  • Gross, K., Wang, H. (2011, December). Calretinin interacts with and reduces mutant huntingtin-caused toxicity. Presented at the Annual Cell Biology Meeting, Denver, CO.
  • Dong, G., Wang, H. (2011, November). Prothymosin-alpha interacts with and reduces mutant huntingtin-caused toxcity in cell culture . Presented at the Annual Neuroscience Meeting, Washington DC.