Sanford School of Medicine Basic Biomedical Sciences

Hongmin Wang, Ph.D.

Hongmin Wang
Assistant Professor
Medicine: Basic Biomedical Sciences, Health Affairs
UMS Lee Med/Sanford School of Medicine Room 344
Phone: 605-677-6408
Teaching Interests:
Biochemistry, Neuroscience, Celllular and Molecular Biology
Research Interests:
Protein degradation in neurodegeneration, molecular mechanisms of neuroprotection
Education:
  • BS, Biology, Shandong Normal University, China,
  • MS, Zoology, Shandong Normal University, China,
  • Postdoctoral Fellow, Neurodegeneration, Johns Hopkins University School of Medicine,
  • Ph D, Zoology/Neuroscience, University of Idaho,
Publications:
  • Dong, G., Gross, K., Qiao, F., Ferguson , J., Callegari, E. A., Rezvani , K., Zhang, ., Gloeckner , C. ., Ueffing , M., Wang, H., (2012), Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity (2012), J Neurochem, vol. 2012, iss. Aug 14 [Epub ahead of print].
  • Rezvani, K., Baalman, K., Teng, Y., Mee, M. P., Dawson, S. P., Wang, H., De Biasi, M., Mayer, R. J., (2012), Proteasomal degradation of the metabotropic glutamate receptor 1a is mediated by Homer-3 via the proteasomal S8 ATPase: Signal transduction and synaptic transmission (2012), J Neurochem, vol. 122, iss. 1, pp. 24-37.
  • Dong, G., Callegari , E. A., Gloeckner , C. J., Ueffing , M., Wang, H., (2012), Mass spectrometric identification of novel posttranslational modification sites in Huntingtin (2012), Proteomics, vol. 12, iss. 12, pp. 2060-4.
  • Lu, L., Wang, H., (2012), Transient focal cerebral ischemia upregulates immunoproteasomal subunits (2012), Cell Mol Neurobiol, vol. 32, iss. 6, pp. 965-70.
  • Dong, G., Callegari , E. A., Gloeckner , C. J., Ueffing, M., Wang, H., (2012), Prothymosin-a interacts with mutant Huntingtin and suppresses its cytotoxicity in Cell culture, J Biol Chem, vol. 287, iss. 2, pp. 1279-89 .
  • Wang, H., Karbowski , ., Monteiro , M. J., (2011), Mitochondrial dynamics and Huntington’s disease: A dance of fate, Mitochondrial Dynamics and Neurodegeneration, pp. 235-257.
  • Dong, G., Ferguson, J. M., Duling, A. J., Nicolas, R. G., Zhang, D., Rezvani, K., Fang, S., Monterio, M. J., Li, S., Li, X. J., Wang, H., (2011), Modeling Pathogenesis of Huntington’s Disease with Inducible Neuroprogenitor Cells, Cell Mol Neurobiol , vol. 31, p. 737.
  • Lim, P. J., Danner, R., Liang, J., Doong, H., Harman, C., Srinivasan, D., Rothenberg, C., Wang, H., Ye, Y., Fang, S., Monteiro, M. J., (2009), Ubiquilin and p97/VCP bind erasin forming a complex involved in ERAD , J Cell Biol, vol. 187, iss. 2, pp. 201-17.
  • Wang, H., Lim, P. J., Karbowski , M., Monteiro, M. J., (2009), Effects of overexpression of huntingtin on mitochondrial integrity , Hum Mol Genet , vol. 18, iss. 4, pp. 737-52.
  • Wang, H., Monteiro, M. J., (2007), Ubiquilin enhances expanded polyglutamine degradation, Biochem Biophys Res Commun, vol. 360, iss. 2, pp. 423-7.
  • Wang, H., Monteiro, M. J., (2007), Ubiquilin overexpression reduces GFP-polyalanine-induced protein aggregates and toxicity, Exp Cell Res , vol. 313, iss. 13, pp. 2810-20..
  • Yu, S. W., Andrabi (co-first authors), S. A., Wang, H., Kim, N. S., Poirier, G. G., Dawson , V. L., Dawson, T. M., (2006), Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death , Proc Natl Acad Sci USA , vol. 103, iss. 48, pp. 18314-9.
  • Andrabi , S. A., Kim (co-first authors), N. S., Yu, S. W., Wang, H., Koh, D. W., Sasaki, M., Klaus, J. A., Otsuka, T., Zhang, Z., Koehler, R. C., Hurn, P. D., Poirier, G. G., Dawson, V. L., Dawson, T. M., , (2006), Poly(ADP-ribose) (PAR) polymer is a death signal , Proc Natl Acad Sci USA , vol. 103, iss. 48, pp. 18308-13.
  • Wang, H., Yin, C., Lim, P. J., Reickher, M., Vogel, B. E., Monteiro, M. J., (2006), Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin , Hum Mol Genet, vol. 15 , iss. 6, pp. 1025-1041.
  • Wang, H., Yu, S. W., Koh, D. W., Lew, J., Coombs, C., Bowers, W., Federoff, H. J., Poirier, G. G., Dawson , T. M., Dawson, V. L., , (2004), Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death, J Neurosci, vol. 24 , iss. 48, pp. 10963-73.
  • Yu, S. W., Wang, H., Dawson , T. M., Dawson, V. L., , (2003), Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity , Neurobiol. Dis. , vol. 14, iss. 3, pp. 303-17.
  • Sheline, C. T., Wang, H., Cai, A., Dawson , V. L., Choi, D. W., (2003), Involvement of poly-ADP ribosyl polymerase-1 in fast but not slow zinc neurotoxicity , Eur J Neurosc, vol. 8, iss. 6, pp. 1402-9.
  • Wang, H., Shimoji, M., Yu, S. W., Dawson , T. M., Dawson, V. L., (2003), Apoptosis inducing factor and PARP mediated injury in the MPTP mouse model of Parkinson’s disease. Parkinson’s disease: the Life Cycle of the Dopamine Neuron , Annals of New York Acad Sci, vol. 991, pp. 132-140.
  • Wang, H., Yu* (co-first author), S. W., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M., Dawson , V. L., (2002), Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor , Science, vol. 297, iss. 5579, pp. 259-263.
  • Wang, H., Chadaram, S. R., Norton, A. S., Laskowski, M. B., (2001), Development of inhibition by ephrin-A5 on outgrowth of embryonic spinal motor neurites , J Neurobiol , vol. 47 , iss. 3, pp. 233-243.
  • Laskowski, M. B., Feng (co-first authors), , G., Feldheim, D. A., Wang, H., Lewis, R., Frisen, J., Flanagan, J. G., Sanes, J. R., (2000), Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers, Neuron, vol. 25, iss. 2, pp. 295-306.
  • Wang, H., Chadaram, S. R., Norton, A. S., Lewis, R., Boyum, J., Trumble, W., Sanes, J. R., Laskowski, M. B., (1999), Positionally selective growth of embryonic spinal cord neurites on muscle membranes , J Neurosci, vol. 19 4984-4993, iss. 12, pp. 4984-4993.
Presentations:
  • Wang, H. (2012, August). Role of Ubiquilin in Huntington's Disease. Presented at the HD2012, Boston MA.
  • Lu, L., Hettinger, C., Dong, G., Jahn, A., Wang, X., Watt, M., Forster, , G., Wang, H. (2012, June). Characterization of Huntington’s Disease Mice Deficient in the Ubiquilin Gene . Presented at the Ubiquitin, Protein Quality Controla and Molecular Pathogenesis Symposium, Deadwood SD.
  • Wang, H. (2012, June). Role of Ubiquilin in Huntington’s Disease . Presented at the Ubiquitin, Protein Quality Controla and Molecular Pathogenesis Symposium, Deadwood SD.
  • Dong, G., Hettinger, C., Watt, M., Forster , G., Wang, H. (2012, May). Overexpression of Ubiquilin Reduces Mutant Huntingtin Caused toxicity in Huntington’s Disease Mice. Presented at the Sanford Health – USD Biomedical Research Symposium, Vermillion SD.
  • Lu, L., Dong, G., Hettinger, C., Watt, M., Forster, G., Wang, H. (2012, May). Ubiquilin Reduces Neuronal Damage and Facilitates Neurological Recovery Following Cerebral Ischemic Stroke . Presented at the Sanford Health – USD Biomedical Research Symposium, Vermillion SD.
  • Gross, K., Wang, H. (2011, December). Calretinin interacts with and reduces mutant huntingtin-caused toxicity. Presented at the Annual Cell Biology Meeting, Denver, CO.
  • Dong, G., Wang, H. (2011, November). Prothymosin-alpha interacts with and reduces mutant huntingtin-caused toxcity in cell culture . Presented at the Annual Neuroscience Meeting, Washington DC.