Sanford School of Medicine Basic Biomedical Sciences

Huabo Su, Ph.D.

Huabo Su
Assistant Professor
Medicine: Basic Biomedical Sciences, Health Affairs
UMS Lee Med/Sanford School of Medicine 130
Phone: 605-677-6783
Teaching Interests:
Biochemistry, molecular biology, cell biology
Research Interests:
Protein neddylation/deneddylation in cardiac physiology and pathophysiology; Molecular mechanisms of progression of diabetic cardiomyopathy; Molecular mechanisms of the regulation of the ubiquitin-proteasome system.
Education:
  • Ph D, Biochemistry and Molecular Biology, Fundan University, 2004
  • MS, Microbiology, Guangxi University, 2001
  • BS, Biology Education, Guangxi Normal University, 1997
Publications:
  • Wang, X., Pattison, J. S., Su, H., (2013), Posttranslational Modification and Quality Control, Circulation Research, vol. 112, iss. 2, pp. 367-381.
  • Tian, Z., Zheng, H., Li, J., Li, Y., Su, H., Wang, X., (2012), Genetically Induced Moderate Inhibition of the Proteasome in Cardiomyocytes Exacerbates Myocardial Ischemia-Reperfusion Injury in Mice, Circulation Research, vol. 111, iss. 5, pp. 532-542.
  • Wang, X., Li, J., Zheng, H., Su, H., Powell, S. R., (2011), Proteasome functional insufficiency in cardiac pathogenesis, Am J Physiol Heart Circ Physiol , vol. 301, iss. 6, pp. H2207-H2219.
  • Su, H., Wang, X., (2011), Autophagy and p62 in cardiac protein quality control, Autophagy, vol. 7, iss. 11, pp. 1382-1383.
  • Su, H., Li, F., Ranek, M. J., Wei, N., Wang, X., (2011), The COP9 signalosome regulates autophagosome maturation , Circulation, vol. 124, iss. 19, pp. 2117-2128.
  • Zheng, Q., Su, H., Tian, Z., Wang, X., (2011), Proteasome malfunction activates macroautophagy in the heart, Am J Cardiovasc Dis , vol. 1, iss. 3, pp. 214-226.
  • Wang, X., Su, H., (2011), FoxO3 hastens autophagy and shrinks the heart but does not curtail pathological hypertrophy in adult mice, Cardiovascular Research, vol. 91, iss. 4, pp. 561-562.
  • Li, J., Horak, K. M., Su, H., Sanbe, A., Robbins, J., Wang, X., (2011), Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice., Journal of Clinical Investigation, vol. 121, iss. 9, pp. 3689-3700.
  • Su, H., Wang, X., (2011), p62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic Stress, Trends in Cardiovascular Medicine, vol. 21, iss. 8, pp. 224-228.
  • Zheng, Q., Su, H., Ranek, M. J., Wang, X., (2011), Autophagy and p62 in cardiac proteinopathy, Circulation Research, vol. 109, iss. 3, pp. 296-308.
  • Su, H., Li, J., Menon, S., Liu, J., Kumarapeli, A. R., Wei, N., Wang, X., (2011), Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice., Circulation Research, vol. 108, iss. 1, pp. 40-50.
  • Lei, D., Li, F., Su, H., Tian, Z., Ye, B., Wei, N., Wang, X., (2010), COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation, Cell Death Differ, vol. 18, iss. 2, pp. 259-70.
  • Tang, M., Li, J., Wei, H., Su, H., Liang, Q., Tian, Z., Horak, K., Molkentin, J., Wang, X., (2010), Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts, Cardiovasc Res, vol. 88, iss. 3, pp. 424-33.
  • Su, H., Wang, X., (2010), The Ubiquitin-Proteasome System in Cardiac Proteinopathy: A Quality Control Perspective, Cardiovasc Res, vol. 85, iss. 2, pp. 253-62.
  • Wang, X., Su, H., (2010), Unraveling enigma in the z-disks, Circ Res, vol. 107, iss. 3, pp. 321-3.
  • Su, H., Huang, W., Wang, X., (2009), The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription, Int J Biochem Cell Biol, vol. 41, iss. 3, pp. 615-24.
  • Kumarapeli, A. R., Su, H., Wei, H., Tang, M., Zheng, H., Horak, K. M., Li, M., Wang, X., (2008), AlphaB-crystallin suppresses pressure overload cardiac hypertrophy. . , Circ Res, vol. 103, iss. 12, pp. 1473-82.
  • Wang, X., Su, H., Mark, R. M., (2008), Protein quality control and degradation in cardiomyocytes, J Mol Cell Cardiol, vol. 457, iss. 1, pp. 11-27.
Awards and Honors:
  • Scientist Development Award (National Center), American Heart Association, 2011
  • New Investigator Travel Award of the Basic Cardiovascular Sciences Conference, American Heart Association, 2008
  • American Heart Association Postdoctoral Fellowship, American Heart Association , 2006
Presentations:
  • Wang, C., Tian, Z., Zheng, Q., Su, H., Li, J., Wang, X. (2011, July). Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart. Presented at the AHA Basic Cardiovascular Sciences 2011 Scientific Sessions, New Orleans, LA, USA.
  • Zheng, Q., Su, H., Ranek, M. J., Wang, X. (2011, July). The Role of p62 in Cardiac Protein Quality Control. Presented at the AHA Basic Cardiovascular Sciences 2011 Scientific Sessions , New Orleans, LA, USA.
  • Li, J., Horak, K. M., Su, H., Sanbe, A., Robbins, J., Wang, X. (2011, July). Enhancement of Proteasomal Function Protects Against Proteinopathy and Myocardial Ischemia-Reperfusion Injury in Mice. Presented at the AHA Basic Cardiovascular Sciences 2011 Scientific Sessions, New Orleans, LA, USA .
  • Su, H., Tian, Z., Wang, C., Said, S., Ranek, M. J., Wang, X. (2011, July). Impaired Autophagosome Removal in Cardiomyocytes Triggers Programmed Necrosis in Mouse Hearts. Presented at the AHA Basic Cardiovascular Sciences 2011 Scientific Sessions, New Orleans, LA, USA .
  • Su, H., Ranek, M. J., Wei, N., Wang, X., (2011, July). The COP9 Signalosome Regulates Autophagy. Presented at the AHA Basic Cardiovascular Sciences 2011 Scientific Sessions, New Orleans, LA.
  • Su, H. (2011, July). The COP9 signalosome in the heart. Presented at the 2011 Inaugural Symposium on Ubiquitin, Protein Quality Control, and Molecular Pathogenesis., Vermillion, SD, USA..
  • Su, H., Li, F., Ranek, M., Wei, N., Wang, X. (2011, July). The COP9 signalosome regulates autophagy.. Presented at the AHA Basic Cardiovascular Sciences Conference 2011, New Orleans, LA, USA.
  • Davis, F., Predmore, J., Wang, P., Li, J., Su, H., Converso, K., Allen, A., Jones, R., Powell, S., Wang, X., Day, S. M. (2010, November). Activation of the ubiquitin proteasome system after myocardial infraction. Presented at the AHA Scientific Sessions, Chicago, IL.
  • Su, H., Li, J., Menon, S., Horak, K., Wei, N., Wang, X. (2008, July). Perinatal cardiomyocyte-restricted knockout of the COP9 signalosome subunit 8 gene compromises proteasome proteolytic function, triggers necrosis, and causes heart failure in mice. . Presented at the AHA Basic Cardiovascular Sciences Conference 2008 , Keystone, CO, USA.
  • Su, H., Li, J., Osinska, H., Menon, S., Horak, K., Li, F., Molkentin, J., Robbins, J., Wei, N., Wang, X. (2008, June). Cardiac ablation of CSN8 perturbs proteasomal proteolysis, activates autophagy, and causes fatal heart failure in adult mice.. Presented at the International Society for Heart Research 2008 (American Section), Cincinnati, OH, USA.
  • Su, H., Li, J., Osinska, H., Menon, S., Li, F., Robbins, J., Wei, N., Wang, X. (2007, April). Genetic inhibition of cullin-based ubiquitin ligase dynamics in adult mouse hearts suffices to cause heart failure.. Presented at the Experimental Biology 2007, Washington DC, USA.
  • Su, H., Menon, S., Horak, K., Li, J., Li, F., Wei, N., Wang, X., (2006, November). Postnatal cardiomyocyte-restricted knockout of a COP9 signalosome gene compromises proteolytic function of the ubiquitin proteasome system and causes congestive heart failure in mice.. Presented at the AHA Scientific Sessions 2006, Chicago, IL, USA..