Sanford School of Medicine Basic Biomedical Sciences

Keith Weaver, Ph.D.

Keith Weaver
Professor
Medicine: Basic Biomedical Sciences, Health Affairs
UMS Lee Med/Sanford School of Medicine 340
Phone: 605-677-51696
Education:
  • Post-doctoral fellow, Microbiology, University of Michigan, 1989
  • Ph D, Microbiology, University of Texas, 1985
  • BS, Microbiology, Pennsylvania State University, 1980
Publications:
  • Clewell, D. B., Weaver, K., Dunny, G. M., Coque, T. M., Francia, M. V., Hayes, F., (2014), Extrachromosomal and Mobile Elements in Enterococci. Transmission, Maintenance, and Epidemiology, NCBI.
  • Johnson, C. M., Chen, Y., Lee, H., Ke, A., Weaver, K., Dunny, G., (2014), Identification of a conserved branched RNA structure that functions as a factor-independent terminator, PNAS.
  • Weaver, K., (2013), Type I Toxin-Antitoxin Loci: hok/sok and fst, Springer, pp. 9-26.
  • Weaver, K., (2013), Scientists are snobs, Nature, vol. 495, pp. 167-168.
  • Brinkman, C. l., Bumgarner, R., Kittichotirat , W., Dunman, P. M., Kuechenmeister , L. J., Weaver, K., (2013), Characterization of the Effects of an rpoC Mutation That Confers Resistance to the Fst Peptide Toxin-Antitoxin System Toxin., Journal of Bacteriology, vol. 195, iss. 1, pp. 156-166.
  • Weaver, K., (2012), The par toxin-antitoxin system from Enterococcus faecalis plasmid pAD1 and its chromosomal homologs, RNA Biology, vol. 9, iss. 12, pp. 1498-1503.
  • Laverde Gomez , J. A., van Schaik , W., Freitas, A. R., Coque, T. M., Weaver, K., Francia, M. V., Witte, W., Werner, G., (2011), A multiresistance megaplasmid pLG1 bearing a hylEfm genomic island in hospital Enterococcus faecium isolates, Int J Med Microbiol, vol. 301, iss. 2, pp. 165-175.
  • Johnson, C. M., Haeming, H. H., Chatterjee, A., Wei-Shou, H., Weaver, K., Dunny, G. M., (2011), RNA-mediated reciprocal regulation between two bacterial operons is RNase III dependent, MBio, vol. 2, iss. 5.
  • Johnson, C. M., Manias, D. A., Haemig, S. E., Shokeen, S. E., Weaver, K., Henkin, T. M., Dunny, G. M., (2010), Direct evidence for control of the pheromone-inducible prgQ operon of Enterococcus , J. Bacteriol, vol. 192, pp. 1634-1642.
  • Shokeen, S., Johnson, C. M., Greeenfield, T. J., Manias, D. A., Dunny, G. M., Weaver, K., (2010), Structural analysis of the Anti-Q-Qs interaction: RNA-mediated regulation of E. faecalis plasmid pCF10 conjugation, Plasmid, vol. 64, pp. 26-35.
  • Chandramohan, L., Ahn, J. S., Weaver, K., Bayles, K. W., (2009), An overlap between the control of programmed cell death in B. anthracis and sporulation. , J. Bacteriol. , vol. 191, iss. 13, pp. 4103-41110.
  • Weaver, K., Reddy, S. G., Brinkman, C. L., Patel, S., Bayles, K. W., Endres, J. L., (2009), Identification and characterization of a family of toxin-antitoxin systems related to the Enterococcus faecalis plasmid pAD1 par addiction module. , Microbiology , vol. 155, iss. 9, pp. 2930-2940.
  • Weaver, K., Kwong, S. M., Firth, N., Francia, M. V., (2009), The RepA_N replicons of Gram-positive bacteria: a family of broadly distributed but narrow host range plasmids. , Plasmid, vol. 61, iss. 2, pp. 94-109.
Presentations:
  • Weaver, K., Reddy, S. G., Johnson, C. Characterization of parEF0409, a chromosomal homolog of the Enterococcus faecalis plasmid pAD1-encoded par toxin-antitoxin locus. Presented at the 2011 111th General Meeting American Society for Microbiology, New Orleans.
  • Johnson, C. M., Haemig, H. H., Manias, D. A., Weaver, K., Dunny, G. M. The prgX and prgQ operons of Enterococcus faecalis plasmid pCF10 reciprocally regulate each others gene expression using antisense RNA. Presented at the 2011 Madison Molecular Genetics of Bacteria and Phage Meeting, Madison, WI.
  • Brinkman, C., Weaver, K. Target of the Fst toxin. Presented at the UNMC/USD F2F WIP 2011, nebraska City.
  • Weaver, K. The E. faecalis EF0409 locus. Presented at the UNMC/USD F2F WIP 2011, Nebraska City.
  • Weaver, K., Clem, A., Molzcyk, C. (2013, June). The E. faecalis parEF0409 chromosomal type I toxin antitoxin locus is regulated by growth phase and carbon source. Presented at the Regulating with RNA in Bacteria, Wurzburg, Germany.
  • Weaver, K., Clem, A. (2012, October). The parEF0409 chromosomal toxin-antitoxin system of Enterococcus faecalis is regulated by growth phase and carbon source. Presented at the Gram positive pathogens, Omaha, NE.
  • Brinkman, C. L., Bumgarner, R., Kittichotirat, W., Dunman, P. M., Kuechenmeister, L. J., Weaver, K. (2012, October). An rpoC mutation confers resistance to the Fst peptide TA system toxin by suppressing induction of stress related transporters. Presented at the Gram-positive pathogens, Omaha, NE.
  • Clem, A., Weaver, K. (2012, August). Regulation of a toxin-antitoxin system in Enterococcus faecalis. Presented at the Med Student Research Forum, Lee Med.
  • Weaver, K. (2012, March). Toxin-antitoxin systems in Enterococcus faecalis: killers or just stressful.