Sanford School of Medicine Basic Biomedical Sciences

Khosrow Rezvani, Ph.D.

Khosrow Rezvani
Assistant Professor
Basic Biomedical Sciences, School of Medicine
UMS Lee Med/Sanford School of Medicine 345
Phone: 605-677-6898
Teaching Interests:
Biochemistry, Molecular Biology and Cancer Biology
Research Interests:
The role of Ubiquitin-proteasome pathway in cancer
Education:
  • Ph D, Molecular and Cell Biology, University of Nottingham, 2002
  • MD, Medical doctor, University of Kashan, Medical school, 1998
Research:
  • The p53 inhibitors Mortalin-2/CHIP complex is required for control of p53 stability in colon cancer, 5) Fight Colorectal Cancer-AACR Fellowship, in memory of Lisa Dubow
  • The p53 inhibitors Mortalin-2/CHIP complex is required for control of p53 stability in colon cancer, Helen Hay Whitney Foundation
  • The p53 inhibitors Mortalin-2/CHIP complex is required for control of p53 stability in colon cancer, The life sciences research foundation
  • The p53 inhibitors Mortalin-2/CHIP complex is required for control of p53 stability in colon cancer, AACR basic cancer research fellowship
Publications:
  • Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X., Wang, H., (2014), Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington’s disease, J Neurochem, vol. 129, iss. 3, pp. 539-47. Epub 2014 Jan 18.. (DOI: 10.1111/jnc.12647)
  • Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X., Wang, H., (2014), The Proteasome Function Reporter GFPu Accumulates in Young Brains of the APPswe/PS1dE9 Alzheimer’s Disease Mouse Model, Cell Mol Neurobiol, vol. 34, iss. 3, pp. 315-322. Epub 2013 Dec 21. . (DOI: 10.1007/s10571-013-0022-9)
  • Rezvani, K., Zhang, D., Wang, H., Telleria, C., Schlenker, E., Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin2 interactions in colon cancer cells , Cell death and Disease/Nature publishing group.
  • Liu, Y., Lü , L., Hettinger, C. L., Dong, G., Zhang, D., Rezvani, K., Wang, X., Wang, H., (2014), Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice, J Neurosci, vol. 34, iss. 8, pp. 2813-21. (DOI: 10.1523/JNEUROSCI.3541-13.2014)
  • Zou, J., Tian, F., Li, J., Pickner, W., Long, M., Rezvani, K., Wang, H., Zhang, D., (2013), FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1. , Biology Open , vol. 2, p. 1022.
  • Tian, F., Sharma, S., Zou, J., Lin, S., Wang, B., Rezvani, K., Wang, H., Parvin, J. D., Ludwig, T., Canman, C. E., Zhang, D., (2013), BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade, Proc Natl Acad Sci U S A, vol. 110, iss. 33, p. 13558.
  • Zou, J., Rezvani, K., Wang, H., Lee, K. S., Zhang, D., (2013), BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stress, Cell Cycle, vol. 12, iss. 14, p. 2255.
  • Rezvani, K., Baalman, ., Yang, Y., Mee, M., Dawson, S., Wang, H., De Biasi, M., mayer, J., (2012), Proteasomal Degradation of the Metabotropic Glutamate Receptor 1??is Mediated by Homer-3 via the Proteasomal S8 ATPase, Journal of Neurochemistry, vol. 122, iss. 1, pp. 24-37. (DOI: 10.1111/j)
  • Dong, G., Ferguson, J. M., Duling, A. J., Nicolas, R. G., Zhang, D., Rezvani, K., Fang, S., Monterio, M. J., Li, S., Li, X. J., Wang, H., (2011), Modeling Pathogenesis of Huntington’s Disease with Inducible Neuroprogenitor Cells, Cell Mol Neurobiol , vol. 31, p. 737.
Presentations:
  • Pattison, J. S., Rezvani, K. Defining the Role of p62 on Protein Degradation Processes and Heart Failure. Presented at the 3rd Floor Research Group, LM19.
  • Rezvani, K. (2014, January). Presented at the Summer 2014 BRIN Undergraduate Research Fellowship program networking event, Dakota Wesleyan University Mitchell SD .
  • Rezvani, K. (2014, January). Ubiquitin-Like (UBX)-Domain-Containing Protein, UBXN2A, Promotes Cell Death by Interfering with the p53-Mortalin2 Interactions in Cancer Cells. Presented at the The Ubiquitin System: From Basic Science to Drug Discovery (A2), Montana.
  • Rezvani, K. (2013, October). Ubiquitin-Like (UBX)-Domain-Containing Protein, UBXN2A, Promotes Cell Death by Interfering with the p53-Mortalin2 Interactions in Cancer Cells. Presented at the The meeting on Cell Death , Cold Spring Harbor, NY 11724-2213.
  • Rezvani, K. (2013, April). Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells . Presented at the South Dakota State University (SDSU), Brookings .
  • Rezvani, K. (2013, April). Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells . Presented at the University of North Dakota (NDSU), Fargo.
  • Rezvani, K. (2013, February). UBXN2A Interferes with the p53-Mortalin2 Interaction in Cancer Cells and Constitutes a Potential Target for Cancer Therapy. Presented at the Ninth AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research, Maui, HI .
  • Rezvani, K. (2013, January). Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells . Presented at the Sanford Cancer center , Sioux Fall.
  • Rezvani, K. (2012, July). Identification and Characterization of Multiple Distinct Proteasome Subpopulations in Brain Regions. Presented at the The 4th annual Ubiquitin Drug Discovery & Diagnostics Conference , Philadelphia .
  • Rezvani, K. (2012, June). UBXN2A interferes with the p53-Mortalin2 interactions in cancer cells and constitutes a potential target for cancer therapy. Presented at the Secound Symposium on Ubiquitin, Protein Quality Control, and Molecular Pathogenesis, Deadwood.
  • Rezvani, K., Starlight, J. (2011, July). Activation of p53 tumor suppressor by UBXN2A as a novel therapeutic approach in colon cancer. Presented at the 2nd Annual Student Research Symposium at Sanford Research/USD, Sioux fall .
  • Rezvani, K. (2011, June). UBXN2A Regulates p53 Localization and Stability through Interaction with Mortalin-2. Presented at the Inaugural Symposium on Ubiquitin, Protein Quality Control, and Molecular Pathogenesis, Vermillion.
  • Rezvani, K., Sane, S. (2011, April). Proteome-wide Profiling of Ubiquitinated and Sumoylated Substrates Targeted by UBX Containing Protein, UBXN2A. Presented at the 2011 IdeaFest, University of South Dakota.
  • Rezvani, K., Boudreau, D. (2011, April). UBXN2A Regulates p53 Localization and Stability through interaction with Mortalin2. Presented at the 2011 IdeaFest, University odf South Dakota.
  • Rezvani, K., Boudreau, D. (2011, February). UBXN2A Regulates p53 Localization and Stability through interaction with Mortalin2. Presented at the 2011 South Dakota Student Research Poster Session, Pierre, SD.