Sanford School of Medicine Basic Biomedical Sciences

Samuel Sathyanesan

Samuel Sathyanesan
Associate Professor
Basic Biomedical Sciences, School of Medicine
UMS Lee Med/Sanford School of Medicine 130
Phone: 605-658-6313
Assistant Professor- Yale School of Medicine (2004-2010) Associate Professor- Yale School of Medicine (2010 - 2012)
Teaching Interests:
Neuroscience, Neurovascular biology, Angiogenesis
Research Interests:
Neuropsychiatric diseases, CNS barriers, Trophic factor signaling
  • Molecular Psychiatry, Yale University School of Medicine, 2004
  • Ph D, Molecular Physiology, University of Notre Dame, 2000
  • Ph D, Biotechnology, University of Madras, 1995
  • Development of a therapeutic trophic factor for neuropsychiatric disorder, SDBOR, (2013 - 2014)
  • A Neurotrophic Approach to Treatment of Cognitive Deficits in Mood Disorders, Center for Brain and Behavioral Research, (2014 - 2015)
  • Computational design of neurotrophic peptides, Sanford School of Medicine, (2014 - 2015)
  • Development of a therapeutic trophic factor for neuropsychiatric disorder, SDBOR, (2014 - 2015)
  • Nanoparticle assisted brain delivery of a therapeutic neurotrophic factor, Office of Research and Sponsored Programs, (2014 - 2014)
  • Nanoparticle Assisted Brain Delivery of a Therapeutic Neurotrophic Factor, University of South Dakota, (2014 - 2014)
  • Duric, V., Banasr, M., Stockmeier, C. A., Simen, A. A., Sathyanesan, S., Overholser, J. C., Jurjus, G. J., Dieter, L., Duman, R. S., (2013), Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects, Int J Neuropsychopharmacology, vol. 16, iss. 1, pp. 69-82. (DOI: 10.1017/S146114571200001)
  • Duman, C. H., Sathyanesan, S., (2013), Evaluating effects of EPO in rodent behavioral assays related to depression., Methods in Molecular Biology, vol. 982, pp. 127-40.
  • Sathyanesan, S., Fournier, N. M., Duman, R. S., (2013), Vascular growth factors in neuropsychiatry, Cell Mol Life Sci, vol. 70, iss. 10, pp. 1739-52. (DOI: 10.1007/s00018-013-1281-9)
  • Ordway, G. A., Szebeni, A., Chandley, M. J., Stockmeier, C. A., Xiang, L., Sathyanesan, S., Turecki, G., Duffourc, M. M., Zhu, M., Zhu, H., Szebeni, K., (2012), Low gene expression of bone morphogenetic protein 7 in brainstem astrocytes in major depression, Int J Neuropsychopharmacology, vol. 15, iss. 7, pp. 855-68.
  • Sathyanesan, M., Girgenti, M. J., Banasr, M., Stone, K., Bruce, C., Guilchicek, E., Wilczak-Havill, K., Nairn, A., Wliliams, K., Sass, S., Duman, J. G., Sathyanesan, S., (2012), A molecular characterization of the choroid plexus and stress-induced gene regulation., Translational Psychiatry, vol. 2, iss. 7.
  • Girgenti, M. J., Collier, E., Sathyanesan, M., Su, X. W., Sathyanesan, S., (2011), Characterization of electroconvulsive seizure-induced TIMP-1 and MMP-9 in hippocampal vasculature, International Journal of Neuropsychopharmacology, vol. 14, iss. 4, pp. 535-44.
  • Beech, R. D., Lowthert, L., Leffert, J. J., Mason, P. N., Taylor, M. M., Umlauf, S., Lin, A., Lee, J. Y., Maloney, K., Muralidharan, A., Lorberg, B., Zhao, H., Sathyanesan, S., Mane, S., Epperson, N., Sinha, R., Blumberg, H., Bhagwagar, Z., (2010), Increased peripheral blood expression of electron transport chain genes in bipolar depression., Bipolar Disorders, vol. 12, iss. 8, pp. 813-824.
  • Duric, V., Banasr, M., Licznerski, P., Schmidt, H. D., Stockmeier, C. A., Simen, A., Sathyanesan, S., Duman, R. S., (2010), A negative regulator of MAP kinase causes depressive behavior, Nature Medicine, vol. 16, iss. 11, pp. 1328-32.
  • Okamoto, H., Voleti, B., Banasr, M., Sarhan, M., Duric, V., Girgenti, M. J., DiLeone, R. J., Sathyanesan, S., Duman, R. S., (2010), Wnt2 expression and signaling is increased by different classes of antidepressant treatments., Biological Psychiatry, vol. 68, iss. 6, pp. 521-527.
  • Banasr, M., Chowdhury, G. M., Terwilliger, R., Sathyanesan, S., Duman, R. S., Behar, K. L., Sanacora, G., (2010), Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole., Molecular Psychiatry, vol. 15, iss. 5, pp. 501-511.
  • Girgenti, M. J., Nisenbaum, L. K., Bymaster, F., Terwilliger, R., Duman, R. S., Sathyanesan, S., (2010), Antipsychotic-induced gene regulation in multiple brain regions., Journal of Neurochemistry, vol. 113, iss. 1, pp. 175-187.
  • Girgenti, M. J., Hunsberger, J., Duman, C. H., Sathyanesan, M., Terwilliger, R., Sathyanesan, S., (2009), Erythropoietin induction by electroconvulsive seizure, gene regulation, and antidepressant-like behavioral effects., Biological Psychiatry, vol. 66, iss. 3, pp. 267-74.
  • Ren, X., Zhou, L., Terwilliger, R., Sathyanesan, S., de Araujo, I. E., (2009), Sweet taste signaling functions as a hypothalamic glucose sensor., Frontiers in Integrative Neuroscience, vol. 3, iss. 12.
  • Duman, C. H., Schlesinger, L., Terwilliger, R., Russell, D. S., Sathyanesan, S., Duman, R. S., (2009), Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise., Behavioural Brain Research, vol. 198, iss. 2, pp. 366-371.
  • Suda, S., Segi-Nishida, E., Sathyanesan, S., Duman, R. S., (2008), A postpartum model in rat: behavioral and gene expression changes induced by ovarian steroid deprivation., Biological Psychiatry, vol. 64, iss. 4, pp. 311-319.
  • Lynch, W. J., Girgenti, M. J., Breslin, F. J., Sathyanesan, S., Taylor, J. R., (2008), Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes., Brain Research, vol. 1213, pp. 166-177.
  • Tanis, K. Q., Duman, R. S., Sathyanesan, S., (2008), CREB binding and activity in brain: regional specificity and induction by electroconvulsive seizure., Biological Psychiatry, vol. 63, iss. 7, pp. 710-20.
  • Hunsberger, J. G., Sathyanesan, S., Bennett, A. H., Duman, C. H., Russell, D. S., Salton, S. R., Duman, R. S., (2007), Antidepressant actions of the exercise-regulated gene VGF., Nature Medicine, vol. 13, iss. 12, pp. 1476-82.
  • Girgenti, M. J., Sathyanesan, S., (2007), Customizing microarrays for neuroscience drug discovery., Expert Opinion on Drug Discovery, vol. 2, iss. 8, pp. 1139-49.
  • Sathyanesan, S., Duman, R. S., (2007), Neurogenic actions of atypical antipsychotic drugs and therapeutic implications., CNS Drugs, vol. 21, iss. 9, pp. 715-25.
  • Kang, H. J., Adams, D. H., Simen, A., Simen, B. B., Rajkowska, G., Stockmeier, C. A., Overholser, J. C., Meltzer, H. Y., Jurjus, G. J., Konick, L. C., Sathyanesan, S., Duman, R. S., (2007), Gene expression profiling in postmortem prefrontal cortex of major depressive disorder., The Journal of Neuroscience, vol. 27, iss. 48, pp. 13329-40.
  • Duman, R. S., Sathyanesan, S., (2007), Epigenetic marking and neuronal plasticity., Biological Psychiatry, vol. 62, iss. 1, pp. 1-3.
  • Tanis, K. Q., Sathyanesan, S., Duman, R. S., (2007), Targeting neurotrophic/growth factor expression and signaling for antidepressant drug development., CNS & Neurological Disorders - Drug Targets, vol. 6, iss. 2, pp. 151-60.
  • Ploski, J. E., Sathyanesan, S., Duman, R. S., (2006), Electroconvulsive seizure-induced gene expression profile of the hippocampus dentate gyrus granule cell layer., Journal of Neurochemistry, vol. 99, iss. 4, pp. 1122-32.
  • Sathyanesan, S., Duman, R. S., (2006), Chromatin remodeling: a novel mechanism of psychotropic drug action., Molecular Pharmacology, vol. 70, iss. 2, pp. 440-3.
  • Sathyanesan, S., Girgenti, M. J., Collier, E. F., Duman, R. S., (2006), Electroconvulsive seizure increases adult hippocampal angiogenesis in rats., European Journal of Neuroscience, vol. 24, iss. 3, pp. 819-28.
  • Sathyanesan, S., Bennett, A., Duman, R. S., (2005), Production of custom microarrays for neuroscience research., Methods, vol. 37, iss. 3, pp. 238-46.
  • Sathyanesan, S., Duman, R. S., (2004), Regulation of neurogenesis and angiogenesis in depression., Current Neurovascular Research, vol. 1, iss. 3, pp. 261-7.
  • Sathyanesan, S., Collier, E. F., Hunsberger, J., Adams, D., Terwilliger, R., Selvanayagam, E., Duman, R. S., (2003), Gene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factors., The Journal of Neuroscience, vol. 23, iss. 34, pp. 10841-51.
Awards and Honors:
  • NARSAD Young Investigator Award, National Alliance for Research in Schizophrenia and Affective Disorders, 2003
  • Rajkowska, G., Mahajan, G., Sathyanesan, M., Stockmeier, C., Sathyanesan, S. (2014, December). Oligodendrocyte Morphometry and Expression of Myelin – Related mRNA in Ventral Prefrontal White Matter in Major Depressive Disorder. Presented at the ACNP 53rd Annual Meeting , Phoenix, Arizona.
  • Sathyanesan, S. (2014, November). Role of the Neurovascular Unit in Neuropsychiatric Disorders. Presented at the Sigma Xi Lecture Series, USD.
  • Sathyanesan, S. (2014, May). Structural modification of therapeutic trophic factor: applications in psychiatry. Presented at the 5th Annual USD-Sanford Health Biomedical Research Symposium, USD.
  • Sathyanesan, S. (2013, May). Characterization of non-erythropoietic EPO towards neuropsychiatric drug development. Presented at the 4th Annual Sanford Health – USD Biomedical Research Symposium, Sanford Center, Sioux Falls.