Sanford School of Medicine Basic Biomedical Sciences

Scot Ouellette

Scot Ouellette
Assistant Professor
Basic Biomedical Sciences, School of Medicine
UMS Lee Med/Sanford School of Medicine 357
Phone: 605-677-6336
I first started working in a Chlamydia research lab as an undergrad. I found Chlamydia to be a fascinating organism and have since focused my research career on it. For more information about the Ouellette Lab, please visit:
Teaching Interests:
Microbiology, Molecular Biology, Cellular Biology
Research Interests:
Various aspects of chlamydial microbiology with a focus on the consequences to the organism of reductive evolutionary processes. One example of ongoing research is how Chlamydia divides. FtsZ, a bacterial tubulin homologue, is considered an essential cell division protein yet is absent in Chlamydia. We have proposed that Chlamydia uses an alternate system based on the bacterial actin homologue, MreB.
  • Pasteur Foundation Post-doctoral fellow, Microbiology, Institut Pasteur, 2013
  • Post-doctoral fellow, Cellular Microbiology, Imperial College London, 2010
  • Ph D, Molecular Sciences, University of Tennessee Health Science Center, 2006
  • BS, Medical Microbiology and Immunology, University of Wisconsin, 2000
  • BS, Molecular Biology, University of Wisconsin, 2000
  • Moore, L. R., Ouellette, S., (2014), Reconceptualizing the chlamydial inclusion as a pathogen-specified parasitic organelle: an expanded role for Inc proteins, Frontiers in Cellular and Infection Microbiology. (DOI: 10.3389/fcimb.2014.00157)
  • Ouellette, S., Rueden, K. J., Gauliard, E., Persons, L., de Boer, P., Ladant, D., (2014), Analysis of MreB interactors in Chlamydia reveals a RodZ homolog but fails to detect an interaction with MraY, Frontiers in Microbiology. (DOI: 10.3389/fmicb.2014.00279)
  • Ouellette, S., Gauliard, E., Antosova, Z., Ladant, D., (2014), A Gateway Compatible Bacterial Adenylate Cyclase-Based Two Hybrid System, Environmental Microbiology Reports, vol. 6, iss. 3, pp. 259-267. (DOI: 10.1111/1758-2229.12123)
  • Ouellette, S., Karimova, G., Subtil, A., Ladant, D., (2012), Chlamydia Co-Opts the Rod-Shape Determining Proteins MreB and Pbp2 for Cell Division, Molecular Microbiology, vol. 85, pp. 164-178.
  • Ouellette, S., Dorsey, F. C., Moshiach, S., Cleveland, J., Carabeo, R. A., (2011), Chlamydia species-dependent differences in the growth requirement for lysosomes, PLoS ONE, vol. 6, iss. 3, p. e16783.
  • Ouellette, S., Carabeo, R. A., (2010), A Functional Slow Recycling Pathway of Transferrin is Required for Growth of Chlamydia, Frontiers in Microbiology, vol. 1, p. 112.
  • Ouellette, S., Hatch, T. P., AbdelRahman, Y. M., Rose, L. A., Belland, R. J., Byrne, G. I., (2006), Global transcriptional upregulation in the absence of increased translation in Chlamydia during IFNgamma-mediated host cell tryptophan starvation, Molecular Microbiology, vol. 62, iss. 5, pp. 1387-1401.
  • Ouellette, S. (2014, May). Reduce, Recycle, Reuse: Chlamydial Cell Division in the Absence of FtsZ. Presented at the 5th Annual USD-Sanford Health Biomedical Research Symposium, Vermillion, SD.