Jun 18, 2014

USD research on vitamin C coated stents is recognized by American Chemical Society

VERMILLION, S.D. -- University of South Dakota researchers Eagappanath Thiruppathi and Gopinath Mani are working on a technique to lower the risks of blood clots in arteries implanted with stents.

Thiruppathi, a Ph.D. student, and Mani, Ph.D., an assistant professor of biomedical engineering, have developed a way to coat stents with vitamin C to function more efficiently for preventing blood clots in stented arteries. The American Chemical Society (ACS) is touting this research by showcasing the article published recently in the ACS journal Langmuir. The article was the topic of a press release that was included in the ACS Office of Public Affairs’ Weekly PressPac, which contains reports of research selected from more than 40 peer-reviewed ACS journals. This service provides leads on the latest advances in science and their impact on the business word. The ACS press release on this research is available at www.acs.org/content/acs/en/pressroom/presspacs/2014/acs-presspac-may-28-2014/coating-stents-with-vitamin-c-could-reduce-clotting-risks.html.

Previous studies have shown that vitamin C is a possible alternative or addition to drugs currently used to coat stents, which are little mesh tubes inserted into blood vessels to prop them open. Today’s stents are an improvement from their initial launch as they are coated with pharmaceuticals that can prevent the affected arteries from reclogging.

According to ACS, about 10,000 to 50,000 people who receive these drug-eluting stents develop “late stent thrombosis” (LST), a potentially fatal complication that happens when clots form and clog the arteries. Drugs used on the stents are helpful in most cases but they might be responsible for causing problems in others, according to Thiruppathi and Mani who set out to find a way to address LST using vitamin C. They discovered that the method of coating a common stent material with vitamin C could have lasting benefits to the patient as the stent would slowly release vitamin C over time. The USD researchers concluded that this technique could be useful for making stents and other implantable medical devices safer. More information about Thiruppathi’s and Mani’s research is available online at http://pubs.acs.org/stoken/presspac/presspac/abs/10.1021/la501448h.

About The University of South Dakota
Founded in 1862, The University of South Dakota is designated as the only public liberal arts university in the state and is home to a comprehensive College of Arts and Sciences, School of Education, School of Health Sciences, the state's only School of Law, School of Medicine, the accredited Beacom School of Business and the College of Fine Arts. USD has an enrollment of more than 10,000 students taught by more than 400 faculty members. More information is available at www.usd.edu/press/news.

This material is available in an alternate format upon request. Please contact University Relations at 605-677-5759. If you are a person with a disability and need a special accommodation to fully participate in any university activity or event, please contact Disability Services at 605-677-6389 as soon as possible, but no later than 48 hours before the event, so that appropriate arrangements may be made.


Peter Carrels
The University of South Dakota
(605) 216-1233
< Back to news
414 East Clark Street • Vermillion, SD 57069
605-677-5759 • 605-677-6534 fax