• postdoctoral training, Physiology, University of Nebraska Medical Center, 2003
• Ph D, Physiology, Beijing Medical University, 1996
• MS, Physiology, Anhui College of Chinese Medicine, 1988
• MD, Medicine, Chengde Medical College, 1981

• UCHL1 mediates A Pro-arrhythmic Effect by Increasing Kv1.5 Protein Level in Atria in High Fat Diet mice, AHA

• Development of Molecularly Imprinted Polymers for Study of UCHL1 Protein Interaction, Center for Brain and Behavior Research (CBBRe) USD, (2018 - 2019)
• Cardiac sympathetic afferent reflex control of venous function, NIH, (2017 - 2021)
• UCHL1 IS INVOLVED IN SYMPATHETIC REGULATION OF GLUCOSE UPTAKE IN SKELETAL MUSCLE, USD CBBRe, (2016 - 2017)
• PARASYMPATHETIC DYSFUNCTION IN OBESITY: EFFECT OF CHOLESTEROL ON VAChT, NIH, (2013 - 2016)
• IDENTIFICATION OF UBIQUITINATION OF VESICULAR ACETYLCHOLINE TRANSPORTER, USD , (2011 - 2012)
• Vagus nerve stimulation protects against cardiac diastolic dysfunction in aging. ARRA, NIH, (2009 - 2011)
• Vagal stimulation prevents cardiac extracellular matrix remodeling and ventricular dysfunction, AHA, (2008 - 2012)

Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

• Antony, R, Aby, K, Gao, H, Eichholz, M, Srinivasan, R, and Li , Y. UCHL1 Regulates Lipid and Perilipin 2 Level in Skeletal Muscle., 855193. Vol. 13 Frontiers in physiology, 2022. (DOI: 10.3389/fphys.2022.855193)
• Aby, K, Antony, R, Eichholz, M, Srinivasan, R, and Li , Y. Enhanced pro-BDNF-p75NTR pathway activity in denervated skeletal muscle., 120067. Vol. 286 Life sciences, 2021. (DOI: 10.1016/j.lfs.2021.120067)
• Antony, R, and Li , Y. BDNF secretion from C2C12 cells is enhanced by methionine restriction., 1347-1351. Vol. 533, Iss. 4 Biochemical and biophysical research communications, 2020. (DOI: 10.1016/j.bbrc.2020.10.017)
• Gao, H, Antony, R, Srinivasan, R, Wu, P, Wang, Xuejun, and Li, Yi-Fan. UCHL1 regulates oxidative activity in skeletal muscle., e0241716. Vol. 15, Iss. 11 PloS One, 2020. (DOI: 10.1371/journal.pone.0241716)
• Gao, H, Freeling, Jessica, Wu, P, Liang, A A., Wang, Xuejun, and Li, Yi-Fan. UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle., 116699. Life sciences, 2019. (DOI: 10.1016/j.lfs.2019.116699)
• Hartnett, Sigurd, Gao, Hongbo, Schnack, Sabrina, and Li, Yi-Fan. Reduced vagal control of the heart in high-fat diet mice: a potential role of increased butyrylcholinesterase. Vol. 3, Iss. 11 Physiological Reports, 2015.
• Zhang, Fan, Hartnett, Sigurd, Sample, Alex, Schnack, Sabrina, and Li, Yi-Fan. Altered Atrial Activities and Potassium Channel Expression in High Fat Diet Fed Mice. Vol. 20, Iss. 10 Experimental & Clinical Cardiology, 2014.
• Li, Shuai, Wang, Xuejun, Li, Yi-Fan, Kost, Curtis, and Martin, Douglas. Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats., 10. Vol. 30, Iss. 8 PLOS One, 2013. (DOI: 10.1371/journal.pone.0078564 )
• Tian, Zongwen, Zheng, Hanqiao, Li, Jie, Li, Yi-Fan, Su, Huabo, and Wang, Xuejun. Genetically Induced Moderate Inhibition of the Proteasome in Cardiomyocytes Exacerbates Myocardial Ischemia-Reperfusion Injury in Mice, 532-542. Vol. 111, Iss. 5 Circulation Research, 2012. (DOI: 10.1161/CIRCRESAHA.112.270983)
• Sharma, N N., Zheng, H, Li, Yi-Fan, and Patel, K K.. Nitric oxide inhibits the expression of AT1 receptors in neurons, C1162-73. Vol. 302, Iss. 8 Am J Physiol Cell Physiol, 2012. (DOI: 10.1152/ajpcell.00258.2011)
• Zheng, Hong, Liu, Xuefei, Li, Yi-Fan, Sharma, Neeru N., and Patel, Kaushik K.. Gene Transfer of Neuronal Nitric Oxide Synthase to the Paraventricular Nucleus Reduces the Enhanced Glutamatergic Tone in Rats With Chronic Heart Failure, 966-973. Vol. 58 Hypertension, 2011. (DOI: 10.1161/HYPERTENSIONAHA.111.176222)
• Sharma, Neeru N., Zheng, Hong , Mehta, Parmender P., Li, Yi-Fan, and Patel, Kaushik K.. Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure:role for CAPON and Ang II , 348-357. Vol. 92 Cardiovascular Research, 2011. (DOI: 10.1093/cvr/cvr217)
• Li, Yi-Fan, and Wang, Xuejun. The Role of the proteasome in heart disease, 141-149. Vol. 1809, Iss. 2 Biochim Biophys Acta - Gene Regulatory Mechanisms , 2011. (DOI: 10.1016/j.bbagrm.2010.09.001)
• Li, Yi-Fan. Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors., 14-19. Vol. 154 Autonomic Neuroscience: Basic and Clinical , 2010. (DOI: 10.1016/j.autneu.2009.09.023)
• Zheng, H, and Li, Yi-Fan. Enhanced angiotensin-mediated excitation of renal sympathetic nerve activity within the paraventricular nucleus of anesthetized rats with heart failure., 1364-1374. Iss. 297 Am J Physiol Regul Integr Comp Physiol, 2009.
• Li, Yi-Fan. Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses., 20-23. Iss. 462 Neurosci Lett, 2009.
• Li, Yi-Fan, LaCroix, Carly, and Freeling, Jessica. Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses. (DOI: 10.1016/j.neulet.2009.06.081)
• Freeling, Jessica, and Li, Yi-Fan. Age-related attenuation of parasympathetic control of the heart in mice. Vol. 7, Iss. 3 International Journal of Physiology, Pathophysiology, and Pharmacology.

• Wu, Penglong, Li, Yi-Fan, Liu, Jinbao, and Wang, Xuejun, Post-MI Cardiac Remodeling and Malfunction in Mice Are Exacerbated by Cardiomyocyte-restricted Ablation of the Uchl1 Gene. Presented at the 2019 Experimental Biology meeting, Orlando, FL. (April 07, 2019)
• Schnack, Sabrina, Gao, Hongbo, Wang, Hongmin, and Li, Yi-Fan, . Alterations Of Growth And Metabolism Related Proteins In Skeletal Muscles Of Ubiquilin-1 Transgenic Mice. Presented at the Nebraska Physiological Society Annual Conference, Vermillion, SD. (October 2015)
• Gao, Hongbo, Schnack, Sabrina, Allen, Jennifer, and Li, Yi-Fan, Effect of Stimulation of β2 Adrenergic Receptor on Glucose Uptake in Skeletal Muscles. Presented at the Nebraska Physiological Society Annual Conference, Vermillion, SD. (October 2015)
• Allen, Jennifer, Gao, Hongbo, Schnack, Sabrina, and Li, Yi-Fan, The Effect of UCHL1 on Glucose Uptake in Skeletal Muscles. Presented at the Nebraska Physiological Society Annual Conference, Vermillion, SD. (October 2015)
• Li, Yi-Fan, Effect of stress on glucose uptake in skeletal muscles: Role of beta adrenergic Receptors. Presented at the Experimental Biology 2015, Boston, MA. (May 2015)
• Hartnett, Sigurd, and Li, Yi-Fan, Ubiquitin C-Terminal Hydrolase L1 regulates Choline Transporter. Presented at the Third Symposium on Ubiquitin Protein Quality Control and Molecular Pathogenesis, Deadwood, SD. (June 2014)
• Martin, Douglas, Wang, Xuejun, Messenger, Ford , Hannah , Kjellsen, Barton, and Li, Shuai, Angiotensin II activates the proteasome and stimulates vascular smooth muscle cell proliferation. . Presented at the Experimental Biology 2014, San Diego California. (April 2014)
• Martin, Douglas, Li, Yi-Fan, Wang, Xuejun, Kost, Curtis, and Shuai, Li, A proteasome inhibitor attenuates angiotensin II induced hypertension, associated vascular remodeling, and vascular smooth muscle cell proliferation. Presented at the Nebraska Physiological Society, Omaha, Nebraska. (October 2013)
• Zhang, Fan, and Li, Yi-Fan, ALTERED UBIQUITIN E3 LIGASE NEDD4-2, Kv1.5, AND Kv4.3 CHANNELS IN ATRIA . Presented at the NPS Annual Conference, Omaha, NE. (October 2013)
• Hartnett, Sigurd, and Li, Yi-Fan, The Role of UCHL1 in Modulating Choline Transporter Function. Presented at the Cardiovascular Forum-Louisville, Louisville, KY. (August 2013)
• Solanki, Rajeshwari, Sample, Alex, and Li, Yi-Fan, UBIQUITIN AND NOREPINEPHRINE TRANSPORTER: A PRELIMINARY STUDY. Presented at the Nebraska Physiological Society Conference, Wayne State College, Wayne, NE. (October 2012)
• Li, Yi-Fan, Ubiquitination of Vesicular Acetylcholine Transporter. Presented at the Experimental Biology 2012, San Diego, CA. (April 2012)
• Freeling, Jessica, and Li, Yi-Fan, Attenuated Parasympathetic Nervous System Control of the Heart in the Aging Mouse. Presented at the NPS-IPS joint annual conference, Des Moines, IA. (October 2011)
• Li, Yi-Fan, Ubiquitin C-terminal Hydrolase L1 and Parasympathetic Cholinergic Function. Presented at the USD PQCD symposium, Vermillion. (May 2011)
• Li, Yi-Fan, Grandi, Max, and Freeling, Jesseca, Effect of Stimulation of α1 Adrenergic Receptors on Heart Rate . Presented at the Experimental Biology, Washington DC. (April 2011)
• Freeling, Jessica, LaCroix, Carly, Grandi, Max, and Li, Yi-Fan, Varenicline Induces Acetylcholine-dependent Bradycardic. Presented at the NPS annual conference, Omaha, NE. (September 2010)
• Grandi, Max, LaCroix, Carly, Freeling, Jessica, and Li, Yi-Fan, Mouse Atrial Preparation and Response to Varenicline. Presented at the SD BRIN/Discover Poster Session, Vermillion. (July 2010)
• Schiernbeck, Cristal, Hutchinson, Katie, Freeling, Jessica, and Li, Yi-Fan, Cholinergic Elements in Two Neuronal Cell Lines. Presented at the SD BRIN/U Discover Poster Session, Vermillion. (July 2010)
• LaCroix, Carly, Freeling, Jesseca, and Li, Yi-Fan, Bradycardic response induced by stimulation of alpha4beta2 nicotinic receptors. Presented at the Experimental Biology, Anaheim, CA. (April 2010)