Phone: (605) 357-1508
The Roux lab investigates the structure and function of the mammalian nuclear envelope in health and disease. We have identified and are functionally characterizing several novel members of the LINC-complex. These proteins are retained on the outer nuclear membrane where they appear to perform specific roles in specialized cell types. We are also investigating the mechanisms by which defects in a single constituent of the nuclear lamina, the intermediate filament scaffold inside the nucleus, lead to a wide variety of diseases called laminopathies. These studies are supported by the BioID method to screen for interacting and proximate proteins.