Sabina Kupershmidt

Sabina Kupershmidt

Assistant Professor

NURSING

SF SEC 118

Phone: (605) 357-1518

Email: Sabina.Kupershmidt@usd.edu

Curriculum Vitae

Bio:

Dr. Kupershmidt has been an Assistant Professor of Nursing at USD in Sioux Falls since 2015. Her research interests are focused on alternative, complementary and integrative health care and student education. Her qualifications include 14 years as a faculty member and principal investigator of a biomedical research lab with numerous peer-reviewed scientific articles and support by extramural funding. She also has administrative and managerial experience in the private sector. As the Interprofessional Education (IPE) & Research Coordinator for Nursing, she directs efforts to integrate IPE curricular requirements and various ongoing IPE projects with the School of Health Sciences and she supports other nursing faculty in research design and methodology to meet the strategic goals of the department. Her office is located on the University of South Dakota Sioux Falls campus.


Teaching Interests:

Active learning and integration of research experiences into teaching, pathopysiology, pharmacology, molecular biology, receptor biology, biochemistry,


Research Interests:

Interprofessional research and education; alternative, complementary and integrative healthcare methods and education;


Education:

  • Ph D, Microbiology and Immunology, Vanderbilt University, 1990
  • BS, Biology, Middle Tennessee State University, 1984

Licensures and Certifications:

  • Certificate of Attendance, South Dakota IPEC
  • First Steps ACP Certified Facilitator, Respecting Choices, Advance Care Planning
  • National Center Ambassador, National Center for Interprofessional Education and Practice
  • Integral Yoga Teacher, Integral Yoga Academy

Research:

  • Using Controlled Breathing to Improve Lung Function as a Possible Preventive Measure for Health Care Associated Pneumonia, Health Affairs Medical Informatics Committee (HAMIC)
  • Defining a Complementary Health Protocol to Prevent Health Care-Associated Pneumonia, internal

Grants:

  • Lighting a SPARK (Serving Underserved Populations through Advance Care Planning, Respect and Knowledge) in South Dakota, Bush Foundation. (2017 - 2019)
  • Enrichment of research education and clinical practice for undergraduate nursing students through meaningful research, Nursing Faculty Small Grant Program. (2017 - 2018)
  • Advance Care Planning in South Dakota: Engaging Interprofessional Teams to Implement Quality Conversations, USD. Grant Role: Principal. (2016 - 2017)

Publications:

Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

  • Tanwar, V, Bylund, J B., Hu, J, Yan, J, Walthall, J M., Mukherjee, A, Heaton, W H., Wang, W D., Potet, F, Rai, M, Kupershmidt, Sabina, Knapik, E W., and Hatzopoulos, A K.. Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway., 1774-88. Vol. 32, Iss. 7. Stem cells (Dayton, Ohio), 2014. (DOI: 10.1002/stem.1703)
  • Liu, L, Hayashi, K, Kaneda, T, Ino, H, Fujino, N, Uchiyama, K, Konno, T, Tsuda, T, Kawashiri, M A., Ueda, K, Higashikata, T, Shuai, W, Kupershmidt, Sabina, Higashida, H, and Yamagishi, M. A novel mutation in the transmembrane nonpore region of the KCNH2 gene causes severe clinical manifestations of long QT syndrome., 61-7. Vol. 10, Iss. 1. Heart rhythm : the official journal of the Heart Rhythm Society, 2013. (DOI: 10.1016/j.hrthm.2012.09.053)
  • Potet, F, Lorinc, A N., Chaigne, S, Hopkins, C R., Venkataraman, R, Stepanovic, S Z., Lewis, L M., Days, E, Sidorov, V Y., Engers, D W., Zou, B, Afshartous, D, George, Jr, A L., Campbell, C M., Balser, J R., Li, M, Baudenbacher, F J., Lindsley, C W., Weaver, C D., and Kupershmidt, Sabina. Identification and characterization of a compound that protects cardiac tissue from human Ether-à-go-go-related gene (hERG)-related drug-induced arrhythmias., 39613-25. Vol. 287, Iss. 47. The Journal of biological chemistry, 2012. (DOI: 10.1074/jbc.M112.380162)
  • Watanabe, H, Yang, T, Stroud, D M., Lowe, J S., Harris, L, Atack, T C., Wang, D W., Hipkens, S B., Leake, B, Hall, L, Kupershmidt, Sabina, Chopra, N, Magnuson, M A., Tanabe, N, Knollmann, B C., George, Jr, A L., and Roden, D M.. Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro., 1001-11. Vol. 124, Iss. 9. Circulation, 2011. (DOI: 10.1161/CIRCULATIONAHA.110.987248)
  • Hayashi, K, Fujino, N, Ino, H, Uchiyama, K, Sakata, K, Konno, T, Masuta, E, Funada, A, Sakamoto, Y, Tsubokawa, T, Hodatsu, A, Yasuda, T, Kanaya, H, Kim, M Y., Kupershmidt, Sabina, Higashida, H, and Yamagishi, M. A KCR1 variant implicated in susceptibility to the long QT syndrome., 50-7. Vol. 50, Iss. 1. Journal of molecular and cellular cardiology, 2011. (DOI: 10.1016/j.yjmcc.2010.10.007)
  • Hayashi, K, Shuai, W, Sakamoto, Y, Higashida, H, Yamagishi, M, and Kupershmidt, Sabina. Trafficking-competent KCNQ1 variably influences the function of HERG long QT alleles., 973-80. Vol. 7, Iss. 7. Heart rhythm : the official journal of the Heart Rhythm Society, 2010. (DOI: 10.1016/j.hrthm.2010.03.038)
  • Nakajima, T, Davies, S S., Matafonova, E, Potet, F, Amarnath, V, Tallman, K A., Serwa, R A., Porter, N A., Balser, J R., Kupershmidt, Sabina, and Roberts, 3rd, L J.. Selective gamma-ketoaldehyde scavengers protect Nav1.5 from oxidant-induced inactivation., 352-9. Vol. 48, Iss. 2. Journal of molecular and cellular cardiology, 2010. (DOI: 10.1016/j.yjmcc.2009.11.016)
  • Stepanovic, S Z., Potet, F, Petersen, C I., Smith, J A., Meiler, J, Balser, J R., and Kupershmidt, Sabina. The evolutionarily conserved residue A653 plays a key role in HERG channel closing., 2555-66. Vol. 587, Iss. Pt 11. The Journal of physiology, 2009. (DOI: 10.1113/jphysiol.2008.166694)
  • Potet, F, Chagot, B, Anghelescu, M, Viswanathan, P C., Stepanovic, S Z., Kupershmidt, Sabina, Chazin, W J., and Balser, J R.. Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of Calmodulin., 8846-54. Vol. 284, Iss. 13. The Journal of biological chemistry, 2009. (DOI: 10.1074/jbc.M806871200)
  • Potet, F, Petersen, C I., Boutaud, O, Shuai, W, Stepanovic, S Z., Balser, J R., and Kupershmidt, Sabina. Genetic screening in C. elegans identifies rho-GTPase activating protein 6 as novel HERG regulator., 257-67. Vol. 46, Iss. 2. Journal of molecular and cellular cardiology, 2009. (DOI: 10.1016/j.yjmcc.2008.10.015)
  • Nakajima, T, Hayashi, K, Viswanathan, P C., Kim, M Y., Anghelescu, M, Barksdale, K A., Shuai, W, Balser, J R., and Kupershmidt, Sabina. HERG is protected from pharmacological block by alpha-1,2-glucosyltransferase function., 5506-13. Vol. 282, Iss. 8. The Journal of biological chemistry, 2007. (DOI: 10.1074/jbc.M605976200)
  • Fukuda, K, Davies, S S., Nakajima, T, Ong, B H., Kupershmidt, Sabina, Fessel, J, Amarnath, V, Anderson, M E., Boyden, P A., Viswanathan, P C., Roberts, 2nd, L J., and Balser, J R.. Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels., 1262-9. Vol. 97, Iss. 12. Circulation research, 2005. (DOI: 10.1161/01.RES.0000195844.31466.e9)
  • Zhai, P, Yamamoto, M, Galeotti, J, Liu, J, Masurekar, M, Thaisz, J, Irie, K, Holle, E, Yu, X, Kupershmidt, Sabina, Roden, D M., Wagner, T, Yatani, A, Vatner, D E., Vatner, S F., and Sadoshima, J. Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice., 3045-56. Vol. 115, Iss. 11. The Journal of clinical investigation, 2005. (DOI: 10.1172/JCI25330)
  • Zhang, M, Houamed, K, Kupershmidt, Sabina, Roden, D, and Satin, L S.. Pharmacological properties and functional role of Kslow current in mouse pancreatic beta-cells: SK channels contribute to Kslow tail current and modulate insulin secretion., 353-63. Vol. 126, Iss. 4. The Journal of general physiology, 2005. (DOI: 10.1085/jgp.200509312)
  • Temple, J, Frias, P, Rottman, J, Yang, T, Wu, Y, Verheijck, E E., Zhang, W, Siprachanh, C, Kanki, H, Atkinson, J B., King, P, Anderson, M E., Kupershmidt, Sabina, and Roden, D M.. Atrial fibrillation in KCNE1-null mice., 62-9. Vol. 97, Iss. 1. Circulation research, 2005. (DOI: 10.1161/01.RES.0000173047.42236.88)
  • Khoo, M S., Kannankeril, P J., Li, J, Zhang, R, Kupershmidt, Sabina, Zhang, W, Atkinson, J B., Colbran, R J., Roden, D M., and Anderson, M E.. Calmodulin kinase II activity is required for normal atrioventricular nodal conduction., 634-40. Vol. 2, Iss. 6. Heart rhythm : the official journal of the Heart Rhythm Society, 2005. (DOI: 10.1016/j.hrthm.2005.03.019)
  • Kanki, H, Kupershmidt, Sabina, Yang, T, Wells, S, and Roden, D M.. A structural requirement for processing the cardiac K+ channel KCNQ1., 33976-83. Vol. 279, Iss. 32. The Journal of biological chemistry, 2004. (DOI: 10.1074/jbc.M404539200)
  • Moskowitz, I P., Pizard, A, Patel, V V., Bruneau, B G., Kim, J B., Kupershmidt, Sabina, Roden, D, Berul, C I., Seidman, C E., and Seidman, J G.. The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system., 4107-16. Vol. 131, Iss. 16. Development (Cambridge, England), 2004. (DOI: 10.1242/dev.01265)
  • Jay, P Y., Harris, B S., Maguire, C T., Buerger, A, Wakimoto, H, Tanaka, M, Kupershmidt, Sabina, Roden, D M., Schultheiss, T M., O'Brien, T X., Gourdie, R G., Berul, C I., and Izumo, S. Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system., 1130-7. Vol. 113, Iss. 8. The Journal of clinical investigation, 2004. (DOI: 10.1172/JCI19846)
  • Yang, P, Kupershmidt, Sabina, and Roden, D M.. Cloning and initial characterization of the human cardiac sodium channel (SCN5A) promoter., 56-65. Vol. 61, Iss. 1. Cardiovascular research, 2004.
  • Kupershmidt, Sabina, Yang, I C., Hayashi, K, Wei, J, Chanthaphaychith, S, Petersen, C I., Johns, D C., George, Jr, A L., Roden, D M., and Balser, J R.. The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines., 2263-5. Vol. 17, Iss. 15. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003. (DOI: 10.1096/fj.02-1057fje)
  • Arad, M, Moskowitz, I P., Patel, V V., Ahmad, F, Perez-Atayde, A R., Sawyer, D B., Walter, M, Li, G H., Burgon, P G., Maguire, C T., Stapleton, D, Schmitt, J P., Guo, X X., Pizard, A, Kupershmidt, Sabina, Roden, D M., Berul, C I., Seidman, C E., and Seidman, J G.. Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy., 2850-6. Vol. 107, Iss. 22. Circulation, 2003. (DOI: 10.1161/01.CIR.0000075270.13497.2B)
  • Kondo, R P., Anderson, R H., Kupershmidt, Sabina, Roden, D M., and Evans, S M.. Development of the cardiac conduction system as delineated by minK-lacZ., 383-91. Vol. 14, Iss. 4. Journal of cardiovascular electrophysiology, 2003.
  • Kupershmidt, Sabina, Yang, I C., Sutherland, M, Wells, K S., Yang, T, Yang, P, Balser, J R., and Roden, D M.. Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system., 93-103. Vol. 56, Iss. 1. Cardiovascular research, 2002.
  • Kupershmidt, Sabina, Yang, T, Chanthaphaychith, S, Wang, Z, Towbin, J A., and Roden, D M.. Defective human Ether-à-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus., 27442-8. Vol. 277, Iss. 30. The Journal of biological chemistry, 2002. (DOI: 10.1074/jbc.M112375200)
  • Tan, H L., Kupershmidt, Sabina, Zhang, R, Stepanovic, S, Roden, D M., Wilde, A A., Anderson, M E., and Balser, J R.. A calcium sensor in the sodium channel modulates cardiac excitability., 442-7. Vol. 415, Iss. 6870. Nature, 2002. (DOI: 10.1038/415442a)
  • Franco, D, Demolombe, S, Kupershmidt, Sabina, Dumaine, R, Dominguez, J N., Roden, D, Antzelevitch, C, Escande, D, and Moorman, A F.. Divergent expression of delayed rectifier K(+) channel subunits during mouse heart development., 65-75. Vol. 52, Iss. 1. Cardiovascular research, 2001.
  • Nicolas, M, Demêmes, D, Martin, A, Kupershmidt, Sabina, and Barhanin, J. KCNQ1/KCNE1 potassium channels in mammalian vestibular dark cells., 132-45. Vol. 153, Iss. 1-2. Hearing research, 2001.
  • Roden, D M., and Kupershmidt, Sabina. From genes to channels: normal mechanisms., 318-26. Vol. 42, Iss. 2. Cardiovascular research, 1999.
  • Kupershmidt, Sabina, Yang, T, Anderson, M E., Wessels, A, Niswender, K D., Magnuson, M A., and Roden, D M.. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system., 146-52. Vol. 84, Iss. 2. Circulation research, 1999.
  • Kupershmidt, Sabina, Snyders, D J., Raes, A, and Roden, D M.. A K+ channel splice variant common in human heart lacks a C-terminal domain required for expression of rapidly activating delayed rectifier current., 27231-5. Vol. 273, Iss. 42. The Journal of biological chemistry, 1998.
  • Kupershmidt, Sabina, Yang, T, and Roden, D M.. Modulation of cardiac Na+ current phenotype by beta1-subunit expression., 441-7. Vol. 83, Iss. 4. Circulation research, 1998.
  • Yang, T, Kupershmidt, Sabina, and Roden, D M.. Anti-minK antisense decreases the amplitude of the rapidly activating cardiac delayed rectifier K+ current., 1246-53. Vol. 77, Iss. 6. Circulation research, 1995.
  • Kupershmidt, Sabina, Rall, G F., Lu, Z Q., and Ben-Porat, T. Cleavage of concatemeric DNA at the internal junction of "translocation" mutants of pseudorabies virus and inversion of their L component appear to be linked., 223-32. Vol. 187, Iss. 1. Virology, 1992.
  • Rall, G F., Kupershmidt, Sabina, Sugg, N, Veach, R A., and Ben-Porat, T. Functions of the sequences at the ends of the inverted repeats of pseudorabies virus., 1506-19. Vol. 66, Iss. 3. Journal of virology, 1992.
  • Rall, G F., Kupershmidt, Sabina, Lu, X Q., Mettenleiter, T C., and Ben-Porat, T. Low-level inversion of the L component of pseudorabies virus is not dependent on sequence homology., 7016-9. Vol. 65, Iss. 12. Journal of virology, 1991.
  • Kupershmidt, Sabina, DeMarchi, J M., Lu, Z Q., and Ben-Porat, T. Analysis of an origin of DNA replication located at the L terminus of the genome of pseudorabies virus., 6283-91. Vol. 65, Iss. 11. Journal of virology, 1991.
  • DeMarchi, J M., Lu, Z Q., Rall, G, Kupershmidt, Sabina, and Ben-Porat, T. Structural organization of the termini of the L and S components of the genome of pseudorabies virus., 4968-77. Vol. 64, Iss. 10. Journal of virology, 1990.

Awards and Honors:

  • 2016 Nexus Award, National Center for Interprofessional Practice and Education, 2016
  • Community Innovation Grant, South Dakota Community Foundation, 2016

Presentations:

  • Kupershmidt, Sabina. Assessing the Effects of Interprofessional Teams on Advance Care Planning. Presented at the 2017 Sanford Nursing Research and EBP Conference, Sioux Falls. (June 29, 2017)
  • Kupershmidt, Sabina, Abou Samra, Haifa, Sudhagoni, Ramu, Fuller, M, Pickthorn, S. Evaluating the Efficacy of Manual vs LUCAS-2 cardiopulmonary resuscitation during Out-of-Hospital Cardiac Arrest in South Dakota.. Presented at the the Midwest Nursing Research Society (MNRS), Minneapolis. (April 6, 2017)
  • Kupershmidt, Sabina, Fischbach, Cheryl, Hegge, Helene, Bloom, Katie, Samra, Haifa A.. Advance Care Planning in South Dakota: An Interprofessional Team Effort. Presented at the Midwest Nursing Research Society, Minneapolis. (April 2017)
  • Kupershmidt, Sabina, Samra, Haifa A., Sudhagoni, Ramu G., Fuller, Max D., Pickthorn, Sean T.. Evaluating the Efficacy of Manual vs LUCAS-2 cardiopulmonary resuscitation during Out-of-Hospital Cardiac Arrest in South Dakota. Presented at the Midwest Nursing Research Society, Minneapolis. (April 2017)
  • Kupershmidt, Sabina, Abou Samra, Haifa, Sudhagoni, Ramu. sing Emergency Medical Services Data to Better Understand Out-of-Hospital Cardiac Arrest in Rural Settings and to Drive Quality Improvement Efforts.. Presented at the The American Heart Association - Scientific Sessions, New Orleans, LA.. (November 12, 2016)
  • Kupershmidt, Sabina. Advance Care Planning in South Dakota: Engaging Interprofessional Teams to Implement Quality Conversations. Presented at the MIPERC conference, Grand Rapids, MI. (September 22, 2016)
  • Dieter, Carla, Fischbach, Cheryl, Hegge, Helene, Kupershmidt, Sabina, Abou Samra, Haifa, Bloom, Katherine. Advance Care Planning in South Dakota: Engaging Interprofessional Teams to Implement Quality Conversations. Presented at the 2016 International Rural Nursing Conference, Rapid City, SD. (July 19, 2016)