Zhongkui Hong

Zhongkui Hong

Assistant Professor


BME 221

Phone: (605) 275-7468

Email: Zhongkui.Hong@usd.edu

Website: http://www.usd.edu/faculty-and-staff/Zhongkui-Hong


Dr Zhongkui Hong is Assistant Professor in the Biomedical Engineering Department at University of South Dakota. He holds a PhD in Polymer chemistry and physics, a MS in Material science, and a Bachelor in Chemical engineering. He has published more than 30 peer-reviewed journal articles and presented over 30 podium and poster presentations at international conferences. His works have received over 2000 citations. His research is currently supported by the American Heart Association (AHA) and South Dakota State Board of Regents.

Teaching Interests:

(1) Molecular, cellular and tissue biomechanics; (2) Biomedical image and signal processing; (3) Force spectroscopy in biomedical research

Research Interests:

A Postdoctoral position is available immediately. My research interests include broad areas of Molecular/Cellular Biomechanics and Tissue engineering. (1) Single molecular Biomechanics; (2) Biomechanics in vascular disease; (3) Biomechanical response of vascular cells, macrophage, and stem cells to the nano-patterned and nano-structural materials; (4) Biomechanics in tissue engineering and regenerative medicine; (5) Vascular tissue engineering. A wide range of techniques are being used in these projects including Cellular biomechanics testing with Atomic force microscopy (AFM), Live cell imaging with Confocal microscopy and AFM, Primary Vascular smooth muscle cell isolation and culture, Cell spreading and migration on 2d gel and 3d gel substrate, Biomedical image and signal processing with Matlab, Vessel ring tissue reconstitution, Physiological and mechanical functions testing on the blood vessel and reconstituted ring tissue with DMT Myograph, High efficiency cell transfection with Electroporation, etc.


  • Ph D, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 2005


  • Summer Undergraduate Research (Miranda Holtquist), BioSNTR, (2016 - 2016)


  • Biomechanics of vascular smooth muscle cell in atherosclerosis, South Dakota Board of Regents. Grant Role: Principal. (2016 - 2017)
  • Novel effects of cholesterol on the biophysical and functional properties of vascular smooth muscle, American Heart Association. Grant Role: Principal. (2015 - 2018)


Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

  • Hong, Kwangseok, Zhao, Guiling, Hong, Zhongkui, Sun, Zhe, Yang, Yan, Clifford, Philip S., Davis, Michael J., Meininger, Gerald A., Hill, Mike A., and . MECHANICAL ACTIVATION OF ANGIOTENSIN II TYPE 1 RECEPTORS CAUSES ACTIN REMODELLING AND MYOGENIC RESPONSIVENESS IN SKELETAL MUSCLE ARTERIOLES. The Journal of Physiology, 2016. (DOI: 10.1113/JP272834)
  • Hong, Zhongkui, Reeves, Kimberley ., Sun, Zhe, Li, Zhaohui, Brown, Nicola ., and Meininger, Gerald A.. Vascular Smooth Muscle Cell Stiffness and Adhesion to Collagen I Modified by Vasoactive Agonists. Vol. 10, Iss. 3. Plos One, 2015. (DOI: 10.1371/journal.pone.0119533)
  • Sehgel, Nancy L., Sun, Zhe, Hong, Zhongkui, Hunter, William C., Hill, Mike A., Vatner, Dorothy E., Vatner, Stephen F., and Meininger, Gerald A.. Augmented vascular smooth muscle cell stiffness and extracellular matrix adhesion when hypertension is superimposed on aging, 370-7. Vol. 65, Iss. 2. Hypertension, 2014. (DOI: 10.1161/HYPERTENSIONAHA.114.04456)
  • Staiculescu, Marius C., Ramirez-Perez, Francisco I., Castorena-Gonzalez, Jorge A., Hong, Zhongkui, Sun, Zhe, Meininger, Gerald A., and Martinez-Lemus, Luis A.. Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction. Frontiers in Physiology, 2014. (DOI: 10.3389/fphys.2014.00413)
  • Hong, Zhongkui, Sun, Z, Li, M, Li, Z, Bunyak, F, Ersoy, I, Trzeciakowski, J P., Staiculescu, M C., Jin, M, Martinez-Lemus, L, Hill, Michael, Palaniappan, K, and Meininger, G A.. Vasoactive agonists exert dynamic and coordinated effects on vascular smooth muscle cell elasticity, cytoskeletal remodelling and adhesion., 1249-66. Vol. 592, Iss. Pt 6. The Journal of physiology, 2014. (DOI: 10.1113/jphysiol.2013.264929)
  • Sehgel, N L., Zhu, Y, Sun, Z, Trzeciakowski, J P., Hong, Zhongkui, Hunter, W C., Vatner, D E., Meininger, G A., and Vatner, S F.. Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension., H1281-7. Vol. 305, Iss. 9. American journal of physiology. Heart and circulatory physiology, 2013. (DOI: 10.1152/ajpheart.00232.2013)
  • Hong, Zhongkui, Ersoy, I, Sun, M, Bunyak, F, Hampel, P, Hong, Zhongkui, Sun, Z, Li, Z, Levitan, I, Meininger, G A., and Palaniappan, K. Influence of membrane cholesterol and substrate elasticity on endothelial cell spreading behavior., 1994-2004. Vol. 101, Iss. 7. Journal of biomedical materials research. Part A, 2013. (DOI: 10.1002/jbm.a.34504)
  • Hong, Zhongkui, Sun, Z, Li, Z, Mesquitta, W T., Trzeciakowski, J P., and Meininger, G A.. Coordination of fibronectin adhesion with contraction and relaxation in microvascular smooth muscle., 73-80. Vol. 96, Iss. 1. Cardiovascular research, 2012. (DOI: 10.1093/cvr/cvs239)
  • Zhu, Y, Qiu, H, Trzeciakowski, J P., Sun, Z, Li, Z, Hong, Zhongkui, Hill, Michael, Hunter, W C., Vatner, D E., Vatner, S F., and Meininger, G A.. Temporal analysis of vascular smooth muscle cell elasticity and adhesion reveals oscillation waveforms that differ with aging., 741-50. Vol. 11, Iss. 5. Aging cell, 2012. (DOI: 10.1111/j.1474-9726.2012.00840.x)
  • Zhang, P, Wu, H, Wu, H, Lù, Z, Deng, C, Hong, Zhongkui, Jing, X, and Chen, X. RGD-conjugated copolymer incorporated into composite of poly(lactide-co-glycotide) and poly(L-lactide)-grafted nanohydroxyapatite for bone tissue engineering., 2667-80. Vol. 12, Iss. 7. Biomacromolecules, 2011. (DOI: 10.1021/bm2004725)
  • Hong, Zhongkui, Luz, Gisela M., Hampel, Paul J., Jin, Minshan, Liu, Aixue, Chen, Xuesi, and Mano, João F.. Mono-dispersed bioactive glass nanospheres: Preparation and effects on biomechanics of mammalian cells, 747-754. Vol. 95A, Iss. 3. Journal of Biomedical Materials Research Part A, 2010. (DOI: 10.1002/jbm.a.32898)
  • Boccaccini, Aldo R., Erol, Melek, Stark, Wendelin J., Mohn, Dirk, Hong, Zhongkui, and Mano, João F.. Polymer/bioactive glass nanocomposites for biomedical applications: A review, 1764 - 1776. Vol. 70, Iss. 13. Composites Science and Technology , 2010. (DOI: http://dx.doi.org/10.1016/j.compscitech.2010.06.002)
  • Hong, Zhongkui. Recent developments in bioactive ceramic/glass: preparation and application in tissue engineering and drug delivery, 239-257. Vol. 3, Iss. 3. Recent Patents on Materials Science, 2010.
  • Couto, Daniela S., Hong, Zhongkui, and Mano, João F.. Development of bioactive and biodegradable chitosan-based injectable systems containing bioactive glass nanoparticles, 115 - 123. Vol. 5, Iss. 1. Acta Biomaterialia , 2009. (DOI: http://dx.doi.org/10.1016/j.actbio.2008.08.006)
  • Hong, Zhongkui, Merino, Esther G., Reis, Rui L., and Mano, João F.. Novel Rice-shaped Bioactive Ceramic Nanoparticles, B25-B29. Vol. 11, Iss. 5. Advanced Engineering Materials, 2009. (DOI: 10.1002/adem.200800378)
  • Hong, Zhongkui, Reis, Rui L., and Mano, João F.. Preparation and in vitro characterization of novel bioactive glass ceramic nanoparticles, 304-313. Vol. 88A, Iss. 2. Journal of Biomedical Materials Research Part A, 2009. (DOI: 10.1002/jbm.a.31848)
  • Hong, Zhongkui, Liu, Aixue, Li Chen, Chen, Xuesi, and Jing, Xiabin. Preparation of bioactive glass ceramic nanoparticles by combination of sol-gel and coprecipitation method, 368 - 372. Vol. 355, Iss. 6. Journal of Non-Crystalline Solids , 2009. (DOI: http://dx.doi.org/10.1016/j.jnoncrysol.2008.12.003)
  • Zhang, P, Hong, Zhongkui, Yu, T, Chen, X, and Jing, X. In vivo mineralization and osteogenesis of nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(L-lactide)., 58-70. Vol. 30, Iss. 1. Biomaterials, 2009. (DOI: 10.1016/j.biomaterials.2008.08.041)
  • Liu, A, Hong, Zhongkui, Zhuang, X, Chen, X, Cui, Y, Liu, Y, and Jing, X. Surface modification of bioactive glass nanoparticles and the mechanical and biological properties of poly(L-lactide) composites., 1005-15. Vol. 4, Iss. 4. Acta biomaterialia, 2008. (DOI: 10.1016/j.actbio.2008.02.013)
  • Hong, Zhongkui, Reis, Rui L., and Mano, João F.. Preparation and in vitro characterization of scaffolds of poly(l-lactic acid) containing bioactive glass ceramic nanoparticles, 1297 - 1306. Vol. 4, Iss. 5. Acta Biomaterialia , 2008. (DOI: http://dx.doi.org/10.1016/j.actbio.2008.03.007)
  • Hong, Zhongkui, Zhang, P, Liu, A, Chen, L, Chen, X, and Jing, X. Composites of poly(lactide-co-glycolide) and the surface modified carbonated hydroxyapatite nanoparticles., 515-22. Vol. 81, Iss. 3. Journal of biomedical materials research. Part A, 2007. (DOI: 10.1002/jbm.a.31038)
  • Xu, Xiuling, Chen, Xuesi, Liu, Aixue, Hong, Zhongkui, and Jing, Xiabin. Electrospun poly(l-lactide)-grafted hydroxyapatite/poly(l-lactide) nanocomposite fibers, 3187 - 3196. Vol. 43, Iss. 8. European Polymer Journal , 2007. (DOI: http://dx.doi.org/10.1016/j.eurpolymj.2007.05.024)
  • Li Chen, Qiu, Xueyu, Xie, Zhigang, Hong, Zhongkui, Sun, Jingru, Chen, Xuesi, and Jing, Xiabin. Poly(l-lactide)/starch blends compatibilized with poly(l-lactide)-g-starch copolymer, 75 - 80. Vol. 65, Iss. 1. Carbohydrate Polymers , 2006. (DOI: http://dx.doi.org/10.1016/j.carbpol.2005.12.029)
  • He, C, Sun, J, Zhao, T, Hong, Zhongkui, Zhuang, X, Chen, X, and Jing, X. Formation of a unique crystal morphology for the poly(ethylene glycol)-poly(epsilon-caprolactone) diblock copolymer., 252-8. Vol. 7, Iss. 1. Biomacromolecules, 2006. (DOI: 10.1021/bm050627f)
  • Hong, Zhongkui, Zhang, P, He, C, Qiu, X, Liu, A, Chen, L, Chen, X, and Jing, X. Nano-composite of poly(L-lactide) and surface grafted hydroxyapatite: mechanical properties and biocompatibility., 6296-304. Vol. 26, Iss. 32. Biomaterials, 2005. (DOI: 10.1016/j.biomaterials.2005.04.018)
  • Qiu, X, Hong, Zhongkui, Hu, J, Chen, L, Chen, X, and Jing, X. Hydroxyapatite surface modified by L-lactic acid and its subsequent grafting polymerization of L-lactide., 1193-9. Vol. 6, Iss. 3. Biomacromolecules, 2005. (DOI: 10.1021/bm049502l)
  • Qiu, Xueyu, Chen, Li, Hu, Junli, Sun, Jingru, Hong, Zhongkui, Liu, Aixue, Chen, Xuesi, and Jing, Xiabin. Surface-modified hydroxyapatite linked by L-lactic acid oligomer in the absence of catalyst, 5177-5185. Vol. 43, Iss. 21. Journal of Polymer Science Part A: Polymer Chemistry, 2005.
  • Li Chen, Qiu, Xueyu, Deng, Mingxiao, Hong, Zhongkui, Luo, Rui, Chen, Xuesi, and Jing, Xiabin. The starch grafted poly(l-lactide) and the physical properties of its blending composites, 5723 - 5729. Vol. 46, Iss. 15. Polymer , 2005. (DOI: http://dx.doi.org/10.1016/j.polymer.2005.05.053)
  • Hong, Zhongkui, Qiu, Xueyu, Sun, Jingru, Deng, Mingxiao, Chen, Xuesi, and Jing, Xiabin. Grafting polymerization of l-lactide on the surface of hydroxyapatite nano-crystals, 6699 - 6706. Vol. 45, Iss. 19. Polymer , 2004. (DOI: http://dx.doi.org/10.1016/j.polymer.2004.07.036)
  • Sun, Jingru, Hong, Zhongkui, Yang, Lixin, Tang, Zhaohui, Chen, Xuesi, and Jing, Xiabin. Study on crystalline morphology of poly(l-lactide)-poly(ethylene glycol) diblock copolymer, 5969 - 5977. Vol. 45, Iss. 17. Polymer , 2004. (DOI: http://dx.doi.org/10.1016/j.polymer.2004.06.026)

Awards and Honors:

  • Scientist Development Grant, American Heart Association, 2015
  • Scholarship award for Vasculata Workshops, North American Vascular Biology Organization, 2013