The Physiology Core Facility provides basic and biological researchers with a central resource for creating models of animal physiology and pathophysiology. While our main focus is exploring the effects of cardiovascular disease and cancer in rodents, we can provide support to any aspect of animal research. We offer both invasive and non-invasive techniques for collecting in vivo physiological data. We provide:
Our staff has extensive surgical experience with a variety of animal models, strains, species and techniques. We can evaluate your needs and provide technical assistance with experimental design and technical training.
How It Works
Researchers may request our trained facility staff to perform techniques or may use the available equipment themselves once trained. Once approved, researchers can use the Booked electronic scheduling platform to remotely reserve stations or equipment.
USD and USD-affiliated researchers may use for the facility for free. External charge rates may apply for outside entities. Contact Core Manager Jessica Freeling at firstname.lastname@example.org for a quote or details about available services.
The Physiology Core Facility works with researchers to use available equipment in new ways to accomplish research goals.
Provides researchers with the necessary equipment to perform survival or non-survival rodent procedures.
Fully-equipped surgical space, including: Anesthesia system, pressure-controlled ventilator, warming pad, surgical microscope and intubation stand
Rodent Hemodynamics System- Powerlab System (ADInstruments) with LabChart 8 software and MPVS Ultra Pressure Volume Loop (PV Loop) System
Non-Invasive Blood Pressure (NIBP) System - IITC
Enables the collection of high-resolution microultrasound images for cardiovascular and cancer research in the rodent model.
Vevo 2100 Ultrasound Imaging System with VevoLAB software, including: Standard echocardiogram functions (B-mode and M-mode echocardiography); Speckle Tracking Echocardiography (STE) (strain analysis); Vascular perfusion analysis (non-linear contrast and microbubble capability); Tissue/tumor quantification (3-D reconstruction and volume assessment); Color and Pulsed Wave (PW) doppler
Isoflurane Anesthesia System
Provides several imaging modality options. Extracted whole rodent organs or tissues, such as tumors, can be imaged with high resolution. Live animals may be tagged with near-infrared fluorescent probes to target tissues of interest.
Isoflurane anesthesia system
Odyssey Classic LI-COR Infrared Imager with MousePOD in vivo Imaging Accessory
Leica S6D Stereomicroscope with EC3 digital camera
Provides workspace for tissue collection.
Secondary surgical or necropsy station
Isoflurane anesthesia system
Aseptic surgical technique
Injection and intubation techniques
Survival surgery-cardiovascular challenge model induction, general surgery
Acute surgery- hemodynamic recordings
Data collection and analysis
New model or method establishment
Necropsy and tissue collection
IACUC protocol development
Close-up of Millar Pressure-Volume Catheter
MVPS Ultra Pressure-Volume Loop (PV Loop) System
Vevo 2100 Ultrasound Imaging System with VevoLAB software
ECG-capable ultrasound collection
Leica S6D Stereomicroscope
MPVS Ultra Pressure Volume Loop (PV Loop) System
Pressure-controlled ventilator and isoflurane vaporizer
3-D reconstruction of mouse colon and associated tumors
Software enabling quantification of tumors
Microbubbles enable quantification of colon vascularity