The University of South Dakota is a vibrant setting of innovation artistry and discovery, with research and creative activity opportunity in all disciplines across campus. In addition to individual research, the university hosts multi-disciplinary competitive research centers that foster academic excellence and spur economic growth.

The Center for Brain and Behavior Research attracts and trains top research students and fellows while promoting innovative research in neuroscience and behavioral science. 

The Missouri River Institute was created at the University of South Dakota to celebrate the history of the great river, study its resources and help the public appreciate all it has to offer.