BASIC BIOMEDICAL SCIENCES
Lee Medicine & Science Hall 146
Phone: (605) 658-6320
Dr. Arun Singh is an Assistant Professor in the division of BBS. He earned his Ph.D. from LMU, Munich. He completed his postdoc at Emory University. He worked at the University of Minnesota as a research associate and then at the University of Iowa as a staff scientist.
The primary research goals of the Singh Lab are directed towards understanding the oscillatory nature of fronto-cortical region and associated network that may underlie motor and cognitive impairments in Parkinson's disease (PD) using EEG and non-invasive neuromodulation (TMS/tES) methods. Our lab studies the relationship between motor and cognitive networks in PD patients and how cognitive impairments affect the gait and balance. Our previous articles have already shed some light on the basic questions related to the gait and balance problems in PD patients.<br>The objectives of our lab projects are (1) to determine the role of cortical, subcortical, and associated network-related oscillatory activities during lower-limb movements (pedaling, gait/walking) in PD patients; (2) to determine neural correlates during dual-task (lower-limb movement with the cognitive task) in PD patients with and without freezing of gait; (3) to investigate the effects of open- and advanced closed-loop neuromodulation approaches on lower-limb pedaling, gait, balance, and cognition in PD patients. To perform experiments, our lab is equipped with EEG brain recordings system, a treadmill machine with sensors to record gait and balance parameters, APDM device to record real-world gait pattern and balance, and the unweighting system to prevent participant's fall. For neuromodulation experiments, we have TMS and tES machines.
- Postdoctoral, Neuroscience, Emory University, 2016
- Ph D, Neuroscience, Ludwig Maximilian University, 2011
- MS, Biotechnology, Devi Ahilya University, 2006
- BS, Biology, Bundelkhand University, 2002
Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.
- Singh, Arun, and Papa, S M.. Striatal oscillations in parkinsonian non-human primates.. Neuroscience, 2020. (DOI: 10.1016/j.neuroscience.2020.09.004)
- Anjum, M F., Dasgupta, S, Mudumbai, R, Singh, Arun, Cavanagh, J F., and Narayanan, N S.. Linear predictive coding distinguishes spectral EEG features of Parkinson's disease., 79-85. Vol. 79. Parkinsonism & related disorders, 2020. (DOI: 10.1016/j.parkreldis.2020.08.001)
- Singh, Arun, Cole, Rachel C., Espinoza, Arturo I., Brown, Darin, Cavanagh, James F., and Narayanan, Nandakumar. Frontal theta and beta oscillations during lower-limb movement in Parkinson's disease. Clinical Neurophysiology, 2020.
- Singh, Arun, and Papa, Stella M.. Aberrant striatal oscillations after dopamine loss in parkinsonian non-human primates, 650770. bioRxiv, 2019.
- Singh, Arun, Trapp, Nicholas T., De Corte, Benjamin, Cao, Scarlett, Kingyon, Johnathon, Boes, Aaron D., and Parker, Krystal L.. Cerebellar Theta Frequency Transcranial Pulsed Stimulation Increases Frontal Theta Oscillations in Patients with Schizophrenia, 1-11. The Cerebellum, 2019.
- Singh, Arun, Cao, Scarlett, Kingyon, Johnathon, and Parker, Krystal L.. Proceedings# 32: Effects of cerebellar delta and theta frequency tACS on cognitive performance in patients with schizophrenia, e99-e100. Vol. 12, Iss. 2. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 2019.
- Beck, Goichi, Singh, Arun, Zhang, Jie, Potts, Lisa F., Woo, Jong-Min, Park, Eun S., Mochizuki, Hideki, Mouradian, M M., and Papa, Stella M.. Role of striatal ?FosB in l-Dopa-induced dyskinesias of parkinsonian nonhuman primates, 18664-18672. Vol. 116, Iss. 37. Proceedings of the National Academy of Sciences, 2019.
- Beck, Goichi, Singh, Arun, and Papa, Stella M.. Dysregulation of striatal projection neurons in Parkinson's disease, 449-460. Vol. 125, Iss. 3. Journal of Neural Transmission, 2018.
- Singh, Arun, Jenkins, Meagan A., Burke, Jr, Kenneth J., Beck, Goichi, Jenkins, Andrew, Scimemi, Annalisa, Traynelis, Stephen F., and Papa, Stella M.. Glutamatergic tuning of hyperactive striatal projection neurons controls the motor response to dopamine replacement in parkinsonian primates, 941-952. Vol. 22, Iss. 4. Cell reports, 2018.
- Singh, Arun, Richardson, Sarah P., Narayanan, Nandakumar, and Cavanagh, James F.. Mid-frontal theta activity is diminished during cognitive control in Parkinson's disease, 113-122. Vol. 117. Neuropsychologia, 2018.
- Singh, Arun. Oscillatory activity in the cortico?basal ganglia?thalamic neural circuits in Parkinson's disease, 2869-2878. Vol. 48, Iss. 8. European Journal of Neuroscience, 2018.
- Kammermeier, Stefan, Dietrich, Lucia, Maierbeck, Kathrin, Plate, Annika, Lorenzl, Stefan, Singh, Arun, Ahmadi, Ahmad, and Bötzel, Kai. Postural stabilization differences in Idiopathic Parkinson's Disease and Progressive Supranuclear Palsy during self-triggered fast forward weight lifting, 743. Vol. 8. Frontiers in neurology, 2018.
- Kammermeier, Stefan, Maierbeck, Kathrin, Dietrich, Lucia, Plate, Annika, Lorenzl, Stefan, Singh, Arun, Bötzel, Kai, and Maurer, Christoph. Qualitative postural control differences in Idiopathic Parkinson's Disease vs. Progressive Supranuclear Palsy with dynamic-on-static platform tilt, 1137-1147. Vol. 129, Iss. 6. Clinical Neurophysiology, 2018.
- Kammermeier, Stefan, Singh, Arun, and Bötzel, Kai. Intermediate latency-evoked Potentials of Multimodal cortical Vestibular areas: galvanic stimulation, 587. Vol. 8. Frontiers in neurology, 2017.
- Kammermeier, Stefan, Dietrich, Lucia, Maierbeck, Kathrin, Plate, Annika, Lorenzl, Stefan, Singh, Arun, and Bötzel, Kai. Neck Vibration Proprioceptive Postural response intact in Progressive supranuclear Palsy unlike idiopathic Parkinson's Disease. Vol. 8. Frontiers in neurology, 2017.
- Singh, Arun, Mewes, Klaus, Gross, Robert E., DeLong, Mahlon R., Obeso, Jose A., and Papa, Stella M.. Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson's disease, 9629-9634. Vol. 113, Iss. 34. Proceedings of the National Academy of Sciences, 2016.
- Singh, Arun, Liang, Li, Kaneoke, Yoshiki, Cao, Xuebing, and Papa, Stella M.. Dopamine regulates distinctively the activity patterns of striatal output neurons in advanced parkinsonian primates, 1533-1544. Vol. 113, Iss. 5. Journal of neurophysiology, 2015.
- Potts, Lisa F., Park, Eun S., Woo, Jong?Min, Dyavar Shetty, Bhagya L., Singh, Arun, Braithwaite, Steven P., Voronkov, Michael, Papa, Stella M., and Mouradian, M M.. Dual ??agonist/??antagonist opioid receptor modulation reduces levodopa?induced dyskinesia and corrects dysregulated striatal changes in the nonhuman primate model of P arkinson disease, 930-941. Vol. 77, Iss. 6. Annals of neurology, 2015.
- Singh, Arun, Gutekunst, Claire A., Uthayathas, Subramaniam, Finberg, John P., Mewes, Klaus, Gross, Robert E., Papa, Stella M., and Feld, Yair. Effects of fibroblast transplantation into the internal pallidum on levodopa-induced dyskinesias in parkinsonian non-human primates, 705-713. Vol. 31, Iss. 6. Neuroscience bulletin, 2015.
- Kammermeier, S, Singh, Arun, Noachtar, S, Krotofil, I, and Bötzel, K. Intermediate latency evoked potentials of cortical multimodal vestibular areas: acoustic stimulation, 614-625. Vol. 126, Iss. 3. Clinical Neurophysiology, 2015.
- Potts, Lisa F., Wu, Hao, Singh, Arun, Marcilla, Irene, Luquin, Maria R., and Papa, Stella M.. Modeling Parkinson's disease in monkeys for translational studies, a critical analysis, 133-143. Vol. 256. Experimental neurology, 2014.
- Levin, Johannes, Singh, Arun, Feddersen, Berend, Mehrkens, Jan?Hinnerk, and Bötzel, Kai. Onset latency of segmental dystonia after deep brain stimulation cessation: A randomized, double?blind crossover trial, 944-949. Vol. 29, Iss. 7. Movement Disorders, 2014.
- Singh, Arun, Plate, Annika, Kammermeier, Stefan, Mehrkens, Jan H., Ilmberger, Josef, and Bötzel, Kai. Freezing of gait-related oscillatory activity in the human subthalamic nucleus, 25-32. Vol. 3, Iss. 1. Basal Ganglia, 2013.
- Singh, Arun, and Bötzel, Kai. Globus pallidus internus oscillatory activity is related to movement speed, 3644-3649. Vol. 38, Iss. 11. European Journal of Neuroscience, 2013.
- Singh, Arun. Pathophysiological Neuronal Oscillations: Invasive Recordings from the Basal Ganglia. In Textbook of Movement Disorders..
- Singh, Arun, Mehrkens, Jan H., and Bötzel, Kai. Effect of micro lesions of the basal ganglia on ballistic movements in patients with deep brain stimulation, 175-177. Vol. 314, Iss. 1-2. Journal of the neurological sciences, 2012.
- Singh, Arun, Kammermeier, Stefan, Mehrkens, Jan H., and Bötzel, Kai. Movement kinematic after deep brain stimulation associated microlesions, 1022-1026. Vol. 83, Iss. 10. J Neurol Neurosurg Psychiatry, 2012.
- Singh, Arun, Levin, Johannes, Mehrkens, Jan H., and Bötzel, Kai. Alpha frequency modulation in the human basal ganglia is dependent on motor task, 960-967. Vol. 33, Iss. 5. European Journal of Neuroscience, 2011.
- Singh, Arun, Kammermeier, Stefan, Plate, Annika, Mehrkens, Jan H., Ilmberger, Josef, and Bötzel, Kai. Pattern of local field potential activity in the globus pallidus internum of dystonic patients during walking on a treadmill, 162-167. Vol. 232, Iss. 2. Experimental neurology, 2011.
- Sharma, Varsha, Babu, P P., Singh, Arun, Singh, Sangeeta, and Singh, Rameshwar. Iron-induced experimental cortical seizures: electroencephalographic mapping of seizure spread in the subcortical brain areas, 680-690. Vol. 16, Iss. 8. Seizure, 2007.
Awards and Honors:
- Travel award, Movement Disorder Society, 2018
- Travel award, MONA2, University of Pittsburgh, 2016
- Travel award, World Parkinson Congress, 2016
- Travel award, World Parkinson Congress, 2013
- Best publication award, LMU, Munich, 2011
- Travel award, EFNS, 2011
- Travel award, Movement Disorder Society, 2011
- Travel award, World Federation of Neurology, 2009
- DFG Research Fellowship, Deutsche Forschungsgemeinschaft, 2008
- Junior Research Fellowship, DST, India, 2006
- Postgraduate Fellowship, DBT, India, 2004