Bernie Wone

Molecular Biology, Integrative Physiology, Functional Genomics, Omics, Biotechnology, Advanced Biostatistics.

My research centers on developing bionanotechnology tools to dissect gene function and to edit genomes in plants and animals, elucidating the regulatory mechanisms underpinning abiotic stress adaptation and tolerance in plants, as well as muscle aging in animals, and translating fundamental knowledge and discoveries to impact human health, agriculture, and society.

Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

Walker, Gabriela, Yockey, Mark, and Wone, Bernard. Globalization and Disability Addiction in Working Populations: Unlocking the Global Correlates to Disability Addiction Calls for the Healthicization of Society. International Journal of Mental Health and Addiction, 2022. (DOI: https://doi.org/10.1007/s11469-022-00834-w)
Wone, Bernard, and Swanson, David. Metabolic profiling and integration of metabolomic and transcriptomic data from pectoralis muscle reveal winter-adaptive metabolic responses of black-capped chickadee and American goldfinch . In Avian Behavioral and Physiological Responses to Challenging Thermal Environments and Extreme Weather Events. Frontiers in Ecology and Evolution Ecophysiology, 2022. (DOI: 10.3389/fevo.2022.866130)
Ariyarathne, Madhavi, and Wone, Bernard. Overexpression of the Selaginella lepidophylla bHLH transcription factor enhances water-use efficiency, growth, and development in Arabidopsis. Plant Science, 2022. (DOI: https://doi.org/10.1016/j.plantsci.2021.111129)
Izuegbunam, Chinenye C., Wijewantha, Nisitha, Wone, Beate, Ariyarathne , Madhavi, Sereda, Grigoriy, and Wone, Bernard. A nano-biomimetic transformation system enables in planta expression of a reporter gene in mature plants and seeds . Nanoscale Advances, 2021. (DOI: https://doi.org/10.1039/D1NA00107H)
Mayer, Jesse J., Wone, Bernard, Alexander, Danny D., Guo, Lining , Ryals, John J., and Cushman, John J.. Metabolic profiling of epidermal and mesophyll tissues under water-deficit stress in Opuntia ficus-indica reveals stress-adaptive metabolic responses . Functional Plant Biology, 2021.
Cynthia, Downs D., Jessi, Brown B., Wone, Bernard, Donovan, Edward E., and Jack, Hayes H.. Effects of selection for mass-independent maximal metabolic rate on food consumption. Physiological and Biochemical Zoology, 2019. (DOI: 10.1086/706206)
Amin, Atia A., Rathnayake, Kumudu K., Yim, Won W., Gracia, Travis T., Wone, Beate, Cushman, John J., and Wone, Bernard. Crassulacean Acid Metabolism Abiotic Stress-Responsive Transcription Factors: A Potential Genetic Engineering Approach for Improving Crop Tolerance to Abiotic Stress. Frontiers in Plant Science, section Plant Systems and Synthetic Biology, 2019. (DOI: 10.3389/fpls.2019.00129)
Wone, Bernard, Pathak, Jaika, and Davidowitz, Goggy. Flight duration and flight muscle ultrastructure of unfed hawk moth. Arthropod Structure & Development, 2018. (DOI: 10.1016/j.asd.2018.05.003)
Wone, Bernard, Won, Yim Y., Schutz, Heidi, Meek, Thomas T., and Garland, Theodore. Mitochondrial haplotypes are not associated with mice selectively bred for high voluntary wheel running. Mitochondrion, 2018. (DOI: 10.1016/j.mito.2018.04.002)
Wone, Bernard, Kinchen, Jason J., Kaup, Elana E., and Wone, Beate. A procession of metabolic alterations accompanying muscle senescence in Manduca sexta . Scientific Reports, 2018. (DOI: 10.1038/s41598-018-19630-5)
Walker, Gabriela, and Wone, Bernard. Towards a Healthy Society: Identifying Socio-Cultural Factors that Might Influence Disabling Addictive Behaviors in Working Populations. In International Journal for Cross-Disciplinary Subjects in Education, Online. Vol. 8, Iss. 4 International Journal for Cross-Disciplinary Subjects in Education, 2017.
Yobi, A, Schlauch, K K., Tillet, R R., Yim, W W., Espinosa, C, Wone, B B., Cushman, J J., and Oliver, M M.. Sporobolus stapfianus: Insights into desiccation tolerance in the resurrection grasses from linking transcriptomics to metabolomics. BMC Plant Biology, 2017. (DOI: 10.1186/s12870-017-1013-7)
Downs, C C., Brown, J J., Wone, Bernard, Donovan, E E., and Hayes, J J.. Speeding up growth: selection for mass-independent maximal metabolic rate alters growth rates. American Naturalist, 2016.
Yang, X, Cushman, J J., Borland, A A., Edwards, E E., Wullschleger, S S., Tusan, G G., Owen, N N., Griffiths, H, Andrews, JA J., De Paoli, H H., Weston, D D., Cottingham, R, Hartwell, J, Davis, S S., Silvera, K, Ming, R, Schlauch, K K., Abraham, P, Stewart, J J., Guo, H H., Albion, R R., Ha, J, Lim, S S., Wone, Bernard, Yim, W W., and et, al. A roadmap for research on crassulacean acid metabolism to enhance sustainable food and bioenergy production in a hotter, drier world, 491-504. Vol. 207 New Phytologist, 2015.
Wone, Bernard, Madsen, P, Donovan, E E., Labocha, M M., Sears, M M., Downs, C C., Sorensen, D D., and Hayes, J J.. A strong response to selection on mass-independent maximal metabolic rate without a correlated response in basal metabolic rate, 419-427. Vol. 114 Heredity, 2015. (DOI: 10.1038/hdy.2014.122)
Wone, Bernard, Donovan, E E., Cushman, J J., and Hayes, J J.. Metabolic rates associated with membrane fatty acids in mice selected for increased maximal metabolic rate, 70-78. Vol. 165 Comp Biochem Physiol A , 2013.
Downs, C C., Brown, J J., Wone, Bernard, Donovan, E E., Hunter, K, and Hayes, J J.. Selection for increased mass-independent maximal metabolic rate suppresses innate but not adaptive immune function, 1471-2954. Vol. 280 Proc R Soc B , 2013.
Miller, W W., Johnson, D D., Gergans, N, Carroll-Moore, E E., Walker, R R., Cody, T T., and Wone, Bernard. Update on the effects of a sierran wildfire on surface runoff water quality, 1185-1195. Vol. 42 J Eviron Qual , 2013.
Yobi, A, Wone, Bernard, Xu, W, Alexander, D D., Guo, L, Ryals, J J., Oliver, M M., and Cushman, J J.. Comparative metabolic profiling between desiccation-sensitive and desiccation-tolerant species of Selaginella reveals novel insights into the resurrection trait, 399-405. Vol. 72 Plant J, 2012.
Yobi, A, Wone, Bernard, Xu, W, Alexander, D D., Guo, L, Ryals, J J., Oliver, M M., and Cushman, J J.. Metabolomic profiling in Selaginella lepidophylla reveals adaptations essential for desiccation tolerance, 369-385. Vol. 6 Mol Plant, 2012.
Oliver, M M., Guo, L, Alexander, D D., Ryals, J J., Wone, Bernard, and Cuahman, J J.. A sister group contrast delineates the biochemical regulation underlying desiccation tolerance in Sporobolus stapfianus, 1231-1248. Vol. 23 Plant Cell, 2011.
Wone, Bernard, Donovan, E E., and Hayes, J J.. Metabolomics of aerobic metabolism in mice selected for increased maximal metabolic rate, 399-405. Vol. 6 Comp Biochem Physiol D, 2011.
Wone, Bernard, Sears, M M., Labocha, M M., Donovan, E E., and Hayes, J J.. Genetic variances and covariances of aerobic metabolic rates in laboratory mice., 3695-3704. Vol. 276 Proc R Soc B, 2009.
Wone, Bernard, and Wone, Beate. Movements, home range, and activity patterns of the horned lizard, Phrynosoma mcallii, 679-686. Vol. 37 J Herp, 2003.
Wone, Beate, Wone, Bernard, Bros, S, and Kutilek, M. Habitat use of the flat-tailed horned lizard (Phrynosoma mcallii) in a disturbed environment, 210-216. Vol. 32 J Herp, 1998.
Wone, Bernard, and Wone, Beate. Observations on the escape behavior of the horned lizard Phrynosoma mcallii, 132. Vol. 26 Herp Review, 1995.
Walker, Gabriela, Yockey, Mark, and Wone, Bernard. Globalization and Addiction Disabilities in Working Populations: Global Correlates to Living with Disabilities Due to Alcohol, Tobacco, Drugs, and Food Overconsumption. Globalization and Health.

Wone, Bernard, Optimizing a biocompatible nanocarrier of genes to enable in planta stable gene editing . Presented at the 10th Plant Genomics & Gene Editing Congress, Raleigh, NC. (October 2023)
Hasan , Mahadi, Wijewardhane1, Sajith , Wone, Bernard, Rezvani, Khosrow, and Sereda, Grigoriy, Calcium-containing nanoparticles for sunscreen formulation, gene transfer, and drug delivery. Presented at the Upper Midwest Association for Campus Sustainability (UMACS) conference, University of South Dakota, Vermillion SD. (September 2023)
Wone, Bernard, Development of a Nano Functional Genomics Tool to Study Gene Function in Plants. Presented at the Plant and Animal Genome Conference, San Diego. (January 2023)
Izuegbunam, Chinenye, Wijewantha, Nisitha, Wone, Beate, Ariyarathne , Madhavi, Sereda, Grigoriy, and Wone, Bernard, A Biocompatible Nanocarrier of Genes Enables Transient Expression of Reporter Genes in Mature Plants and Seeds. Presented at the Plant Biology 2022, Portland, OR. (July 2022)
Ariyarathne, Madhavi, and Wone, Bernard, Elucidating key transcriptional regulators that induce the desiccation tolerance response in Selaginella lepidophylla. Presented at the Plant Biology 2021 (July 2021)
Malwattage, Naleeka, Gracia, Trabis, Cushman, John, and Wone, Bernard, Enhancing Abiotic Stress Response via a Kalanchoe fedtschenkoi NF-Y Transcription Factor in C3 Plants. Presented at the Experimental Biology 2020 (April 2020)
Del Grosso, Avery, Wone, Beate, and Wone, Bernard, Transcriptional Dynamics Underpinning Muscle Senescence in Manduca sexta. Presented at the Experimental Biology 2020 (April 2020)
Malwattage, Naleeka, Gracia, Travis M., Cushman, John C., and Wone, Bernard, Abiotic Stress Response Functions of the Obligate CAM Plant NF-Y Transcription Factor. Presented at the Plant Biology 2019, San Jose, CA. (August 2019)
Izuegbunam, Chinenye , Yim, Won C., Cushman, John C., and Wone, Bernard, Characterization of a CAM Halophyte Homeodomain Type Transcription Factor in C3 Arabidopsis thaliana. Presented at the Plant Biology 2019, San Jose, CA. (August 2019)
Rathnayake, Kumudu N., Gracia, Travis M., Cushman, John C., and Wone, Bernard, Potential Of Enhancing Crop Plant Abiotic Stress Tolerance And Biomass Utilizing Crassulacean Acid Metabolism Plant Transcription Factors. Presented at the Plant Biology 2019, San Jose, CA. (August 2019)
Ariyarathne, Madhavi, Yim, Won C., , and Wone, Bernard, Role of a Selaginella lepidophylla bHLH Transcription Factor under Water-deficit Stress Condition. Presented at the Plant Biology 2019, San Jose, CA. (August 2019)
Rathnayake, Kumudu N., Garcia, Travis M., Cushman, John C., and Wone, Bernard, A Novel NAC83 Transcription Factor from Kalanchoe fedtschenkoi Enhances Drought and Salt Tolerance in Arabidopsis . Presented at the International Plant & Animal Genome XXVII, San Diego, CA. (January 2019)
Wone, Bernard, Cheviron, Zachary A., and Swanson, David, Unraveling the Complexity of Seasonal Phenotypic Flexibility in Small Birds via Omics Integration. Presented at the APS Intersociety Meeting: Comparative Physiology: Complexity & Integration, New Orleans, LA. (October 2018)
Amin, Atia B., Gracia, Travis M., Wone, Beate, Cushman, John C., and Wone, Bernard, Functional characterization of a Kalanchoe fedtschenkoi MYB transcription factor putatively involved in regulation of the crassulacean acid metabolism (CAM) . Presented at the Plant Biology 2018, Montreal, Canada. (July 2018)
Garcia, Travis M., Wone, Bernard, Yim, Won C., Lim, Sung D., Ha, Jungmin, Schlauch, Karen A., and Cushman, John C., Characterization of the Transcriptional Regulation of Crassulacean Acid Metabolism (CAM) in Kalanchoe fedtschenkoi Mesophyll Tissue. Presented at the Biology of CAM Plants, Phoenix, AZ. (April 2018)
Rathnayake, Kumudu N., Gracia, Travis M., Cushman, John C., and Wone, Bernard, Functional Characterization of a Kalanchoe fedtschenkoi NAC (KfNAC) Transcription Factor in Arabidopsis thaliana . Presented at the Biology of CAM Plants, Phoenix, AZ. (April 2018)
Walker, Gabriela, Yockey, Mark, and Wone, Bernard, Identifying Globalization Factors that Might Lead to Addictive Behaviors Culminating in Disability. Presented at the 16th Annual Hawaii International Conference on Education, Honolulu, Hawaii. (January 04, 2018)
Rathnayake, Kumudu N., Koster, Karen, Oliver, Melvin, Alexander, Danny, and Wone, Bernard, A comparative metabolomic study between constitutively desiccation tolerant Syntrichia ruralis and inducibly desiccation tolerant Physcomitrella patens. Presented at the International Plant & Animal Genome XXVI, San Diego, CA. (January 2018)
Rathnayake, Kumudu N., Koster, Karen, Alexander, Danny, and Wone, Bernard, Desiccation Tolerance in the Moss Physcomitrella patens: Insights into Metabolic Pathway Alterations during Acquisition of Desiccation Tolerance. . Presented at the MOSS 2017, Honolulu, HI. (June 23, 2017)
Walker, Gabriela, and Wone, Bernard, Socio-Cultural Factors Impacting Disabling Addictive Behaviors in Work-Aged Populations. Presented at the Canada International Conference on Education (CICE 2017), University of Toronto Mississauga, Canada. (June 2017)
Rathnayake, Kumudu N., Wone, Bernard, Alexander, Danny, and Koster, Karen, The Acquisition of Desiccation Tolerance in the Moss Physcomitrella patens: a metabolomic analysis. . Presented at the Plant Biology 2017, Honolulu, HI. (June 2017)
Wone, Bernard, Kinchen, Jason M., and Swanson, David, Seasonal Metabotypes in Small Birds. Presented at the Experimental Biology Annual Meeting, Chicago, IL. (April 2017)
Wone, Beate, Kinchen, Jason M., Kaup, Elana R., and Wone, Bernard, Time course metabolic profiling of senescing flight muscles in the hawk moth, Manduca sexta. Presented at the Experimental Biology Annual Meeting (April 2017)
Garcia, T M., Wone, Bernard, Yim, W C., Lim, S D., Ha, J, Schlauch, K A., and Cushman, J C., Characterization of the Transcriptional Regulation of Crassulacean Acid Metabolism (CAM) in Kalanchoe laxiflora mesophyll Tissue. Presented at the International Plant & Animal Genome XXV, San Diego, CA. (January 2017)
Yim, W C., Ha, J, Lim, S D., Wone, Bernard, Albion, R L., Yin, H, Yang, X, and Cushman, J C., Genome Sequencing of the Common Ice Plant (Mesembryanthemum crystallinum L.). Presented at the International Plant & Animal Genome XXV, San Diego, CA. (January 2017)
Yim, W C., Lim, S D., Wone, Bernard, Albion, R L., Mayer, J A., and Cushman, J C., Transcriptome Analysis & Beyond: Advanced Approaches for Transcriptome Analysis in Diploid and Polyploid Plant Species. Presented at the International Plant & Animal Genome XXV, San Diego, CA. (January 2017)
Wone, Beate, Kinchen, Jason M., Kaup, Elana R., and Wone, Bernard, Metabolic changes underpinning aging flight muscles in the hawk moth, Manduca sexta. Presented at the American Physiological Society Intersociety Meeting: The Integrative Biology of Exercise, Phoenix, AZ. (November 2016)
Meyer, J A., Yim, W C., Wone, Bernard, Patterson, A H., and Cushman, J C., Generating a Robust Genome and Transcriptome for Prickly Pear Cactus. Presented at the International Plant & Animal Genome XXIV, San Diego, CA. (January 2016)
Yim, W C., Lim, S D., Ha, J, Wone, Bernard, Albion, R L., Cushman, J C., Yin, H, and Yang, X, High Quality De Novo Genome Assemblies of the Common Ice Plant (Mesembryanthemum crystallinum L.) - a Functional Genomics Resource for Crassulacean Acid Metabolism (CAM) and Halophytism. Presented at the International Plant & Animal Genome XXIV, San Diego, CA. (January 2016)
Wone, Bernard, Covariates, random effects, false discovery rates and beyond. Presented at the 9th International Congress of Comparative Physiology and Biochemistry, Kraków, Poland. (August 2015)
Wone, Bernard, Bilgi, B G., Schlauch, K A., and Cushman, J C., Metabolome dynamics of crassulacean acid metabolism (CAM) in the facultative CAM species, Mesembryanthemum crystallinum. Presented at the 20th Penn State Plant Biology Symposium, Plant Stress-Omics in a Changing Climate, Penn State, State College, PA. (April 2015)
Wone, Bernard, Ojha, J, and Davidowitz, G, Animal models of human muscle aging and disease: the hawk moth, Manduca sexta, flies forward. Presented at the Experimental Biology Annual Meeting, Boston, MA. (March 2015)
Wone, Bernard, Yim, W C., Albion, R L., Schlauch, K A., and Cushman, J C., Uncovering transcriptional gene regulatory networks operating in the facultative CAM species, Mesembryanthemum crystallinum. Presented at the International Plant & Animal Genome XXII, San Diego, CA. (January 2015)
Wone, Bernard, Ojha, J, and Davidowitz, G, Age related changes in flight muscle ultrastructures of the hawk moth, Manduca sexta: a novel non-vertebrate animal model for investigating vertebrate skeletal muscle function, disease, degeneration, and aging. Presented at the American Physiological Society Intersociety Meeting: Comparative Approaches to Grand Challenges in Physiology, San Diego, CA. (October 2014)
Wone, Bernard, Bilgi, B G., Albion, R L., Yim, W C., Tillet, R L., Schlauch, K A., and Cushman, J C., Transcriptional dynamics of crassulacean acid metabolism (CAM) in the facultative CAM species, Mesembryanthemum crystallinum. Presented at the 34th New Phytologist Symposium: Systems biology and ecology of CAM plants, Tahoe City, CA. (July 2014)
Wone, Bernard, Ojha, J, Contreras, H L., and Davidowitz, G, More is not always better: a hidden cost of the flight-fecundity trade-off in the hawk moth. Presented at the Experimental Biology Annual Meeting, San Diego, CA. (April 2014)
Wone, Bernard, Bilgi, B G., Albion, R L., Yim, W C., Schlauch, K A., and Cushman, J C., Transcriptomic and Metabolomic Analysis of CAM in Ice Plant. Presented at the International Plant & Animal Genome XXII, Functional Genomics of C4 and CAM Photosynthesis workshop, San Diego, CA. (January 2014)
Wone, Bernard, Schlauch, K A., and Cushman, J C., Identifying temporal regulatory networks operating within mesophyll cells in a CAM plant. Presented at the International Symposium on C4 and CAM Plant Biology, Champaign, IL. (August 2013)

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