I have a long standing interest in the physiological mechanisms that underlie the
development of hypertension (high blood pressure). Hypertension afflicts approximately
30% of the population (including several members of my family). Hypertension is also
a major risk factor for the development of other diseases such as renal failure, heart
failure, atherosclerosis, stroke, coronary artery disease and myocardial infarction.
Moreover, as of 2015 the American Heart Association reports that hypertension continues
to increase in prevalence. Despite the significant health impact of hypertension,
little is known about the mechanisms that trigger the development of high blood pressure.
Accordingly, better understanding of the mechanisms underlying the development of
high blood pressure should foster new therapeutic approaches to prevent and treat
Citations listed below are presented in a standardized, modified format for
display purposes only. They do not necessarily reflect the preferred style and conventions
of the faculty member or discipline.
- Martin, Douglas, and Eyster, Kathleen. Assessing direct vascular actions of estrogens. In Estrogen Receptors, edited by Kathleen Eyster. New York: Springer, 2016.
- Martin, Douglas, and Wang, Xuejun. The COP9 Signalosome and Vascular Function: Intriguing Possibilities?, 33-52. Vol. 5, Iss. 1. Am J Cardiovasc Dis, 2015.
- Wang, Xuejun, and Martin, Douglas. The COP9 signalosome and Cullin RING Ligases in the heart, 1-18. Vol. 5, Iss. 1. Am J Cardiovasc Dis, 2015.
- Ranek, Mark J., Kost, Curtis, Hu, Chengjun, Martin, Douglas, and Wang, Xuejun. Muscarinic 2 Receptors Modulate Cardiac Proteasome Function in a Protein Kinase G-dependent
Manner, 43-51. Epub 2014 Feb 5.. Vol. 69, Iss. 4. J Mol Cell Cardiol, 2014. (DOI: 10.1016/j.yjmcc.2014.01.017)
- Li, Shuai, Wang, Xuejun, Li, Yi-Fan, Kost, Curtis, and Martin, Douglas. Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension
and aortic remodeling in rats., 10. Vol. 30, Iss. 8. PLOS One, 2013. (DOI: 10.1371/journal.pone.0078564 )
- Eyster, Kathleen, Breitkopf, N P., and Martin, Douglas. Antihypertensive activity of soy and soy-derived compounds. In Soy: Nutrition, consumption and health, edited by Aamir Ahmad, 79-104. Hauppauge, NY: Nova Scientific Publishers, 2012.
- Martin, Douglas, Klinkova, Olga, and Eyster, Kathleen. Regional differences in sexually dimorphic protein expression in the spontaneously
hypertensive rat (SHR), 103-114. Vol. 362. Molecular and Cellular Biochemistry, 2012.
- Bardal, Stan K., Waechter, Jason E., and Martin, Douglas. Applied Pharmacology. St. Louis Missouri : Elsevier/Sauders, 2011.
- Tatchum-Talom, Rabelais, Eyster, Kathleen, Kost, Curtis, and Martin, Douglas. Blood pressure and mesenteric vascular reactivity in SHR seven months after gonadectomy, 357-364. Vol. 57. J Cardiovasc Pharm, 2011.
- Mark-Kappeler, Connie J., Martin, Douglas, and Eyster, Kathleen. Estrogens and selective estrogen receptor modulators (SERMs) regulate gene and protein
expression in the mesenteric arteries, 42-49. Vol. 55. Vascular Pharmacology, 2011. (DOI: 10.1016/j.vph.2011.05.002)
- Song, Jin, Eyster, Kathleen, Kost, Curtis, Kjellsen, Bart, and Martin, Douglas. Involvement of protein kinase C-CPI-17 in androgen modulation of angiotensin II-renal
vasoconstriction., 614-621. Vol. 85, Iss. 3. Cardiovasc Res, 2010.