Hong Zheng

Assistant Professor

BASIC BIOMEDICAL SCIENCES

Lee Medicine & Science Hall 132

Phone: (605) 658-6397

Email: Hong.Zheng@usd.edu

Website: http://sites.google.com/a/usd.edu/hongzheng-lab/

Research Interests:

Neuroscience and Physiology. One of the projects is to define the interaction of neurotransmitters/modulators within the central nervous system in regulation of sympathetic outflow and cardiovascular functions in chronic heart failure and obesity. In particular, We are interested in investigating the interactions of neuro-humoral components and adipokines (including leptin, ghrelin) regulation of cardiovascular function and renal function in the disease conditions. Another project is to determine that increased proteases in the renal tubular fluid contribute to the enhanced renal epithelial sodium channel activity, providing a novel mechanistic insight for sodium retention commonly observed in chronic heart failure. The long-term significance and direction of these experiments will be to gain insight into beneficial effects of renal denervation on sodium fluid retention endemic to chronic heart failure.


Education:

  • Physiology, University of Nebraska Medical Center, 2005
  • MD, Medicine, Peking University Health Science Center, 1993

Publications:

Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

  • Zheng, Hong, Katsurada, K, Liu, X, Knuepfer, M M., and Patel, K P.. Specific Afferent Renal Denervation Prevents Reduction in Neuronal Nitric Oxide Synthase Within the Paraventricular Nucleus in Rats With Chronic Heart Failure., 667-675. Vol. 72, Iss. 3. Hypertension (Dallas, Tex. : 1979), 2018. (DOI: 10.1161/HYPERTENSIONAHA.118.11071)
  • Zheng, Hong, and Patel, K P.. Integration of renal sensory afferents at the level of the paraventricular nucleus dictating sympathetic outflow., 57-64. Vol. 204. Autonomic neuroscience : basic & clinical, 2017. (DOI: 10.1016/j.autneu.2016.08.008)
  • Zheng, Hong, Liu, X, Li, Y, and Patel, K P.. A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity., 2361675. Vol. 2017. Neural plasticity, 2017. (DOI: 10.1155/2017/2361675)
  • Stern, J E., Son, S, Biancardi, V C., Zheng, Hong, Sharma, N, and Patel, K P.. Astrocytes Contribute to Angiotensin II Stimulation of Hypothalamic Neuronal Activity and Sympathetic Outflow., 1483-1493. Vol. 68, Iss. 6. Hypertension (Dallas, Tex. : 1979), 2016. (DOI: 10.1161/HYPERTENSIONAHA.116.07747)
  • Mahata, S K., Zheng, Hong, Mahata, S, Liu, X, and Patel, K P.. Effect of heart failure on catecholamine granule morphology and storage in chromaffin cells., 309-23. Vol. 230, Iss. 3. The Journal of endocrinology, 2016. (DOI: 10.1530/JOE-16-0146)
  • Zheng, Hong, Liu, X, Sharma, N M., and Patel, K P.. Renal denervation improves cardiac function in rats with chronic heart failure: Effects on expression of ?-adrenoceptors., H337-46. Vol. 311, Iss. 2. American journal of physiology. Heart and circulatory physiology, 2016. (DOI: 10.1152/ajpheart.00999.2015)
  • Patel, K P., Xu, B, Liu, X, Sharma, N M., and Zheng, Hong. Renal Denervation Improves Exaggerated Sympathoexcitation in Rats With Heart Failure: A Role for Neuronal Nitric Oxide Synthase in the Paraventricular Nucleus., 175-84. Vol. 68, Iss. 1. Hypertension (Dallas, Tex. : 1979), 2016. (DOI: 10.1161/HYPERTENSIONAHA.115.06794)
  • Zheng, Hong, Liu, X, Sharma, N M., Li, Y, Pliquett, R U., and Patel, K P.. Urinary Proteolytic Activation of Renal Epithelial Na+ Channels in Chronic Heart Failure., 197-205. Vol. 67, Iss. 1. Hypertension (Dallas, Tex. : 1979), 2016. (DOI: 10.1161/HYPERTENSIONAHA.115.05838)
  • Xu, B, Zheng, Hong, Liu, X, and Patel, K P.. Activation of afferent renal nerves modulates RVLM-projecting PVN neurons., H1103-11. Vol. 308, Iss. 9. American journal of physiology. Heart and circulatory physiology, 2015. (DOI: 10.1152/ajpheart.00862.2014)
  • Zheng, Hong, Liu, X, Li, Y, Mishra, P K., and Patel, K P.. Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes., R138-48. Vol. 306, Iss. 2. American journal of physiology. Regulatory, integrative and comparative physiology, 2014. (DOI: 10.1152/ajpregu.00323.2013)
  • Zheng, Hong, Liu, X, and Patel, K P.. Centrally mediated erectile dysfunction in rats with type 1 diabetes: role of angiotensin II and superoxide., 2165-76. Vol. 10, Iss. 9. The journal of sexual medicine, 2013. (DOI: 10.1111/jsm.12248)
  • Patel, K P., Salgado, H C., Liu, X, and Zheng, Hong. Exercise training normalizes the blunted central component of the baroreflex in rats with heart failure: role of the PVN., H173-81. Vol. 305, Iss. 2. American journal of physiology. Heart and circulatory physiology, 2013. (DOI: 10.1152/ajpheart.00009.2013)
  • Zheng, Hong, Sharma, N M., Liu, X, and Patel, K P.. Exercise training normalizes enhanced sympathetic activation from the paraventricular nucleus in chronic heart failure: role of angiotensin II., R387-94. Vol. 303, Iss. 4. American journal of physiology. Regulatory, integrative and comparative physiology, 2012. (DOI: 10.1152/ajpregu.00046.2012)
  • Patel, K P., and Zheng, Hong. Central neural control of sympathetic nerve activity in heart failure following exercise training., H527-37. Vol. 302, Iss. 3. American journal of physiology. Heart and circulatory physiology, 2012. (DOI: 10.1152/ajpheart.00676.2011)
  • Zheng, Hong, Mayhan, William, and Patel, K P.. Exercise training improves the defective centrally mediated erectile responses in rats with type I diabetes., 3086-97. Vol. 8, Iss. 11. The journal of sexual medicine, 2011. (DOI: 10.1111/j.1743-6109.2011.02442.x)
  • Zheng, Hong, Liu, X, Li, Y, Sharma, N M., and Patel, K P.. Gene transfer of neuronal nitric oxide synthase to the paraventricular nucleus reduces the enhanced glutamatergic tone in rats with chronic heart failure., 966-73. Vol. 58, Iss. 5. Hypertension (Dallas, Tex. : 1979), 2011. (DOI: 10.1161/HYPERTENSIONAHA.111.176222)
  • Zheng, Hong, Liu, X, Rao, U S., and Patel, K P.. Increased renal ENaC subunits and sodium retention in rats with chronic heart failure., F641-9. Vol. 300, Iss. 3. American journal of physiology. Renal physiology, 2011. (DOI: 10.1152/ajprenal.00254.2010)
  • Patel, K P., Mayhan, William, Bidasee, K R., and Zheng, Hong. Enhanced angiotensin II-mediated central sympathoexcitation in streptozotocin-induced diabetes: role of superoxide anion., R311-20. Vol. 300, Iss. 2. American journal of physiology. Regulatory, integrative and comparative physiology, 2011. (DOI: 10.1152/ajpregu.00246.2010)