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Samuel Sathyanesan

Samuel Sathyanesan



Lee Medicine & Science Hall 130

Phone: (605) 658-6313




Assistant Professor- Yale School of Medicine (2004-2010)<br>Associate Professor- Yale School of Medicine (2010 - 2012)<br>

Teaching Interests:

Neuroscience, Neurovascular biology, Angiogenesis

Research Interests:

Neuropsychiatric diseases, CNS barriers, Trophic factor signaling


  • Molecular Psychiatry, Yale University School of Medicine, 2004
  • Ph D, Molecular Physiology, University of Notre Dame, 2000
  • Ph D, Biotechnology, University of Madras, 1995


  • Cardiac sympathetic afferent reflex control of venous function, NIH. Grant Role: Co-Principal. (2017 - 2021)
  • Characterization of trophic factor induced antidepressant action, NIH. Grant Role: Principal. (2016 - 2021)
  • Characterization of trophic factor induced antidepressant action (RO1 MH106640-01 - PMDA), NIH. Grant Role: Principal. (2016 - Present)
  • A Neurotrophic Approach to Treatment of Cognitive Deficits in Mood Disorders, Center for Brain and Behavioral Research. Grant Role: Co-Principal. (2014 - 2015)
  • Development of a therapeutic trophic factor for neuropsychiatric disorder, SDBOR. Grant Role: Principal. (2014 - 2015)
  • Computational design of neurotrophic peptides, Sanford School of Medicine. Grant Role: Principal. (2014 - 2015)
  • Nanoparticle assisted brain delivery of a therapeutic neurotrophic factor, Office of Research and Sponsored Programs. Grant Role: Co-Principal. (2014 - 2014)
  • Development of a therapeutic trophic factor for neuropsychiatric disorder, SDBOR. Grant Role: Principal. (2013 - 2014)


Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

  • Staton, Clarissa D., Yaeger, Jazmine D., Khalid, Delan H., Haroun, Fadi H., Fernandez, Belissa S., Fernandez, Jessica S., Summers, Bali K., Summers, Tangi R., Sathyanesan, Monica H., Newton, Samuel S., and Summers, Cliff H.. Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression, 79-94. Vol. 143. Vermillion: Neuropharmacology, 2018. (DOI: 10.1016/j.neuropharm.2018.09.016)
  • Sane, Sanam, Abdullah, Ammara, Nelson, Morgan, Wang, Hongmin, Chauhan, Subhash C., Newton, Samuel, and Rezvani, Khosrow. Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy. Edited by Helen Neumann. Storrs, Connecticut: Cell Stress Chaperones / Springer, 2015. (DOI: 10.1007/s12192-015-0661-5)
  • Sathyanesan, Monica, Girgenti, Matthew J., Warner-Schmidt, Jennifer, and Newton, Samuel. Indomethacin induced gene regulation in the rat hippocampus, 12. Vol. 8, Iss. 59. London: Molecular Brain/BioMed Central/ Springer Nature, 2015. (DOI: 10.1186/s13041-015-0150-x)
  • Rajkowska, Grazyna, Mahajan, Gouri, Sathyanesan, Monica, Iyo, Abiye, Moulana, Mohadetheh, Kyle, Patrick, Woolverton, William, Miguel-Hidalgo, Jose Javier, Stockmeier, Craig, and Newton, Samuel. Oligodendrocyte Morphometry and Expression of Myelin - Related mRNA in Ventral Prefrontal White Matter in Major Depressive Disorder. Edited by Florian Holsboer, Alan Schatzberg, MD, 10. Vol. 65. Journal of Psychiatric Research / Elsevier, 2015. (DOI: 10.1016/j.jpsychires.2015.04.010)
  • Duric, Vanja, Banasr, Mounira, Stockmeier, Craig A., Simen, Arthur A., Sathyanesan, Samuel, Overholser, James C., Jurjus, George J., Dieter, Lesa, and Duman, Ronald S.. Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects, 69-82. Vol. 16, Iss. 1. Int J Neuropsychopharmacology, 2013. (DOI: 10.1017/S146114571200001)
  • Duman, Catharine H., and Sathyanesan, Samuel. Evaluating effects of EPO in rodent behavioral assays related to depression., 127-40. Vol. 982. Methods in Molecular Biology, 2013.
  • Sathyanesan, Samuel, Fournier, Neil M., and Duman, Ronald S.. Vascular growth factors in neuropsychiatry, 1739-52. Vol. 70, Iss. 10. Cell Mol Life Sci, 2013. (DOI: 10.1007/s00018-013-1281-9)
  • Sathyanesan, Monica, Girgenti, Matthew J., Banasr, Mounira, Stone, Kathryn, Bruce, Can, Guilchicek, E, Wilczak-Havill, K, Nairn, Angus, Wliliams, Kenneth, Sass, Sandy, Duman, John G., and Sathyanesan, Samuel. A molecular characterization of the choroid plexus and stress-induced gene regulation.. Vol. 2, Iss. 7. Translational Psychiatry, 2012.
  • Ordway, Gregory A., Szebeni, Attila, Chandley, Michelle J., Stockmeier, Craig A., Xiang, Lianbin, Sathyanesan, Samuel, Turecki, Gustavo, Duffourc, Michelle M., Zhu, Meng-Yang, Zhu, Hobart, and Szebeni, Katalin. Low gene expression of bone morphogenetic protein 7 in brainstem astrocytes in major depression, 855-68. Vol. 15, Iss. 7. Int J Neuropsychopharmacology, 2012.
  • Girgenti, Matthew J., Collier, Emily, Sathyanesan, Monica, Su, Xiao W., and Sathyanesan, Samuel. Characterization of electroconvulsive seizure-induced TIMP-1 and MMP-9 in hippocampal vasculature, 535-44. Vol. 14, Iss. 4. International Journal of Neuropsychopharmacology, 2011.
  • Beech, Robert D., Lowthert, Lori, Leffert, Janine J., Mason, Portia N., Taylor, Mary M., Umlauf, Sheila, Lin, Aiping, Lee, Ji Y., Maloney, Kathleen, Muralidharan, Anjana, Lorberg, Boris, Zhao, Hongyu, Sathyanesan, Samuel, Mane, Shrikant, Epperson, Neill, Sinha, Rajita, Blumberg, Hilary, and Bhagwagar, Zubin. Increased peripheral blood expression of electron transport chain genes in bipolar depression., 813-824. Vol. 12, Iss. 8. Bipolar Disorders, 2010.
  • Duric, Vanja, Banasr, Mounira, Licznerski, Pawel, Schmidt, Heath D., Stockmeier, Craig A., Simen, Arthur, Sathyanesan, Samuel, and Duman, Ronald S.. A negative regulator of MAP kinase causes depressive behavior, 1328-32. Vol. 16, Iss. 11. Nature Medicine, 2010.
  • Okamoto, Hideki, Voleti, Bhavya, Banasr, Mounira, Sarhan, Maysa, Duric, Vanja, Girgenti, Matthew J., DiLeone, Ralph J., Sathyanesan, Samuel, and Duman, Ronald S.. Wnt2 expression and signaling is increased by different classes of antidepressant treatments., 521-527. Vol. 68, Iss. 6. Biological Psychiatry, 2010.
  • Banasr, Mounira, Chowdhury, G M., Terwilliger, Rosemarie, Sathyanesan, Samuel, Duman, Ronald S., Behar, K L., and Sanacora, G. Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole., 501-511. Vol. 15, Iss. 5. Molecular Psychiatry, 2010.
  • Girgenti, Matthew J., Nisenbaum, Laura K., Bymaster, Franklin, Terwilliger, Rosemarie, Duman, Ronald S., and Sathyanesan, Samuel. Antipsychotic-induced gene regulation in multiple brain regions., 175-187. Vol. 113, Iss. 1. Journal of Neurochemistry, 2010.
  • Girgenti, Matthew J., Hunsberger, Joshua, Duman, Catharine H., Sathyanesan, Monica, Terwilliger, Rose, and Sathyanesan, Samuel. Erythropoietin induction by electroconvulsive seizure, gene regulation, and antidepressant-like behavioral effects., 267-74. Vol. 66, Iss. 3. Biological Psychiatry, 2009.
  • Ren, Xueying, Zhou, Ligang, Terwilliger, Rosemarie, Sathyanesan, Samuel, and de Araujo, Ivan E.. Sweet taste signaling functions as a hypothalamic glucose sensor.. Vol. 3, Iss. 12. Frontiers in Integrative Neuroscience, 2009.
  • Duman, Catharine H., Schlesinger, Lee, Terwilliger, Rosemarie, Russell, David S., Sathyanesan, Samuel, and Duman, Ronald S.. Peripheral insulin-like growth factor-I produces antidepressant-like behavior and contributes to the effect of exercise., 366-371. Vol. 198, Iss. 2. Behavioural Brain Research, 2009.
  • Suda, Shiro, Segi-Nishida, Eri, Sathyanesan, Samuel, and Duman, Ronald S.. A postpartum model in rat: behavioral and gene expression changes induced by ovarian steroid deprivation., 311-319. Vol. 64, Iss. 4. Biological Psychiatry, 2008.
  • Lynch, Wendy J., Girgenti, Matthew J., Breslin, Florence J., Sathyanesan, Samuel, and Taylor, Jane R.. Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes., 166-177. Vol. 1213. Brain Research, 2008.
  • Tanis, Keith Q., Duman, Ronald S., and Sathyanesan, Samuel. CREB binding and activity in brain: regional specificity and induction by electroconvulsive seizure., 710-20. Vol. 63, Iss. 7. Biological Psychiatry, 2008.
  • Hunsberger, Joshua G., Sathyanesan, Samuel, Bennett, Alicia H., Duman, Catharine H., Russell, David S., Salton, Stephen R., and Duman, Ronald S.. Antidepressant actions of the exercise-regulated gene VGF., 1476-82. Vol. 13, Iss. 12. Nature Medicine, 2007.
  • Kang, Hyo J., Adams, David H., Simen, Arthur, Simen, Birgitte B., Rajkowska, Grazyna, Stockmeier, Craig A., Overholser, James C., Meltzer, Herbert Y., Jurjus, George J., Konick, Lisa C., Sathyanesan, Samuel, and Duman, Ronald S.. Gene expression profiling in postmortem prefrontal cortex of major depressive disorder., 13329-40. Vol. 27, Iss. 48. The Journal of Neuroscience, 2007.
  • Duman, Ronald S., and Sathyanesan, Samuel. Epigenetic marking and neuronal plasticity., 1-3. Vol. 62, Iss. 1. Biological Psychiatry, 2007.
  • Tanis, Keith Q., Sathyanesan, Samuel, and Duman, Ronald S.. Targeting neurotrophic/growth factor expression and signaling for antidepressant drug development., 151-60. Vol. 6, Iss. 2. CNS & Neurological Disorders - Drug Targets, 2007.
  • Girgenti, Matthew J., and Sathyanesan, Samuel. Customizing microarrays for neuroscience drug discovery., 1139-49. Vol. 2, Iss. 8. Expert Opinion on Drug Discovery, 2007.
  • Sathyanesan, Samuel, and Duman, Ronald S.. Neurogenic actions of atypical antipsychotic drugs and therapeutic implications., 715-25. Vol. 21, Iss. 9. CNS Drugs, 2007.
  • Ploski, Jonathan E., Sathyanesan, Samuel, and Duman, Ronald S.. Electroconvulsive seizure-induced gene expression profile of the hippocampus dentate gyrus granule cell layer., 1122-32. Vol. 99, Iss. 4. Journal of Neurochemistry, 2006.
  • Sathyanesan, Samuel, and Duman, Ronald S.. Chromatin remodeling: a novel mechanism of psychotropic drug action., 440-3. Vol. 70, Iss. 2. Molecular Pharmacology, 2006.
  • Sathyanesan, Samuel, Girgenti, Matthew J., Collier, Emily F., and Duman, Ronald S.. Electroconvulsive seizure increases adult hippocampal angiogenesis in rats., 819-28. Vol. 24, Iss. 3. European Journal of Neuroscience, 2006.
  • Sathyanesan, Samuel, Bennett, Alicia, and Duman, Ronald S.. Production of custom microarrays for neuroscience research., 238-46. Vol. 37, Iss. 3. Methods, 2005.
  • Sathyanesan, Samuel, and Duman, Ronald S.. Regulation of neurogenesis and angiogenesis in depression., 261-7. Vol. 1, Iss. 3. Current Neurovascular Research, 2004.
  • Sathyanesan, Samuel, Collier, Emily F., Hunsberger, Joshua, Adams, David, Terwilliger, Rosemarie, Selvanayagam, Emmanuel, and Duman, Ronald S.. Gene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factors., 10841-51. Vol. 23, Iss. 34. The Journal of Neuroscience, 2003.

Awards and Honors:

  • NARSAD Young Investigator Award, National Alliance for Research in Schizophrenia and Affective Disorders, 2003


  • Krupp, Kevin T., Yaeger, Jazmine D., Jones, Nathan T., Staton, Clarissa D., Summers, Tangi R., Newton, Samuel S., Summers, Cliff H.. Carbamoylated erythropoietin (cEPo) reduces anxiety during social interaction in the stress-alternatives model. Presented at the Society for Neuroscience 48th annual Meeting, San Diego, CA. (November 7, 2018)
  • Yaeger, Jazmine D., Staton, Clarissa D., Sathyanesan, Samuel, Summers, Cliff H.. Prior experience, an orexin 2 receptor agonist, and cEPo promote anxiolytic behaviors. Presented at the International Behavioral Neuroscience Society 27th annual meeting, Boca Raton, FL. (June 29, 2018)
  • Rajkowska, Grazyna, Mahajan, Gouri, Sathyanesan, Monica, Stockmeier, Craig, Sathyanesan, Samuel. Oligodendrocyte Morphometry and Expression of Myelin - Related mRNA in Ventral Prefrontal White Matter in Major Depressive Disorder. Presented at the ACNP 53rd Annual Meeting , Phoenix, Arizona. (December 7, 2014)
  • Sathyanesan, Samuel. Characterization of non-erythropoietic EPO towards neuropsychiatric drug development. Presented at the 4th Annual Sanford Health - USD Biomedical Research Symposium, Sanford Center, Sioux Falls. (May 16, 2013)