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Yi-Fan Li

Yi-Fan Li



Lee Medicine & Science Hall 145

Phone: (605) 658-6319


Teaching Interests:

Medical Physiology

Research Interests:

Neurohormonal regulation in cardiovascular diseases, aging, and diabetes


  • postdoctoral training, Physiology, University of Nebraska Medical Center, 2003
  • Ph D, Physiology, Beijing Medical University, 1996
  • MS, Physiology, Anhui College of Chinese Medicine, 1988
  • MD, Medicine, Chengde Medical College, 1981


  • UCHL1 mediates A Pro-arrhythmic Effect by Increasing Kv1.5 Protein Level in Atria in High Fat Diet mice, AHA


  • Cardiac sympathetic afferent reflex control of venous function, NIH. Grant Role: Co-Principal. (2017 - 2021)
  • Vagus nerve stimulation protects against cardiac diastolic dysfunction in aging. ARRA, NIH. Grant Role: Principal. (2009 - 2011)
  • Vagal stimulation prevents cardiac extracellular matrix remodeling and ventricular dysfunction, AHA. Grant Role: Principal. (2008 - 2012)


Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

  • Gao, H, Antony, R, Srinivasan, R, Wu, P, Wang, Xuejun, and Li, Yi-Fan. UCHL1 regulates oxidative activity in skeletal muscle., e0241716. Vol. 15, Iss. 11. PloS One, 2020. (DOI: 10.1371/journal.pone.0241716)
  • Gao, H, Freeling, Jessica, Wu, P, Liang, A P., Wang, Xuejun, and Li, Yi-Fan. UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle., 116699. Life sciences, 2019. (DOI: 10.1016/j.lfs.2019.116699)
  • Hartnett, Sigurd, Gao, Hongbo, Schnack, Sabrina, and Li, Yi-Fan. Reduced vagal control of the heart in high-fat diet mice: a potential role of increased butyrylcholinesterase. Vol. 3, Iss. 11. Physiological Reports, 2015.
  • Zhang, Fan, Hartnett, Sigurd, Sample, Alex, Schnack, Sabrina, and Li, Yi-Fan. Altered Atrial Activities and Potassium Channel Expression in High Fat Diet Fed Mice. Vol. 20, Iss. 10. Experimental & Clinical Cardiology, 2014.
  • Li, Shuai, Wang, Xuejun, Li, Yi-Fan, Kost, Curtis, and Martin, Douglas. Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats., 10. Vol. 30, Iss. 8. PLOS One, 2013. (DOI: 10.1371/journal.pone.0078564 )
  • Tian, Zongwen, Zheng, Hanqiao, Li, Jie, Li, Yi-Fan, Su, Huabo, and Wang, Xuejun. Genetically Induced Moderate Inhibition of the Proteasome in Cardiomyocytes Exacerbates Myocardial Ischemia-Reperfusion Injury in Mice, 532-542. Vol. 111, Iss. 5. Circulation Research, 2012. (DOI: 10.1161/CIRCRESAHA.112.270983)
  • Sharma, N M., Zheng, H, Li, Yi-Fan, and Patel, K P.. Nitric oxide inhibits the expression of AT1 receptors in neurons, C1162-73. Vol. 302, Iss. 8. Am J Physiol Cell Physiol, 2012. (DOI: 10.1152/ajpcell.00258.2011)
  • Zheng, Hong, Liu, Xuefei, Li, Yi-Fan, Sharma, Neeru M., and Patel, Kaushik P.. Gene Transfer of Neuronal Nitric Oxide Synthase to the Paraventricular Nucleus Reduces the Enhanced Glutamatergic Tone in Rats With Chronic Heart Failure, 966-973. Vol. 58. Hypertension, 2011. (DOI: 10.1161/HYPERTENSIONAHA.111.176222)
  • Sharma, Neeru M., Zheng, Hong, Mehta, Parmender P., Li, Yi-Fan, and Patel, Kaushik P.. Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure:role for CAPON and Ang II, 348-357. Vol. 92. Cardiovascular Research, 2011. (DOI: 10.1093/cvr/cvr217)
  • Li, Yi-Fan, and Wang, Xuejun. The Role of the proteasome in heart disease, 141-149. Vol. 1809, Iss. 2. Biochim Biophys Acta - Gene Regulatory Mechanisms , 2011. (DOI: 10.1016/j.bbagrm.2010.09.001)
  • Li, Yi-Fan. Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors., 14-19. Vol. 154. Autonomic Neuroscience: Basic and Clinical , 2010. (DOI: 10.1016/j.autneu.2009.09.023)
  • Zheng, H, and Li, Yi-Fan. Enhanced angiotensin-mediated excitation of renal sympathetic nerve activity within the paraventricular nucleus of anesthetized rats with heart failure., 1364-1374. Iss. 297. Am J Physiol Regul Integr Comp Physiol, 2009.
  • Li, Yi-Fan. Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses., 20-23. Iss. 462. Neurosci Lett, 2009.
  • Li, Yi-Fan, LaCroix, Carly, and Freeling, Jessica. Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses.. (DOI: 10.1016/j.neulet.2009.06.081)
  • Freeling, Jessica, and Li, Yi-Fan. Age-related attenuation of parasympathetic control of the heart in mice. Vol. 7, Iss. 3. International Journal of Physiology, Pathophysiology, and Pharmacology.


  • Wu, Penglong, Li, Yi-Fan, Liu, Jinbao, Wang, Xuejun. Post-MI Cardiac Remodeling and Malfunction in Mice Are Exacerbated by Cardiomyocyte-restricted Ablation of the Uchl1 Gene. Presented at the 2019 Experimental Biology meeting, Orlando, FL. (April 7, 2019)
  • Schnack, Sabrina, Gao, Hongbo, Wang, Hongmin, Li, Yi-Fan. . Alterations Of Growth And Metabolism Related Proteins In Skeletal Muscles Of Ubiquilin-1 Transgenic Mice. Presented at the Nebraska Physiological Society Annual Conference, Vermillion, SD. (October 2015)
  • Gao, Hongbo, Schnack, Sabrina, Allen, Jennifer, Li, Yi-Fan. Effect of Stimulation of ?2 Adrenergic Receptor on Glucose Uptake in Skeletal Muscles. Presented at the Nebraska Physiological Society Annual Conference, Vermillion, SD. (October 2015)
  • Allen, Jennifer, Gao, Hongbo, Schnack, Sabrina, Li, Yi-Fan. The Effect of UCHL1 on Glucose Uptake in Skeletal Muscles. Presented at the Nebraska Physiological Society Annual Conference, Vermillion, SD. (October 2015)
  • Li, Yi-Fan. Effect of stress on glucose uptake in skeletal muscles: Role of beta adrenergic Receptors. Presented at the Experimental Biology 2015, Boston, MA. (May 2015)
  • Hartnett, Sigurd, Li, Yi-Fan. Ubiquitin C-Terminal Hydrolase L1 regulates Choline Transporter. Presented at the Third Symposium on Ubiquitin Protein Quality Control and Molecular Pathogenesis, Deadwood, SD. (June 2014)
  • Martin, Douglas, Wang, Xuejun, Messenger, Ford, Hannah, Kjellsen, Barton, Li, Shuai. Angiotensin II activates the proteasome and stimulates vascular smooth muscle cell proliferation.. Presented at the Experimental Biology 2014, San Diego California. (April 2014)
  • Martin, Douglas, Li, Yi-Fan, Wang, Xuejun, Kost, Curtis, Shuai, Li. A proteasome inhibitor attenuates angiotensin II induced hypertension, associated vascular remodeling, and vascular smooth muscle cell proliferation. Presented at the Nebraska Physiological Society , Omaha, Nebraska. (October 2013)
  • Zhang, Fan, Li, Yi-Fan. ALTERED UBIQUITIN E3 LIGASE NEDD4-2, Kv1.5, AND Kv4.3 CHANNELS IN ATRIA. Presented at the NPS Annual Conference, Omaha, NE. (October 2013)
  • Hartnett, Sigurd, Li, Yi-Fan. The Role of UCHL1 in Modulating Choline Transporter Function. Presented at the Cardiovascular Forum-Louisville, Louisville, KY. (August 2013)
  • Solanki, Rajeshwari, Sample, Alex, Li, Yi-Fan. UBIQUITIN AND NOREPINEPHRINE TRANSPORTER: A PRELIMINARY STUDY. Presented at the Nebraska Physiological Society Conference, Wayne State College, Wayne, NE. (October 2012)
  • Li, Yi-Fan. Ubiquitination of Vesicular Acetylcholine Transporter. Presented at the Experimental Biology 2012, San Diego, CA. (April 2012)
  • Freeling, Jessica, Li, Yi-Fan. Attenuated Parasympathetic Nervous System Control of the Heart in the Aging Mouse. Presented at the NPS-IPS joint annual conference, Des Moines, IA. (October 2011)
  • Li, Yi-Fan. Ubiquitin C-terminal Hydrolase L1 and Parasympathetic Cholinergic Function. Presented at the USD PQCD symposium, Vermillion. (May 2011)
  • Li, Yi-Fan, Grandi, Max, Freeling, Jesseca. Effect of Stimulation of ?1 Adrenergic Receptors on Heart Rate. Presented at the Experimental Biology, Washington DC. (April 2011)
  • Freeling, Jessica, LaCroix, Carly, Grandi, Max, Li, Yi-Fan. Varenicline Induces Acetylcholine-dependent Bradycardic. Presented at the NPS annual conference, Omaha, NE. (September 2010)
  • Grandi, Max, LaCroix, Carly, Freeling, Jessica, Li, Yi-Fan. Mouse Atrial Preparation and Response to Varenicline. Presented at the SD BRIN/Discover Poster Session, Vermillion. (July 2010)
  • Schiernbeck, Cristal, Hutchinson, Katie, Freeling, Jessica, Li, Yi-Fan. Cholinergic Elements in Two Neuronal Cell Lines. Presented at the SD BRIN/U Discover Poster Session, Vermillion. (July 2010)
  • LaCroix, Carly, Freeling, Jesseca, Li, Yi-Fan. Bradycardic response induced by stimulation of alpha4beta2 nicotinic receptors. Presented at the Experimental Biology, Anaheim, CA. (April 2010)