Research in the Weimer Lab is focused on understanding the processes that control development of the cerebral cortex and how disruption in these processes leads to various neuropediatric diseases. Specifically, the team explores a number of mechanisms involved in neural stem cell proliferation, neuronal polarity, and axonal outgrowth and trafficking with the hope of advancing our knowledge of neurobiology and aiding in the future treatment of rare neural developmental disorders. This includes projects focused on Batten disease, cortical malformations, white matter disorders, neurofibromatosis, and Alzheimer's disease.