Nirmal Parajuli

Nirmal Parajuli

Research Assistant Professor

BASIC BIOMEDICAL SCIENCES

Lee Medicine & Science Hall 257

Phone: (605) 658-6347

Email: Nirmal.Parajuli@usd.edu

Research Interests:

My research interests are to understand the molecular mechanisms that involve protein quality control in cardiovascular biology.


Education:

  • Postdoctoral Fellow, Cardiovascular Biology, University of Alberta, 2017
  • Postdoctoral Fellow, Cardiovascular Biology, Johns Hopkins University, 2013
  • Ph D, Cardiovascular Biology, University of Giessen, 2010

Publications:

Citations listed below are presented in a standardized, modified format for display purposes only. They do not necessarily reflect the preferred style and conventions of the faculty member or discipline.

  • Parajuli, Nirmal, Takahara, S, Matsumura, N, Kim, T T., Ferdaoussi, M, Migglautsch, A K., Zechner, R, Breinbauer, R, Kershaw, E E., and Dyck JRB. Atglistatin ameliorates functional decline in heart failure via adipocyte-specific inhibition of adipose triglyceride lipase.. American journal of physiology. heart and circulatory physiology, 2018. (DOI: 10.1152/ajpheart.00308.2018)
  • Kim, T T., Parajuli, Nirmal, Sung, M M., Bairwa, S C., Levasseur, J, Soltys, C M., Wishart, D S., Madsen, K, Schertzer, J D., and Dyck JRB. Fecal transplant from resveratrol-fed donors improves glycaemia and cardiovascular features of the metabolic syndrome in mice.. American journal of physiology. endocrinology and metabolism, 2018. (DOI: 10.1152/ajpendo.00471.2017)
  • Matsumura, N, Zordoky, B N., Robertson, I M., Hamza, S M., Parajuli, Nirmal, Soltys, C M., Beker, D L., Grant, M K., Razzoli, M, Bartolomucci, A, and Dyck JRB. Co-administration of resveratrol with doxorubicin in young mice attenuates detrimental late-occurring cardiovascular changes.. Cardiovascular research, 2018. (DOI: 10.1093/cvr/cvy064)
  • Byrne, Nikole J., Parajuli, Nirmal, Levasseur, Jody L., Boisvenue, Jamie, Beker, Donna, Masson, Grant, Fedak, Paul W., Verma, Subodh, and Dyck, Jason R.. Empagliflozin prevents worsening of cardiac function in an experimental model of pressure overload-induced heart failure, 142. JACC: basic to translational science, 2017. (DOI: 10.1016/j.jacbts.2017.07.003)
  • Pate, Vaibhav B., Mori, Jun, McLean, Brent A., Basu, Ratnadeep, Das, Subhash K., Ramprasath, Tharmarajan, Parajuli, Nirmal, Penninger, Josef M., Grant, Maria B., Lopaschuk, Gary D., and Oudit, Gavin Y.. ACE2 deficiency worsens epicardial adipose tissue inflammation and cardiac dysfunction in response to diet-induced obesity, 85-95. Vol. 65, Iss. 1. Diabetes, 2016. (DOI: 10.2337/db15-0399)
  • Hsu, Ying-Han R., Yogasundaram, Haran, Parajuli, Nirmal, Valtuille, Lucas, Sergi, Consolato, and Oudit, Gavin Y.. MELAS syndrome and cardiomyopathy: linking mitochondrial function to heart failure pathogenesis, 103-116. Vol. 21, Iss. 1. Heart Fail Rev, 2016. (DOI: 10.1007/s10741-015-9524-5)
  • Parajuli, Nirmal, Bairwa, S, Kershaw, EE, and Dyck, JR. The effects of adipocyte-specific adipose triglyceride lipase deletion on cardiac function. Vol. 32, Iss. 10. Canadian journal of cardiology, 2016.
  • Bairwa, Suresh C., Parajuli, Nirmal, and Dyck, Jason R. B.. The role of AMPK in cardiomyocyte health and survival, 2199-2210. Vol. 1862, Iss. 12. Biochim Biophys Acta, 2016. (DOI: 10.1016/j.bbadis.2016.07.001)
  • *Seimetz, Michael, *Parajuli, Nirmal, Pichl, Alexandra, Bednorz, Mariola, Ghofrani, Hossein A., Schermuly, Ralph T., Seeger, Werner, Grimminger, Friedrich, and Weissmann, Norbert. Cigarette smoke-induced emphysema and pulmonary hypertension can be prevented by phosphodiesterase 4 and 5 inhibition in mice. Vol. 10, Iss. 6. PLOS ONE, 2015. (DOI: 10.1371/journal.pone.0129327 * Equal contribution)
  • Parajuli, Nirmal, Valtuille, Lucas, Basu, Ratnadeep, Famulski, Konrad S., Halloran, Philip F., Sergi, Consolato, and Oudit, Gavin Y.. Determinants of ventricular arrhythmias in human explanted hearts with dilated cardiomyopathy, 1286-1296. Vol. 45, Iss. 12. Eur J Clin Invest., 2015. (DOI: 10.1111/eci.12549)
  • Das, Subhash K., Wang, Wang, Zhabyeyev, Pavel, Basu, Ratnadeep, McLean, Brent, Fan, Dong, Parajuli, Nirmal, DesAulniers, Jessica, Patel, Vaibhav B., Hajjar, Roger J., Dyck, Jason R. B., Kassiri, Zamaneh, and Oudit, Gavin Y.. Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy. Vol. 5. Scientific reports , 2015. (DOI: 10.1038/srep18132)
  • McLean, Brent A., Zhabyeyev, Pavel, Patel, Vaibhav B., Basu, Ratnadeep, Parajuli, Nirmal, DesAulniers, Jessica, Murray, Allan G., Kassiri, Zamaneh, Vanhaesebroeck, Bart, and Oudit, Gavin Y.. PI3K alpha is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart, 292-303. Vol. 105, Iss. 3. Cardiovascular research, 2015. (DOI: 10.1093/cvr/cvv016)
  • Parajuli, Nirmal, Ramprasath, Tharmarajan, Zhabyeyev, Pavel, Patel, Vaibhav B., and Oudit, Gavin Y.. The role of neurohumoral activation in cardiac fibrosis and heart failure. In Cardiac Fibrosis and Heart Failure: Cause or Effect?, 347--381. Springer, Cham, 2015. (DOI: 10.1007/978-3-319-17437-2)
  • Patel, Vaibhav B., Clarke, Nicola, Wang, Zuocheng, Fan, Dong, Parajuli, Nirmal, Basu, Ratnadeep, Putko, Brendan, Kassiri, Zamaneh, Turner, Anthony J., and Oudit, Gavin Y.. Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS, 167-176. Vol. 66. Journal of molecular and cellular cardiology, 2014. (DOI: 10.1016/j.yjmcc.2013.11.017)
  • Patel, Vaibhav B., Zhong, Jiu-Chang, Fan, Dong, Basu, Ratnadeep, Morton, Jude S., Parajuli, Nirmal, McMurtry, Michael S., Davidge, Sandra T., Kassiri, Zamaneh, and Oudit, Gavin Y.. Angiotensin-converting enzyme 2 is a critical determinant of angiotensin ii-induced loss of vascular smooth muscle cells and adverse vascular remodeling, 157-164. Vol. 64, Iss. 1. Hypertension, 2014. (DOI: 10.1161/HYPERTENSIONAHA.114.03388)
  • Valtuille, Lucas, Parajuli, Nirmal, Famulski, Konrad S., Halloran, Philip F., Consolato, Sergi, and Oudit, Gavin Y.. Determinants of Vt occurrence in patients with nonischemic and dilated cardiomyopathy: insights from the study of explanted human hearts. Vol. 130. Circulation, 2014.
  • Lee, Jiwon, Shen, Mengcheng, Parajuli, Nirmal, Oudit, Gavin Y., McMurtry, Michael S., and Kassiri, Zamaneh. Gender-dependent aortic remodelling in patients with bicuspid aortic valve-associated thoracic aortic aneurysm, 939-949. Vol. 92, Iss. 9. Journal of molecular medicine, 2014. (DOI: 10.1007/s00109-014-1178-6)
  • Wang, Wang, Patel, Vaibhav B., Parajuli, Nirmal, Fan, Dong, Basu, Ratnadeep, Wang, Zuocheng, Ramprasath, Tharmarajan, Kassiri, Zamaneh, Penninger, Josef M., and Oudit, Gavin Y.. Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease, 847-858. Vol. 92, Iss. 8. Journal of molecular medicine, 2014. (DOI: 10.1007/s00109-014-1149-y)
  • Parajuli, Nirmal, Basu, Ratnadeep, Famulski, Konrad S., Nagendran, Jayan, Kim, Daniel H., Mullen, John C., Buchholz, Holger, Halloran, Philip F., and Oudit, Gavin Y.. Left ventricular assist device normalizes multiple pathogenic pathways in both the left and right ventricle in patients with dilated cardiomyopathy. Vol. 130. Circulation, 2014.
  • Parajuli, Nirmal, Patel, Vaibhav B., Wang, Wang, Basu, Ratnadeep, and Oudit, Gavin Y.. Loss of NOX2 (gp91(phox)) prevents oxidative stress and progression to advanced heart failure, 331-340. Vol. 127, Iss. 5-6. Clinical science, 2014. (DOI: 10.1042/CS20130787)
  • Esfandiary, A, Sommer, N, Pak, O, Kressig, F, Parajuli, Nirmal, Malczyk, M, Grimminger, F, Ghofrani, AH, Seeger, W, Schermuly, RT, and others. Mitochondria and metabolic dysfunction in pulmonary hypertension: the role of mitochondrial uncoupling protein 2 in hypoxia-induced pulmonary hypertension, 1. Vol. 189. Am J Respir Crit Care Med, 2014.
  • Takawale, Abhijit, Fan, Dong, Basu, Ratnadeep, Shen, Mengcheng, Parajuli, Nirmal, Wang, Wang, Wang, Xiuhua, Oudit, Gavin Y., and Kassiri, Zamaneh. Myocardial recovery from ischemia-reperfusion is compromised in the absence of tissue inhibitor of metalloproteinase 4, 652-U198. Vol. 7, Iss. 4. Circulation -heart failure, 2014. (DOI: 10.1161/CIRCHEARTFAILURE.114.001113)
  • Seimetz, Michael, Parajuli, Nirmal, Pichl, Alexandra, Schermuly, Ralph T., Grimminger, Friedrich, Seeger, Werner, Ghofrani, Hossein A., and Weissmann, Norbert. Phosphodiesterase inhibitors as promising therapies for cigarette smoke-induced emphysema and pulmonary hypertension (PH) in mice. Vol. 44. European respiratory journal, 2014.
  • Das, Subhash K., Wang, Wang, Zhabyeyev, Pavel, McLean, Brent A., Fan, Dong, Basu, Ratnadeep, Parajuli, Nirmal, Kassiri, Zamaneh, Dyck, Jason R., Najjar, Roger J., Andrews, Nancy C., and Oudit, Gavin Y.. Resveratrol prevents iron-overload cardiomyopathy by up regulating serca2a and by exerting anti-oxidant effects. Vol. 130. Circulation, 2014.
  • Patel, Vaibhav B., Parajuli, Nirmal, and Oudit, Gavin Y.. Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications, 471-482. Vol. 126, Iss. 7-8. Clinical science, 2014. (DOI: 10.1042/CS20130344)
  • *Weissmann, Norbert, *Lobo, Borja, *Pichl, Alexandra, *Parajuli, Nirmal, Seimetz, Michael, Puig-Pey, Raquel, Ferrer, Elisabet, Peinado, Victor I., Dominguez-Fandos, David, Fysikopoulos, Athanasios, Stasch, Johannes-Peter, Ghofrani, Hossein A., Coll-Bonfill, Nuria, Frey, Reiner, Schermuly, Ralph T., Garcia-Lucio, Jessica, Blanco, Isabel, Bednorz, Mariola, Tura-Ceide, Olga, Tadele, Elsa, Brandes, Ralf P., Grimminger, Jan, Klepetko, Walter, Jaksch, Peter, Rodriguez-Roisin, Robert, Seeger, Werner, Grimminger, Friedrich, and Barbera, Joan A.. Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema, 1359-1373. Vol. 189, Iss. 11. Am J Respir Crit Care Med, 2014. (DOI: 10.1164/rccm.201311-2037OC * Equal contribution)
  • Parajuli, Nirmal, Ramprasath, Tharmarajan, Patel, Vaibhav B., Wang, Wang, Putko, Brendan, Mori, Jun, and Oudit, Gavin Y.. Targeting angiotensin-converting enzyme 2 as a new therapeutic target for cardiovascular diseases, 558-565. Vol. 92, Iss. 7. Canadian journal of physiology and pharmacology, 2014. (DOI: 10.1139/cjpp-2013-0488)
  • Patel, VB, Clarke, NE, Wang, Zhenqiang, Putko, B, Parajuli, Nirmal, Lo, J, Turner, AJ, and Oudit, GY. Angiotensin II induced proteolytic cleavage of angiotensin Converting Enzyme 2 Is Mediated Via the Tnf-Alpha Converting Enzyme (TACE/ADAM-17): A Positive feedback mechanism in the renin angiotensin system, S115. Vol. 29, Iss. 10. Canadian journal of cardiology, 2013.
  • Pichl, Alexandra, Parajuli, Nirmal, Seimetz, Michael, Fysikopoulos, Athanasios, Haag, Daniela, Reiter, Rudolf, Grimminger, Jan, Seeger, Werner, Schermuly, Ralph T., Grimminger, Friedrich, and others. A possible role of serotonin for the development of tobacco-smoke induced lung emphysema and pulmonary hypertension, A2275--A2275. American Thoracic Society, 2012.
  • Sarkar, Kakali, Cai, Zheqing, Gupta, Rigu, Parajuli, Nirmal, Fox-Talbot, Karen, Darshan, Medha S., Gonzalez, Frank J., and Semenza, Gregg L.. Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning, 10504-10509. Vol. 109, Iss. 26. Proceedings of the National Academy of Sciences of the United States of America, 2012. (DOI: 10.1073/pnas.1208314109)
  • Parajuli, Nirmal, Yuan, Yuan, Zheng, Xiaoxu, Bedja, Djahida, and Cai, Zheqing P.. Phosphatase PTEN is critically involved in post-myocardial infarction remodeling through the Akt/interleukin-10 signaling pathway. Vol. 107, Iss. 2. Basic research in cardiology, 2012. (DOI: 10.1007/s00395-012-0248-6)
  • Seimetz, Michael, Parajuli, Nirmal, Pichl, Alexandra, Stasch, Johannes-Peter, Frey, Reiner, Schermuly, Ralph T., Seeger, Werner, Grimminger, Friedrich, Ghofrani, Hossein A., and Weissmann, Norbert. Prevention of cigarette smoke-induced pulmonary hypertension by the soluble guanylate cyclase stimulator riociguat, A3416--A3416. American Thoracic Society, 2012.
  • Cai, Zheqing P., Parajuli, Nirmal, Zheng, Xiaoxu, and Becker, Lewis. Remote ischemic preconditioning confers late protection against myocardial ischemia-reperfusion injury in mice by upregulating interleukin-10. Vol. 107, Iss. 4. Basic research in cardiology, 2012. (DOI: 10.1007/s00395-012-0277-1)
  • Pichl, A, Parajuli, Nirmal, Seimetz, M, Stasch, JP, Frey, R, Schermuly, RT, Seeger, W, Grimminger, F, Ghofrani, HA, and Weissmann, N. Stimulation of soluble guanylate cyclase by riociguat prevents tobacco smoke-induced pulmonary hypertension in mice. Vol. 66, Iss. 06. Pneumologie, 2012.
  • Seimetz, Michael, Parajuli, Nirmal, Pichl, Alexandra, Stasch, Johannes-Peter, Frey, Reiner, Schermuly, Ralph T., Ghofrani, Hossein A., Seeger, Werner, Grimminger, Friedrich, and Weissmann, Norbert. Effects of the soluble guanylate cyclase stimulator riociguat on emphysema development in tobacco-smoke exposed mice, A3107--A3107. American Thoracic Society, 2011.
  • *Seimetz, Michael, *Parajuli, Nirmal, Pichl, Alexandra, Veit, Florian, Kwapiszewska, Grazyna, Weisel, Friederike C., Milger, Katrin, Egemnazarov, Bakytbek, Turowska, Agnieszka, Fuchs, Beate, Nikam, Sandeep, Roth, Markus, Sydykov, Akylbek, Medebach, Thomas, Klepetko, Walter, Jaksch, Peter, Dumitrascu, Rio, Garn, Holger, Voswinckel, Robert, Kostin, Sawa, Seeger, Werner, Schermuly, Ralph T., Grimminger, Friedrich, Ghofrani, Hossein A., and Weissmann, Norbert. Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice, 293-305. Vol. 147, Iss. 2. Cell, 2011. (DOI: 10.1016/j.cell.2011.08.035 * Equal contribution)
  • Zu, Lingyun, Zheng, Xiaoxu, Wang, Bing, Parajuli, Nirmal, Steenbergen, Charles, Becker, Lewis C., and Cai, Zheqing P.. Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by ischemia-reperfusion, H2177-H2186. Vol. 300, Iss. 6. American Journal of Physiology-Heart and Circulatory Physiology, 2011. (DOI: 10.1152/ajpheart.01138.2010)
  • Wempe, Frank, De-Zolt, Silke, Koli, Katri, Bangsow, Thorsten, Parajuli, Nirmal, Dumitrascu, Rio, Sterner-Kock, Anja, Weissmann, Norbert, Keski-Oja, Jorma, and von Melchner, Harald. Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD, 246-253. Vol. 3, Iss. 3-4. Disease models & mechanisms, 2010. (DOI: 10.1242/dmm.004234)
  • Roth, Markus, Rupp, Markus, Hofmann, Simone, Mittal, Manish, Fuchs, Beate, Sommer, Natascha, Parajuli, Nirmal, Quanz, Karin, Schubert, Dominic, Dony, Eva, Schermuly, Ralph T., Ghofrani, Hossein A., Sausbier, Ulrike, Rutschmann, Katrin, Wilhelm, Sarah, Seeger, Werner, Ruth, Peter, Grimminger, Friedrich, Sausbier, Matthias, and Weissmann, Norbert. Heme oxygenase-2 and large-conductance Ca(2+)-activated K(+) channels lung vascular effects of hypoxia, 353-364. Vol. 180, Iss. 4. Am J Respir Crit Care Med, 2009. (DOI: 10.1164/rccm.200806-848OC)
  • Parajuli, Nirmal, Seimetz, M, Roth, M, Fuchs, B, Schermuly, R, Ghofrani, H, Schudt, C, Hesslinger, C, Seeger, W, Grimminger, F, and others. Alveolar remodeling in a mouse model of chronic tobacco smoke inhalation. Vol. 62. Pneumologie, 2008.
  • Gurung, Y B., Parajuli, Nirmal, Miyazaki, Y, Imai, S, and Kobayashi, K. Rumen ciliate faunae of water buffalo (Bubalus bubalis) and goat (Capra hircus) in Nepal., 265-7. Vol. 64, Iss. 3. The Journal of veterinary medical science, 2002.