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USD research on vitamin C coated stents is recognized by American Chemical Society

VERMILLION, S.D. -- University of South Dakota researchers Eagappanath Thiruppathi and Gopinath Mani are working on a technique to lower the risks of blood clots in arteries implanted with stents.

Thiruppathi, a Ph.D. student, and Mani, Ph.D., an assistant professor of biomedical engineering, have developed a way to coat stents with vitamin C to function more efficiently for preventing blood clots in stented arteries. The American Chemical Society (ACS) is touting this research by showcasing the article published recently in the ACS journal Langmuir. The article was the topic of a press release that was included in the ACS Office of Public Affairs’ Weekly PressPac, which contains reports of research selected from more than 40 peer-reviewed ACS journals. This service provides leads on the latest advances in science and their impact on the business word. The ACS press release on this research is available at

Previous studies have shown that vitamin C is a possible alternative or addition to drugs currently used to coat stents, which are little mesh tubes inserted into blood vessels to prop them open. Today’s stents are an improvement from their initial launch as they are coated with pharmaceuticals that can prevent the affected arteries from reclogging.

According to ACS, about 10,000 to 50,000 people who receive these drug-eluting stents develop “late stent thrombosis” (LST), a potentially fatal complication that happens when clots form and clog the arteries. Drugs used on the stents are helpful in most cases but they might be responsible for causing problems in others, according to Thiruppathi and Mani who set out to find a way to address LST using vitamin C. They discovered that the method of coating a common stent material with vitamin C could have lasting benefits to the patient as the stent would slowly release vitamin C over time. The USD researchers concluded that this technique could be useful for making stents and other implantable medical devices safer. More information about Thiruppathi’s and Mani’s research is available online at


Founded in 1862 and the first university in the Dakotas, the University of South Dakota is the only public liberal arts university in the state, with 202 undergraduate and 78 graduate programs in the College of Arts & Sciences, School of Education, Knudson School of Law, Sanford School of Medicine, School of Health Sciences, Beacom School of Business and College of Fine Arts. With an enrollment of nearly 10,000 students and more than 400 faculty, USD has a 16:1 student/faculty ratio, and it ranks among the best in academics and affordability. USD’s 18 athletic programs compete at the NCAA Division I level.

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Hanna DeLange
USD News