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USD's materials research includes work in biomedical engineering, chemistry, and physics. USD researchers collaborate with industry professionals to bring new technologies to market as well as carrying out fundamental research in order to elucidate physical processes, improve human health, and protect the environment.

This research has resulted in antimicrobial materials for protective clothing, medical and dental devices and sanitized surfaces; drug-eluting stents for the successful treatment of coronary artery disease; engineered tissues to repair damaged joints; cost-effective solar energy alternatives; remediation of pollutants in air or water; and the development of high purity, detector-grade germanium crystals to search for new forms of energy.

Key research strengths and facilities include: