The principal investigator for the grant is X.J. Wang, M.D., Ph.D., professor of basic biomedical sciences and the director of the M.D./Ph.D. program in the medical school. The grant will provide $358,750 annually from the National Institutes of Health. Dr. Wang has received the grant every year since 2002. It was recently renewed for a five-year period from April 1, 2009 through March 31, 2014.

The title of Dr. Wang's grant is "Molecular Pathogenesis of Protein Surplus Cardiomyopathy." Other medical school investigators who are participating in the project include Drs. Doug Martin, Curt Kost and Huabo Su. "Despite recent advances in its clinical management, congestive heart failure remains the leading cause of death in the US," Dr. Wang said. "This research will help deepen our understanding on the molecular mechanisms underlying the progression of various heart diseases to congestive heart failure, which will ultimately facilitate the search for new measures to prevent or more effectively treat this common and yet life-threatening disorder."

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