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As of July 1, IRB applications are submitted through Cayuse IRB, the new online submission system. Please see the instructions and guidance below. The system provides guidance to new users, however, office staff is available if you need assistance. Contact the IRB office at 605-658-3743 or to ask questions or schedule a training.

Office Staff

Linda Rupp
IRB Coordinator, 605-658-3743

Jackie Stelling, M.B.A.
Reviewer, 605-658-3763

Ann Waterbury, M.B.A., C.I.M.
Director, 605-658-3767


If you are unsure if your study requires IRB review, please submit a determination application. Follow the below steps for “New Protocol.”

New Protocol

  • New users, request an account.
  • Existing users, login to Cayuse
  • For USD affiliates, the username is your full USD email address and associated password.
  • Click on Cayuse IRB.
  • Short, helpful tutorials for how to use Cayuse IRB can be accessed by clicking on “Menu” then “Help.”


CITI Training

All researchers must be CITI trained. Please login to CITI and take one of the following two courses, every three years:

  • GRP 1 Biomedical Research Investigators and Key Personnel, Basic Course.
  • GRP 2 Social Behavioral Research for Investigators and Key Personnel, Basic Course.

Training FAQ

CITI Training Registration Guide

Existing Protocols

Applications submitted in A-Tune or by email may be amended, continued, or closed by emailing a completed form to